JP2012130342A5 - - Google Patents
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- Publication number
- JP2012130342A5 JP2012130342A5 JP2012009515A JP2012009515A JP2012130342A5 JP 2012130342 A5 JP2012130342 A5 JP 2012130342A5 JP 2012009515 A JP2012009515 A JP 2012009515A JP 2012009515 A JP2012009515 A JP 2012009515A JP 2012130342 A5 JP2012130342 A5 JP 2012130342A5
- Authority
- JP
- Japan
- Prior art keywords
- side region
- nucleic acid
- acid molecule
- stranded rna
- bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 39
- 230000014509 gene expression Effects 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 14
- 230000001629 suppression Effects 0.000 claims description 10
- 230000009368 gene silencing by RNA Effects 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 230000001939 inductive effect Effects 0.000 claims 4
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000002585 base Substances 0.000 description 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 1
- 108091030071 RNAI Proteins 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 230000030279 gene silencing Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012009515A JP5804642B2 (ja) | 2010-07-08 | 2012-01-20 | 遺伝子発現制御のための一本鎖核酸分子 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010156122 | 2010-07-08 | ||
| JP2010156122 | 2010-07-08 | ||
| JP2010174915 | 2010-08-03 | ||
| JP2010174915 | 2010-08-03 | ||
| JP2010230808 | 2010-10-13 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010230808 | 2010-10-13 | ||
| JP2010269824 | 2010-12-02 | ||
| JP2010269824 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2012009515A JP5804642B2 (ja) | 2010-07-08 | 2012-01-20 | 遺伝子発現制御のための一本鎖核酸分子 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537086A Division JP4968811B2 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015150156A Division JP6162182B2 (ja) | 2010-07-08 | 2015-07-29 | 遺伝子発現制御のための一本鎖核酸分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012130342A JP2012130342A (ja) | 2012-07-12 |
| JP2012130342A5 true JP2012130342A5 (enExample) | 2013-10-03 |
| JP5804642B2 JP5804642B2 (ja) | 2015-11-04 |
Family
ID=45441339
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537086A Expired - Fee Related JP4968811B2 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
| JP2012009515A Expired - Fee Related JP5804642B2 (ja) | 2010-07-08 | 2012-01-20 | 遺伝子発現制御のための一本鎖核酸分子 |
| JP2015150156A Expired - Fee Related JP6162182B2 (ja) | 2010-07-08 | 2015-07-29 | 遺伝子発現制御のための一本鎖核酸分子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537086A Expired - Fee Related JP4968811B2 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015150156A Expired - Fee Related JP6162182B2 (ja) | 2010-07-08 | 2015-07-29 | 遺伝子発現制御のための一本鎖核酸分子 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8785121B2 (enExample) |
| EP (2) | EP2431466B1 (enExample) |
| JP (3) | JP4968811B2 (enExample) |
| KR (1) | KR101849798B1 (enExample) |
| CN (2) | CN104818276B (enExample) |
| AU (1) | AU2011274854B2 (enExample) |
| BR (1) | BR112013000481A2 (enExample) |
| CA (1) | CA2804511C (enExample) |
| DK (2) | DK2933333T3 (enExample) |
| ES (2) | ES2670017T3 (enExample) |
| HU (2) | HUE026520T2 (enExample) |
| MX (1) | MX352568B (enExample) |
| NZ (2) | NZ704812A (enExample) |
| PT (2) | PT2431466E (enExample) |
| RU (1) | RU2628311C2 (enExample) |
| SG (2) | SG186899A1 (enExample) |
| TW (2) | TWI527901B (enExample) |
| WO (1) | WO2012005368A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG186899A1 (en) * | 2010-07-08 | 2013-02-28 | Bonac Corp | Single-strand nucleic acid molecule for controlling gene expression |
| ES2533129T3 (es) | 2010-08-03 | 2015-04-07 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Ｖｅｇｆ遺伝子の発現抑制用一本鎖核酸分子 |
