JP2019511491A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019511491A5 JP2019511491A5 JP2018547320A JP2018547320A JP2019511491A5 JP 2019511491 A5 JP2019511491 A5 JP 2019511491A5 JP 2018547320 A JP2018547320 A JP 2018547320A JP 2018547320 A JP2018547320 A JP 2018547320A JP 2019511491 A5 JP2019511491 A5 JP 2019511491A5
- Authority
- JP
- Japan
- Prior art keywords
- expression
- targeting ligand
- oligomeric compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 37
- 230000002401 inhibitory effect Effects 0.000 claims 32
- 239000003446 ligand Substances 0.000 claims 31
- 230000008685 targeting Effects 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 19
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 108091030071 RNAI Proteins 0.000 claims 12
- 230000009368 gene silencing by RNA Effects 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 108091081021 Sense strand Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 claims 1
- 101100539150 Homo sapiens UBAP1 gene Proteins 0.000 claims 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- FVMMQJUBNMOPPR-WLDMJGECSA-N N-[(3R,4R,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]formamide Chemical compound OC[C@H]1OC(O)[C@H](NC=O)[C@@H](O)[C@H]1O FVMMQJUBNMOPPR-WLDMJGECSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 1
- 102100029779 Ubiquitin-associated protein 1 Human genes 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- RHLMXWCISNJNDH-UHFFFAOYSA-N n-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide Chemical compound COC1=CC=C(C=2C=C(C=CC=2)C(=O)N(C)C)C=C1S(=O)(=O)NC(C=1)=CC=CC=1NCCNC(=O)C1=CC=CC(C)=C1 RHLMXWCISNJNDH-UHFFFAOYSA-N 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021189879A JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
| JP2024074913A JP2024097862A (ja) | 2016-03-07 | 2024-05-02 | 治療化合物用の標的化リガンド |
| JP2025092644A JP2025120251A (ja) | 2016-03-07 | 2025-06-03 | 治療化合物用の標的化リガンド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662304652P | 2016-03-07 | 2016-03-07 | |
| US62/304,652 | 2016-03-07 | ||
| US201662370754P | 2016-08-04 | 2016-08-04 | |
| US62/370,754 | 2016-08-04 | ||
| US201662426916P | 2016-11-28 | 2016-11-28 | |
| US62/426,916 | 2016-11-28 | ||
| PCT/US2017/021175 WO2017156012A1 (en) | 2016-03-07 | 2017-03-07 | Targeting ligands for therapeutic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189879A Division JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511491A JP2019511491A (ja) | 2019-04-25 |
| JP2019511491A5 true JP2019511491A5 (enExample) | 2020-04-16 |
| JP6983797B2 JP6983797B2 (ja) | 2021-12-17 |
Family
ID=59723428
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547320A Active JP6983797B2 (ja) | 2016-03-07 | 2017-03-07 | 治療化合物用の標的化リガンド |
| JP2021189879A Active JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
| JP2024074913A Withdrawn JP2024097862A (ja) | 2016-03-07 | 2024-05-02 | 治療化合物用の標的化リガンド |
| JP2025092644A Pending JP2025120251A (ja) | 2016-03-07 | 2025-06-03 | 治療化合物用の標的化リガンド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189879A Active JP7485642B2 (ja) | 2016-03-07 | 2021-11-24 | 治療化合物用の標的化リガンド |
| JP2024074913A Withdrawn JP2024097862A (ja) | 2016-03-07 | 2024-05-02 | 治療化合物用の標的化リガンド |
