MX352568B - Molecula de acido nucleico de cadena simple para el control de la expresion de genes. - Google Patents
Molecula de acido nucleico de cadena simple para el control de la expresion de genes.Info
- Publication number
- MX352568B MX352568B MX2013000315A MX2013000315A MX352568B MX 352568 B MX352568 B MX 352568B MX 2013000315 A MX2013000315 A MX 2013000315A MX 2013000315 A MX2013000315 A MX 2013000315A MX 352568 B MX352568 B MX 352568B
- Authority
- MX
- Mexico
- Prior art keywords
- end region
- nucleic acid
- acid molecule
- region
- strand nucleic
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
Abstract
La presente invención se refiere a una nueva molécula de ácido nucleico que puede inhibir la expresión de un gen y que se puede producir en forma fácil y eficaz. La molécula de ácido nucleico es una molécula de ácido nucleico de cadena simple que incluye una secuencia inhibitoria de expresión que inhibe la expresión de un gen blanco. La molécula de ácido nucleico de cadena simple incluye, en secuencia desde el extremo 5' al extremo 3': una región de extremo 5' (Xc); una región interna (Z); y una región de extremo 3' (Yc). La región interna (Z) está compuesta por una región interna del extremo 5' (X) y una región interna del extremo 3' (Y) que están unidas entre sí. La región del extremo 5' (Xc) es complementaria a la región interna del extremo 5' (X). La región del extremo 3' (Yc) es complementaria a la región interna del extremo 3(Y). Al menos una de la región interna (Z), la región del extremo 5' (Xc), y la región del extremo 3' (Yc) incluye la secuencia inhibitoria de expresión. De acuerdo a esta molécula de ácido nucleico de cadena simple, es posible inhibir la expresión del gen blanco.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010156122 | 2010-07-08 | ||
JP2010174915 | 2010-08-03 | ||
JP2010230806 | 2010-10-13 | ||
JP2010230808 | 2010-10-13 | ||
JP2010269824 | 2010-12-02 | ||
JP2010269823 | 2010-12-02 | ||
PCT/JP2011/065737 WO2012005368A1 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013000315A MX2013000315A (es) | 2013-05-01 |
MX352568B true MX352568B (es) | 2017-11-29 |
Family
ID=45441339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000315A MX352568B (es) | 2010-07-08 | 2011-07-08 | Molecula de acido nucleico de cadena simple para el control de la expresion de genes. |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP2431466B1 (es) |
JP (3) | JP4968811B2 (es) |
KR (1) | KR101849798B1 (es) |
CN (2) | CN104818276B (es) |
AU (1) | AU2011274854B2 (es) |
BR (1) | BR112013000481A2 (es) |
CA (1) | CA2804511C (es) |
DK (2) | DK2431466T3 (es) |
ES (2) | ES2670017T3 (es) |
HK (1) | HK1181423A1 (es) |
HU (2) | HUE037500T2 (es) |
MX (1) | MX352568B (es) |
NZ (2) | NZ606232A (es) |
PT (2) | PT2431466E (es) |
RU (1) | RU2628311C2 (es) |
SG (2) | SG196779A1 (es) |
TW (2) | TWI573870B (es) |
WO (1) | WO2012005368A1 (es) |
Families Citing this family (31)
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US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Vegf遺伝子の発現抑制用一本鎖核酸分子 |
JP6283859B2 (ja) | 2012-03-29 | 2018-02-28 | 国立大学法人九州大学 | ペリオスチン遺伝子の発現抑制核酸分子、ペリオスチン遺伝子の発現抑制方法、およびその用途 |
WO2013180038A1 (ja) | 2012-05-26 | 2013-12-05 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
CN105899663B (zh) | 2013-12-26 | 2019-07-26 | 学校法人东京医科大学 | 用于基因表达控制的人工模拟miRNA及其用途 |
CN106068324B (zh) | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
US10337009B2 (en) | 2014-12-15 | 2019-07-02 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting TGF-β1 expression |
MX2017008587A (es) | 2014-12-27 | 2017-10-20 | Bonac Corp | Mirna natural para controlar la expresion de gen y uso del mismo. |
JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
RU2714257C2 (ru) | 2015-10-30 | 2020-02-13 | Бонак Корпорейшн | КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ В СТАБИЛЬНОМ СОСТОЯНИИ ОДНОЦЕПОЧЕЧНУЮ МОЛЕКУЛУ НУКЛЕИНОВОЙ КИСЛОТЫ, КОТОРАЯ ПОДАВЛЯЕТ ЭКСПРЕССИЮ ГЕНА TGF-β1 |
