JP2011506492A5 - - Google Patents
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- Publication number
- JP2011506492A5 JP2011506492A5 JP2010538291A JP2010538291A JP2011506492A5 JP 2011506492 A5 JP2011506492 A5 JP 2011506492A5 JP 2010538291 A JP2010538291 A JP 2010538291A JP 2010538291 A JP2010538291 A JP 2010538291A JP 2011506492 A5 JP2011506492 A5 JP 2011506492A5
- Authority
- JP
- Japan
- Prior art keywords
- gemcitabine
- composition according
- compound
- erlotinib
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 6
- 229960005277 gemcitabine Drugs 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N trilaurin Chemical compound CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 claims 4
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 3
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 3
- 229960001433 erlotinib Drugs 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000005639 Lauric acid Substances 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 claims 1
- 229940082004 sodium laurate Drugs 0.000 claims 1
- FIWQZURFGYXCEO-UHFFFAOYSA-M sodium;decanoate Chemical compound [Na+].CCCCCCCCCC([O-])=O FIWQZURFGYXCEO-UHFFFAOYSA-M 0.000 claims 1
- 229940093633 tricaprin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US812907P | 2007-12-19 | 2007-12-19 | |
| US61/008,129 | 2007-12-19 | ||
| PCT/CA2008/002190 WO2009076761A1 (en) | 2007-12-19 | 2008-12-18 | Medium-chain length fatty acids, salts and triglycerides in combination with gemcitabine for treatment of pancreatic cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506492A JP2011506492A (ja) | 2011-03-03 |
| JP2011506492A5 true JP2011506492A5 (enExample) | 2012-02-02 |
| JP5473937B2 JP5473937B2 (ja) | 2014-04-16 |
Family
ID=40795145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538291A Expired - Fee Related JP5473937B2 (ja) | 2007-12-19 | 2008-12-18 | 膵臓癌の治療のためのゲムシタビンと併用した中鎖脂肪酸、その塩およびトリグリセリド |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8946190B2 (enExample) |
| EP (1) | EP2231166B1 (enExample) |
| JP (1) | JP5473937B2 (enExample) |
| KR (1) | KR101603351B1 (enExample) |
| CN (1) | CN101903028B (enExample) |
| AU (1) | AU2008338204B2 (enExample) |
| BR (1) | BRPI0821395A2 (enExample) |
| CA (1) | CA2708679C (enExample) |
| DK (1) | DK2231166T3 (enExample) |
| ES (1) | ES2414617T3 (enExample) |
| MX (1) | MX2010006867A (enExample) |
| NZ (1) | NZ586249A (enExample) |
| PT (1) | PT2231166E (enExample) |
| TW (1) | TWI448290B (enExample) |
| WO (1) | WO2009076761A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2427416B1 (en) | 2009-05-04 | 2016-03-09 | Prometic Pharma Smt Limited | Substituted aromatic compounds and pharmaceutical uses thereof |
| CN105997967B (zh) | 2010-10-27 | 2019-08-23 | 普罗米蒂克医药Smt有限公司 | 用于治疗癌症的化合物和组合物 |
| CN102617679B (zh) * | 2012-03-13 | 2014-11-26 | 北京大学 | 一种共轭亚油酸与吉西他滨连接的前体药物制备方法及其应用 |
| WO2014126969A1 (en) * | 2013-02-12 | 2014-08-21 | Bend Research, Inc. | Solid dispersions of low-water solubility actives |
| US9737538B2 (en) | 2013-02-12 | 2017-08-22 | Bend Research, Inc. | Solid dispersions of low-water solubility actives |
| US11351139B2 (en) | 2013-02-28 | 2022-06-07 | Basf As | Composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same |
| US10463684B2 (en) | 2014-01-29 | 2019-11-05 | Board Of Regents, The Uneversety Of Texas System | Nucleobase analogue derivatives and their applications |
| MA53188A1 (fr) | 2018-10-11 | 2021-12-31 | Basf As | Composés aromatiques et leurs utilisations pharmaceutiques |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68928756T2 (de) * | 1989-03-13 | 1999-03-04 | Cellegy Pharma Inc | Topische Zubereitungen enthaltend aliphatische Amine zur Behandlung von Hautkrankheiten |
| US6340705B1 (en) * | 1999-09-10 | 2002-01-22 | Monsanto Technology, Llc | Use of α-linolenic acid metabolites for treatment or prevention of cancer |
| DK1900364T3 (da) * | 2001-04-18 | 2014-01-13 | Prometic Biosciences Inc | Fedtsyrer, glycerider og analoger med medium kædelængde som neutrofile overlevelses- og aktiveringsfaktorer |
| JP2005507874A (ja) * | 2001-08-29 | 2005-03-24 | ユーエムディー， インコーポレイテッド | 癌治療のための化学療法剤及び膜流出システム阻害剤の経膣送達 |
| US20060012880A1 (en) * | 2002-05-02 | 2006-01-19 | Law Benjamin P | Optical device with refractive and diffractive properties |
| BRPI0407276A (pt) * | 2003-02-07 | 2006-01-31 | Prometic Biosciences Inc | ácidos graxos, glicerìdeos e análogos com comprimento de cadeia médio, como estimulantes de eritropoiese |
| ES2264886B1 (es) * | 2005-05-12 | 2008-02-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
-
2008
- 2008-12-18 JP JP2010538291A patent/JP5473937B2/ja not_active Expired - Fee Related
- 2008-12-18 CN CN2008801221273A patent/CN101903028B/zh not_active Expired - Fee Related
- 2008-12-18 BR BRPI0821395-0A patent/BRPI0821395A2/pt not_active IP Right Cessation
- 2008-12-18 DK DK08862479.6T patent/DK2231166T3/da active
- 2008-12-18 KR KR1020107015015A patent/KR101603351B1/ko not_active Expired - Fee Related
- 2008-12-18 AU AU2008338204A patent/AU2008338204B2/en not_active Ceased
- 2008-12-18 NZ NZ586249A patent/NZ586249A/en not_active IP Right Cessation
- 2008-12-18 WO PCT/CA2008/002190 patent/WO2009076761A1/en not_active Ceased
- 2008-12-18 MX MX2010006867A patent/MX2010006867A/es active IP Right Grant
- 2008-12-18 EP EP08862479A patent/EP2231166B1/en not_active Not-in-force
- 2008-12-18 ES ES08862479T patent/ES2414617T3/es active Active
- 2008-12-18 CA CA2708679A patent/CA2708679C/en active Active
- 2008-12-18 PT PT88624796T patent/PT2231166E/pt unknown
- 2008-12-18 US US12/809,380 patent/US8946190B2/en active Active
- 2008-12-18 TW TW097149396A patent/TWI448290B/zh not_active IP Right Cessation