| JP2025092644A Pending JP2025120251A (ja) | 2016-03-07 | 2025-06-03 | 治療化合物用の標的化リガンド |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10246709B2 (enExample) |
| EP (1) | EP3426261A4 (enExample) |
| JP (4) | JP6983797B2 (enExample) |
| KR (3) | KR102830443B1 (enExample) |
| CN (2) | CN113797348A (enExample) |
| AU (3) | AU2017229469B2 (enExample) |
| BR (1) | BR112018068230B1 (enExample) |
| CA (1) | CA3011946A1 (enExample) |
| IL (3) | IL296377A (enExample) |
| JO (2) | JOP20170057B1 (enExample) |
| MX (3) | MX2018009854A (enExample) |
| NZ (2) | NZ744357A (enExample) |
| TW (3) | TWI783434B (enExample) |
| UY (1) | UY37146A (enExample) |
| WO (1) | WO2017156012A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201620526A (zh) | 2014-06-17 | 2016-06-16 | 愛羅海德研究公司 | 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法 |
| JOP20210043A1 (ar) | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| IL296377A (en) | 2016-03-07 | 2022-11-01 | Arrowhead Pharmaceuticals Inc | Targeting ligands for therapeutic compounds and uses of same |
| CA3023764A1 (en) | 2016-06-06 | 2017-12-14 | Arrowhead Pharmaceuticals, Inc. | 5'-cyclo-phosphonate modified nucleotides |
| JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
| CN116942841A (zh) | 2016-09-02 | 2023-10-27 | 箭头药业股份有限公司 | 靶向配体 |
| US10450565B2 (en) | 2017-01-10 | 2019-10-22 | Arrowhead Pharmaceuticals, Inc. | Alpha-1 antitrypsin (AAT) RNAi agents, compositions including AAT RNAi agents, and methods of use |
| CA3048661A1 (en) | 2017-01-30 | 2018-08-02 | Arrowhead Pharmaceuticals Inc. | Compositions and methods for inhibition of factor xii gene expression |
| SG11201912178VA (en) | 2017-09-11 | 2020-01-30 | Arrowhead Pharmaceuticals Inc | Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3) |
| KR20250004009A (ko) | 2017-09-14 | 2025-01-07 | 애로우헤드 파마슈티컬스 인코포레이티드 | 안지오포이에틴-유사 3 (ANGPTL3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물, 및 사용 방법 |
| CA3079413A1 (en) | 2017-10-17 | 2019-04-25 | Arrowhead Pharmaceuticals, Inc. | Rnai agents and compositions for inhibiting expression of asialoglycoprotein receptor 1 |
| AU2019342117A1 (en) * | 2018-09-19 | 2021-03-04 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of 17beta-HSD type 13- (HSD17B13), compositions thereof, and methods of use |
| CN111377985B (zh) * | 2018-12-29 | 2023-11-10 | 苏州瑞博生物技术股份有限公司 | 化合物和缀合物及其制备方法和用途 |
| MX2021015003A (es) | 2019-06-06 | 2022-01-24 | Arrowhead Pharmaceuticals Inc | Metodos para el tratamiento de la deficiencia de alfa-1 antitripsina (aatd). |
| JP2022536945A (ja) | 2019-06-18 | 2022-08-22 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｂ型肝炎ウイルス（ＨＢＶ）ワクチンおよびＨＢＶを標的化するＲＮＡｉの組合せ |
| AU2020301419A1 (en) | 2019-06-25 | 2022-01-20 | Amgen Inc. | Purification methods for carbohydrate-linked oligonucleotides |
| CN114929282B (zh) | 2019-09-03 | 2025-09-19 | 阿克丘勒斯治疗公司 | 脱唾液酸糖蛋白受体介导的治疗活性缀合物的递送 |
| GB2627637B (en) * | 2020-03-04 | 2024-11-20 | Verve Therapeutics Inc | A method for reducing the risk of coronary disease |
| EP4126967A1 (en) | 2020-03-23 | 2023-02-08 | Amgen Inc. | Monoclonal antibodies to chemically-modified nucleic acids and uses thereof |
| AU2021242321B2 (en) | 2020-03-26 | 2025-09-04 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of PNPLA3, pharmaceutical compositions thereof, and methods of use |
