RU2515926C2 - Двойное нацеливание нп mir-208 и mir 499 в лечении заболеваний сердца - Google Patents
Двойное нацеливание нп mir-208 и mir 499 в лечении заболеваний сердца Download PDFInfo
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- RU2515926C2 RU2515926C2 RU2011136640/10A RU2011136640A RU2515926C2 RU 2515926 C2 RU2515926 C2 RU 2515926C2 RU 2011136640/10 A RU2011136640/10 A RU 2011136640/10A RU 2011136640 A RU2011136640 A RU 2011136640A RU 2515926 C2 RU2515926 C2 RU 2515926C2
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- mir
- antisense oligonucleotide
- sequence
- expression
- heart
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- C12N2330/00—Production
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US14991509P | 2009-02-04 | 2009-02-04 | |
| US61/149,915 | 2009-02-04 | ||
| PCT/US2010/023234 WO2010091204A1 (en) | 2009-02-04 | 2010-02-04 | Dual targeting of mir-208 and mir-499 in the treatment of cardiac disorders |
Publications (2)
| Publication Number | Publication Date |
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| RU2011136640A RU2011136640A (ru) | 2013-03-10 |
| RU2515926C2 true RU2515926C2 (ru) | 2014-05-20 |
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| EP (1) | EP2393945A4 (enExample) |
| JP (1) | JP5943608B2 (enExample) |
| KR (1) | KR20110128838A (enExample) |
| CN (1) | CN102356162A (enExample) |
| AU (1) | AU2010210605B2 (enExample) |
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| CA (1) | CA2751489A1 (enExample) |
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| UA (1) | UA105029C2 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718534C2 (ru) * | 2015-06-05 | 2020-04-08 | Мираджен Терапьютикс, Инк. | Ингибиторы mir-155 для лечения кожной t-клеточной лимфомы (ctcl) |
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| US9416360B2 (en) | 2010-11-05 | 2016-08-16 | MiRagen Therapeutics, Inc. | Base modified oligonucleotides |
| CA2818174A1 (en) * | 2010-12-15 | 2012-06-21 | Miragen Therapeutics | Blood-borne mirnas as surrogate markers of drug efficacy for cardiac conditions |
| WO2012083005A2 (en) * | 2010-12-15 | 2012-06-21 | Miragen Therapeutics | Microrna inhibitors comprising locked nucleotides |
| KR20140091688A (ko) | 2011-10-06 | 2014-07-22 | 미라젠 세러퓨틱스 인코포레이티드 | 마이크로rna 조절에 의한 전신 에너지 항상성의 제어 |
| EP2584040A1 (en) | 2011-10-17 | 2013-04-24 | Pharmahungary 2000 Kft. | Compounds for treatment of ischemic injury |
| CA2876180C (en) * | 2012-06-21 | 2019-11-19 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| CN102980920A (zh) * | 2012-11-14 | 2013-03-20 | 华东师范大学 | 同时检测miRNAs与蛋白标记物的硅纳米线芯片及其检测方法和应用 |
| CN105154445B (zh) * | 2014-06-12 | 2018-07-27 | 中国科学院上海生命科学研究院 | 新的肌营养不良肌病的血清miRNA标志物 |
| AR101449A1 (es) * | 2014-08-04 | 2016-12-21 | Miragen Therapeutics Inc | Inhibidores de myh7b y usos de los mismos |
| SG11201705907XA (en) | 2015-01-20 | 2017-08-30 | Miragen Therapeutics Inc | Mir-92 inhibitors and uses thereof |
| EP3875477A1 (en) | 2015-04-17 | 2021-09-08 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
| KR102813968B1 (ko) | 2017-10-10 | 2025-05-29 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Ctla-4 변이체 면역조절 단백질 및 이의 용도 |
| US12297253B2 (en) | 2018-01-03 | 2025-05-13 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| CN108815535B (zh) * | 2018-08-08 | 2020-05-19 | 哈尔滨医科大学 | 一种抗心肌肌钙蛋白抗体修饰并载有miR-21的脂质体及其制备方法和应用 |
| CN119246849B (zh) * | 2024-12-09 | 2025-03-14 | 上海基灵生物科技有限公司 | 一种检测犬心脏损伤的试剂盒及应用 |
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2013
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| RU2311921C2 (ru) * | 2000-09-13 | 2007-12-10 | Чугаи Сейяку Кабусики Кайся | Лекарственные средства для лечения ишемических заболеваний |
| RU2283865C2 (ru) * | 2000-12-07 | 2006-09-20 | Сантелион С.А.С | Последовательность, расположенная выше гена carp, вектор, содержащий эту последовательность, и их использование |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718534C2 (ru) * | 2015-06-05 | 2020-04-08 | Мираджен Терапьютикс, Инк. | Ингибиторы mir-155 для лечения кожной t-клеточной лимфомы (ctcl) |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2393945A1 (en) | 2011-12-14 |
| RU2011136640A (ru) | 2013-03-10 |
| CA2751489A1 (en) | 2010-08-12 |
| JP2012516856A (ja) | 2012-07-26 |
| CN102356162A (zh) | 2012-02-15 |
| JP5943608B2 (ja) | 2016-07-05 |
| BRPI1008517A2 (pt) | 2016-03-08 |
| AU2010210605B2 (en) | 2015-08-13 |
| UA105029C2 (uk) | 2014-04-10 |
| EP2393945A4 (en) | 2013-08-07 |
| KR20110128838A (ko) | 2011-11-30 |
| NZ594365A (en) | 2013-03-28 |
| US20140179764A1 (en) | 2014-06-26 |
| WO2010091204A1 (en) | 2010-08-12 |
| MX2011008190A (es) | 2011-10-06 |
| US8629119B2 (en) | 2014-01-14 |
| AU2010210605A1 (en) | 2011-08-25 |
| US20120035243A1 (en) | 2012-02-09 |
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