MX352568B - Molecula de acido nucleico de cadena simple para el control de la expresion de genes. - Google Patents

Molecula de acido nucleico de cadena simple para el control de la expresion de genes.

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Publication number
MX352568B
MX352568B MX2013000315A MX2013000315A MX352568B MX 352568 B MX352568 B MX 352568B MX 2013000315 A MX2013000315 A MX 2013000315A MX 2013000315 A MX2013000315 A MX 2013000315A MX 352568 B MX352568 B MX 352568B
Authority
MX
Mexico
Prior art keywords
end region
nucleic acid
acid molecule
region
strand nucleic
Prior art date
Application number
MX2013000315A
Other languages
English (en)
Other versions
MX2013000315A (es
Inventor
Ohgi Tadaaki
Suzuki Hiroshi
Hayashi Hirotake
Shirohzu Hisao
Hamasaki Tomohiro
Itoh Akihiro
Original Assignee
Bonac Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonac Corp filed Critical Bonac Corp
Publication of MX2013000315A publication Critical patent/MX2013000315A/es
Publication of MX352568B publication Critical patent/MX352568B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una nueva molécula de ácido nucleico que puede inhibir la expresión de un gen y que se puede producir en forma fácil y eficaz. La molécula de ácido nucleico es una molécula de ácido nucleico de cadena simple que incluye una secuencia inhibitoria de expresión que inhibe la expresión de un gen blanco. La molécula de ácido nucleico de cadena simple incluye, en secuencia desde el extremo 5' al extremo 3': una región de extremo 5' (Xc); una región interna (Z); y una región de extremo 3' (Yc). La región interna (Z) está compuesta por una región interna del extremo 5' (X) y una región interna del extremo 3' (Y) que están unidas entre sí. La región del extremo 5' (Xc) es complementaria a la región interna del extremo 5' (X). La región del extremo 3' (Yc) es complementaria a la región interna del extremo 3(Y). Al menos una de la región interna (Z), la región del extremo 5' (Xc), y la región del extremo 3' (Yc) incluye la secuencia inhibitoria de expresión. De acuerdo a esta molécula de ácido nucleico de cadena simple, es posible inhibir la expresión del gen blanco.
MX2013000315A 2010-07-08 2011-07-08 Molecula de acido nucleico de cadena simple para el control de la expresion de genes. MX352568B (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2010156122 2010-07-08
JP2010174915 2010-08-03
JP2010230808 2010-10-13
JP2010230806 2010-10-13
JP2010269823 2010-12-02
JP2010269824 2010-12-02
PCT/JP2011/065737 WO2012005368A1 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子

Publications (2)

Publication Number Publication Date
MX2013000315A MX2013000315A (es) 2013-05-01
MX352568B true MX352568B (es) 2017-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000315A MX352568B (es) 2010-07-08 2011-07-08 Molecula de acido nucleico de cadena simple para el control de la expresion de genes.

Country Status (17)

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EP (2) EP2431466B1 (es)
JP (3) JP4968811B2 (es)
KR (1) KR101849798B1 (es)
CN (2) CN104818276B (es)
AU (1) AU2011274854B2 (es)
BR (1) BR112013000481A2 (es)
CA (1) CA2804511C (es)
DK (2) DK2431466T3 (es)
ES (2) ES2670017T3 (es)
HU (2) HUE037500T2 (es)
MX (1) MX352568B (es)
NZ (2) NZ704812A (es)
PT (2) PT2933333T (es)
RU (1) RU2628311C2 (es)
SG (2) SG186899A1 (es)
TW (2) TWI527901B (es)
WO (1) WO2012005368A1 (es)

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Publication number Publication date
EP2431466A1 (en) 2012-03-21
CN104818276B (zh) 2020-12-11
PT2431466E (pt) 2016-01-08
HUE037500T2 (hu) 2018-08-28
EP2933333B1 (en) 2018-02-21
AU2011274854A1 (en) 2013-02-14
DK2431466T3 (en) 2016-01-11
TWI527901B (zh) 2016-04-01
CN104818276A (zh) 2015-08-05
CA2804511C (en) 2021-07-06
NZ606232A (en) 2015-06-26
NZ704812A (en) 2017-01-27
TWI573870B (zh) 2017-03-11
BR112013000481A2 (pt) 2019-10-15
TW201627500A (zh) 2016-08-01
JPWO2012005368A1 (ja) 2013-09-05
CN102918156A (zh) 2013-02-06
KR20130090792A (ko) 2013-08-14
EP2431466B1 (en) 2015-10-07
JP6162182B2 (ja) 2017-07-12
SG186899A1 (en) 2013-02-28
ES2670017T3 (es) 2018-05-29
RU2013105329A (ru) 2014-08-20
JP5804642B2 (ja) 2015-11-04
PT2933333T (pt) 2018-04-24
HK1181423A1 (zh) 2013-11-08
CA2804511A1 (en) 2012-01-12
SG196779A1 (en) 2014-02-13
AU2011274854B2 (en) 2015-04-16
EP2933333A1 (en) 2015-10-21
JP2012130342A (ja) 2012-07-12
TW201217523A (en) 2012-05-01
MX2013000315A (es) 2013-05-01
JP4968811B2 (ja) 2012-07-04
EP2431466A4 (en) 2012-04-25
DK2933333T3 (en) 2018-04-30
ES2550487T3 (es) 2015-11-10
WO2012005368A1 (ja) 2012-01-12
KR101849798B1 (ko) 2018-04-17
HUE026520T2 (en) 2016-06-28
CN102918156B (zh) 2015-11-25
JP2015231381A (ja) 2015-12-24
RU2628311C2 (ru) 2017-08-15

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