| US20230250125A1 (en) | 2020-04-01 | 2023-08-10 | Janssen Biopharma, Inc. | Nucleic acid polymers |
| WO2021206182A1 (ja) * | 2020-04-10 | 2021-10-14 | 学校法人 聖マリアンナ医科大学 | 化合物、造影剤、及び化合物の製造方法 |
| WO2021254360A1 (zh) * | 2020-06-16 | 2021-12-23 | 上海拓界生物医药科技有限公司 | 一种碳水化合物分子簇及其制备方法和医药用途 |
| US20230348905A1 (en) | 2020-09-15 | 2023-11-02 | Arrowhead Pharmaceuticals, Inc. | Methods for the reduction of z-aat protein levels |
| EP4240855A1 (en) | 2020-11-05 | 2023-09-13 | Amgen Inc. | Methods for treating atherosclerotic cardiovascular disease with lpa-targeted rnai constructs |
| IL303886A (en) | 2020-12-23 | 2023-08-01 | Flagship Pioneering Inc | Compositions of modified trems and uses thereof |
| EP4326334A1 (en) | 2021-04-23 | 2024-02-28 | GanNA Bio, Inc. | Glycan modified nucleic acids, methods of preparation, and therapeutic uses |
| US11549112B1 (en) | 2021-06-21 | 2023-01-10 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of xanthine dehydrogenase (XDH), pharmaceutical compositions thereof, and methods of use |
| WO2023274395A1 (zh) * | 2021-07-02 | 2023-01-05 | 上海拓界生物医药科技有限公司 | 一种核酸配体及其缀合物、其制备方法和用途 |
| CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
| US20250283089A1 (en) | 2022-04-08 | 2025-09-11 | Arrowhead Pharmaceuticals, Inc. | Treatment of a non-alcoholic fatty liver disease |
| WO2023215306A1 (en) * | 2022-05-02 | 2023-11-09 | Amgen Inc. | Processes for making nag-25, a carbohydrate targeting moiety, and its intermediates |
| WO2023233290A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Sciences Ireland Unlimited Company | Rnai agents targeting pd-l1 |
| EP4544043A1 (en) | 2022-06-22 | 2025-04-30 | Flagship Pioneering Innovations VI, LLC | Compositions of modified trems and uses thereof |
| WO2024197017A2 (en) | 2023-03-21 | 2024-09-26 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of complement factor b (cfb) pharmaceutical compositions thereof, and methods of use |
| WO2024245410A1 (zh) | 2023-05-31 | 2024-12-05 | 上海拓界生物医药科技有限公司 | 一种靶向LPA的dsRNA及其应用 |
| WO2025021831A1 (en) | 2023-07-24 | 2025-01-30 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
| GB202311324D0 (en) | 2023-07-24 | 2023-09-06 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
| GB202311334D0 (en) | 2023-07-24 | 2023-09-06 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
| WO2025038661A1 (en) | 2023-08-14 | 2025-02-20 | Arrowhead Pharmaceuticals, Inc. | Oligonucleotide synthesis methods |
| WO2025042786A1 (en) | 2023-08-18 | 2025-02-27 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| WO2025049773A1 (en) | 2023-08-30 | 2025-03-06 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of inhibin subunit beta e (inhbe), pharmaceutical compositions thereof, and methods of use |
| WO2025074157A1 (en) | 2023-10-06 | 2025-04-10 | Glaxosmithkline Intellectual Property (No.3) Limited | Treatment of a non-alcoholic fatty liver disease |
| TW202523695A (zh) | 2023-11-22 | 2025-06-16 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 用於治療非酒精性脂肪性肝病之方法及組成物 |
| US20250333742A1 (en) | 2024-04-25 | 2025-10-30 | Insitro, Inc. | Compositions and methods for treating metabolic dysfunction-associated steatotic liver disease |
