JP2011524903A5 - - Google Patents
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- JP2011524903A5 JP2011524903A5 JP2011514598A JP2011514598A JP2011524903A5 JP 2011524903 A5 JP2011524903 A5 JP 2011524903A5 JP 2011514598 A JP2011514598 A JP 2011514598A JP 2011514598 A JP2011514598 A JP 2011514598A JP 2011524903 A5 JP2011524903 A5 JP 2011524903A5
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 14
- 239000000945 filler Substances 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- 239000000872 buffer Substances 0.000 claims 8
- 239000001509 sodium citrate Substances 0.000 claims 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 8
- 239000000314 lubricant Substances 0.000 claims 7
- 239000004067 bulking agent Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000006172 buffering agent Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 239000008176 lyophilized powder Substances 0.000 claims 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 3
- 229920003109 sodium starch glycolate Polymers 0.000 claims 3
- 229940079832 sodium starch glycolate Drugs 0.000 claims 3
- 239000008109 sodium starch glycolate Substances 0.000 claims 3
- 239000000454 talc Substances 0.000 claims 3
- 229910052623 talc Inorganic materials 0.000 claims 3
- 239000008181 tonicity modifier Substances 0.000 claims 3
- -1 2,5-dichlorophenyl Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000003021 water soluble solvent Substances 0.000 claims 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229940049654 glyceryl behenate Drugs 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 235000019814 powdered cellulose Nutrition 0.000 claims 1
- 229920003124 powdered cellulose Polymers 0.000 claims 1
- 229920003133 pregelled starch Polymers 0.000 claims 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 229940032147 starch Drugs 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000008215 water for injection Substances 0.000 claims 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims 1
- 0 CC(C)(C(C(*)NC(C)(C)P)=O)NC(*)C(NCBOC(CC(O)=O)(CC(O)=O)C(O)=O)=O Chemical compound CC(C)(C(C(*)NC(C)(C)P)=O)NC(*)C(NCBOC(CC(O)=O)(CC(O)=O)C(O)=O)=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13224408P | 2008-06-17 | 2008-06-17 | |
| US61/132,244 | 2008-06-17 | ||
| US21149909P | 2009-03-31 | 2009-03-31 | |
| US61/211,499 | 2009-03-31 | ||
| PCT/US2009/003602 WO2009154737A1 (en) | 2008-06-17 | 2009-06-16 | Boronate ester compounds and pharmaceutical compositions thereof |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014103397A Division JP5926319B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103396A Division JP6110813B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103398A Division JP2014169317A (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103395A Division JP6010066B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524903A JP2011524903A (ja) | 2011-09-08 |
| JP2011524903A5 true JP2011524903A5 (enExample) | 2012-08-02 |
| JP5566380B2 JP5566380B2 (ja) | 2014-08-06 |
Family
ID=41061278
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514598A Active JP5566380B2 (ja) | 2008-06-17 | 2009-06-16 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103397A Active JP5926319B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103396A Active JP6110813B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103395A Active JP6010066B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103398A Withdrawn JP2014169317A (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2017128843A Withdrawn JP2017214396A (ja) | 2008-06-17 | 2017-06-30 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2019216272A Withdrawn JP2020055829A (ja) | 2008-06-17 | 2019-11-29 