JP2011026348A5 - - Google Patents
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- Publication number
- JP2011026348A5 JP2011026348A5 JP2010249363A JP2010249363A JP2011026348A5 JP 2011026348 A5 JP2011026348 A5 JP 2011026348A5 JP 2010249363 A JP2010249363 A JP 2010249363A JP 2010249363 A JP2010249363 A JP 2010249363A JP 2011026348 A5 JP2011026348 A5 JP 2011026348A5
- Authority
- JP
- Japan
- Prior art keywords
- calcitonin
- pharmaceutical composition
- oral
- amount
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 16
- 102000055006 Calcitonin Human genes 0.000 claims 12
- 108060001064 Calcitonin Proteins 0.000 claims 12
- 229960004015 calcitonin Drugs 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 8
- 229940124447 delivery agent Drugs 0.000 claims 8
- XRTHAPZDZPADIL-UHFFFAOYSA-N 8-[(5-chloro-2-hydroxybenzoyl)amino]octanoic acid Chemical compound OC(=O)CCCCCCCNC(=O)C1=CC(Cl)=CC=C1O XRTHAPZDZPADIL-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 229960003773 calcitonin (salmon synthetic) Drugs 0.000 claims 4
- 108010068072 salmon calcitonin Proteins 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- -1 (5-chloro) -8-aminocaprylic acid disodium salt Chemical compound 0.000 claims 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960002446 octanoic acid Drugs 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40013902P | 2002-08-01 | 2002-08-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525407A Division JP2005535689A (ja) | 2002-08-01 | 2003-07-31 | カルシトニンの経口投与 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013249349A Division JP5941035B2 (ja) | 2002-08-01 | 2013-12-02 | カルシトニンの経口投与 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011026348A JP2011026348A (ja) | 2011-02-10 |
| JP2011026348A5 true JP2011026348A5 (enExample) | 2011-12-15 |
Family
ID=31495795
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525407A Withdrawn JP2005535689A (ja) | 2002-08-01 | 2003-07-31 | カルシトニンの経口投与 |
| JP2010249363A Pending JP2011026348A (ja) | 2002-08-01 | 2010-11-08 | カルシトニンの経口投与 |
| JP2013249349A Expired - Fee Related JP5941035B2 (ja) | 2002-08-01 | 2013-12-02 | カルシトニンの経口投与 |
| JP2016001745A Pending JP2016056190A (ja) | 2002-08-01 | 2016-01-07 | カルシトニンの経口投与 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525407A Withdrawn JP2005535689A (ja) | 2002-08-01 | 2003-07-31 | カルシトニンの経口投与 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013249349A Expired - Fee Related JP5941035B2 (ja) | 2002-08-01 | 2013-12-02 | カルシトニンの経口投与 |
| JP2016001745A Pending JP2016056190A (ja) | 2002-08-01 | 2016-01-07 | カルシトニンの経口投与 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20060135402A1 (enExample) |
| EP (1) | EP1526871A1 (enExample) |
| JP (4) | JP2005535689A (enExample) |
| KR (6) | KR20130004389A (enExample) |
| CN (1) | CN1671418A (enExample) |
| AR (1) | AR040737A1 (enExample) |
| AU (1) | AU2003260346B2 (enExample) |
| BR (1) | BR0313177A (enExample) |
| CA (1) | CA2494212A1 (enExample) |
| IL (1) | IL166337A (enExample) |
| MX (1) | MXPA05001266A (enExample) |
| NO (1) | NO20051023L (enExample) |
| NZ (1) | NZ537944A (enExample) |
| PE (1) | PE20040724A1 (enExample) |
| PL (1) | PL373143A1 (enExample) |
| RU (1) | RU2355417C2 (enExample) |
| TW (1) | TWI307279B (enExample) |
| WO (1) | WO2004012772A1 (enExample) |
| ZA (1) | ZA200500516B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007035718A2 (en) | 2005-09-19 | 2007-03-29 | Emisphere Technologies, Inc. | Crystalline forms of the di-sodium salt of n-(5-chlorosalicyloyl)-8-aminocaprylic acid |
| GB0522566D0 (en) * | 2005-11-04 | 2005-12-14 | Novartis Ag | Organic compounds |
| CN107050433A (zh) * | 2007-03-02 | 2017-08-18 | 诺华股份有限公司 | 降钙素的口服施用 |