| WO2025245188A2 (en) | 2024-05-21 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Methods of treating liver steatosis and non-alcoholic fatty liver disease |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4751219A (en) | 1985-02-05 | 1988-06-14 | Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek | Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides |
| NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
| US6172045B1 (en) | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
| US6908903B1 (en) | 1994-12-07 | 2005-06-21 | Aletheon Pharmaceuticals, Inc. | Cluster clearing agents |
| US20030119724A1 (en) | 1995-11-22 | 2003-06-26 | Ts`O Paul O.P. | Ligands to enhance cellular uptake of biomolecules |
| JP2000501414A (ja) | 1995-11-22 | 2000-02-08 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 生体分子の細胞取り込みを高めるリガンド |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| CN1231675A (zh) | 1996-09-26 | 1999-10-13 | 味之素株式会社 | 修饰的生理活性蛋白及含有该蛋白的药物组合物 |
| US6300319B1 (en) | 1998-06-16 | 2001-10-09 | Isis Pharmaceuticals, Inc. | Targeted oligonucleotide conjugates |
| MXPA01004239A (es) * | 1998-10-30 | 2002-06-04 | Daiichi Seiyaku Co | Compuesto dds y metodo para la medicion del mismo. |
| US6383812B1 (en) | 1999-05-28 | 2002-05-07 | Academia Sinica | Anti liver disease drug R-YEEE and method of synthesizing branched galactose-terminal glycoproteins |
| US8541548B2 (en) | 1999-06-07 | 2013-09-24 | Arrowhead Madison Inc. | Compounds and methods for reversible modification of biologically active molecules |
| US20080281041A1 (en) | 1999-06-07 | 2008-11-13 | Rozema David B | Reversibly Masked Polymers |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| WO2002081628A2 (en) | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| KR101215789B1 (ko) | 2000-03-30 | 2012-12-26 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| CA2431839A1 (en) | 2000-12-01 | 2002-06-06 | Paul O. P. Ts'o | Conjugates of glycosylated/galactosylated peptide |
| SI1407044T2 (en) | 2000-12-01 | 2018-03-30 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Rna interference mediating small rna molecules |
| WO2002085908A1 (en) | 2001-04-24 | 2002-10-31 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| EP3231445A1 (en) | 2001-05-18 | 2017-10-18 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US7109165B2 (en) | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| AU2002313699A1 (en) | 2001-07-20 | 2003-03-03 | Ribozyme Pharmacuticals, Inc. | Enzymatic nucleic acid peptide conjugates |
| US7439043B2 (en) | 2001-10-10 | 2008-10-21 | Neose Technologies, Inc. | Galactosyl nucleotide sugars |
| US20100240730A1 (en) | 2002-02-20 | 2010-09-23 | Merck Sharp And Dohme Corp. | RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA) |
| EP1543019A2 (en) | 2002-09-11 | 2005-06-22 | Santaris Pharma A/S | Modified pna molecules |
| ATE479752T1 (de) | 2003-03-07 | 2010-09-15 | Alnylam Pharmaceuticals Inc | Therapeutische zusammensetzungen |
| AU2004227414A1 (en) | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | iRNA conjugates |
| WO2004094595A2 (en) | 2003-04-17 | 2004-11-04 | Alnylam Pharmaceuticals Inc. | MODIFIED iRNA AGENTS |
| US7851615B2 (en) | 2003-04-17 | 2010-12-14 | Alnylam Pharmaceuticals, Inc. | Lipophilic conjugated iRNA agents |
