BR112013000481A2 - molécula de ácido nucléico de filamento simples para controle da expressão genética - Google Patents
molécula de ácido nucléico de filamento simples para controle da expressão genéticaInfo
- Publication number
- BR112013000481A2 BR112013000481A2 BR112013000481-9A BR112013000481A BR112013000481A2 BR 112013000481 A2 BR112013000481 A2 BR 112013000481A2 BR 112013000481 A BR112013000481 A BR 112013000481A BR 112013000481 A2 BR112013000481 A2 BR 112013000481A2
- Authority
- BR
- Brazil
- Prior art keywords
- region
- nucleic acid
- acid molecule
- stranded nucleic
- expression
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 7
- 108020004707 nucleic acids Proteins 0.000 title abstract 7
- 150000007523 nucleic acids Chemical class 0.000 title abstract 7
- 102000039446 nucleic acids Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000000295 complement effect Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
molécula de ácido nucléico de filamento simples para controle da expressão genética. fornece-se uma nova molécula de ácido nucléico que pode inibir a expressão de um gene e pode ser produzida fácil e eficientemente. a molécula de ácida nucléico é uma molécula de ácido nucléico de filamento simples incluindo uma sequência inibótória da expressão que inibe a expressão de um gene alvo. a molécula de ácido nucléico de filamento simples inclui, na sequência do lado 5<39> ao lado 3 <39>; uma região do lado 5<39> (xc); uma região interna (z); e uma região do lado 3 <39> (yc). a região interna (z) é composta de uma região do lado 5<39> interno (x) e uma região do lado 3<39> interno (y) que são ligados uma ás outras. a região do lado 5<39> (xc) é complementar á região do lado 5<39> interno (x). a região do lado 3 <39> (yc) é complementar á região do lado 3<39> interno (y). no mínimo, uma da região interna (z), a região do lado 5<39> (xc) e a região do lado 3<39> (yc) inclui a sequência inibitória da expressão. de acordo com essa molécula de ácido nucléico de filamento simples, é possível inibir a expressão do gene alvo.
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010156122 | 2010-07-08 | ||
| JP2010-156122 | 2010-07-08 | ||
| JP2010174915 | 2010-08-03 | ||
| JP2010-174915 | 2010-08-03 | ||
| JP2010-230806 | 2010-10-13 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010-230808 | 2010-10-13 | ||
| JP2010230808 | 2010-10-13 | ||
| JP2010-269823 | 2010-12-02 | ||
| JP2010269824 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| US2010-269824 | 2010-12-02 | ||
| PCT/JP2011/065737 WO2012005368A1 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013000481A2 true BR112013000481A2 (pt) | 2019-10-15 |
Family
ID=45441339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013000481-9A BR112013000481A2 (pt) | 2010-07-08 | 2011-07-08 | molécula de ácido nucléico de filamento simples para controle da expressão genética |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP2933333B1 (pt) |
| JP (3) | JP4968811B2 (pt) |
| KR (1) | KR101849798B1 (pt) |
| CN (2) | CN104818276B (pt) |
| AU (1) | AU2011274854B2 (pt) |
| BR (1) | BR112013000481A2 (pt) |
| CA (1) | CA2804511C (pt) |
| DK (2) | DK2933333T3 (pt) |
| ES (2) | ES2670017T3 (pt) |
| HK (1) | HK1181423A1 (pt) |
| HU (2) | HUE026520T2 (pt) |
| MX (1) | MX352568B (pt) |
| NZ (2) | NZ704812A (pt) |
| PT (2) | PT2933333T (pt) |
| RU (1) | RU2628311C2 (pt) |
| SG (2) | SG186899A1 (pt) |
| TW (2) | TWI573870B (pt) |
| WO (1) | WO2012005368A1 (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Ｖｅｇｆ遺伝子の発現抑制用一本鎖核酸分子 |
| CN104220598B (zh) * | 2012-03-29 | 2018-05-01 | 国立大学法人九州大学 | 骨膜素基因的表达抑制核酸分子、骨膜素基因的表达抑制方法及其用途 |
