JP2020519661A5 - - Google Patents
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- JP2020519661A5 JP2020519661A5 JP2019563132A JP2019563132A JP2020519661A5 JP 2020519661 A5 JP2020519661 A5 JP 2020519661A5 JP 2019563132 A JP2019563132 A JP 2019563132A JP 2019563132 A JP2019563132 A JP 2019563132A JP 2020519661 A5 JP2020519661 A5 JP 2020519661A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- composition
- pharmaceutical composition
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 31
- 208000002193 Pain Diseases 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 18
- 208000004550 Postoperative Pain Diseases 0.000 claims description 11
- 208000004296 neuralgia Diseases 0.000 claims description 8
- 208000021722 neuropathic pain Diseases 0.000 claims description 8
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims description 7
- 208000005298 acute pain Diseases 0.000 claims description 7
- 239000003981 vehicle Substances 0.000 claims description 4
- 208000009935 visceral pain Diseases 0.000 claims description 4
- 208000000094 Chronic Pain Diseases 0.000 claims description 3
- 206010011224 Cough Diseases 0.000 claims description 3
- 206010021639 Incontinence Diseases 0.000 claims description 3
- 206010065390 Inflammatory pain Diseases 0.000 claims description 3
- 108010052164 Sodium Channels Proteins 0.000 claims description 3
- 102000018674 Sodium Channels Human genes 0.000 claims description 3
- 210000003815 abdominal wall Anatomy 0.000 claims description 3
- 206010003119 arrhythmia Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000002969 morbid Effects 0.000 claims description 3
- 201000006417 multiple sclerosis Diseases 0.000 claims description 3
- 201000001119 neuropathy Diseases 0.000 claims description 3
- 230000007823 neuropathy Effects 0.000 claims description 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- 101000654356 Homo sapiens Sodium channel protein type 10 subunit alpha Proteins 0.000 claims description 2
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims description 2
- 102100031374 Sodium channel protein type 10 subunit alpha Human genes 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims description 2
- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 17
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 claims 1
- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 206010017999 Gastrointestinal pain Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507172P | 2017-05-16 | 2017-05-16 | |
| US62/507,172 | 2017-05-16 | ||
| US201762547718P | 2017-08-18 | 2017-08-18 | |
| US62/547,718 | 2017-08-18 | ||
| PCT/US2018/032939 WO2018213426A1 (en) | 2017-05-16 | 2018-05-16 | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519661A JP2020519661A (ja) | 2020-07-02 |
| JP2020519661A5 true JP2020519661A5 (enExample) | 2021-07-26 |
| JP7104070B2 JP7104070B2 (ja) | 2022-07-20 |
Family
ID=62567801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563132A Active JP7104070B2 (ja) | 2017-05-16 | 2018-05-16 | ナトリウムチャネルの調節因子としての重水素化ピリドンアミドおよびそのプロドラッグ |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11358977B2 (enExample) |
| EP (1) | EP3625214B1 (enExample) |
| JP (1) | JP7104070B2 (enExample) |
| KR (1) | KR102714561B1 (enExample) |
| CN (1) | CN110740993B (enExample) |