| JP6283859B2 (ja) * | 2012-03-29 | 2018-02-28 | 国立大学法人九州大学 | ペリオスチン遺伝子の発現抑制核酸分子、ペリオスチン遺伝子の発現抑制方法、およびその用途 |
| US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| SG10201805087VA (en) | 2013-12-27 | 2018-07-30 | Bonac Corp | Artificial match-type mirna for controlling gene expression and use therefor |
| HK1244035A1 (en) * | 2014-12-15 | 2018-07-27 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression |
| WO2016104775A1 (ja) | 2014-12-27 | 2016-06-30 | 株式会社ボナック | 遺伝子発現制御のための天然型ｍｉＲＮＡおよびその用途 |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| EP3369816B1 (en) | 2015-10-30 | 2024-03-13 | Toray Industries, Inc. | Composition stably containing single-stranded nucleic acid molecule that suppresses expression of tgf-beta1 gene |
| JP6634095B2 (ja) | 2015-12-29 | 2020-01-22 | 国立大学法人北海道大学 | プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途 |
| EP3409779A4 (en) | 2016-01-26 | 2019-07-03 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| WO2017131237A1 (ja) | 2016-01-30 | 2017-08-03 | 株式会社ボナック | 人工単一ガイドｒｎａ及びその用途 |
| CN108342386B (zh) * | 2017-01-22 | 2022-04-15 | 广州市锐博生物科技有限公司 | 一种多聚寡核酸分子及其在多靶标干扰中的应用 |
| JP7188087B2 (ja) | 2017-02-06 | 2022-12-13 | 日産化学株式会社 | 一本鎖オリゴヌクレオチド |
| US20200038427A1 (en) | 2017-03-31 | 2020-02-06 | Bonac Corporation | Cyclic nucleic acid molecule having gene expression control function |
| WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | Ｂ型肝炎治療用核酸分子 |
| WO2019022257A1 (ja) | 2017-07-28 | 2019-01-31 | 杏林製薬株式会社 | 線維症治療剤 |
| CN119506283A (zh) * | 2017-09-15 | 2025-02-25 | 联邦科学技术研究组织 | Rna分子 |
| JP7208911B2 (ja) | 2017-10-11 | 2023-01-19 | 日東電工株式会社 | 核酸分子発現の調節 |
| WO2019074110A1 (ja) | 2017-10-13 | 2019-04-18 | 株式会社ボナック | 一本鎖核酸分子およびその製造方法 |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| EP3778886A4 (en) | 2018-03-30 | 2022-11-02 | Toray Industries, Inc. | Method for producing hairpin single-stranded rna molecule |
| US20210115485A1 (en) | 2018-03-30 | 2021-04-22 | Sumitomo Chemical Company, Limited | Method for producing single-strand rna |
| CN112673102A (zh) * | 2018-10-02 | 2021-04-16 | 东丽株式会社 | 发夹型单链rna分子的制备方法 |
| WO2020152869A1 (ja) | 2019-01-25 | 2020-07-30 | 杏林製薬株式会社 | 線維症治療剤 |
| EP4726043A3 (en) | 2019-02-18 | 2026-06-24 | Ajinomoto Co., Inc. | Method for producing modified oligonucleotide including complementary sequence |
| CN114502566B (zh) | 2019-10-11 | 2025-02-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| CN115003680B (zh) | 2020-01-29 | 2025-01-28 | 住友化学株式会社 | 制备核酸寡聚物的方法 |
| KR20220133878A (ko) | 2020-01-29 | 2022-10-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| JP7613130B2 (ja) * | 2020-03-25 | 2025-01-15 | 味の素株式会社 | リガーゼ変異体 |
| CN115335387A (zh) | 2020-03-27 | 2022-11-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| KR20230034969A (ko) | 2020-07-09 | 2023-03-10 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| KR20230074205A (ko) | 2020-09-24 | 2023-05-26 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| EP4410770A4 (en) | 2021-09-28 | 2026-03-25 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF PURIFIED DICHLOROACETIC ACID |
| EP4488282A4 (en) | 2022-03-23 | 2025-11-19 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS |
| JP7201190B1 (ja) | 2022-06-03 | 2023-01-10 | 株式会社セツロテック | 遺伝子改変動物由来の動物繊維 |
| JP7825064B2 (ja) | 2022-10-27 | 2026-03-05 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
| WO2025229953A1 (ja) | 2024-04-30 | 2025-11-06 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