| US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
| JPWO2004101619A1 (ja) | 2003-05-15 | 2006-10-26 | 塩野義製薬株式会社 | 機能的糖ペプチドの合理的設計および合成 |
| US7582744B2 (en) | 2004-08-10 | 2009-09-01 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides |
| US20090203132A1 (en) | 2004-09-09 | 2009-08-13 | Swayze Eric E | Pyrrolidinyl groups for attaching conjugates to oligomeric compounds |
| US20060148740A1 (en) | 2005-01-05 | 2006-07-06 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| US20080206869A1 (en) | 2005-01-24 | 2008-08-28 | Avaris Ab | Nucleic Acid Complex |
| US8658211B2 (en) | 2006-08-18 | 2014-02-25 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
| KR101133799B1 (ko) | 2006-08-18 | 2012-04-24 | 에프. 호프만-라 로슈 아게 | 폴리뉴클레오타이드의 생체내 전달을 위한 다가접합체 |
| EP2604284A1 (en) | 2007-02-16 | 2013-06-19 | KTB Tumorforschungsgesellschaft mbH | Receptor And Antigen Targeted Prodrug |
| WO2008131419A2 (en) | 2007-04-23 | 2008-10-30 | Alnylam Pharmaceuticals, Inc. | Glycoconjugates of rna interference agents |
| US20090247608A1 (en) * | 2007-12-04 | 2009-10-01 | Alnylam Pharmaceuticals, Inc. | Targeting Lipids |
| EP2231194B1 (en) | 2007-12-04 | 2017-02-22 | Alnylam Pharmaceuticals Inc. | Folate-irna conjugates |
| EP2245039A4 (en) | 2008-01-31 | 2012-06-06 | Alnylam Pharmaceuticals Inc | OPTIMIZED METHODS FOR EXPORING DSRNA TO TARGET THE PCSK9 GEN |
| WO2009142822A2 (en) | 2008-03-26 | 2009-11-26 | Alnylam Pharmaceuticals, Inc. | 2-f modified rna interference agents |
| EP3604533A1 (en) | 2008-04-11 | 2020-02-05 | Arbutus Biopharma Corporation | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| JP2012513953A (ja) | 2008-09-23 | 2012-06-21 | アルニラム ファーマスーティカルズ インコーポレイテッド | 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾 |
| CA2739895C (en) | 2008-10-20 | 2018-09-25 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin |
| US8987435B2 (en) | 2008-10-24 | 2015-03-24 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
| CA2743139C (en) | 2008-11-10 | 2019-04-02 | Alnylam Pharmaceuticals, Inc. | Novel lipids and compositions for the delivery of therapeutics |
| KR102229618B1 (ko) | 2009-05-05 | 2021-03-18 | 알닐람 파마슈티칼스 인코포레이티드 | 지질 조성물 |
| NZ622843A (en) | 2009-06-10 | 2015-10-30 | Tekmira Pharmaceuticals Corp | Improved lipid formulation |
| WO2011005980A1 (en) * | 2009-07-09 | 2011-01-13 | Intradigm Corporation | Novel heterobifunctional polyethylene glycol reagents, their preparation and uses thereof |
| US8552163B2 (en) | 2009-09-25 | 2013-10-08 | Johns Hopkins University | Liver-targeting agents and their synthesis |
| TWI391144B (zh) | 2009-10-26 | 2013-04-01 | Iner Aec Executive Yuan | 一種定量肝殘餘功能的檢驗方法與其新穎肝受體造影檢驗藥劑 |
| TWI388338B (zh) | 2009-10-26 | 2013-03-11 | Iner Aec Executive Yuan | 對聚合醣鏈進行放射標誌以作為肝受體造影劑之方法 |
| WO2011072290A2 (en) | 2009-12-11 | 2011-06-16 | The Regents Of The University Of Michigan | Targeted dendrimer-drug conjugates |
| NZ601737A (en) | 2010-02-24 | 2013-06-28 | Arrowhead Res Corp | Compositions for targeted delivery of sirna |
| WO2011120053A1 (en) | 2010-03-26 | 2011-09-29 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| WO2011163121A1 (en) | 2010-06-21 | 2011-12-29 | Alnylam Pharmaceuticals, Inc. | Multifunctional copolymers for nucleic acid delivery |