| AU (1) | AU2018271110A1 (enExample) |
| BR (1) | BR112019024016A2 (enExample) |
| CA (1) | CA3063901A1 (enExample) |
| CL (1) | CL2019003239A1 (enExample) |
| CO (1) | CO2019013021A2 (enExample) |
| ES (1) | ES2927712T3 (enExample) |
| IL (1) | IL270680B (enExample) |
| MA (1) | MA49137A (enExample) |
| MX (1) | MX390793B (enExample) |
| UA (1) | UA124857C2 (enExample) |
| WO (1) | WO2018213426A1 (enExample) |
| ZA (1) | ZA201907619B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3752152A1 (en) * | 2018-02-12 | 2020-12-23 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
| KR102812202B1 (ko) | 2018-11-02 | 2025-05-23 | 머크 샤프 앤드 돔 엘엘씨 | Nav1.8 억제제로서의 2-아미노-n-헤테로아릴-니코틴아미드 |
| EP3907218A4 (en) * | 2019-01-04 | 2022-09-21 | Jiangsu Hengrui Medicine Co., Ltd. | 6-OXO-1,6-DIHYDROPYRIDAZINE DERIVATIVE, METHOD FOR PREPARATION AND MEDICAL USE |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| US12441703B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020151728A1 (zh) * | 2019-01-25 | 2020-07-30 | 江苏恒瑞医药股份有限公司 | 2-氧代-1,2-二氢吡啶类衍生物、其制备方法及其在医药上的应用 |
| BR112021014178A2 (pt) * | 2019-02-20 | 2021-09-21 | Jiangsu Hengrui Medicine Co., Ltd. | Derivado de pró-fármaco de 6-oxo-1,6-diidropiridazina, método de preparação para o mesmo e aplicação do mesmo na medicina |
| WO2020206119A1 (en) * | 2019-04-02 | 2020-10-08 | Vertex Pharmaceuticals Incorporated | Process for making pyridone amides and prodrugs thereof useful as modulators of sodium channels |
| WO2020219867A1 (en) * | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| KR20220034853A (ko) * | 2019-07-16 | 2022-03-18 | 브리스톨-마이어스 스큅 컴퍼니 | 인터류킨의 조정에서의 전구약물 |
| WO2021018165A1 (zh) * | 2019-07-30 | 2021-02-04 | 江苏恒瑞医药股份有限公司 | 吡啶苯甲酰胺类衍生物、其制备方法及其在医药上的应用 |
| WO2021032074A1 (zh) * | 2019-08-19 | 2021-02-25 | 江苏恒瑞医药股份有限公司 | 苯甲酰胺稠芳环类衍生物、其制备方法及其在医药上的应用 |
| HUE069128T2 (hu) | 2019-12-06 | 2025-02-28 | Vertex Pharma | Szubsztituált tetrahidrofurán vegyületek mint nátriumcsatornák modulátorai |
| CN114437062B (zh) * | 2020-04-30 | 2024-05-17 | 成都海博为药业有限公司 | 一种可作为钠通道调节剂的化合物及其用途 |
| JP7323723B2 (ja) | 2020-06-17 | 2023-08-08 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｎａｖ１．８阻害剤としての２－オキソイミダゾリジン－４－カルボキサミド |
| CN113880771B (zh) * | 2020-07-03 | 2023-09-19 | 福建盛迪医药有限公司 | 一种选择性Nav抑制剂的结晶形式及其制备方法 |
| TW202214259A (zh) * | 2020-08-19 | 2022-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種選擇性ＮａＶ抑制劑的前藥及其晶型 |
| WO2022037647A1 (zh) * | 2020-08-19 | 2022-02-24 | 江苏恒瑞医药股份有限公司 | 一种选择性Nav抑制剂的结晶形式及其制备方法 |
| CN111808019B (zh) * | 2020-09-08 | 2020-11-27 | 上海济煜医药科技有限公司 | 一种并环化合物及其应用 |
| WO2022129281A1 (en) * | 2020-12-18 | 2022-06-23 | Glaxosmithkline Intellectual Property Development Limited | Nitrogen containing 2,3-dihydroquinazolinone compounds as nav1.8 inhibitors |
| JP2024502231A (ja) * | 2020-12-18 | 2024-01-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Ｎａｖ１．８電位依存性ナトリウムチャネルを阻害するためおよびＮａｖ１．８介在疾患を治療するために有用な化学化合物 |
| TW202302118A (zh) * | 2021-02-26 | 2023-01-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種選擇性ｎａｖ抑制劑的可藥用鹽、結晶形式及其製備方法 |
| KR20240005878A (ko) | 2021-05-07 | 2024-01-12 | 머크 샤프 앤드 돔 엘엘씨 | Nav1.8 억제제로서의 시클로알킬 3-옥소피페라진 카르복스아미드 및 시클로헤테로알킬 3-옥소피페라진 카르복스아미드 |