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| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5631148A (en) * | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| GB9621367D0 (en) | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| FR2790757B1 (fr) | 1999-03-09 | 2003-08-01 | Bioalliance Pharma | Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant. |
| US6962906B2 (en) | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| TWI321054B (en) | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
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| WO2003072745A2 (en) * | 2002-02-22 | 2003-09-04 | Eshleman James R | Antigene locks and therapeutic uses thereof |
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| EP2256191A4 (en) * | 2008-02-15 | 2011-07-06 | Riken | CYCLIC SINGLE NUCLEIC ACID COMPLEX AND METHOD FOR THE PRODUCTION THEREOF |
| JP5187580B2 (ja) | 2008-12-26 | 2013-04-24 | 丸紅建材リース株式会社 | 掘削機の泥土飛散防止装置 |
| JP2010174915A (ja) | 2009-01-27 | 2010-08-12 | Toyota Motor Corp | 高圧ガスタンク |
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| JP5233790B2 (ja) | 2009-03-26 | 2013-07-10 | 船井電機株式会社 | 液晶モジュール |
| JP2010269823A (ja) | 2009-05-21 | 2010-12-02 | British American Tobacco Japan Kk | 喫煙品用容器 |
| JP4885255B2 (ja) | 2009-05-21 | 2012-02-29 | 株式会社エフピコ | 包装用容器 |
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| WO2011132672A1 (ja) | 2010-04-19 | 2011-10-27 | 独立行政法人理化学研究所 | 機能性核酸の安定化法 |
| SG186899A1 (en) * | 2010-07-08 | 2013-02-28 | Bonac Corp | Single-strand nucleic acid molecule for controlling gene expression |
-
2011
- 2011-07-08 SG SG2013000211A patent/SG186899A1/en unknown
- 2011-07-08 EP EP11746147.5A patent/EP2431466B1/en active Active
- 2011-07-08 ES ES15169933.7T patent/ES2670017T3/es active Active
- 2011-07-08 KR KR1020127033429A patent/KR101849798B1/ko not_active Expired - Fee Related
- 2011-07-08 CN CN201510226685.6A patent/CN104818276B/zh not_active Expired - Fee Related
- 2011-07-08 US US13/254,150 patent/US8785121B2/en active Active
- 2011-07-08 CN CN201180027223.1A patent/CN102918156B/zh not_active Expired - Fee Related
- 2011-07-08 DK DK15169933.7T patent/DK2933333T3/en active
- 2011-07-08 PT PT117461475T patent/PT2431466E/pt unknown
- 2011-07-08 EP EP15169933.7A patent/EP2933333B1/en active Active
- 2011-07-08 TW TW100124393A patent/TWI527901B/zh not_active IP Right Cessation
- 2011-07-08 HU HUE11746147A patent/HUE026520T2/en unknown
- 2011-07-08 ES ES11746147.5T patent/ES2550487T3/es active Active
- 2011-07-08 JP JP2011537086A patent/JP4968811B2/ja not_active Expired - Fee Related
- 2011-07-08 NZ NZ704812A patent/NZ704812A/en unknown
- 2011-07-08 TW TW104143857A patent/TWI573870B/zh not_active IP Right Cessation
- 2011-07-08 WO PCT/JP2011/065737 patent/WO2012005368A1/ja not_active Ceased
- 2011-07-08 AU AU2011274854A patent/AU2011274854B2/en not_active Ceased
- 2011-07-08 HU HUE15169933A patent/HUE037500T2/hu unknown
- 2011-07-08 PT PT151699337T patent/PT2933333T/pt unknown
- 2011-07-08 NZ NZ606232A patent/NZ606232A/en not_active IP Right Cessation
- 2011-07-08 CA CA2804511A patent/CA2804511C/en active Active
- 2011-07-08 SG SG2013097233A patent/SG196779A1/en unknown
- 2011-07-08 BR BR112013000481-9A patent/BR112013000481A2/pt not_active Application Discontinuation
- 2011-07-08 DK DK11746147.5T patent/DK2431466T3/en active
- 2011-07-08 RU RU2013105329A patent/RU2628311C2/ru active
- 2011-07-08 MX MX2013000315A patent/MX352568B/es active IP Right Grant
-
2012
- 2012-01-20 JP JP2012009515A patent/JP5804642B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-12 US US14/303,315 patent/US20150011605A1/en not_active Abandoned
-
2015
- 2015-07-29 JP JP2015150156A patent/JP6162182B2/ja not_active Expired - Fee Related
- 2015-10-29 US US14/927,270 patent/US20160108400A1/en not_active Abandoned
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