JP4968811B2 - 遺伝子発現制御のための一本鎖核酸分子 - Google Patents

遺伝子発現制御のための一本鎖核酸分子 Download PDF

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Publication number
JP4968811B2
JP4968811B2 JP2011537086A JP2011537086A JP4968811B2 JP 4968811 B2 JP4968811 B2 JP 4968811B2 JP 2011537086 A JP2011537086 A JP 2011537086A JP 2011537086 A JP2011537086 A JP 2011537086A JP 4968811 B2 JP4968811 B2 JP 4968811B2
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nucleic acid
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JPWO2012005368A1 (ja
Inventor
忠明 大木
宏剛 林
久男 白水
智洋 濱崎
彰浩 伊藤
鈴木　　寛
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Bonac Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011537086A 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子 Expired - Fee Related JP4968811B2 (ja)

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JP2011537086A JP4968811B2 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子

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JP2010156122 2010-07-08
JP2010156122 2010-07-08
JP2010174915 2010-08-03
JP2010174915 2010-08-03
JP2010230808 2010-10-13
JP2010230808 2010-10-13
JP2010230806 2010-10-13
JP2010230806 2010-10-13
JP2010269824 2010-12-02
JP2010269823 2010-12-02
JP2010269824 2010-12-02
JP2010269823 2010-12-02
PCT/JP2011/065737 WO2012005368A1 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子
JP2011537086A JP4968811B2 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子

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JP2011537086A Expired - Fee Related JP4968811B2 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子
JP2012009515A Expired - Fee Related JP5804642B2 (ja) 2010-07-08 2012-01-20 遺伝子発現制御のための一本鎖核酸分子
JP2015150156A Expired - Fee Related JP6162182B2 (ja) 2010-07-08 2015-07-29 遺伝子発現制御のための一本鎖核酸分子

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JP2015150156A Expired - Fee Related JP6162182B2 (ja) 2010-07-08 2015-07-29 遺伝子発現制御のための一本鎖核酸分子

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EP (2) EP2431466B1 (enExample)
JP (3) JP4968811B2 (enExample)
KR (1) KR101849798B1 (enExample)
CN (2) CN104818276B (enExample)
AU (1) AU2011274854B2 (enExample)
BR (1) BR112013000481A2 (enExample)
CA (1) CA2804511C (enExample)
DK (2) DK2431466T3 (enExample)
ES (2) ES2550487T3 (enExample)
HU (2) HUE026520T2 (enExample)
MX (1) MX352568B (enExample)
NZ (2) NZ606232A (enExample)
PT (2) PT2933333T (enExample)
RU (1) RU2628311C2 (enExample)
SG (2) SG196779A1 (enExample)
TW (2) TWI527901B (enExample)
WO (1) WO2012005368A1 (enExample)

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WO2013133393A1 (ja) * 2012-03-07 2013-09-12 学校法人東京医科大学 Ｖｅｇｆ遺伝子の発現抑制用一本鎖核酸分子
KR20140139512A (ko) * 2012-03-29 2014-12-05 고쿠리쓰다이가쿠호진 규슈다이가쿠 페리오스틴 유전자의 발현 억제 핵산 분자, 페리오스틴 유전자의 발현 억제 방법 및 그 용도
US9663784B2 (en) 2012-05-26 2017-05-30 Bonac Corporation Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
CN105899663B (zh) 2013-12-26 2019-07-26 学校法人东京医科大学 用于基因表达控制的人工模拟miRNA及其用途
CN106068324B (zh) 2013-12-27 2020-12-29 株式会社博纳克 控制基因表达的人工匹配型miRNA及其用途
WO2016098782A1 (ja) 2014-12-15 2016-06-23 株式会社ボナック ＴＧＦ－β１発現抑制のための一本鎖核酸分子
WO2016104775A1 (ja) 2014-12-27 2016-06-30 株式会社ボナック 遺伝子発現制御のための天然型ｍｉＲＮＡおよびその用途
JP6602847B2 (ja) 2015-03-27 2019-11-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
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WO2018182008A1 (ja) 2017-03-31 2018-10-04 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
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WO2019074110A1 (ja) 2017-10-13 2019-04-18 株式会社ボナック 一本鎖核酸分子およびその製造方法
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
EP3778914A4 (en) 2018-03-30 2022-01-19 Sumitomo Chemical Company, Ltd. Method for producing single-strand rna
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ES2981806T3 (es) * 2018-10-02 2024-10-10 Toray Industries Método para producir moléculas de ARN monocatenario en horquilla
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KR20220079832A (ko) 2019-10-11 2022-06-14 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN115003682A (zh) 2020-01-29 2022-09-02 住友化学株式会社 核酸寡聚物的制造方法
US12391716B2 (en) 2020-01-29 2025-08-19 Sumitomo Chemical Company, Limited Process of preparing nucleic acid oligomer
JP7613130B2 (ja) * 2020-03-25 2025-01-15 味の素株式会社 リガーゼ変異体
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KR20230034969A (ko) 2020-07-09 2023-03-10 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
KR20230074205A (ko) 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN117980285A (zh) 2021-09-28 2024-05-03 住友化学株式会社 纯化二氯乙酸的制造方法
CN118891269A (zh) 2022-03-23 2024-11-01 住友化学株式会社 核酸寡聚物的制造方法
JP7201190B1 (ja) 2022-06-03 2023-01-10 株式会社セツロテック 遺伝子改変動物由来の動物繊維
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CA2804511A1 (en) 2012-01-12
MX2013000315A (es) 2013-05-01
SG196779A1 (en) 2014-02-13
AU2011274854B2 (en) 2015-04-16
EP2431466A1 (en) 2012-03-21
ES2550487T3 (es) 2015-11-10
EP2431466B1 (en) 2015-10-07
JP6162182B2 (ja) 2017-07-12
CN104818276A (zh) 2015-08-05
MX352568B (es) 2017-11-29
JP5804642B2 (ja) 2015-11-04
TW201217523A (en) 2012-05-01
JP2012130342A (ja) 2012-07-12
NZ606232A (en) 2015-06-26
TWI527901B (zh) 2016-04-01
CN102918156B (zh) 2015-11-25
RU2013105329A (ru) 2014-08-20
AU2011274854A1 (en) 2013-02-14
CN102918156A (zh) 2013-02-06
EP2431466A4 (en) 2012-04-25
DK2431466T3 (en) 2016-01-11
ES2670017T3 (es) 2018-05-29
CN104818276B (zh) 2020-12-11
KR101849798B1 (ko) 2018-04-17
PT2933333T (pt) 2018-04-24
DK2933333T3 (en) 2018-04-30
EP2933333A1 (en) 2015-10-21
HK1181423A1 (zh) 2013-11-08
WO2012005368A1 (ja) 2012-01-12
EP2933333B1 (en) 2018-02-21
TWI573870B (zh) 2017-03-11
TW201627500A (zh) 2016-08-01
CA2804511C (en) 2021-07-06
HUE037500T2 (hu) 2018-08-28
JP2015231381A (ja) 2015-12-24
HUE026520T2 (en) 2016-06-28
KR20130090792A (ko) 2013-08-14
SG186899A1 (en) 2013-02-28
NZ704812A (en) 2017-01-27
JPWO2012005368A1 (ja) 2013-09-05
PT2431466E (pt) 2016-01-08
RU2628311C2 (ru) 2017-08-15
BR112013000481A2 (pt) 2019-10-15

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