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2021109909A Withdrawn JP2021165288A (ja) | 2008-06-17 | 2021-07-01 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2023145377A Withdrawn JP2023158150A (ja) | 2008-06-17 | 2023-09-07 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2025141388A Pending JP2025172854A (ja) | 2008-06-17 | 2025-08-27 | ボロン酸エステル化合物およびその医薬組成物 |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014103397A Active JP5926319B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103396A Active JP6110813B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103395A Active JP6010066B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103398A Withdrawn JP2014169317A (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2017128843A Withdrawn JP2017214396A (ja) | 2008-06-17 | 2017-06-30 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2019216272A Withdrawn JP2020055829A (ja) | 2008-06-17 | 2019-11-29 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2021109909A Withdrawn JP2021165288A (ja) | 2008-06-17 | 2021-07-01 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2023145377A Withdrawn JP2023158150A (ja) | 2008-06-17 | 2023-09-07 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2025141388A Pending JP2025172854A (ja) | 2008-06-17 | 2025-08-27 | ボロン酸エステル化合物およびその医薬組成物 |
Country Status (39)
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2628620T3 (es) | 2005-11-09 | 2017-08-03 | Onyx Therapeutics, Inc. | Compuesto para inhibición de enzimas |
| CA2657213C (en) | 2006-06-19 | 2017-01-03 | Proteolix, Inc. | Peptide epoxyketones for proteasome inhibition |
| KR20100088664A (ko) | 2007-10-04 | 2010-08-10 | 오닉스 세라퓨틱스, 인크. | 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성 |
| EA030685B1 (ru) | 2008-06-17 | 2018-09-28 | Милленниум Фармасьютикалз, Инк. | Способ получения соединения боронатного эфира |
| KR101023994B1 (ko) | 2008-08-28 | 2011-03-28 | 한국생산기술연구원 | 디지털 밴드용 커넥터, 리셉터클 및 커넥터 조립체 |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| US20110236428A1 (en) | 2008-10-21 | 2011-09-29 | Onyx Therapeutics, Inc. | Combination therapy with peptide epoxyketones |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
| MX2012010017A (es) | 2010-03-01 | 2012-10-01 | Onyx Therapeutics Inc | Compuestos de para la inhibicion de inmunoproteasomas. |
| US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| AU2011312264B2 (en) * | 2010-10-05 | 2015-07-02 | Fresenius Kabi Usa, Llc | Bortezomib formulations stabilised with boric acid |
| CN102784114B (zh) * | 2011-05-14 | 2016-03-02 | 山东新时代药业有限公司 | 一种硼替佐米冻干粉针及其制备方法 |
| MX2013015308A (es) | 2011-06-22 | 2014-05-20 | Cephalon Inc | Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso. |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤に応答するバイオマーカー |
| WO2013071142A1 (en) | 2011-11-11 | 2013-05-16 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
| US9732101B2 (en) | 2012-01-18 | 2017-08-15 | Wisconsin Alumni Research Foundation | Bioreversible boronates for delivery of molecules into cells |
| WO2013110005A1 (en) | 2012-01-18 | 2013-07-25 | Wisconsin Alumni Research Foundation | Boronate-mediated delivery of molecules into cells |
| EP2810066B1 (en) * | 2012-01-24 | 2019-07-31 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
| US20140357596A1 (en) | 2012-01-24 | 2014-12-04 | Millennium Pharmaceuticals, Inc. | Method of treatment of nasopharyngeal cancer |
| CA2866135A1 (en) * | 2012-03-02 | 2014-09-06 | Dr. Reddy's Laboratories Limited | Pharmaceutical compositions comprising boronic acid compounds |
| CA2784240C (en) | 2012-03-27 | 2014-07-08 | Innopharma, Inc. | Stable bortezomib formulations |
| WO2014011695A2 (en) | 2012-07-09 | 2014-01-16 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
