|
US723561A
(en)
*
|
1902-03-28 |
1903-03-24 |
Helen M Van Etten |
Artificial fuel.
|
|
US4166452A
(en)
|
1976-05-03 |
1979-09-04 |
Generales Constantine D J Jr |
Apparatus for testing human responses to stimuli
|
|
US4256108A
(en)
|
1977-04-07 |
1981-03-17 |
Alza Corporation |
Microporous-semipermeable laminated osmotic system
|
|
US4265874A
(en)
|
1980-04-25 |
1981-05-05 |
Alza Corporation |
Method of delivering drug with aid of effervescent activity generated in environment of use
|
|
US4738851A
(en)
|
1985-09-27 |
1988-04-19 |
University Of Iowa Research Foundation, Inc. |
Controlled release ophthalmic gel formulation
|
|
US4882150A
(en)
|
1988-06-03 |
1989-11-21 |
Kaufman Herbert E |
Drug delivery system
|
|
US5521222A
(en)
|
1989-09-28 |
1996-05-28 |
Alcon Laboratories, Inc. |
Topical ophthalmic pharmaceutical vehicles
|
|
US5077033A
(en)
|
1990-08-07 |
1991-12-31 |
Mediventures Inc. |
Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
|
|
DK0495421T3
(da)
|
1991-01-15 |
1996-12-09 |
Alcon Lab Inc |
Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
|
|
US5728536A
(en)
*
|
1993-07-29 |
1998-03-17 |
St. Jude Children's Research Hospital |
Jak kinases and regulation of Cytokine signal transduction
|
|
CA2174080A1
(en)
*
|
1993-10-12 |
1995-04-20 |
Paul Edward Aldrich |
1n-alkyl-n-arylpyrimidinamines and derivatives thereof
|
|
IL114193A
(en)
|
1994-06-20 |
2000-02-29 |
Teva Pharma |
Ophthalmic pharmaceutical compositions based on sodium alginate
|
|
ES2094688B1
(es)
|
1994-08-08 |
1997-08-01 |
Cusi Lab |
Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
|
|
US6316635B1
(en)
*
|
1995-06-07 |
2001-11-13 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
GB9523675D0
(en)
*
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
IT1283911B1
(it)
|
1996-02-05 |
1998-05-07 |
Farmigea Spa |
Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
|
|
US6696448B2
(en)
*
|
1996-06-05 |
2004-02-24 |
Sugen, Inc. |
3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
|
|
US6784194B2
(en)
*
|
1996-12-06 |
2004-08-31 |
Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) |
Therapeutic use of a thienylcyclohexylamine derivative
|
|
US5800807A
(en)
|
1997-01-29 |
1998-09-01 |
Bausch & Lomb Incorporated |
Ophthalmic compositions including glycerin and propylene glycol
|
|
US6316429B1
(en)
*
|
1997-05-07 |
2001-11-13 |
Sugen, Inc. |
Bicyclic protein kinase inhibitors
|
|
US6486185B1
(en)
*
|
1997-05-07 |
2002-11-26 |
Sugen, Inc. |
3-heteroarylidene-2-indolinone protein kinase inhibitors
|
|
GB9718913D0
(en)
*
|
1997-09-05 |
1997-11-12 |
Glaxo Group Ltd |
Substituted oxindole derivatives
|
|
US6133305A
(en)
*
|
1997-09-26 |
2000-10-17 |
Sugen, Inc. |
3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
|
|
US6261547B1
(en)
|
1998-04-07 |
2001-07-17 |
Alcon Manufacturing, Ltd. |
Gelling ophthalmic compositions containing xanthan gum
|
|
US6197934B1
(en)
|
1998-05-22 |
2001-03-06 |
Collagenesis, Inc. |
Compound delivery using rapidly dissolving collagen film
|
|
GB9828511D0
(en)
*
|
1998-12-24 |
1999-02-17 |
Zeneca Ltd |
Chemical compounds
|
|
US6841567B1
(en)
*
|
1999-02-12 |
2005-01-11 |
Cephalon, Inc. |
Cyclic substituted fused pyrrolocarbazoles and isoindolones
|
|
US6624171B1
(en)
*
|
1999-03-04 |
2003-09-23 |
Smithkline Beecham Corporation |
Substituted aza-oxindole derivatives
|
|
US6080747A
(en)
*
|
1999-03-05 |
2000-06-27 |
Hughes Institute |
JAK-3 inhibitors for treating allergic disorders
|
|
GB9914258D0
(en)
*
|
1999-06-18 |
1999-08-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
WO2001045641A2
(en)
*
|
1999-11-30 |
2001-06-28 |
Parker Hughes Institute |
Inhibitors of thrombin induced platelet aggregation
|
|
CA2395520A1
(en)
*
|
1999-12-21 |
2001-06-28 |
Sugen, Inc. |
4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
|
|
WO2001056993A2
(en)
*
|
2000-02-05 |
2001-08-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compositions useful as inhibitors of erk
|
|
IL145757A
(en)
*
|
2000-02-05 |
2007-12-03 |
Vertex Pharma |
History of pyrazole and pharmaceutical preparations containing them
|
|
GB0004886D0
(en)
*
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
US6608048B2
(en)
*
|
2000-03-28 |
2003-08-19 |
Wyeth Holdings |
Tricyclic protein kinase inhibitors
|
|
GB0016877D0
(en)
*
|
2000-07-11 |
2000-08-30 |
Astrazeneca Ab |
Chemical compounds
|
|
AR035721A1
(es)
*
|
2000-12-20 |
2004-07-07 |
Sugen Inc |
Indolinonas 4-aril sustituidas; sus composiciones farmaceuticas y metodo para modular la actividad catalitica de una proteina quinasa
|
|
AUPR279101A0
(en)
*
|
2001-01-30 |
2001-02-22 |
Cytopia Pty Ltd |
Protein kinase signalling
|
|
