JP2011520965A5 - - Google Patents
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- Publication number
- JP2011520965A5 JP2011520965A5 JP2011510594A JP2011510594A JP2011520965A5 JP 2011520965 A5 JP2011520965 A5 JP 2011520965A5 JP 2011510594 A JP2011510594 A JP 2011510594A JP 2011510594 A JP2011510594 A JP 2011510594A JP 2011520965 A5 JP2011520965 A5 JP 2011520965A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- sglt2
- sglt2 inhibitor
- uric acid
- hyperuricemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 claims 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 5
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 229940116269 uric acid Drugs 0.000 claims 5
- 201000001431 Hyperuricemia Diseases 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 238000003786 synthesis reaction Methods 0.000 claims 4
- 108091006269 SLC5A2 Proteins 0.000 claims 3
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 201000005569 Gout Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000003064 xanthine oxidase inhibitor Substances 0.000 claims 2
- 208000013016 Hypoglycemia Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000002218 hypoglycaemic effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 0 CCOc1ccc(Cc(c*(*[C@@]([C@]([C@](*)[C@@]2O)O)O[C@@]2NO)cc2)c2Cl)cc1 Chemical compound CCOc1ccc(Cc(c*(*[C@@]([C@]([C@](*)[C@@]2O)O)O[C@@]2NO)cc2)c2Cl)cc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5535208P | 2008-05-22 | 2008-05-22 | |
| US61/055,352 | 2008-05-22 | ||
| PCT/US2009/044156 WO2009143020A1 (en) | 2008-05-22 | 2009-05-15 | Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014128550A Division JP2014205700A (ja) | 2008-05-22 | 2014-06-23 | Ｓｇｌｔ２阻害剤を使用する高尿酸血症の治療方法およびｓｇｌｔ２阻害剤を含有する組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520965A JP2011520965A (ja) | 2011-07-21 |
| JP2011520965A5 true JP2011520965A5 (enExample) | 2012-06-14 |
| JP5820269B2 JP5820269B2 (ja) | 2015-11-24 |
Family
ID=40810833
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510594A Expired - Fee Related JP5820269B2 (ja) | 2008-05-22 | 2009-05-15 | Ｓｇｌｔ２阻害剤を使用する高尿酸血症の治療方法およびｓｇｌｔ２阻害剤を含有する組成物 |
| JP2014128550A Pending JP2014205700A (ja) | 2008-05-22 | 2014-06-23 | Ｓｇｌｔ２阻害剤を使用する高尿酸血症の治療方法およびｓｇｌｔ２阻害剤を含有する組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014128550A Pending JP2014205700A (ja) | 2008-05-22 | 2014-06-23 | Ｓｇｌｔ２阻害剤を使用する高尿酸血症の治療方法およびｓｇｌｔ２阻害剤を含有する組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8791077B2 (enExample) |
| EP (2) | EP2668953A1 (enExample) |
| JP (2) | JP5820269B2 (enExample) |
| CN (1) | CN102105153B (enExample) |
| BR (1) | BRPI0913129A2 (enExample) |
| CA (1) | CA2725047A1 (enExample) |
| ES (1) | ES2526930T3 (enExample) |
| MX (1) | MX2010012656A (enExample) |
| WO (1) | WO2009143020A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| CA2801930A1 (en) | 2010-06-16 | 2011-12-22 | Takeda Pharmaceuticals U.S.A., Inc. | Novel modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors |
| US20140093563A1 (en) * | 2011-06-13 | 2014-04-03 | Ranbaxy Laboratories Limited | Febuxostat compositions |
| RU2014134845A (ru) * | 2012-01-27 | 2016-03-20 | Тейдзин Фарма Лимитед | Терапевтическое средство против диабета |
| WO2014149789A1 (en) * | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | Combination of canagliflozin and probenecid for the treament of hyperuricemia |
| EP2981269B9 (en) | 2013-04-04 | 2023-12-06 | Boehringer Ingelheim Vetmedica GmbH | Treatment of metabolic disorders in equine animals |
| PL3082829T3 (pl) | 2013-12-17 | 2021-09-06 | Boehringer Ingelheim Vetmedica Gmbh | Inhibitory sglt2 do leczenia zaburzeń metabolicznych u zwierząt kotowatych |
| PL3096765T3 (pl) | 2014-01-23 | 2019-05-31 | Boehringer Ingelheim Vetmedica Gmbh | Leczenie zaburzeń metabolicznych u zwierząt psowatych |
| KR102662473B1 (ko) | 2014-04-01 | 2024-05-03 | 베링거잉겔하임베트메디카게엠베하 | 말과 동물에서 대사 장애의 치료 |
| AU2015320975B2 (en) | 2014-09-25 | 2020-10-08 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment of SGLT2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals |
