BR112015002280A2 - produção de gado resistente a vfa por substituição de alelo - Google Patents
produção de gado resistente a vfa por substituição de aleloInfo
- Publication number
- BR112015002280A2 BR112015002280A2 BR112015002280A BR112015002280A BR112015002280A2 BR 112015002280 A2 BR112015002280 A2 BR 112015002280A2 BR 112015002280 A BR112015002280 A BR 112015002280A BR 112015002280 A BR112015002280 A BR 112015002280A BR 112015002280 A2 BR112015002280 A2 BR 112015002280A2
- Authority
- BR
- Brazil
- Prior art keywords
- vfa
- production
- allele substitution
- resistant
- resistant cattle
- Prior art date
Links
- 108700028369 Alleles Proteins 0.000 title abstract 2
- 241000283690 Bos taurus Species 0.000 title abstract 2
- 238000006467 substitution reaction Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 238000010362 genome editing Methods 0.000 abstract 1
- 244000144980 herd Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
resumo “produção de gado resistente à vfa por substituição de alelo” as células, genes e proteínas abrangendo uma proteína ou gene eif4g resistente a proteases. animal de rebanho geneticamente modificado compreendendo uma modificação genômica a um gene eif4g.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261677904P | 2012-07-31 | 2012-07-31 | |
US13/836,860 US10058078B2 (en) | 2012-07-31 | 2013-03-15 | Production of FMDV-resistant livestock by allele substitution |
PCT/US2013/051222 WO2014022120A1 (en) | 2012-07-31 | 2013-07-19 | Production of fmdv-resistant livestock by allele substitution |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015002280A2 true BR112015002280A2 (pt) | 2019-01-15 |
Family
ID=50026918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015002280A BR112015002280A2 (pt) | 2012-07-31 | 2013-07-19 | produção de gado resistente a vfa por substituição de alelo |
Country Status (15)
Country | Link |
---|---|
US (2) | US10058078B2 (pt) |
EP (2) | EP3540050A1 (pt) |
JP (1) | JP6446360B2 (pt) |
KR (1) | KR20150036792A (pt) |
CN (1) | CN104837989A (pt) |
AR (1) | AR091948A1 (pt) |
AU (1) | AU2013296901B2 (pt) |
BR (1) | BR112015002280A2 (pt) |
CA (1) | CA2880616A1 (pt) |
CL (1) | CL2015000248A1 (pt) |
MX (1) | MX366723B (pt) |
NZ (1) | NZ629582A (pt) |
PH (1) | PH12015500213A1 (pt) |
RU (1) | RU2015106818A (pt) |
WO (1) | WO2014022120A1 (pt) |
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US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US10779518B2 (en) | 2013-10-25 | 2020-09-22 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
WO2015070083A1 (en) | 2013-11-07 | 2015-05-14 | Editas Medicine,Inc. | CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS |
US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
US20180142307A1 (en) * | 2014-02-11 | 2018-05-24 | California Institute Of Technology | Recording and mapping lineage information and molecular events in individual cells |
CN106459951A (zh) * | 2014-03-26 | 2017-02-22 | 马里兰大学派克分院 | 驯养的大型动物的受精卵中的靶向基因组编辑 |
EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
EP3365356B1 (en) | 2015-10-23 | 2023-06-28 | President and Fellows of Harvard College | Nucleobase editors and uses thereof |
GB2568182A (en) | 2016-08-03 | 2019-05-08 | Harvard College | Adenosine nucleobase editors and uses thereof |
AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