| ITMI20121394A1 (it) | 2012-08-06 | 2014-02-07 | Chemi Spa | Esteri di bortezomib e loro formulazioni |
| EP3008212A4 (en) * | 2013-06-10 | 2017-05-24 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
| JP6165986B2 (ja) * | 2013-08-23 | 2017-07-19 | シントン・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂ．Ｖ． | ボルテゾミブを含む医薬組成物 |
| MX2016003979A (es) * | 2013-10-03 | 2016-06-15 | Millennium Pharm Inc | Metodo para profilaxis o tratamiento de lupus eritematoso sistemico y/o nefritis lupica. |
| EP3102585B1 (en) * | 2014-02-03 | 2021-05-19 | Ohio State Innovation Foundation | Boronic acid esters and pharmaceutical formulations thereof |
| WO2015151775A1 (ja) * | 2014-03-31 | 2015-10-08 | 富士フイルム株式会社 | 水分解用光電極、水分解装置 |
| UY36132A (es) | 2014-05-20 | 2015-11-30 | Millennium Pharm Inc | Métodos para terapia de cáncer |
| EP3177292B1 (en) | 2014-08-07 | 2020-11-25 | Mayo Foundation for Medical Education and Research | Compounds and methods for treating cancer |
| US9738664B2 (en) | 2014-10-29 | 2017-08-22 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of HIV protease |
| EP3031811A1 (en) | 2014-12-09 | 2016-06-15 | Teva Pharmaceuticals Ltd. | Malic acid esters of bortezomib |
| MA41505A (fr) * | 2015-02-11 | 2017-12-19 | Millennium Pharm Inc | Nouvelle forme cristalline d'un inhibiteur de protéasome |
| MA41555A (fr) * | 2015-02-17 | 2017-12-26 | Millennium Pharm Inc | Polythérapie pour le traitement du cancer |
| CZ2015233A3 (cs) | 2015-04-03 | 2016-10-12 | Zentiva, K.S. | Způsob přípravy Ixazomib citrátu |
| CZ2015253A3 (cs) | 2015-04-15 | 2016-10-26 | Zentiva, K.S. | Nové formy Ixazomib citrátu |
| WO2016205790A2 (en) * | 2015-06-19 | 2016-12-22 | Hanlin Scientific, Inc. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
| CN108135916B (zh) * | 2015-06-19 | 2022-01-28 | 北京科辉智药生物科技有限责任公司 | 手性特异性含硼化合物及其在治疗癌症或淀粉样变性中的应用 |
| EP3120836A1 (de) | 2015-07-22 | 2017-01-25 | Stada Arzneimittel Ag | Gebrauchsfertige bortezomib-lösung |
| EP3120837A1 (de) | 2015-07-22 | 2017-01-25 | Stada Arzneimittel Ag | Verfahren zur herstellung einer bortezomibester-lösung |
| US20180282351A1 (en) | 2015-09-16 | 2018-10-04 | Mylan Laboratories Ltd | Amorphous Ixazomib Citrate |
| CN106608883A (zh) * | 2015-10-21 | 2017-05-03 | 北京大学 | 蛋白酶体抑制剂mln9708的合成方法 |
| EP3370729B1 (en) | 2015-11-04 | 2023-09-27 | Takeda Pharmaceutical Company Limited | Methods for the identification, evaluation and treatment of patients having multiple myeloma |
| CN106986884A (zh) * | 2016-01-20 | 2017-07-28 | 成都贝斯凯瑞生物科技有限公司 | 一种高效的高纯度含硼化合物制备方法 |
| CN105622658B (zh) * | 2016-03-18 | 2018-06-19 | 中国药科大学 | 非肽类蛋白酶体抑制剂、其药物组合物、制备方法和应用 |
| WO2017163190A1 (en) * | 2016-03-23 | 2017-09-28 | Dr. Reddy’S Laboratories Limited | Amorphous ixazomib citrate and solid dispersion thereof |
| CN107224569A (zh) * | 2016-03-26 | 2017-10-03 | 复旦大学 | 一种硼替佐米水溶性药用组合物及其制备方法和用途 |
| CZ2016204A3 (cs) | 2016-04-08 | 2017-11-01 | Zentiva, K.S. | Formulace Ixazomib citrátu formy 3 |
| EP4582145A3 (en) | 2016-06-21 | 2025-09-17 | Assia Chemical Industries LTD | Solid state forms of ixazomib citrate |
| JP6802899B2 (ja) * | 2016-07-25 | 2020-12-23 | 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ，Ｉｎｃ． | 置換ボロン酸化合物、該化合物を含む医薬組成物およびその使用 |
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| WO2018160717A1 (en) | 2017-02-28 | 2018-09-07 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
| WO2018158697A1 (en) | 2017-03-03 | 2018-09-07 | Fresenius Kabi Oncology Limited | A process for the preparation of ixazomib citrate |
| WO2018173071A1 (en) * | 2017-03-20 | 2018-09-27 | Msn Laboratories Private Limited, R&D Center | Novel crystalline forms of ixazomib citrate and its process for preparation thereof |