| NZ739429A (en) * | 2015-08-27 | 2023-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Liquid pharmaceutical compositions comprising sglt-2 inhibitors |
| KR101863604B1 (ko) * | 2016-04-08 | 2018-06-04 | 한국 한의학 연구원 | 익지 추출물을 유효성분으로 함유하는 고요산혈증 또는 고요산혈증 관련 대사 장애의 예방, 개선 또는 치료용 조성물 |
| WO2018167589A1 (en) | 2017-03-16 | 2018-09-20 | Inventia Healthcare Private Limited | Pharmaceutical composition comprising dapagliflozin |
| WO2019087239A1 (ja) * | 2017-10-30 | 2019-05-09 | 合同会社カルナヘルスサポート | 腎症治療剤 |
| WO2019092770A1 (ja) * | 2017-11-07 | 2019-05-16 | 合同会社カルナヘルスサポート | 網膜疾患治療剤 |
| AU2018444285A1 (en) * | 2018-10-01 | 2021-05-20 | Astrazeneca Ab | Compositions for reducing serum uric acid |
| BR112021010708A2 (pt) | 2018-12-06 | 2021-08-24 | Arthrosi Therapeutics, Inc. | Formas cristalinas de um composto para tratar ou prevenir gota ou hiperuricemia |
| AU2019392750B2 (en) | 2018-12-06 | 2025-07-10 | Arthrosi Therapeutics, Inc. | Methods for treating or preventing gout or hyperuricemia |
| WO2020178821A1 (en) * | 2019-03-03 | 2020-09-10 | Algatechnologies Ltd. | Compositions comprising algae powder and uses thereof |
| JP6831961B2 (ja) * | 2019-10-23 | 2021-02-24 | 株式会社カルナヘルスサポート | 網膜疾患治療剤 |
| US11759474B2 (en) | 2019-11-28 | 2023-09-19 | Boehringer Ingelheim Vetmedica Gmbh | Use of SGLT-2 inhibitors in the drying-off of non-human mammals |
| EP4164624A4 (en) * | 2020-06-10 | 2024-10-16 | Arthrosi Therapeutics, Inc. | METHODS OF TREATMENT OR PREVENTION OF CHRONIC KIDNEY DISEASE |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346094A (en) * | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| CA2102591C (en) | 1992-11-12 | 2000-12-26 | Kenji Tsujihara | Hypoglycemic agent |
| US5830873A (en) | 1994-05-11 | 1998-11-03 | Tanabe Seiyaku Co., Ltd. | Propiophenone derivative and a process for preparing the same |
| JP2814950B2 (ja) | 1994-05-11 | 1998-10-27 | 田辺製薬株式会社 | 血糖降下剤 |
| JP3034192B2 (ja) | 1995-11-07 | 2000-04-17 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
| JP3059088B2 (ja) | 1995-11-07 | 2000-07-04 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
| JP3065235B2 (ja) | 1995-11-07 | 2000-07-17 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
| JP3006513B2 (ja) | 1995-11-07 | 2000-02-07 | 田辺製薬株式会社 | 医薬組成物 |
| PT850948E (pt) | 1996-12-26 | 2002-08-30 | Tanabe Seiyaku Co | Derivados propiofenona e processo para a preparacao dos mesmos |
| JPH10245391A (ja) | 1997-03-03 | 1998-09-14 | Dainippon Ink & Chem Inc | ７−グリコシロキシベンゾピラン誘導体を有効成分とする糖尿病治療剤 |
| US6515117B2 (en) * | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| US6555519B2 (en) | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
| US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| EP2163555A1 (en) | 2000-11-02 | 2010-03-17 | Ajinomoto Co., Inc. | New pyrazole derivatives and diabetic medicine containing them |
| DE60230591D1 (de) * | 2001-02-26 | 2009-02-12 | Kissei Pharmaceutical | Glykopyranosyloxypyrazolderivate und deren medizinische verwendung |
| CA2438595C (en) * | 2001-02-27 | 2011-08-09 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and medicinal use thereof |
| WO2002080935A1 (en) | 2001-04-04 | 2002-10-17 | Ortho Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators |
| WO2002083066A2 (en) | 2001-04-11 | 2002-10-24 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
| CA2672001A1 (en) | 2001-04-27 | 2002-11-07 | Ajinomoto Co., Inc. | N-substituted pyrazole-o-glycoside derivatives and therapeutic agent for diabetes containing the same |
| ATE369787T1 (de) | 2001-06-20 | 2007-09-15 | Purdue Research Foundation | Druckmanschette mit körperbeleuchtung zur verwendung bei der optischen nichtinvasiven messung von blutparametern |
| KR100945455B1 (ko) | 2002-03-22 | 2010-03-05 | 깃세이 야쿠힌 고교 가부시키가이샤 | 글루코피라노실옥시벤질 벤젠 유도체의 결정 |
| BRPI0408140B8 (pt) | 2003-03-14 | 2018-12-11 | Astellas Pharma Inc | derivado de c-glicosídeo ou seu sal, composição farmacêutica e uso do derivado de c-glicosídeo ou seu sal |
| US7439232B2 (en) | 2003-04-01 | 2008-10-21 | Taisho Pharmaceutical Co., Ltd. | Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same |
| JPWO2004089966A1 (ja) * | 2003-04-01 | 2006-07-06 | 大正製薬株式会社 | 選択的なヘテロアリール５−チオ−β−Ｄ−アルドヘキソピラノシドの製造法 |
