JP2014518287A5 - - Google Patents

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JP2014518287A5
JP2014518287A5 JP2014519578A JP2014519578A JP2014518287A5 JP 2014518287 A5 JP2014518287 A5 JP 2014518287A5 JP 2014519578 A JP2014519578 A JP 2014519578A JP 2014519578 A JP2014519578 A JP 2014519578A JP 2014518287 A5 JP2014518287 A5 JP 2014518287A5
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JP2014519578A
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JP5876150B2 (ja
JP2014518287A (ja
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Priority claimed from PCT/EP2012/063852 external-priority patent/WO2013010964A1/en
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別の実施態様において、式 (I)の化合物からの式(II)の化合物又は式 (II’) の化合物の調製（例えば、解離による）は好適な溶媒又は溶媒の混合物の存在下で行なわれる。例えば、このような反応溶媒は極性溶媒もしくは極性溶媒の混合物又は極性溶媒系、例えば、水又は水性媒体である。別の実施態様において、このような反応は溶媒を含まない媒体中で行なわれる。更なる実施態様において、式(II)又は式 (II’) の化合物は好適な溶媒又は溶媒の混合物から単離され、又は得られる。
上記調製の方法は好適な溶媒、又は溶媒の混合物中で行なわれてもよい。こうして得られる、式 (I)、(II)又は (II’) の化合物、或いはそれらの塩はそれ自体通例の様式でこのような溶媒又は溶媒の混合物から単離されてもよい（例えば、結晶形態又は非晶質の形態で）。必要により、式 (I)、(II)又は (II’) の化合物、或いはそれらの塩の精製、クロマトグラフィー分離、スラリー化、懸濁、溶解、結晶化、沈澱（例えば、非溶媒、逆溶媒又は貧溶媒による）、濾過、洗浄、凍結乾燥等は、例えば、一種以上の好適な溶媒又は溶媒の混合物の存在下で行なわれてもよい。続いて、必要により、溶媒又は溶媒の混合物が除去されてもよく（例えば、蒸発されてもよく）、又は、例えば、式 (I)、(II)又は (II’) の化合物、或いはこれらの塩を、例えば、単離形態、純粋な形態、沈澱形態、固体（例えば、結晶性又は非晶質の）形態、凍結乾燥形態等の形態で得るために固体物質が集められてもよく、又は単離されてもよい。このような工程は、必要により、一層低い温度、周囲温度又は高温で行なわれてもよい。必要により、このような操作は繰り返されてもよく、かつ／又は得られた物質に別途適用されてもよい。更に必要により、このような操作は以上の一つ以上の調製工程とは独立に、又は依存して行なわれてもよい。更に必要により、得られた物質が乾燥されてもよい（例えば、高温で）。実施態様において、その物質が噴霧乾燥、凍結乾燥又はドラム乾燥されてもよい。更なる実施態様において、その物質が単離形態、沈澱形態、結晶化形態、凍結乾燥形態、非晶質の形態又は固体形態であってもよい。別の実施態様において、その物質が溶液形態又は懸濁形態であってもよい。更に別の実施態様において、その物質が塩形態又は遊離形態であってもよい。更に別の実施態様において、その物質が粗形態又は精製形態であってもよい。
JP2014519578A 2011-07-15 2012-07-13 置換キナゾリン、これらの調製及び医薬組成物中のこれらの使用 Active JP5876150B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11174266 2011-07-15
EP11174266.4 2011-07-15
EP12170055.3 2012-05-30
EP12170055 2012-05-30
PCT/EP2012/063852 WO2013010964A1 (en) 2011-07-15 2012-07-13 Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions

Publications (3)

Publication Number Publication Date
JP2014518287A JP2014518287A (ja) 2014-07-28
JP2014518287A5 true JP2014518287A5 (ja) 2015-03-26
JP5876150B2 JP5876150B2 (ja) 2016-03-02

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ID=46506460

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JP2014519578A Active JP5876150B2 (ja) 2011-07-15 2012-07-13 置換キナゾリン、これらの調製及び医薬組成物中のこれらの使用

Country Status (17)

Country Link
US (3) US8962636B2 (ja)
EP (2) EP3517539B1 (ja)
JP (1) JP5876150B2 (ja)
KR (2) KR20190062621A (ja)
CN (1) CN103781788B (ja)
AU (1) AU2012285904C1 (ja)
BR (1) BR112014000938A2 (ja)
CA (1) CA2841552C (ja)
CL (1) CL2014000076A1 (ja)
DK (2) DK2731947T3 (ja)
EA (1) EA030121B1 (ja)
ES (2) ES2713566T3 (ja)
HU (2) HUE061596T2 (ja)
MX (1) MX366629B (ja)
NZ (1) NZ618698A (ja)
PL (2) PL2731947T3 (ja)
WO (1) WO2013010964A1 (ja)

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