CA2804511C - Single-stranded nucleic acid molecule for controlling gene expression - Google Patents

Single-stranded nucleic acid molecule for controlling gene expression Download PDF

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Publication number
CA2804511C
CA2804511C CA2804511A CA2804511A CA2804511C CA 2804511 C CA2804511 C CA 2804511C CA 2804511 A CA2804511 A CA 2804511A CA 2804511 A CA2804511 A CA 2804511A CA 2804511 C CA2804511 C CA 2804511C
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Canada
Prior art keywords
region
side region
stranded rna
rna molecule
expression
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CA2804511A
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English (en)
French (fr)
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CA2804511A1 (en
Inventor
Tadaaki Ohgi
Hirotake Hayashi
Hisao SHIROHZU
Tomohiro HAMASAKI
Akihiro Itoh
Hiroshi Suzuki
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Toray Industries Inc
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Bonac Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2804511A 2010-07-08 2011-07-08 Single-stranded nucleic acid molecule for controlling gene expression Active CA2804511C (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
JP2010156122 2010-07-08
JP2010-156122 2010-07-08
JP2010-174915 2010-08-03
JP2010174915 2010-08-03
JP2010-230808 2010-10-13
JP2010230808 2010-10-13
JP2010-230806 2010-10-13
JP2010230806 2010-10-13
JP2010269824 2010-12-02
JP2010-269823 2010-12-02
JP2010269823 2010-12-02
JP2010-269824 2010-12-02
PCT/JP2011/065737 WO2012005368A1 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子

Publications (2)

Publication Number Publication Date
CA2804511A1 CA2804511A1 (en) 2012-01-12
CA2804511C true CA2804511C (en) 2021-07-06

Family

ID=45441339

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2804511A Active CA2804511C (en) 2010-07-08 2011-07-08 Single-stranded nucleic acid molecule for controlling gene expression

Country Status (17)

Country Link
EP (2) EP2431466B1 (enExample)
JP (3) JP4968811B2 (enExample)
KR (1) KR101849798B1 (enExample)
CN (2) CN104818276B (enExample)
AU (1) AU2011274854B2 (enExample)
BR (1) BR112013000481A2 (enExample)
CA (1) CA2804511C (enExample)
DK (2) DK2431466T3 (enExample)
ES (2) ES2550487T3 (enExample)
HU (2) HUE026520T2 (enExample)
MX (1) MX352568B (enExample)
NZ (2) NZ606232A (enExample)
PT (2) PT2933333T (enExample)
RU (1) RU2628311C2 (enExample)
SG (2) SG196779A1 (enExample)
TW (2) TWI527901B (enExample)
WO (1) WO2012005368A1 (enExample)

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Also Published As

Publication number Publication date
CA2804511A1 (en) 2012-01-12
MX2013000315A (es) 2013-05-01
SG196779A1 (en) 2014-02-13
AU2011274854B2 (en) 2015-04-16
EP2431466A1 (en) 2012-03-21
JP4968811B2 (ja) 2012-07-04
ES2550487T3 (es) 2015-11-10
EP2431466B1 (en) 2015-10-07
JP6162182B2 (ja) 2017-07-12
CN104818276A (zh) 2015-08-05
MX352568B (es) 2017-11-29
JP5804642B2 (ja) 2015-11-04
TW201217523A (en) 2012-05-01
JP2012130342A (ja) 2012-07-12
NZ606232A (en) 2015-06-26
TWI527901B (zh) 2016-04-01
CN102918156B (zh) 2015-11-25
RU2013105329A (ru) 2014-08-20
AU2011274854A1 (en) 2013-02-14
CN102918156A (zh) 2013-02-06
EP2431466A4 (en) 2012-04-25
DK2431466T3 (en) 2016-01-11
ES2670017T3 (es) 2018-05-29
CN104818276B (zh) 2020-12-11
KR101849798B1 (ko) 2018-04-17
PT2933333T (pt) 2018-04-24
DK2933333T3 (en) 2018-04-30
EP2933333A1 (en) 2015-10-21
HK1181423A1 (zh) 2013-11-08
WO2012005368A1 (ja) 2012-01-12
EP2933333B1 (en) 2018-02-21
TWI573870B (zh) 2017-03-11
TW201627500A (zh) 2016-08-01
HUE037500T2 (hu) 2018-08-28
JP2015231381A (ja) 2015-12-24
HUE026520T2 (en) 2016-06-28
KR20130090792A (ko) 2013-08-14
SG186899A1 (en) 2013-02-28
NZ704812A (en) 2017-01-27
JPWO2012005368A1 (ja) 2013-09-05
PT2431466E (pt) 2016-01-08
RU2628311C2 (ru) 2017-08-15
BR112013000481A2 (pt) 2019-10-15

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