JP2014511361A5 - - Google Patents
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- JP2014511361A5 JP2014511361A5 JP2013550891A JP2013550891A JP2014511361A5 JP 2014511361 A5 JP2014511361 A5 JP 2014511361A5 JP 2013550891 A JP2013550891 A JP 2013550891A JP 2013550891 A JP2013550891 A JP 2013550891A JP 2014511361 A5 JP2014511361 A5 JP 2014511361A5
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- Prior art keywords
- antigen
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- binding fragment
- pharmaceutical composition
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- Prior art date
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- 239000000427 antigen Substances 0.000 claims 33
- 102000036639 antigens Human genes 0.000 claims 33
- 108091007433 antigens Proteins 0.000 claims 33
- 239000012634 fragment Substances 0.000 claims 33
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 25
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 12
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 11
- 238000008214 LDL Cholesterol Methods 0.000 claims 10
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims 9
- 238000002347 injection Methods 0.000 claims 7
- 239000007924 injection Substances 0.000 claims 7
- 239000000243 solution Substances 0.000 claims 7
- 102000006991 Apolipoprotein B-100 Human genes 0.000 claims 6
- 108010008150 Apolipoprotein B-100 Proteins 0.000 claims 6
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 6
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 4
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 4
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 206010003211 Arteriosclerosis coronary artery Diseases 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 208000032928 Dyslipidaemia Diseases 0.000 claims 3
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 3
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 claims 3
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 3
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 201000001386 familial hypercholesterolemia Diseases 0.000 claims 3
- 208000019622 heart disease Diseases 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 102000018616 Apolipoproteins B Human genes 0.000 claims 2
- 108010027006 Apolipoproteins B Proteins 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 108010023302 HDL Cholesterol Proteins 0.000 claims 2
- 108010028554 LDL Cholesterol Proteins 0.000 claims 2
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 2
- 239000012669 liquid formulation Substances 0.000 claims 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229940071643 prefilled syringe Drugs 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305089A EP2481758A1 (en) | 2011-01-28 | 2011-01-28 | Human antibodies to PSCK9 for use in methods of treating particular groups of subjects (11566) |
| EP11305088.4A EP2650016A1 (en) | 2011-01-28 | 2011-01-28 | Human antibodies to PSCK9 for use in methods of treatment based on particular dosage regimens (11565) |
| EP11305089.2 | 2011-01-28 | ||
| EP11305088.4 | 2011-01-28 | ||
| EP11305514 | 2011-04-29 | ||
| EP11305513 | 2011-04-29 | ||
| EP11305513.1 | 2011-04-29 | ||
| EP11305514.9 | 2011-04-29 | ||
| EP11306040 | 2011-08-12 | ||
| EP11306039.6 | 2011-08-12 | ||
| EP11306039 | 2011-08-12 | ||
| EP11306040.4 | 2011-08-12 | ||
| EP11306202 | 2011-09-22 | ||
| EP11306202.0 | 2011-09-22 | ||
| EP11306201.2 | 2011-09-22 | ||
| EP11306201 | 2011-09-22 | ||
| EP11306449.7 | 2011-11-08 | ||
| EP11306450.5 | 2011-11-08 | ||
| EP11306449 | 2011-11-08 | ||
| EP11306450 | 2011-11-08 | ||
| PCT/EP2012/051320 WO2012101252A2 (en) | 2011-01-28 | 2012-01-27 | Human antibodies to pcsk9 for use in methods of treating particular groups of subjects |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000849A Division JP2017095490A (ja) | 2011-01-28 | 2017-01-06 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511361A JP2014511361A (ja) | 2014-05-15 |
| JP2014511361A5 true JP2014511361A5 (enExample) | 2015-03-19 |
| JP6375113B2 JP6375113B2 (ja) | 2018-08-15 |
Family
ID=45529125
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550892A Pending JP2014508142A (ja) | 2011-01-28 | 2012-01-27 | Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物 |
| JP2013550891A Active JP6375113B2 (ja) | 2011-01-28 | 2012-01-27 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2017000850A Pending JP2017095491A (ja) | 2011-01-28 | 2017-01-06 | Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物 |
| JP2017000849A Pending JP2017095490A (ja) | 2011-01-28 | 2017-01-06 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2018168406A Active JP6730388B2 (ja) | 2011-01-28 | 2018-09-10 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2020114604A Active JP7140800B2 (ja) | 2011-01-28 | 2020-07-02 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2022116860A Pending JP2022141869A (ja) | 2011-01-28 | 2022-07-22 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2024112158A Pending JP2024138473A (ja) | 2011-01-28 | 2024-07-12 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550892A Pending JP2014508142A (ja) | 2011-01-28 | 2012-01-27 | Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000850A Pending JP2017095491A (ja) | 2011-01-28 | 2017-01-06 | Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物 |
| JP2017000849A Pending JP2017095490A (ja) | 2011-01-28 | 2017-01-06 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2018168406A Active JP6730388B2 (ja) | 2011-01-28 | 2018-09-10 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2020114604A Active JP7140800B2 (ja) | 2011-01-28 | 2020-07-02 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2022116860A Pending JP2022141869A (ja) | 2011-01-28 | 2022-07-22 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
| JP2024112158A Pending JP2024138473A (ja) | 2011-01-28 | 2024-07-12 | 被験者の特定のグループを処置する方法において使用するためのｐｃｓｋ９に対するヒト抗体 |
Country Status (37)
Families Citing this family (144)
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| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
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