| US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| EP3088524A4 (en) | 2013-12-26 | 2017-08-09 | Tokyo Medical University | Artificial mimic mirna for controlling gene expression, and use of same |
| JP6425142B2 (ja) | 2013-12-27 | 2018-11-21 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型ｍｉＲＮＡおよびその用途 |
| WO2016098782A1 (ja) | 2014-12-15 | 2016-06-23 | 株式会社ボナック | ＴＧＦ－β１発現抑制のための一本鎖核酸分子 |
| MX2017008587A (es) | 2014-12-27 | 2017-10-20 | Bonac Corp | Mirna natural para controlar la expresion de gen y uso del mismo. |
| CN108064289A (zh) | 2015-03-27 | 2018-05-22 | 株式会社博纳克 | 具有递送功能和基因表达调控能力的单链核酸分子 |
| AU2016346703B2 (en) | 2015-10-30 | 2020-07-02 | Hirofumi Takeuchi | Composition stably containing single-stranded nucleic acid molecule that suppresses expression of TGF-β1 gene |
| EP3399037A4 (en) | 2015-12-29 | 2019-05-29 | National University Corporation Hokkaido University | SINGLE-NUCLEIC NUCLEIC ACID MOLECULE INHIBITING THE EXPRESSION OF A PRORENIN OR PRORENIN RECEPTOR GENE AND USE THEREOF |
| CA3013179A1 (en) | 2016-01-30 | 2017-08-03 | Bonac Corporation | Artificial single guide rna and use thereof |
| US20200038427A1 (en) | 2017-03-31 | 2020-02-06 | Bonac Corporation | Cyclic nucleic acid molecule having gene expression control function |
| WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | Ｂ型肝炎治療用核酸分子 |
| BR112020001412A2 (pt) | 2017-07-28 | 2020-08-04 | Kyorin Pharmaceutical Co., Ltd. | inibidor de fosforilação da proteína smad2/3, agente terapêutico para fibrose, e, moléculas de ácido nucleico de fita dupla e de fita simples. |
| AU2018333285C1 (en) * | 2017-09-15 | 2023-10-05 | Commonwealth Scientific And Industrial Research Organisation | RNA molecules |
| JP7208911B2 (ja) | 2017-10-11 | 2023-01-19 | 日東電工株式会社 | 核酸分子発現の調節 |
| EP3696269A4 (en) * | 2017-10-13 | 2021-09-01 | Bonac Corporation | SINGLE STRAND NUCLEIC ACID MOLECULE AND ITS PRODUCTION PROCESS |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| WO2019189591A1 (ja) | 2018-03-30 | 2019-10-03 | 住友化学株式会社 | 一本鎖ｒｎａの製造方法 |
| WO2019189722A1 (ja) | 2018-03-30 | 2019-10-03 | 東レ株式会社 | ヘアピン型一本鎖ｒｎａ分子の製造方法 |
| CN112673102A (zh) * | 2018-10-02 | 2021-04-16 | 东丽株式会社 | 发夹型单链rna分子的制备方法 |
| US20220088057A1 (en) | 2019-01-25 | 2022-03-24 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for fibrosis |
| KR20220079832A (ko) | 2019-10-11 | 2022-06-14 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| CN115003680A (zh) | 2020-01-29 | 2022-09-02 | 住友化学株式会社 | 制备核酸寡聚物的方法 |
| US20230312635A1 (en) | 2020-01-29 | 2023-10-05 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
| EP3885434A1 (en) | 2020-03-25 | 2021-09-29 | Ajinomoto Co., Inc. | Ligase mutant |
| KR20220160010A (ko) | 2020-03-27 | 2022-12-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| CN115867559A (zh) | 2020-07-09 | 2023-03-28 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| KR20230074205A (ko) | 2020-09-24 | 2023-05-26 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| WO2023054350A1 (ja) | 2021-09-28 | 2023-04-06 | 住友化学株式会社 | 精製ジクロロ酢酸の製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5631148A (en) * | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| FR2790757B1 (fr) * | 1999-03-09 | 2003-08-01 | Bioalliance Pharma | Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant. |
| TWI321054B (en) | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
| WO2003072745A2 (en) * | 2002-02-22 | 2003-09-04 | Eshleman James R | Antigene locks and therapeutic uses thereof |
| PT1527176E (pt) * | 2002-08-05 | 2007-04-30 | Atugen Ag | Novas formas de muléculas de arn de interferência |