| JP2004359630A (ja) | 2003-06-06 | 2004-12-24 | Yamanouchi Pharmaceut Co Ltd | ジフルオロジフェニルメタン誘導体及びその塩 |
| US20050027128A1 (en) * | 2003-07-30 | 2005-02-03 | Robbins Timothy A. | Substituted thiazoles |
| UA86042C2 (en) | 2003-08-01 | 2009-03-25 | Янссен Фармацевтика Н.В. | Substituted indazole-o-glucosides |
| LT2896397T (lt) | 2003-08-01 | 2017-11-27 | Mitsubishi Tanabe Pharma Corporation | Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį |
| US7375090B2 (en) | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
| CA2550441C (en) * | 2003-12-26 | 2012-08-28 | Kissei Pharmaceutical Co., Ltd. | Benzimidazole derivatives and medical uses thereof |
| CN103435581B (zh) | 2004-03-16 | 2015-08-19 | 贝林格尔.英格海姆国际有限公司 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
| CA2560005A1 (en) | 2004-03-31 | 2005-10-13 | Kissei Pharmaceutical Co., Ltd. | Phenol derivative, medicinal composition containing the same, and medicinal use thereof |
| JP2005350375A (ja) | 2004-06-09 | 2005-12-22 | Kikkoman Corp | 血中尿酸値低下剤 |
| US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| DE102004034690A1 (de) | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
| WO2006010557A1 (de) | 2004-07-27 | 2006-02-02 | Boehringer Ingelheim International Gmbh | D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| WO2006018150A1 (de) | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| AR051446A1 (es) | 2004-09-23 | 2007-01-17 | Bristol Myers Squibb Co | Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2) |
| JP2006117651A (ja) | 2004-09-27 | 2006-05-11 | Taisho Pharmaceut Co Ltd | Ｓｇｌｔ２の活性阻害剤 |
| WO2006035796A1 (ja) | 2004-09-29 | 2006-04-06 | Kissei Pharmaceutical Co., Ltd. | １－（β－Ｄ－グリコピラノシル）－３－置換含窒素ヘテロ環化合物、それを含有する医薬組成物及びその医薬用途 |
| DE102004048388A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| CN100457143C (zh) * | 2004-11-29 | 2009-02-04 | 成都华西天然药物有限公司 | 一种治疗痛风的药物 |
| DE102004058449A1 (de) | 2004-12-03 | 2006-06-14 | Merck Patent Gmbh | Tetrahydropyranderivate |
| TW200637839A (en) | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| EP1924571B1 (en) * | 2005-08-30 | 2010-10-13 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| EA200801773A1 (ru) | 2006-02-15 | 2009-02-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Глюкопиранозилзамещенные производные бензонитрила, фармацевтические композиции, содержащие такие соединения, их применение и способ их получения |
| AR061026A1 (es) | 2006-05-19 | 2008-07-30 | Taisho Pharmaceutical Co Ltd | Compuesto glicitol c-fenilo y preparacion farmaceutica |
| JP5230613B2 (ja) | 2006-05-23 | 2013-07-10 | テラコス・インコーポレイテッド | グルコース輸送体阻害剤およびその使用方法 |
| US7919598B2 (en) | 2006-06-28 | 2011-04-05 | Bristol-Myers Squibb Company | Crystal structures of SGLT2 inhibitors and processes for preparing same |
| TWI448291B (zh) * | 2006-11-09 | 2014-08-11 | Boehringer Ingelheim Int | 使用ｓｇｌｔ-２抑制劑之組合療法及彼等之醫藥組合物 |
| TW200904405A (en) * | 2007-03-22 | 2009-02-01 | Bristol Myers Squibb Co | Pharmaceutical formulations containing an SGLT2 inhibitor |
| US8603989B2 (en) * | 2008-05-22 | 2013-12-10 | Bristol-Myers Squibb Company | Method for treating and preventing kidney stones employing an SGLT2 inhibitor and composition containing same |
-
2009
- 2009-05-15 BR BRPI0913129A patent/BRPI0913129A2/pt not_active IP Right Cessation
- 2009-05-15 CA CA2725047A patent/CA2725047A1/en not_active Abandoned
- 2009-05-15 MX MX2010012656A patent/MX2010012656A/es active IP Right Grant
- 2009-05-15 US US12/993,750 patent/US8791077B2/en not_active Expired - Fee Related
- 2009-05-15 WO PCT/US2009/044156 patent/WO2009143020A1/en not_active Ceased
- 2009-05-15 CN CN200980128978.3A patent/CN102105153B/zh not_active Expired - Fee Related
- 2009-05-15 JP JP2011510594A patent/JP5820269B2/ja not_active Expired - Fee Related
- 2009-05-15 ES ES09751249.5T patent/ES2526930T3/es active Active
- 2009-05-15 EP EP13181659.7A patent/EP2668953A1/en not_active Withdrawn
- 2009-05-15 EP EP09751249.5A patent/EP2291189B1/en not_active Not-in-force
-
2014
- 2014-06-23 JP JP2014128550A patent/JP2014205700A/ja active Pending
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