| CN106916177B (zh) * | 2017-03-23 | 2019-04-23 | 南京陵瑞医药科技有限公司 | 一种氘代的二肽硼酸或其酯类化合物及其合成方法与用途 |
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| CN108794520B (zh) * | 2017-05-02 | 2020-07-24 | 北京大学 | 包括埃沙佐米在内的硼酸柠檬酸酯类化合物的合成方法 |
| CN109305980B (zh) * | 2017-07-28 | 2022-10-11 | 成都奥璟生物科技有限公司 | 一种硼酸酯化合物、其合成方法及其用途 |
| PL3672977T3 (pl) | 2017-08-24 | 2022-09-26 | Merck Patent Gmbh | Pochodne kwasu boronowego |
| WO2019038406A1 (en) | 2017-08-25 | 2019-02-28 | Synthon B.V. | PROCESS FOR THE PREPARATION OF IXAZOMIB OR ITS INTERMEDIATES |
| EP3676272A4 (en) * | 2017-09-02 | 2021-04-21 | Sun Pharmaceutical Industries Limited | IXAZOMIB CITRATE PREPARATION PROCESS |
| CA3075714A1 (en) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
| CN109251218B (zh) * | 2017-12-05 | 2021-08-24 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的硼酸酯化合物的制备方法及其晶型 |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| US10118937B1 (en) | 2018-01-03 | 2018-11-06 | Scinopharm Taiwan, Ltd. | Process for preparing ixazomib citrate and intermediates therefor |
| CN110041353A (zh) * | 2018-01-16 | 2019-07-23 | 成都译山生物科技有限公司 | 一种新的硼酸水杨酸酯类衍生物及其药物组合物 |
| MX2020009290A (es) | 2018-03-05 | 2020-09-28 | Arcus Biosciences Inc | Inhibidores de la arginasa. |
| US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
| CN110540547A (zh) * | 2018-05-28 | 2019-12-06 | 秦艳茹 | 一种肽硼酸酯类化合物的合成与用途 |
| JP2021531310A (ja) | 2018-07-26 | 2021-11-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | ボロン酸誘導体 |
| EP3831834A4 (en) * | 2018-08-02 | 2021-10-27 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | AZETIDINE DERIVATIVE BORATE |
| CN115403603A (zh) | 2018-09-14 | 2022-11-29 | 成都奥璟生物科技有限公司 | 一种硼酸酯类药物及其用途 |
| ES3034676T3 (en) | 2018-11-16 | 2025-08-21 | Arcus Biosciences Inc | Inhibitors of arg1 and/or arg2 |
| CN110357787A (zh) * | 2019-08-02 | 2019-10-22 | 苏州艾和医药科技有限公司 | 依沙佐米合成工艺研究 |
| AR120457A1 (es) | 2019-11-14 | 2022-02-16 | Amgen Inc | Síntesis mejorada del compuesto inhibidor de g12c de kras |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| KR20250008774A (ko) | 2022-05-11 | 2025-01-15 | 셀진 코포레이션 | T 세포 요법 및 그의 생산과 관련된 방법 및 용도 |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
| CN119451969A (zh) | 2022-06-30 | 2025-02-14 | 普林斯匹亚生物制药公司 | 环状硼酸酯及其用途 |
| EP4611798A1 (en) | 2022-11-02 | 2025-09-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
| CN116396312A (zh) * | 2022-12-26 | 2023-07-07 | 重庆迈德凯医药有限公司 | 一种枸橼酸艾沙佐米的制备方法 |
| WO2025117822A1 (en) * | 2023-11-28 | 2025-06-05 | University Of Notre Dame Du Lac | Glucose-triggered gelation of supramolecular peptide nanocoils with glucose-binding motifs |
| CN117964650B (zh) * | 2024-03-28 | 2024-06-07 | 成都硕德药业有限公司 | 一种枸橼酸伊沙佐米的制备方法 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US449082A (en) * | 1891-03-24 | milbeadt | ||
| US2160413A (en) | 1935-04-16 | 1939-05-30 | Schering Ag | Polyiodo derivatives of acylamino acids and their salts and a method of making the same |
| NZ203706A (en) | 1982-04-22 | 1986-03-14 | Squibb & Sons Inc | Occlusive multi-layer wound dressing and hydrocolloidal granules for wound treatment |
| US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
| JPS6197352A (ja) * | 1984-10-17 | 1986-05-15 | Dai Ichi Kogyo Seiyaku Co Ltd | 安定性に優れた組成物 |
| JPS6233170A (ja) | 1985-08-07 | 1987-02-13 | Tokuyama Soda Co Ltd | 環状ポリエ−テル化合物 |
| JPH0813759B2 (ja) | 1986-09-01 | 1996-02-14 | 富士写真フイルム株式会社 | アルコキシベンゼン誘導体の製造方法 |
| JP2512303B2 (ja) | 1987-03-20 | 1996-07-03 | 呉羽化学工業株式会社 | ２−オキサゾリン−４，５−ジオンのフエニルヒドラゾン誘導体 |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US5242904A (en) * | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
| EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
