JP2012516856A5 - - Google Patents
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- Publication number
- JP2012516856A5 JP2012516856A5 JP2011548431A JP2011548431A JP2012516856A5 JP 2012516856 A5 JP2012516856 A5 JP 2012516856A5 JP 2011548431 A JP2011548431 A JP 2011548431A JP 2011548431 A JP2011548431 A JP 2011548431A JP 2012516856 A5 JP2012516856 A5 JP 2012516856A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- inhibitor
- pharmaceutical combination
- antisense oligonucleotide
- cardiac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 claims 29
- 108091056170 miR-499 stem-loop Proteins 0.000 claims 17
- 108091050885 miR-499-1 stem-loop Proteins 0.000 claims 17
- 108091038523 miR-499-2 stem-loop Proteins 0.000 claims 17
- 108091071651 miR-208 stem-loop Proteins 0.000 claims 16
- 108091084446 miR-208a stem-loop Proteins 0.000 claims 16
- 108091062547 miR-208a-1 stem-loop Proteins 0.000 claims 16
- 108091055375 miR-208a-2 stem-loop Proteins 0.000 claims 16
- 108091047268 miR-208b stem-loop Proteins 0.000 claims 15
- 239000000074 antisense oligonucleotide Substances 0.000 claims 9
- 238000012230 antisense oligonucleotides Methods 0.000 claims 9
- 108091034117 Oligonucleotide Proteins 0.000 claims 8
- 230000000747 cardiac effect Effects 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- 230000003938 response to stress Effects 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 210000002064 heart cell Anatomy 0.000 claims 3
- 108091092539 MiR-208 Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020880 Hypertrophy Diseases 0.000 claims 1
- 230000009787 cardiac fibrosis Effects 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14991509P | 2009-02-04 | 2009-02-04 | |
| US61/149,915 | 2009-02-04 | ||
| PCT/US2010/023234 WO2010091204A1 (en) | 2009-02-04 | 2010-02-04 | Dual targeting of mir-208 and mir-499 in the treatment of cardiac disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012516856A JP2012516856A (ja) | 2012-07-26 |
| JP2012516856A5 true JP2012516856A5 (enExample) | 2013-03-21 |
| JP5943608B2 JP5943608B2 (ja) | 2016-07-05 |
Family
ID=42542383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548431A Expired - Fee Related JP5943608B2 (ja) | 2009-02-04 | 2010-02-04 | 心臓障害の治療におけるｍｉｒ−２０８およびｍｉｒ−４９９の二重ターゲティング |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8629119B2 (enExample) |
| EP (1) | EP2393945A4 (enExample) |
| JP (1) | JP5943608B2 (enExample) |
| KR (1) | KR20110128838A (enExample) |
| CN (1) | CN102356162A (enExample) |
| AU (1) | AU2010210605B2 (enExample) |
| BR (1) | BRPI1008517A2 (enExample) |
| CA (1) | CA2751489A1 (enExample) |
| MX (1) | MX2011008190A (enExample) |
| NZ (1) | NZ594365A (enExample) |
| RU (1) | RU2515926C2 (enExample) |
| UA (1) | UA105029C2 (enExample) |
| WO (1) | WO2010091204A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5995855B2 (ja) * | 2010-11-05 | 2016-09-21 | ミラゲン セラピューティクス，インコーポレイテッド | 塩基修飾オリゴヌクレオチド |
| WO2012083004A2 (en) * | 2010-12-15 | 2012-06-21 | Miragen Therapeutics | Blood-borne mirnas as surrogate markers of drug efficacy for cardiac conditions |
| CA2817371A1 (en) * | 2010-12-15 | 2012-06-21 | Miragen Therapeutics | Microrna inhibitors comprising locked nucleotides |
| US9428749B2 (en) | 2011-10-06 | 2016-08-30 | The Board Of Regents, The University Of Texas System | Control of whole body energy homeostasis by microRNA regulation |
| EP2584040A1 (en) | 2011-10-17 | 2013-04-24 | Pharmahungary 2000 Kft. | Compounds for treatment of ischemic injury |
| CN104685056A (zh) * | 2012-06-21 | 2015-06-03 | 米拉根医疗股份有限公司 | 包含锁核酸基序的基于寡核苷酸的抑制剂 |
| CN102980920A (zh) * | 2012-11-14 | 2013-03-20 | 华东师范大学 | 同时检测miRNAs与蛋白标记物的硅纳米线芯片及其检测方法和应用 |
| CN105154445B (zh) * | 2014-06-12 | 2018-07-27 | 中国科学院上海生命科学研究院 | 新的肌营养不良肌病的血清miRNA标志物 |
| WO2016022536A2 (en) * | 2014-08-04 | 2016-02-11 | MiRagen Therapeutics, Inc. | Inhibitors of myh7b and uses thereof |
| HK1249108A1 (zh) | 2015-01-20 | 2018-10-26 | 米拉根医疗股份有限公司 | Mir-92抑制剂及其用途 |
| PT3283508T (pt) | 2015-04-17 | 2021-06-21 | Alpine Immune Sciences Inc | Proteínas imuno modulatórias com afinidades afináveis |