| CA2812046A1 (en) | 2010-09-15 | 2012-03-22 | Alnylam Pharmaceuticals, Inc. | Modified irna agents |
| WO2012068187A1 (en) | 2010-11-19 | 2012-05-24 | Merck Sharp & Dohme Corp. | Poly(amide) polymers for the delivery of oligonucleotides |
| US8501930B2 (en) * | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| EP3192800A1 (en) | 2010-12-17 | 2017-07-19 | Arrowhead Pharmaceuticals, Inc. | Galactose cluster-pharmacokinetic modulator targeting moiety for sirna |
| EP2658981B1 (en) | 2010-12-29 | 2016-09-28 | F.Hoffmann-La Roche Ag | Small molecule conjugates for intracellular delivery of nucleic acids |
| SG10201604074TA (en) | 2011-04-21 | 2016-07-28 | Isis Pharmaceuticals Inc | Modulation of hepatitis b virus (hbv) expression |
| TWI695066B (zh) * | 2011-06-30 | 2020-06-01 | 美商艾羅海德製藥公司 | 用於抑制b型肝炎病毒基因表現之組合物及方法 |
| HK1199736A1 (en) | 2011-08-26 | 2015-07-17 | 箭头研究公司 | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
| EP3453761A1 (en) | 2011-08-29 | 2019-03-13 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| JP2015515530A (ja) * | 2012-04-18 | 2015-05-28 | アローヘッド リサーチ コーポレイション | インビボ核酸送達のためのポリ（アクリラート）ポリマー |
| TW201808342A (zh) | 2012-05-02 | 2018-03-16 | 喜納製藥公司 | 包含四ｇａｌｎａｃ之新穎結合物及傳送寡核苷酸之方法 |
| US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| AR090905A1 (es) | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica |
| US9150602B2 (en) | 2012-07-24 | 2015-10-06 | Atomic Energy Council, Institute Of Nuclear Energy Research | Precursor used for labeling hepatorcyte receptor and containing trisaccharide and diamide demercaptide ligand, method for preparing the same, radiotracer and pharmaceutical composition of the same |
| EP4253395A3 (en) | 2012-08-06 | 2023-11-29 | Alnylam Pharmaceuticals, Inc. | Processes for the preparation of carbohydrate conjugated rna agents |
| BR112015010116A2 (pt) | 2012-11-15 | 2017-08-22 | Roche Innovation Ct Copenhagen As | COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| HK1215718A1 (zh) | 2013-01-30 | 2016-09-09 | F. Hoffmann-La Roche Ag | Lna寡核苷酸碳水化合物缀合物 |
| SG10201803157XA (en) | 2013-05-01 | 2018-05-30 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| IL296543B2 (en) | 2013-05-01 | 2025-02-01 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating HBV and TTR expression |
| EP4039278A1 (en) | 2013-07-11 | 2022-08-10 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| WO2015069587A2 (en) | 2013-11-06 | 2015-05-14 | Merck Sharp & Dohme Corp. | Peptide containing conjugates for dual molecular delivery of oligonucleotides |
| KR20200102553A (ko) | 2014-05-01 | 2020-08-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | 성장 호르몬 수용체 발현을 조절하기 위한 조성물 및 방법 |
| EP3151839A4 (en) * | 2014-06-06 | 2018-02-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds |
| TW201620526A (zh) | 2014-06-17 | 2016-06-16 | 愛羅海德研究公司 | 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法 |
| RU2017101140A (ru) | 2014-07-01 | 2018-08-02 | Джима Тт С.П.А. | Упаковка для курительных изделий |
| AU2015317958A1 (en) | 2014-09-15 | 2017-05-04 | Qubole, Inc. | Systems and methods for providing metadata-aware background caching in data analysis |
| RU2017114156A (ru) | 2014-10-10 | 2018-11-15 | Ф. Хоффманн-Ля Рош Аг | N-ацетилгалактозаминовые (galnac) фосфорамитиды, их конъюгаты с нуклеиновыми кислотами и их применение |