| US5106948A (en) | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
| US5159060A (en) * | 1988-05-27 | 1992-10-27 | Mayo Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
| DE3827340A1 (de) | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
| MX9206628A (es) | 1991-11-22 | 1993-05-01 | Boehringer Ingelheim Pharma | Ester de prolinaboronato y metodo para su preparacion. |
| EP0583536B1 (en) | 1992-08-14 | 1997-03-05 | The Procter & Gamble Company | Liquid detergents containing an alpha-amino boronic acid |
| US5442100A (en) | 1992-08-14 | 1995-08-15 | The Procter & Gamble Company | β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids |
| US5935944A (en) * | 1993-09-10 | 1999-08-10 | Neutron Technology Corporation | Formulation for I.V. administration of the boron delivery drug, boronophenylalanine (BPA) |
| US5492900A (en) * | 1993-09-10 | 1996-02-20 | Neutron Technology Corporation | Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA) |
| US6060462A (en) * | 1993-10-20 | 2000-05-09 | Dupont Pharmaceuticals Company | Electrophilic peptide analogs as inhibitors of trypsin-like enzymes |
| FR2712602B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
| US5574017A (en) * | 1994-07-05 | 1996-11-12 | Gutheil; William G. | Antibacterial agents |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US5614649A (en) * | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
| JP3403009B2 (ja) * | 1996-07-12 | 2003-05-06 | キヤノン株式会社 | 可動部材の変位と気泡成長を伴う液体吐出方法、該吐出方法に用いられる液体吐出ヘッド、ヘッドカートリッジ及びこれらを用いた液体吐出装置 |
| US5834487A (en) | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
| US6271199B2 (en) | 1997-02-15 | 2001-08-07 | Millennium Pharmaceuticals, Inc. | Treatment of infarcts |
| WO1999015183A1 (en) | 1997-09-25 | 1999-04-01 | Proscript Inc. | PROTEASOME INHIBITORS, UBIQUITIN PATHWAY INHIBITORS OR AGENTS THAT INTERFERE WITH THE ACTIVATION OF NF-λB VIA THE UBIQUITIN PROTEASOME PATHWAY TO TREAT INFLAMMATORY AND AUTOIMMUNE DISEASES |
| WO1999030707A1 (en) | 1997-12-16 | 1999-06-24 | Cephalon Inc. | Multicatalytic protease inhibitors for use as anti-tumor agents |
| US6075150A (en) | 1998-01-26 | 2000-06-13 | Cv Therapeutics, Inc. | α-ketoamide inhibitors of 20S proteasome |
| WO2000024392A1 (en) | 1998-10-26 | 2000-05-04 | Sumitomo Pharmaceuticals Company, Limited | β-AMYLOID FORMATION INHIBITORS |
| US6169076B1 (en) | 1999-03-31 | 2001-01-02 | Glcosyn Pharmaceuticals, Inc. | P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols |
| US6121149A (en) * | 1999-04-22 | 2000-09-19 | Advanced Micro Devices, Inc. | Optimized trench/via profile for damascene filling |
| KR100307027B1 (ko) | 1999-06-17 | 2001-11-01 | 서평원 | 액정 표시장치 및 이것을 이용한 이동 통신 단말기의 표시장치 |
| AU5788800A (en) | 1999-07-07 | 2001-01-22 | Du Pont Pharmaceuticals Company | Peptide boronic acid inhibitors of hepatitis c virus protease |
| SE0100714D0 (sv) | 2000-07-13 | 2001-02-28 | Ap Biotech Ab | Reaction vessel and method for distributing fluid in such a vessel |
| US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
| JP2002145848A (ja) * | 2000-11-10 | 2002-05-22 | Kyorin Pharmaceut Co Ltd | アルケニルアミノ酸誘導体及びその製造法 |
| EP1217000A1 (en) * | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
| CA2435124A1 (en) * | 2001-01-25 | 2002-08-01 | Millennium Pharmaceuticals, Inc. | Formulation of boronic acid compounds |
| US6933290B2 (en) | 2001-05-30 | 2005-08-23 | Novartis Ag | 2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives |
| DE10131283A1 (de) | 2001-06-28 | 2003-01-09 | Philips Corp Intellectual Pty | Phased Array Antenne |
| JPWO2003033507A1 (ja) | 2001-10-12 | 2005-02-03 | 杏林製薬株式会社 | ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
| JPWO2003033506A1 (ja) | 2001-10-12 | 2005-02-03 | 杏林製薬株式会社 | アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
