UA105029C2 - ПОДВІЙНЕ НАЦІЛЮВАННЯ НА miR-208 І miR-499 У ЛІКУВАННІ ЗАХВОРЮВАНЬ СЕРЦЯ - Google Patents

ПОДВІЙНЕ НАЦІЛЮВАННЯ НА miR-208 І miR-499 У ЛІКУВАННІ ЗАХВОРЮВАНЬ СЕРЦЯ

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Publication number
UA105029C2
UA105029C2 UAA201110646A UAA201110646A UA105029C2 UA 105029 C2 UA105029 C2 UA 105029C2 UA A201110646 A UAA201110646 A UA A201110646A UA A201110646 A UAA201110646 A UA A201110646A UA 105029 C2 UA105029 C2 UA 105029C2
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Ukraine
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mir
subject
cardiac disorders
treatment
dual targeting
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UAA201110646A
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English (en)
Russian (ru)
Inventor
Ерік Олсон
Єва ван Руідж
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Борд Оф Ріджентс, Зе Юніверсіті Оф Техас Сістем
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Publication of UA105029C2 publication Critical patent/UA105029C2/uk

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2320/00—Applications; Uses
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    • C12N2320/31—Combination therapy
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    • C12N2330/00—Production
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

Винахід стосується способу лікування патологічної гіпертрофії серця, серцевої недостатності або інфаркту міокарда у індивідуума, який потребує цього, що включає введення індивідууму першого антисмислового олігонуклеотиду, який містить послідовність, яка щонайменше частково комплементарна зрілій послідовності miR-208a або miR-208b, і другого антисмислового олігонуклеотиду, який містить послідовність, яка щонайменше частково комплементарна зрілій послідовності miR-499, де перший і другий олігонуклеотиди складають від приблизно 8 до приблизно 18 нуклеотидів в довжину, і де експресія або активність miR-208a або miR-208b і miR-499 знижується у клітинах серця індивідуума.
UAA201110646A 2009-02-04 2010-02-04 ПОДВІЙНЕ НАЦІЛЮВАННЯ НА miR-208 І miR-499 У ЛІКУВАННІ ЗАХВОРЮВАНЬ СЕРЦЯ UA105029C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14991509P 2009-02-04 2009-02-04
PCT/US2010/023234 WO2010091204A1 (en) 2009-02-04 2010-02-04 Dual targeting of mir-208 and mir-499 in the treatment of cardiac disorders

Publications (1)

Publication Number Publication Date
UA105029C2 true UA105029C2 (uk) 2014-04-10

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US (2) US8629119B2 (uk)
EP (1) EP2393945A4 (uk)
JP (1) JP5943608B2 (uk)
KR (1) KR20110128838A (uk)
CN (1) CN102356162A (uk)
AU (1) AU2010210605B2 (uk)
BR (1) BRPI1008517A2 (uk)
CA (1) CA2751489A1 (uk)
MX (1) MX2011008190A (uk)
NZ (1) NZ594365A (uk)
RU (1) RU2515926C2 (uk)
UA (1) UA105029C2 (uk)
WO (1) WO2010091204A1 (uk)

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RU2011136640A (ru) 2013-03-10
JP2012516856A (ja) 2012-07-26
RU2515926C2 (ru) 2014-05-20
AU2010210605B2 (en) 2015-08-13
NZ594365A (en) 2013-03-28
BRPI1008517A2 (pt) 2016-03-08
EP2393945A1 (en) 2011-12-14
WO2010091204A1 (en) 2010-08-12
US20140179764A1 (en) 2014-06-26
US20120035243A1 (en) 2012-02-09
EP2393945A4 (en) 2013-08-07
JP5943608B2 (ja) 2016-07-05
KR20110128838A (ko) 2011-11-30
CA2751489A1 (en) 2010-08-12
AU2010210605A1 (en) 2011-08-25
MX2011008190A (es) 2011-10-06
US8629119B2 (en) 2014-01-14
CN102356162A (zh) 2012-02-15

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