WO2017115872A1 (ja) | 2015-12-29 | 2017-07-06 | 国立大学法人北海道大学 | プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途 |
AU2017213405B2 (en) | 2016-01-30 | 2021-02-04 | Bonac Corporation | Artificial single guide RNA and use thereof |
JPWO2018182008A1 (ja) | 2017-03-31 | 2020-02-06 | 株式会社ボナック | 遺伝子発現制御機能を有する環状型核酸分子 |
WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | B型肝炎治療用核酸分子 |
TW201910514A (zh) | 2017-07-28 | 2019-03-16 | 日商杏林製藥股份有限公司 | 纖維化治療劑 |
MX2020002872A (es) * | 2017-09-15 | 2020-10-05 | Commw Scient Ind Res Org | Moléculas de arn. |
EP3696270A4 (en) | 2017-10-11 | 2021-07-07 | Nitto Denko Corporation | REGULATION OF THE EXPRESSION OF NUCLEIC ACID MOLECULES |
EP3696269A4 (en) * | 2017-10-13 | 2021-09-01 | Bonac Corporation | SINGLE STRAND NUCLEIC ACID MOLECULE AND ITS PRODUCTION PROCESS |
TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
EP3778914A4 (en) * | 2018-03-30 | 2022-01-19 | Sumitomo Chemical Company, Ltd. | PROCEDURE FOR DELIVERING SINGLE STRAND RNA |
KR20200136363A (ko) | 2018-03-30 | 2020-12-07 | 도레이 카부시키가이샤 | 헤어핀형 1개쇄 rna 분자의 제조 방법 |
KR20210069628A (ko) * | 2018-10-02 | 2021-06-11 | 도레이 카부시키가이샤 | 헤어핀형 단일쇄 rna 분자의 제조 방법 |
WO2020152869A1 (ja) | 2019-01-25 | 2020-07-30 | 杏林製薬株式会社 | 線維症治療剤 |
JPWO2021070494A1 (es) | 2019-10-11 | 2021-04-15 | ||
KR20220133878A (ko) | 2020-01-29 | 2022-10-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
WO2021153770A1 (en) | 2020-01-29 | 2021-08-05 | Sumitomo Chemical Company, Limited | Process of preparing nucleic acid oligomer |
EP3885434A1 (en) | 2020-03-25 | 2021-09-29 | Ajinomoto Co., Inc. | Ligase mutant |
JPWO2021193954A1 (es) | 2020-03-27 | 2021-09-30 | ||
JPWO2022009959A1 (es) | 2020-07-09 | 2022-01-13 | ||
EP4219520A1 (en) | 2020-09-24 | 2023-08-02 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
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2011
- 2011-07-08 HU HUE15169933A patent/HUE037500T2/hu unknown
- 2011-07-08 ES ES15169933.7T patent/ES2670017T3/es active Active
- 2011-07-08 HU HUE11746147A patent/HUE026520T2/en unknown
- 2011-07-08 JP JP2011537086A patent/JP4968811B2/ja active Active
- 2011-07-08 MX MX2013000315A patent/MX352568B/es active IP Right Grant
- 2011-07-08 CA CA2804511A patent/CA2804511C/en active Active
- 2011-07-08 DK DK11746147.5T patent/DK2431466T3/en active
- 2011-07-08 AU AU2011274854A patent/AU2011274854B2/en active Active
- 2011-07-08 PT PT117461475T patent/PT2431466E/pt unknown
- 2011-07-08 PT PT151699337T patent/PT2933333T/pt unknown
- 2011-07-08 CN CN201510226685.6A patent/CN104818276B/zh active Active
- 2011-07-08 CN CN201180027223.1A patent/CN102918156B/zh active Active
- 2011-07-08 SG SG2013097233A patent/SG196779A1/en unknown
- 2011-07-08 WO PCT/JP2011/065737 patent/WO2012005368A1/ja active Application Filing
- 2011-07-08 EP EP11746147.5A patent/EP2431466B1/en active Active
- 2011-07-08 NZ NZ606232A patent/NZ606232A/en not_active IP Right Cessation
- 2011-07-08 TW TW104143857A patent/TWI573870B/zh active
- 2011-07-08 KR KR1020127033429A patent/KR101849798B1/ko active IP Right Grant
- 2011-07-08 BR BR112013000481-9A patent/BR112013000481A2/pt not_active Application Discontinuation
- 2011-07-08 SG SG2013000211A patent/SG186899A1/en unknown
- 2011-07-08 RU RU2013105329A patent/RU2628311C2/ru active
- 2011-07-08 NZ NZ704812A patent/NZ704812A/en unknown
- 2011-07-08 DK DK15169933.7T patent/DK2933333T3/en active
- 2011-07-08 TW TW100124393A patent/TWI527901B/zh active
- 2011-07-08 EP EP15169933.7A patent/EP2933333B1/en active Active
- 2011-07-08 ES ES11746147.5T patent/ES2550487T3/es active Active
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2012
- 2012-01-20 JP JP2012009515A patent/JP5804642B2/ja active Active
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- 2013-07-24 HK HK13108676.9A patent/HK1181423A1/zh not_active IP Right Cessation
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2015
- 2015-07-29 JP JP2015150156A patent/JP6162182B2/ja active Active
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