EP3601562A1 (en) | 2017-03-23 | 2020-02-05 | President and Fellows of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
EP3676376A2 (en) | 2017-08-30 | 2020-07-08 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
KR20200121782A (ko) | 2017-10-16 | 2020-10-26 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
CN112218945A (zh) * | 2018-05-08 | 2021-01-12 | 国立大学法人大阪大学 | 纯合细胞的制作方法 |
CN108998406B (zh) * | 2018-08-03 | 2022-05-10 | 福州大学 | 一种人类原代培养细胞基因组编辑、定点基因敲入方法 |
CN108998540A (zh) * | 2018-08-18 | 2018-12-14 | 兰州大学 | 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用 |
BR112021018606A2 (pt) | 2019-03-19 | 2021-11-23 | Harvard College | Métodos e composições para editar sequências de nucleotídeos |
DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
CN111534519B (zh) * | 2020-05-26 | 2021-12-14 | 中国农业科学院北京畜牧兽医研究所 | 识别猪eIF4G1基因的sgRNA及其编码DNA和应用 |
CN111944770B (zh) * | 2020-08-27 | 2022-04-15 | 中国农业科学院兰州兽医研究所 | 一种口蹄疫病毒致弱突变株及其制备方法和应用 |
GB202118058D0 (en) | 2021-12-14 | 2022-01-26 | Univ Warwick | Methods to increase yields in crops |
WO2023196818A1 (en) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | Genetic complementation compositions and methods |
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-
2013
- 2013-03-15 US US13/836,860 patent/US10058078B2/en active Active
- 2013-07-19 EP EP19159141.1A patent/EP3540050A1/en not_active Withdrawn
- 2013-07-19 CA CA2880616A patent/CA2880616A1/en not_active Abandoned
- 2013-07-19 WO PCT/US2013/051222 patent/WO2014022120A1/en active Application Filing
- 2013-07-19 EP EP13825988.2A patent/EP2880153A4/en not_active Ceased
- 2013-07-19 KR KR1020157005357A patent/KR20150036792A/ko not_active Application Discontinuation
- 2013-07-19 CN CN201380048009.3A patent/CN104837989A/zh active Pending
- 2013-07-19 JP JP2015525450A patent/JP6446360B2/ja not_active Expired - Fee Related
- 2013-07-19 BR BR112015002280A patent/BR112015002280A2/pt not_active Application Discontinuation
- 2013-07-19 MX MX2015001299A patent/MX366723B/es active IP Right Grant
- 2013-07-19 NZ NZ629582A patent/NZ629582A/en not_active IP Right Cessation
- 2013-07-19 RU RU2015106818A patent/RU2015106818A/ru not_active Application Discontinuation
- 2013-07-19 AU AU2013296901A patent/AU2013296901B2/en not_active Ceased
- 2013-07-31 AR ARP130102723A patent/AR091948A1/es unknown
-
2015
- 2015-01-30 PH PH12015500213A patent/PH12015500213A1/en unknown
- 2015-01-30 CL CL2015000248A patent/CL2015000248A1/es unknown
-
2018
- 2018-07-13 US US16/035,411 patent/US20180310536A1/en not_active Abandoned
Also Published As
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NZ629582A (en) | 2017-07-28 |
JP2015523098A (ja) | 2015-08-13 |
MX2015001299A (es) | 2015-06-05 |
MX366723B (es) | 2019-07-22 |
PH12015500213A1 (en) | 2015-03-30 |
EP2880153A1 (en) | 2015-06-10 |
AR091948A1 (es) | 2015-03-11 |
US10058078B2 (en) | 2018-08-28 |
CL2015000248A1 (es) | 2015-10-02 |
US20140041066A1 (en) | 2014-02-06 |
RU2015106818A (ru) | 2016-09-27 |
EP3540050A1 (en) | 2019-09-18 |
JP6446360B2 (ja) | 2018-12-26 |
CN104837989A (zh) | 2015-08-12 |
US20180310536A1 (en) | 2018-11-01 |
CA2880616A1 (en) | 2014-02-06 |
AU2013296901A1 (en) | 2015-02-12 |
AU2013296901B2 (en) | 2019-05-09 |
EP2880153A4 (en) | 2016-03-30 |
WO2014022120A1 (en) | 2014-02-06 |
KR20150036792A (ko) | 2015-04-07 |
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