| WO2016149020A1 (en) | 2015-03-17 | 2016-09-22 | Arrowhead Research Corporation | Rna interference agents |
| EP3271482A4 (en) * | 2015-03-17 | 2019-02-13 | Arrowhead Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING THE GENE EXPRESSION OF FACTOR XII |
| CN108271387B (zh) * | 2015-08-07 | 2023-06-27 | 箭头药业股份有限公司 | 乙型肝炎病毒感染的RNAi疗法 |
| JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| IL296377A (en) | 2016-03-07 | 2022-11-01 | Arrowhead Pharmaceuticals Inc | Targeting ligands for therapeutic compounds and uses of same |
| CN116942841A (zh) | 2016-09-02 | 2023-10-27 | 箭头药业股份有限公司 | 靶向配体 |
| US10450565B2 (en) | 2017-01-10 | 2019-10-22 | Arrowhead Pharmaceuticals, Inc. | Alpha-1 antitrypsin (AAT) RNAi agents, compositions including AAT RNAi agents, and methods of use |
| CA3048661A1 (en) | 2017-01-30 | 2018-08-02 | Arrowhead Pharmaceuticals Inc. | Compositions and methods for inhibition of factor xii gene expression |
-
2017
- 2017-03-07 IL IL296377A patent/IL296377A/en unknown
- 2017-03-07 KR KR1020237010168A patent/KR102830443B1/ko active Active
- 2017-03-07 US US15/452,423 patent/US10246709B2/en active Active
- 2017-03-07 NZ NZ744357A patent/NZ744357A/en unknown
- 2017-03-07 BR BR112018068230-6A patent/BR112018068230B1/pt active IP Right Grant
- 2017-03-07 CN CN202110938247.8A patent/CN113797348A/zh active Pending
- 2017-03-07 KR KR1020187027235A patent/KR102348425B1/ko active Active
- 2017-03-07 AU AU2017229469A patent/AU2017229469B2/en active Active
- 2017-03-07 CA CA3011946A patent/CA3011946A1/en active Pending
- 2017-03-07 UY UY0001037146A patent/UY37146A/es active IP Right Grant
- 2017-03-07 NZ NZ785880A patent/NZ785880A/en unknown
- 2017-03-07 TW TW110112971A patent/TWI783434B/zh active
- 2017-03-07 CN CN201780016137.8A patent/CN109069529B/zh active Active
- 2017-03-07 JO JOP/2017/0057A patent/JOP20170057B1/ar active
- 2017-03-07 KR KR1020227000160A patent/KR102515329B1/ko active Active
- 2017-03-07 TW TW106107454A patent/TWI727009B/zh active
- 2017-03-07 EP EP17763911.9A patent/EP3426261A4/en active Pending
- 2017-03-07 JP JP2018547320A patent/JP6983797B2/ja active Active
- 2017-03-07 WO PCT/US2017/021175 patent/WO2017156012A1/en not_active Ceased
- 2017-03-07 MX MX2018009854A patent/MX2018009854A/es unknown
- 2017-03-07 TW TW111137872A patent/TWI842117B/zh active
-
2018
- 2018-08-14 MX MX2023006332A patent/MX2023006332A/es unknown
- 2018-08-14 MX MX2023006334A patent/MX2023006334A/es unknown
- 2018-09-04 IL IL261598A patent/IL261598B/en unknown
-
2019
- 2019-03-25 US US16/363,108 patent/US20190211333A1/en not_active Abandoned
-
2021
- 2021-02-24 US US17/184,575 patent/US12116573B2/en active Active
- 2021-08-19 JO JOP/2021/0231A patent/JOP20210231A1/ar unknown
- 2021-11-23 IL IL288341A patent/IL288341B2/en unknown
- 2021-11-24 JP JP2021189879A patent/JP7485642B2/ja active Active
-
2023
- 2023-05-17 AU AU2023203102A patent/AU2023203102B2/en active Active
-
2024
- 2024-05-02 JP JP2024074913A patent/JP2024097862A/ja not_active Withdrawn
- 2024-09-04 US US18/824,808 patent/US20250243485A1/en active Pending
-
2025
- 2025-06-03 JP JP2025092644A patent/JP2025120251A/ja active Pending
- 2025-08-06 AU AU2025213612A patent/AU2025213612A1/en active Pending