| KR20190118688A (ko) * | 2015-06-05 | 2019-10-18 | 미라젠 세러퓨틱스 인코포레이티드 | 피부 t 세포 림프종(ctcl) 치료용 mir-155 억제제 |
| CA3198255A1 (en) | 2017-10-10 | 2019-04-18 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
| WO2019136179A1 (en) | 2018-01-03 | 2019-07-11 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| CN108815535B (zh) * | 2018-08-08 | 2020-05-19 | 哈尔滨医科大学 | 一种抗心肌肌钙蛋白抗体修饰并载有miR-21的脂质体及其制备方法和应用 |
| CN119246849B (zh) * | 2024-12-09 | 2025-03-14 | 上海基灵生物科技有限公司 | 一种检测犬心脏损伤的试剂盒及应用 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004522411A (ja) | 2000-07-31 | 2004-07-29 | ジーン ロジック インコーポレイテッド | 分子毒性学モデリング |
| RU2311921C2 (ru) * | 2000-09-13 | 2007-12-10 | Чугаи Сейяку Кабусики Кайся | Лекарственные средства для лечения ишемических заболеваний |
| CZ20031569A3 (cs) * | 2000-12-07 | 2003-11-12 | Gencell S. A. | Polynukleotidy obsahující fragment sekvence v protisměru od genu CARP, vektory a expresní kazety, které je obsahují, a jejich použití |
| US20050124568A1 (en) | 2001-05-18 | 2005-06-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of acetyl-CoA-carboxylase gene expression using short interfering nucleic acid (siNA) |
| US6964950B2 (en) * | 2001-07-25 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of C-reactive protein expression |
| IL161100A0 (en) | 2001-09-28 | 2004-08-31 | Max Planck Gesellschaft | Identification of novel genes coding for small temporal rnas |
| WO2003065993A2 (en) | 2002-02-04 | 2003-08-14 | Gene Logic, Inc. | Primary rat hepatocyte toxicity modeling |
| US20080214437A1 (en) | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
| US7781415B2 (en) | 2003-02-07 | 2010-08-24 | Roche Madison Inc. | Process for delivering sirna to cardiac muscle tissue |
| EP1648914A4 (en) | 2003-07-31 | 2009-12-16 | Regulus Therapeutics Inc | OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA |
| WO2005047505A2 (en) | 2003-08-07 | 2005-05-26 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro rnas |
| WO2005017145A1 (ja) | 2003-08-13 | 2005-02-24 | Japan Biological Informatics Consortium | 機能性ｒｎａが制御する被制御遺伝子の同定・予測方法及びその利用方法 |
| US20050256072A1 (en) | 2004-02-09 | 2005-11-17 | University Of Massachusetts | Dual functional oligonucleotides for use in repressing mutant gene expression |
| EP2295604B1 (en) | 2004-02-09 | 2015-04-08 | Thomas Jefferson University | Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features |
| AU2005214904B2 (en) | 2004-02-13 | 2011-07-21 | Rockefeller University | Anti-microRNA oligonucleotide molecules |
| AU2005250432B2 (en) | 2004-05-28 | 2011-09-15 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US7635563B2 (en) | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| WO2006013561A2 (en) | 2004-08-02 | 2006-02-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions and methods for diagnosing and treating post traumatic stress disorder |
| JP2006101790A (ja) | 2004-10-06 | 2006-04-20 | Japan Health Science Foundation | 高血圧症のリスクの評価方法 |
| WO2006047454A2 (en) | 2004-10-21 | 2006-05-04 | Rutgers, The State University Of New Jersey | Rational probe optimization for detection of micrornas |
| CA2857881A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| WO2006063356A1 (en) | 2004-12-10 | 2006-06-15 | Isis Phamaceuticals, Inc. | Regulation of epigenetic control of gene expression |
| US20060185027A1 (en) | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| EP1959012A3 (en) | 2004-12-29 | 2009-12-30 | Exiqon A/S | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAs and their target mRNAs |
| US8071306B2 (en) | 2005-01-25 | 2011-12-06 | Merck Sharp & Dohme Corp. | Methods for quantitating small RNA molecules |
| US9085774B2 (en) | 2005-04-19 | 2015-07-21 | Basf Plant Science Gmbh | Methods controlling gene expression |
| SI2002003T1 (sl) | 2005-05-27 | 2016-05-31 | Ospedale San Raffaele S.R.L. | Genski vektor, ki vsebuje mi-RNA |
| US20070077582A1 (en) | 2005-09-16 | 2007-04-05 | Primera Biosystems, Inc. | Method for quantitative detection of short RNA molecules |
| US20070092882A1 (en) | 2005-10-21 | 2007-04-26 | Hui Wang | Analysis of microRNA |
| AU2006326517B2 (en) | 2005-12-12 | 2013-02-21 | The University Of North Carolina At Chapel Hill | MicroRNAs that regulate muscle cell proliferation and differentiation |
