MX2013000315A - Molecula de acido nucleico de cadena simple para el control de la expresion de genes. - Google Patents
Molecula de acido nucleico de cadena simple para el control de la expresion de genes.Info
- Publication number
- MX2013000315A MX2013000315A MX2013000315A MX2013000315A MX2013000315A MX 2013000315 A MX2013000315 A MX 2013000315A MX 2013000315 A MX2013000315 A MX 2013000315A MX 2013000315 A MX2013000315 A MX 2013000315A MX 2013000315 A MX2013000315 A MX 2013000315A
- Authority
- MX
- Mexico
- Prior art keywords
- end region
- nucleic acid
- acid molecule
- region
- strand nucleic
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Nueva molécula de ácido nucleico que puede inhibir la expresión de un gen y que se puede producir en forma fácil y eficaz. La molécula de ácido nucleico es una molécula de ácido nucleico de cadena simple que incluye una secuencia inhibitoria de expresión que inhibe la expresión de un gen blanco. La molécula de ácido nucleico de cadena simple incluye, en secuencia desde el extremo 5' al extremo 3': una región de extremo 5' (Xc); una región interna (Z); y una región de extremo 3' (Yc). La región interna (Z) está compuesta por una región interna del extremo 5' (X) y una región interna del extremo 3' (Y) que están unidas entre sí. La región del extremo 5' (Xc) es complementaria a la región interna del extremo 5' (X). La región del extremo 3' (Yc) es complementaria a la región interna del extremo 3(Y). Al menos una de la región interna (Z), la región del extremo 5' (Xc), y la región del extremo 3' (Yc) incluye la secuencia inhibitoria de expresión. De acuerdo a esta molécula de ácido nucleico de cadena simple, es posible inhibir la expresión del gen blanco.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010156122 | 2010-07-08 | ||
JP2010174915 | 2010-08-03 | ||
JP2010230808 | 2010-10-13 | ||
JP2010230806 | 2010-10-13 | ||
JP2010269824 | 2010-12-02 | ||
JP2010269823 | 2010-12-02 | ||
PCT/JP2011/065737 WO2012005368A1 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013000315A true MX2013000315A (es) | 2013-05-01 |
MX352568B MX352568B (es) | 2017-11-29 |
Family
ID=45441339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000315A MX352568B (es) | 2010-07-08 | 2011-07-08 | Molecula de acido nucleico de cadena simple para el control de la expresion de genes. |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP2933333B1 (es) |
JP (3) | JP4968811B2 (es) |
KR (1) | KR101849798B1 (es) |
CN (2) | CN104818276B (es) |
AU (1) | AU2011274854B2 (es) |
BR (1) | BR112013000481A2 (es) |
CA (1) | CA2804511C (es) |
DK (2) | DK2431466T3 (es) |
ES (2) | ES2550487T3 (es) |
HK (1) | HK1181423A1 (es) |
HU (2) | HUE037500T2 (es) |
MX (1) | MX352568B (es) |
NZ (2) | NZ704812A (es) |
PT (2) | PT2933333T (es) |
RU (1) | RU2628311C2 (es) |
SG (2) | SG196779A1 (es) |
TW (2) | TWI573870B (es) |
WO (1) | WO2012005368A1 (es) |
Families Citing this family (32)
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US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Vegf遺伝子の発現抑制用一本鎖核酸分子 |
CA2868716A1 (en) | 2012-03-29 | 2013-10-03 | Kyushu University National University Corporation | Nucleic acid molecule capable of inhibiting expression of periostin gene, method for inhibiting expression of periostin gene, and use of said nucleic acid molecule |
JP6126088B2 (ja) * | 2012-05-26 | 2017-05-10 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
US10612020B2 (en) | 2013-12-26 | 2020-04-07 | Tokyo Medical University | Artificial mimic miRNA for controlling gene expression, and use of same |
AU2014370829B2 (en) | 2013-12-27 | 2021-03-11 | Bonac Corporation | Artificial match-type miRNA for controlling gene expression and use therefor |
WO2016098782A1 (ja) | 2014-12-15 | 2016-06-23 | 株式会社ボナック | TGF-β1発現抑制のための一本鎖核酸分子 |
ES2872527T3 (es) | 2014-12-27 | 2021-11-02 | Bonac Corp | miARN natural para controlar la expresión génica y uso del mismo |
JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
CN108350457B (zh) * | 2015-10-30 | 2021-10-01 | 株式会社博纳克 | 稳定地含有抑制TGF-β1基因的表达的单链核酸分子的组合物 |
CN108473988A (zh) | 2015-12-29 | 2018-08-31 | 国立大学法人北海道大学 | 抑制肾素原基因或肾素原受体基因表达的单链核酸分子及其用途 |
CA3013179A1 (en) | 2016-01-30 | 2017-08-03 | Bonac Corporation | Artificial single guide rna and use thereof |