| AU2022284886A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| US20240294512A1 (en) | 2021-06-04 | 2024-09-05 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| CN117794918A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | 经取代的四氢呋喃类似物作为钠通道调节剂 |
| US20240285596A1 (en) | 2021-06-04 | 2024-08-29 | Vertex Pharmaceuticals Incorporated | Solid dosage forms and dosing regimens comprising (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide |
| US20240368135A1 (en) | 2021-06-04 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| US20240400544A1 (en) | 2021-06-04 | 2024-12-05 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| UY39882A (es) | 2021-08-02 | 2023-06-15 | Eurofarma Laboratorios S A | COMPUESTOS NACILHIDRAZÓNICOS INHIBIDORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE ESTOS Y KITS |
| UY39881A (es) | 2021-08-02 | 2023-06-15 | Eurofarma Laboratorios S A | “COMPUESTOS N-ACILHIDRAZÓNICOS INHIBIDORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE ESTOS Y KITS” |
| US20250222012A1 (en) * | 2021-11-02 | 2025-07-10 | Schedule 1 Therapeutics, Inc. | Use of cannabinoid compositions for treating pain associated with small fiber neuropathy |
| JP2025513454A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| AU2023255558A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| TW202404969A (zh) | 2022-04-22 | 2024-02-01 | 美商維泰克斯製藥公司 | 用於治療疼痛之雜芳基化合物 |
| CN119522214A (zh) | 2022-04-22 | 2025-02-25 | 沃泰克斯药物股份有限公司 | 用于治疗疼痛的杂芳基化合物 |
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| TW202523313A (zh) | 2023-10-23 | 2025-06-16 | 美商維泰克斯製藥公司 | 用於治療疼痛之雜芳基化合物 |
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| TWI606048B (zh) | 2013-01-31 | 2017-11-21 | 帝人製藥股份有限公司 | 唑苯衍生物 |
| JP6337109B2 (ja) | 2013-07-19 | 2018-06-06 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ナトリウムチャネルの調節剤としてのスルホンアミド |
| TWI703154B (zh) | 2013-12-13 | 2020-09-01 | 美商維泰克斯製藥公司 | 作為鈉通道調節劑之吡啶酮醯胺之前藥 |
| UY37806A (es) | 2017-07-11 | 2020-01-31 | Vertex Pharma | Carboxamidas como moduladores de los canales de sodio |
| EP3752152A1 (en) | 2018-02-12 | 2020-12-23 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
-
2018
- 2018-05-16 UA UAA201911875A patent/UA124857C2/uk unknown
- 2018-05-16 IL IL270680A patent/IL270680B/en unknown
- 2018-05-16 US US16/614,015 patent/US11358977B2/en active Active
- 2018-05-16 BR BR112019024016A patent/BR112019024016A2/pt active Search and Examination
- 2018-05-16 KR KR1020197037074A patent/KR102714561B1/ko active Active
- 2018-05-16 CN CN201880037064.5A patent/CN110740993B/zh active Active
- 2018-05-16 AU AU2018271110A patent/AU2018271110A1/en not_active Abandoned
- 2018-05-16 JP JP2019563132A patent/JP7104070B2/ja active Active
- 2018-05-16 EP EP18730543.8A patent/EP3625214B1/en active Active
- 2018-05-16 MX MX2019013574A patent/MX390793B/es unknown
- 2018-05-16 WO PCT/US2018/032939 patent/WO2018213426A1/en not_active Ceased
- 2018-05-16 ES ES18730543T patent/ES2927712T3/es active Active
- 2018-05-16 CA CA3063901A patent/CA3063901A1/en active Pending
- 2018-05-16 MA MA049137A patent/MA49137A/fr unknown
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2019
- 2019-11-12 CL CL2019003239A patent/CL2019003239A1/es unknown
- 2019-11-18 ZA ZA2019/07619A patent/ZA201907619B/en unknown
- 2019-11-21 CO CONC2019/0013021A patent/CO2019013021A2/es unknown
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