DE60232510D1
(de)
*
|
2001-06-15 |
2009-07-16 |
Vertex Pharma |
5-(2-aminopyrimidin-4-yl)benzisoxazole als proteinkinasehemmer
|
|
US6939874B2
(en)
*
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
US7115617B2
(en)
*
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
US6433018B1
(en)
*
|
2001-08-31 |
2002-08-13 |
The Research Foundation Of State University Of New York |
Method for reducing hypertrophy and ischemia
|
|
EP1436259A1
(en)
*
|
2001-09-10 |
2004-07-14 |
Congxin Liang |
3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone derivatives as kinase inhibitors
|
|
EP1453516A2
(de)
*
|
2001-10-17 |
2004-09-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
|
|
DK1438053T3
(da)
*
|
2001-10-17 |
2008-12-08 |
Boehringer Ingelheim Pharma |
Pyrimidinderivater, lægemiddel indeholdende disse forbindelser, deres anvendelse og fremgangsmåder til deres fremstilling
|
|
TWI329105B
(en)
*
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
US6998391B2
(en)
*
|
2002-02-07 |
2006-02-14 |
Supergen.Inc. |
Method for treating diseases associated with abnormal kinase activity
|
|
US7288547B2
(en)
*
|
2002-03-11 |
2007-10-30 |
Schering Ag |
CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents
|
|
AU2003231880A1
(en)
*
|
2002-05-30 |
2003-12-19 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of jak and cdk2 protein kinases
|
|
BR0313059B8
(pt)
*
|
2002-07-29 |
2021-07-27 |
Rigel Pharmaceuticals |
composto, e, composição farmacêutica
|
|
BR0314603A
(pt)
*
|
2002-09-20 |
2005-07-26 |
Alcon Inc |
Uso de inibidores da sìntese de citoquina para o tratamento de distúrbios de olhos secos
|
|
EP2172460A1
(en)
*
|
2002-11-01 |
2010-04-07 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of JAK and other protein kinases
|
|
AR042052A1
(es)
*
|
2002-11-15 |
2005-06-08 |
Vertex Pharma |
Diaminotriazoles utiles como inhibidores de proteinquinasas
|
|
CN102358738A
(zh)
*
|
2003-07-30 |
2012-02-22 |
里格尔药品股份有限公司 |
2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途
|
|
EP1663242B1
(en)
*
|
2003-08-07 |
2011-04-27 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds and uses as anti-proliferative agents
|
|
DE10349423A1
(de)
*
|
2003-10-16 |
2005-06-16 |
Schering Ag |
Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
|
|
JP2007514775A
(ja)
*
|
2003-12-19 |
2007-06-07 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
１−（２，４−ピリミジンジアミノ）−２−シクロペンタンカルボキサイミド合成中間体の立体異性体および立体異性体混合物
|
|
US7754714B2
(en)
*
|
2004-05-18 |
2010-07-13 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
|
WO2006028833A1
(en)
*
|
2004-09-01 |
2006-03-16 |
Rigel Pharmaceuticals, Inc. |
Synthesis of 2,4-pyrimidinediamine compounds
|
|
EP1794134A1
(de)
*
|
2004-09-29 |
2007-06-13 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 2-anilinopyrimidine als zellzyklus -kinase oder rezeptortyrosin-kinase inhibitoren, deren herstellung und verwendung als arzneimittel
|
|
JP5095409B2
(ja)
*
|
2004-11-24 |
2012-12-12 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
スピロ２，４−ピリミジンジアミン化合物およびその使用
|
|
JP4801096B2
(ja)
*
|
2005-01-19 |
2011-10-26 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
２，４−ピリミジンジアミン化合物のプロドラッグおよびそれらの使用
|
|
US20070203161A1
(en)
*
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
EP1904457B1
(en)
*
|
2005-06-08 |
2017-09-06 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
CA2607901C
(en)
*
|
2005-06-13 |
2016-08-16 |
Rigel Pharmaceuticals, Inc. |
Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine
|
|
WO2007053844A2
(en)
*
|
2005-10-31 |
2007-05-10 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for treating inflammatory disorders
|
|
US7713987B2
(en)
*
|
2005-12-06 |
2010-05-11 |
Rigel Pharmaceuticals, Inc. |
Pyrimidine-2,4-diamines and their uses
|
|
JP4653842B2
(ja)
*
|
2006-02-17 |
2011-03-16 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
自己免疫疾患を治療または予防するための２，４−ピリミジンジアミン化合物
|
|
JP2009528295A
(ja)
*
|
2006-02-24 |
2009-08-06 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
Ｊａｋ経路の阻害のための組成物および方法
|
|
GB0605691D0
(en)
*
|
2006-03-21 |
2006-05-03 |
Novartis Ag |
Organic Compounds
|
|
ATE497496T1
(de)
*
|
2006-10-19 |
2011-02-15 |
Rigel Pharmaceuticals Inc |
2,4-pyridimediamon-derivate als hemmer von jak- kinasen zur behandlung von autoimmunerkrankungen
|
|
WO2009003136A1
(en)
*
|
2007-06-26 |
2008-12-31 |
Rigel Pharmaceuticals, Inc. |
Substituted pyrimidine-2, 4 -diamines for treating cell proliferative disorders
|
|
CA2691914C
(en)
*
|
2007-07-11 |
2012-06-26 |
Pfizer Inc. |
Pharmaceutical compositions and methods of treating dry eye disorders
|
|
CN101903357A
(zh)
*
|
2007-07-17 |
2010-12-01 |
里格尔药品股份有限公司 |
作为pkc抑制剂的环状胺取代的嘧啶二胺
|