| WO2004015075A2 (en) * | 2002-08-08 | 2004-02-19 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
| CN1860228B (zh) * | 2003-09-30 | 2010-04-28 | 安琪士摩奇株式会社 | 订书钉型寡核苷酸及包含该订书钉型寡核苷酸的药物 |
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| CN101124339A (zh) * | 2004-12-30 | 2008-02-13 | 托德·M·豪泽 | 使用自我保护寡核苷酸调节基因表达的组合物和方法 |
| WO2007108621A1 (en) * | 2006-03-17 | 2007-09-27 | Bioneer Corporation | Sirna for inhibiting nf-kb/rela expression |
| JP5296328B2 (ja) * | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | １本鎖環状ｒｎａおよびその製造方法 |
| JP2011504730A (ja) * | 2007-11-29 | 2011-02-17 | 蘇州瑞博生物技術有限公司 | 標的遺伝子の発現を干渉する複合体分子およびその合成方法 |
| US20110159586A1 (en) * | 2007-12-07 | 2011-06-30 | Halo-Bio Rnai Therapeutics, Inc. | Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides |
| JP5540312B2 (ja) * | 2008-02-15 | 2014-07-02 | 独立行政法人理化学研究所 | 環状１本鎖核酸複合体およびその製造方法 |
| JP5187580B2 (ja) | 2008-12-26 | 2013-04-24 | 丸紅建材リース株式会社 | 掘削機の泥土飛散防止装置 |
| JP2010174915A (ja) | 2009-01-27 | 2010-08-12 | Toyota Motor Corp | 高圧ガスタンク |
| JP5449815B2 (ja) | 2009-03-26 | 2014-03-19 | 住友化学株式会社 | 偏光板の製造方法 |
| JP5233790B2 (ja) | 2009-03-26 | 2013-07-10 | 船井電機株式会社 | 液晶モジュール |
| JP4885255B2 (ja) | 2009-05-21 | 2012-02-29 | 株式会社エフピコ | 包装用容器 |
| JP2010269823A (ja) | 2009-05-21 | 2010-12-02 | British American Tobacco Japan Kk | 喫煙品用容器 |
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2011
- 2011-07-08 HU HUE11746147A patent/HUE026520T2/en unknown
- 2011-07-08 JP JP2011537086A patent/JP4968811B2/ja active Active
- 2011-07-08 CN CN201510226685.6A patent/CN104818276B/zh active Active
- 2011-07-08 TW TW104143857A patent/TWI573870B/zh active
- 2011-07-08 CA CA2804511A patent/CA2804511C/en active Active
- 2011-07-08 MX MX2013000315A patent/MX352568B/es active IP Right Grant
- 2011-07-08 PT PT151699337T patent/PT2933333T/pt unknown
- 2011-07-08 BR BR112013000481-9A patent/BR112013000481A2/pt not_active Application Discontinuation
- 2011-07-08 CN CN201180027223.1A patent/CN102918156B/zh active Active
- 2011-07-08 RU RU2013105329A patent/RU2628311C2/ru active
- 2011-07-08 SG SG2013000211A patent/SG186899A1/en unknown
- 2011-07-08 AU AU2011274854A patent/AU2011274854B2/en active Active
- 2011-07-08 PT PT117461475T patent/PT2431466E/pt unknown
- 2011-07-08 SG SG2013097233A patent/SG196779A1/en unknown
- 2011-07-08 NZ NZ704812A patent/NZ704812A/en unknown
- 2011-07-08 ES ES15169933.7T patent/ES2670017T3/es active Active
- 2011-07-08 HU HUE15169933A patent/HUE037500T2/hu unknown
- 2011-07-08 WO PCT/JP2011/065737 patent/WO2012005368A1/ja active Application Filing
- 2011-07-08 DK DK15169933.7T patent/DK2933333T3/en active
- 2011-07-08 KR KR1020127033429A patent/KR101849798B1/ko active IP Right Grant
- 2011-07-08 EP EP15169933.7A patent/EP2933333B1/en active Active
- 2011-07-08 EP EP11746147.5A patent/EP2431466B1/en active Active
- 2011-07-08 ES ES11746147.5T patent/ES2550487T3/es active Active
- 2011-07-08 NZ NZ606232A patent/NZ606232A/en not_active IP Right Cessation
- 2011-07-08 TW TW100124393A patent/TWI527901B/zh active
- 2011-07-08 DK DK11746147.5T patent/DK2431466T3/en active
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2012
- 2012-01-20 JP JP2012009515A patent/JP5804642B2/ja not_active Expired - Fee Related
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2013
- 2013-07-24 HK HK13108676.9A patent/HK1181423A1/zh not_active IP Right Cessation
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2015
- 2015-07-29 JP JP2015150156A patent/JP6162182B2/ja active Active
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