EP3604528A4 (en) | 2017-03-31 | 2021-01-13 | Bonac Corporation | CYCLIC NUCLEIC ACID MOLECULE HAVING A GENE EXPRESSION CONTROL FUNCTION |
JPWO2018199338A1 (ja) * | 2017-04-27 | 2020-03-12 | 国立大学法人広島大学 | B型肝炎治療用核酸分子 |
SG11201913541QA (en) | 2017-07-28 | 2020-02-27 | Kyorin Pharmaceutical Co Ltd | Therapeutic agent for fibrosis |
WO2019051563A1 (en) * | 2017-09-15 | 2019-03-21 | Commonwealth Scientific And Industrial Research Organisation | RNA MOLECULES |
CN111201319A (zh) | 2017-10-11 | 2020-05-26 | 日东电工株式会社 | 核酸分子表达的调节 |
US20210188895A1 (en) * | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
CN111819280A (zh) | 2018-03-30 | 2020-10-23 | 东丽株式会社 | 发夹型单链rna分子的制备方法 |
JP6817493B2 (ja) * | 2018-03-30 | 2021-01-20 | 住友化学株式会社 | 一本鎖rnaの製造方法 |
JP7405086B2 (ja) * | 2018-10-02 | 2023-12-26 | 東レ株式会社 | ヘアピン型一本鎖rna分子の製造方法 |
JP7241098B2 (ja) | 2019-01-25 | 2023-03-16 | 杏林製薬株式会社 | 線維症治療剤 |
EP4043473A4 (en) | 2019-10-11 | 2024-03-27 | Sumitomo Chemical Co | METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS |
EP4098655A4 (en) | 2020-01-29 | 2024-02-28 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS |
CN115003680A (zh) | 2020-01-29 | 2022-09-02 | 住友化学株式会社 | 制备核酸寡聚物的方法 |
EP3885434A1 (en) | 2020-03-25 | 2021-09-29 | Ajinomoto Co., Inc. | Ligase mutant |
KR20220160010A (ko) | 2020-03-27 | 2022-12-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
US20230242570A1 (en) | 2020-07-09 | 2023-08-03 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
EP4219520A1 (en) | 2020-09-24 | 2023-08-02 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
JPWO2023054350A1 (es) | 2021-09-28 | 2023-04-06 |
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JP2010174915A (ja) | 2009-01-27 | 2010-08-12 | Toyota Motor Corp | 高圧ガスタンク |
JP5233790B2 (ja) | 2009-03-26 | 2013-07-10 | 船井電機株式会社 | 液晶モジュール |
JP5449815B2 (ja) | 2009-03-26 | 2014-03-19 | 住友化学株式会社 | 偏光板の製造方法 |
JP2010269823A (ja) | 2009-05-21 | 2010-12-02 | British American Tobacco Japan Kk | 喫煙品用容器 |
JP4885255B2 (ja) | 2009-05-21 | 2012-02-29 | 株式会社エフピコ | 包装用容器 |
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2011
- 2011-07-08 SG SG2013097233A patent/SG196779A1/en unknown
- 2011-07-08 DK DK11746147.5T patent/DK2431466T3/en active
- 2011-07-08 BR BR112013000481-9A patent/BR112013000481A2/pt not_active Application Discontinuation
- 2011-07-08 RU RU2013105329A patent/RU2628311C2/ru active
- 2011-07-08 PT PT151699337T patent/PT2933333T/pt unknown
- 2011-07-08 DK DK15169933.7T patent/DK2933333T3/en active
- 2011-07-08 SG SG2013000211A patent/SG186899A1/en unknown
- 2011-07-08 TW TW104143857A patent/TWI573870B/zh active
- 2011-07-08 MX MX2013000315A patent/MX352568B/es active IP Right Grant
- 2011-07-08 EP EP15169933.7A patent/EP2933333B1/en active Active
- 2011-07-08 NZ NZ704812A patent/NZ704812A/en unknown
- 2011-07-08 JP JP2011537086A patent/JP4968811B2/ja active Active
- 2011-07-08 HU HUE15169933A patent/HUE037500T2/hu unknown
- 2011-07-08 NZ NZ606232A patent/NZ606232A/en not_active IP Right Cessation
- 2011-07-08 ES ES11746147.5T patent/ES2550487T3/es active Active
- 2011-07-08 ES ES15169933.7T patent/ES2670017T3/es active Active
- 2011-07-08 CN CN201510226685.6A patent/CN104818276B/zh active Active
- 2011-07-08 HU HUE11746147A patent/HUE026520T2/en unknown
- 2011-07-08 PT PT117461475T patent/PT2431466E/pt unknown
- 2011-07-08 AU AU2011274854A patent/AU2011274854B2/en active Active
- 2011-07-08 WO PCT/JP2011/065737 patent/WO2012005368A1/ja active Application Filing
- 2011-07-08 CA CA2804511A patent/CA2804511C/en active Active
- 2011-07-08 EP EP11746147.5A patent/EP2431466B1/en active Active
- 2011-07-08 KR KR1020127033429A patent/KR101849798B1/ko active IP Right Grant
- 2011-07-08 CN CN201180027223.1A patent/CN102918156B/zh active Active
- 2011-07-08 TW TW100124393A patent/TWI527901B/zh active
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2012
- 2012-01-20 JP JP2012009515A patent/JP5804642B2/ja not_active Expired - Fee Related
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2013
- 2013-07-24 HK HK13108676.9A patent/HK1181423A1/zh not_active IP Right Cessation
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2015
- 2015-07-29 JP JP2015150156A patent/JP6162182B2/ja active Active
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