| US7524883B2 (en) | 2002-01-08 | 2009-04-28 | Eisai R&D Management Co., Ltd. | Eponemycin and epoxomicin analogs and uses thereof |
| WO2003105860A1 (en) | 2002-06-14 | 2003-12-24 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
| EP1396269A1 (en) | 2002-09-09 | 2004-03-10 | Trigen Limited | Boronic acid salts of multivalent metals used in the preparation of a medicament for treating thrombosis |
| US20060084592A1 (en) | 2002-09-09 | 2006-04-20 | Trigen Limited | Peptide boronic acid inhibitors |
| TW200418791A (en) | 2003-01-23 | 2004-10-01 | Bristol Myers Squibb Co | Pharmaceutical compositions for inhibiting proteasome |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| CN1867572B (zh) * | 2003-08-14 | 2012-03-28 | 赛福伦公司 | 蛋白酶体抑制剂及其使用方法 |
| GB0405267D0 (en) | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
| RS65253B1 (sr) * | 2004-03-30 | 2024-03-29 | Millennium Pharm Inc | Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline |
| CN102875642A (zh) | 2004-05-10 | 2013-01-16 | 普罗特奥里克斯公司 | 用于酶抑制的化合物 |
| WO2006008660A2 (en) | 2004-07-20 | 2006-01-26 | Affinium Pharmaceuticals, Inc. | Streptococcus pneumoniae enoyl- (acyl-carrier-protein) reductase (fabk) |
| TW200618820A (en) | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
| CN101120006A (zh) * | 2005-02-11 | 2008-02-06 | 赛福伦公司 | 蛋白酶体抑制剂及其使用方法 |
| US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| AU2006242446A1 (en) | 2005-04-29 | 2006-11-09 | Kosan Biosciences Incorporated | Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either in combination with a proteasome inhibitor |
| MX2008000318A (es) | 2005-07-05 | 2008-03-11 | Tufts College | Inhibidores de la proteina alfa de activacion del fibroblasto. |
| ZA200804679B (en) * | 2005-12-08 | 2010-02-24 | Millenium Pharmaceuticals Inc | Bicyclic compounds with kinase inhibitory activity |
| JP2009524681A (ja) | 2006-01-27 | 2009-07-02 | フェノミックス コーポレーション | Ｃ型肝炎ウイルスセリンプロテアーゼインヒビターおよびそのための使用 |
| CN101415691B (zh) | 2006-02-03 | 2011-12-14 | 大正制药株式会社 | 三唑衍生物 |
| CL2007002499A1 (es) * | 2006-08-30 | 2008-03-14 | Phenomix Corp | Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes. |
| WO2009006473A2 (en) | 2007-07-05 | 2009-01-08 | Trustees Of Tufts College | Pro-soft polypeptide proteasome inhibitors, and methods of use thereof |
| KR20140042933A (ko) | 2007-08-06 | 2014-04-07 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아좀 억제제 |
| US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
| ITMI20072397A1 (it) | 2007-12-20 | 2009-06-21 | Gambro Lundia Ab | Apparecchiatura medicale per il trattamento extracorporeo |
| EA030685B1 (ru) * | 2008-06-17 | 2018-09-28 | Милленниум Фармасьютикалз, Инк. | Способ получения соединения боронатного эфира |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| EP2702706B1 (en) | 2011-04-29 | 2014-12-24 | Telefonaktiebolaget LM Ericsson (PUBL) | Decentralised control of interference reduction in a wireless communication system |
| JP5724951B2 (ja) | 2012-06-11 | 2015-05-27 | 日立金属株式会社 | ネットワーク管理装置 |
| JP6357023B2 (ja) | 2014-06-06 | 2018-07-11 | 任天堂株式会社 | 情報処理プログラム、情報処理装置、情報処理装置の制御方法および情報処理システム |
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2015
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2016
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2017
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2018
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2019
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2020
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2021
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2023
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2025
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