| EP1966390A1 (en) | 2005-12-29 | 2008-09-10 | Exiqon A/S | Detection of tissue origin of cancer |
| JP5213723B2 (ja) | 2006-01-27 | 2013-06-19 | アイシス ファーマシューティカルズ， インコーポレーテッド | マイクロｒｎａの調節に使用するためのオリゴマー化合物及び組成物 |
| MX2008012219A (es) | 2006-04-03 | 2008-10-02 | Santaris Pharma As | Composicion farmaceutica que comprende oligonucleotidos antisentido anti-miarn. |
| KR101485495B1 (ko) * | 2006-08-01 | 2015-01-22 | 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 베타-마이오신 중사슬의 발현을 활성화하는 마이크로-ｒｎａ의 동정 |
| US20090306181A1 (en) | 2006-09-29 | 2009-12-10 | Children's Medical Center Corporation | Compositions and methods for evaluating and treating heart failure |
| US8906870B2 (en) | 2006-10-09 | 2014-12-09 | Julius-Maximilians-Universitaet Wuerzberg | MicroRNA (miRNA) for the diagnosis and treatment of heart diseases |
| CA2681568C (en) | 2006-11-23 | 2019-01-08 | Querdenker Aps | Oligonucleotides for modulating target rna activity |
| EA200900782A1 (ru) * | 2006-12-14 | 2009-12-30 | Новартис Аг | Композиции и способы, предназначенные для лечения мышечных и сердечно-сосудистых нарушений |
| EP3536788A1 (en) | 2006-12-21 | 2019-09-11 | QIAGEN GmbH | Microrna target site blocking oligos and uses thereof |
| WO2008074328A2 (en) | 2006-12-21 | 2008-06-26 | Exiqon A/S | Microrna target site blocking oligos and uses thereof |
| WO2008147837A1 (en) | 2007-05-23 | 2008-12-04 | Dharmacon, Inc. | Micro-rna scaffolds, non-naturally occurring micro-rnas, and methods for optimizing non-naturally occurring micro-rnas |
| CN101808649B (zh) | 2007-07-31 | 2014-05-21 | 得克萨斯系统大学董事会 | 控制肌球蛋白表达和肌纤维身份的微小rna |
| US20100292099A1 (en) | 2007-08-23 | 2010-11-18 | Keren Pharmaceutical, Inc. | Targeting of rna with external guide sequences |
| AU2008306327B2 (en) | 2007-10-04 | 2014-05-15 | Roche Innovation Center Copenhagen A/S | Micromirs |
| WO2009058818A2 (en) | 2007-10-29 | 2009-05-07 | The Board Of Regents Of The University Of Texas System | Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling |
| JP5654352B2 (ja) | 2007-11-09 | 2015-01-14 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | ｍｉＲ−１５ファミリーのマイクロＲＮＡによる心筋細胞生存及び心臓修復の調節 |
| WO2009114681A2 (en) | 2008-03-13 | 2009-09-17 | Dharmacon, Inc. | Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy |
| US20090326049A1 (en) | 2008-04-04 | 2009-12-31 | Alexander Aristarkhov | Blocking oligos for inhibition of microrna and sirna activity and uses thereof |
| EP2297322A1 (en) | 2008-06-04 | 2011-03-23 | The Board of Regents of The University of Texas System | Modulation of gene expression through endogenous small rna targeting of gene promoters |
| EP2303292A4 (en) | 2008-06-09 | 2013-01-02 | New York Medical College | COMPOSITIONS WITH CARDIAL STEM CELLS WITH OVEREXPRESSION OF SPECIFIC MICRORNAS AND METHOD FOR THEIR USE IN THE REPAIR OF THE CARED MYOCARDIC |
| US8987435B2 (en) | 2008-10-24 | 2015-03-24 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
-
2010
- 2010-02-04 CA CA 2751489 patent/CA2751489A1/en not_active Abandoned
- 2010-02-04 NZ NZ59436510A patent/NZ594365A/xx not_active IP Right Cessation
- 2010-02-04 BR BRPI1008517A patent/BRPI1008517A2/pt not_active IP Right Cessation
- 2010-02-04 KR KR20117020396A patent/KR20110128838A/ko not_active Ceased
- 2010-02-04 US US13/147,784 patent/US8629119B2/en not_active Expired - Fee Related
- 2010-02-04 CN CN2010800123730A patent/CN102356162A/zh active Pending
- 2010-02-04 EP EP20100739137 patent/EP2393945A4/en not_active Withdrawn
- 2010-02-04 JP JP2011548431A patent/JP5943608B2/ja not_active Expired - Fee Related
- 2010-02-04 RU RU2011136640/10A patent/RU2515926C2/ru not_active IP Right Cessation
- 2010-02-04 MX MX2011008190A patent/MX2011008190A/es active IP Right Grant
- 2010-02-04 AU AU2010210605A patent/AU2010210605B2/en not_active Ceased
- 2010-02-04 WO PCT/US2010/023234 patent/WO2010091204A1/en not_active Ceased
- 2010-02-04 UA UAA201110646A patent/UA105029C2/uk unknown
-
2013
- 2013-12-12 US US14/104,886 patent/US20140179764A1/en not_active Abandoned
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