| WO2009019307A2 (en) * | 2007-08-09 | 2009-02-12 | Novartis Ag | Oral calcitonin compositions and applications thereof |
| KR101344369B1 (ko) | 2007-11-02 | 2013-12-24 | 에미스페어 테크놀로지스, 인코포레이티드 | 비타민 ｂ12 결핍 치료방법 |
| JP5985985B2 (ja) * | 2009-08-03 | 2016-09-06 | エミスフィアー テクノロジーズ インコーポレイテッドＥｍｉｓｐｈｅｒｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ，Ｉｎｃ． | 胃腸への影響が減少した即効型ナプロキセン組成物 |
| WO2012130193A1 (en) | 2011-03-31 | 2012-10-04 | Zentiva, K.S. | Non-covalent soluble complexes of teriparatide with polysaccharides and a dosage form of teriparatide for oral administration |
| CN104095828A (zh) * | 2014-07-29 | 2014-10-15 | 中国药科大学 | 一种降钙素口服肠溶组合物及其制备方法 |
| US10583177B2 (en) * | 2015-02-09 | 2020-03-10 | Entera Bio Ltd. | Formulations for oral administration of active agents |
| CN104961687B (zh) * | 2015-06-03 | 2017-07-25 | 苏州维泰生物技术有限公司 | 1,2‑二嗪衍生物及其制剂、用途 |
| CN116850132A (zh) | 2016-08-17 | 2023-10-10 | 安提拉生物有限公司 | 用于口服的活性剂的制剂 |
| CR20230308A (es) | 2020-12-11 | 2023-09-08 | Civi Biopharma Inc | Entrega oral de conjugados antisentido que tienen por blanco a pcsk9 |
| CA3216091A1 (en) | 2021-04-22 | 2022-10-27 | Henrik Oerum | Oral delivery of oligonucleotides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| AU4218400A (en) * | 1999-04-05 | 2000-10-23 | Emisphere Technologies, Inc. | Lyophilized solid dosage forms and methods of making |
| IL145546A0 (en) * | 1999-04-05 | 2002-06-30 | Emisphere Tech Inc | Disodium salts, monohydrates, and ethanol solvates for delivering active agents |
| US7049283B2 (en) * | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
-
2003
- 2003-07-30 AR AR20030102740A patent/AR040737A1/es unknown
- 2003-07-30 TW TW092120855A patent/TWI307279B/zh not_active IP Right Cessation
- 2003-07-30 PE PE2003000747A patent/PE20040724A1/es not_active Application Discontinuation
- 2003-07-31 MX MXPA05001266A patent/MXPA05001266A/es unknown
- 2003-07-31 KR KR1020127031292A patent/KR20130004389A/ko not_active Ceased
- 2003-07-31 US US10/523,421 patent/US20060135402A1/en not_active Abandoned
- 2003-07-31 NZ NZ537944A patent/NZ537944A/en not_active IP Right Cessation
- 2003-07-31 WO PCT/EP2003/008498 patent/WO2004012772A1/en not_active Ceased
- 2003-07-31 KR KR1020057001733A patent/KR20050032101A/ko not_active Ceased
- 2003-07-31 CA CA002494212A patent/CA2494212A1/en not_active Abandoned
- 2003-07-31 JP JP2004525407A patent/JP2005535689A/ja not_active Withdrawn
- 2003-07-31 BR BR0313177-7A patent/BR0313177A/pt not_active Application Discontinuation
- 2003-07-31 CN CNA038182955A patent/CN1671418A/zh active Pending
- 2003-07-31 KR KR1020177022695A patent/KR20170097232A/ko not_active Ceased
- 2003-07-31 KR KR1020107029690A patent/KR20110014690A/ko not_active Ceased
- 2003-07-31 EP EP03766387A patent/EP1526871A1/en not_active Ceased
- 2003-07-31 KR KR1020147016376A patent/KR20140084354A/ko not_active Ceased
- 2003-07-31 RU RU2005105691/15A patent/RU2355417C2/ru not_active IP Right Cessation
- 2003-07-31 KR KR1020167025673A patent/KR20160113319A/ko not_active Ceased
- 2003-07-31 PL PL03373143A patent/PL373143A1/xx unknown
- 2003-07-31 AU AU2003260346A patent/AU2003260346B2/en not_active Ceased
-
2005
- 2005-01-17 IL IL166337A patent/IL166337A/en active IP Right Grant
- 2005-01-19 ZA ZA200500516A patent/ZA200500516B/xx unknown
- 2005-02-25 NO NO20051023A patent/NO20051023L/no unknown
-
2007
- 2007-05-24 US US11/805,748 patent/US7569539B2/en not_active Expired - Fee Related
-
2010
- 2010-11-08 JP JP2010249363A patent/JP2011026348A/ja active Pending
-
2013
- 2013-12-02 JP JP2013249349A patent/JP5941035B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-07 JP JP2016001745A patent/JP2016056190A/ja active Pending
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