|
US723561A
(en)
*
|
1902-03-28 |
1903-03-24 |
Helen M Van Etten |
Artificial fuel.
|
|
US4166452A
(en)
*
|
1976-05-03 |
1979-09-04 |
Generales Constantine D J Jr |
Apparatus for testing human responses to stimuli
|
|
US4256108A
(en)
*
|
1977-04-07 |
1981-03-17 |
Alza Corporation |
Microporous-semipermeable laminated osmotic system
|
|
US4265874A
(en)
|
1980-04-25 |
1981-05-05 |
Alza Corporation |
Method of delivering drug with aid of effervescent activity generated in environment of use
|
|
US4738851A
(en)
|
1985-09-27 |
1988-04-19 |
University Of Iowa Research Foundation, Inc. |
Controlled release ophthalmic gel formulation
|
|
US4882150A
(en)
|
1988-06-03 |
1989-11-21 |
Kaufman Herbert E |
Drug delivery system
|
|
US5521222A
(en)
|
1989-09-28 |
1996-05-28 |
Alcon Laboratories, Inc. |
Topical ophthalmic pharmaceutical vehicles
|
|
US5077033A
(en)
|
1990-08-07 |
1991-12-31 |
Mediventures Inc. |
Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
|
|
JP2594486B2
(ja)
|
1991-01-15 |
1997-03-26 |
アルコン ラボラトリーズ インコーポレイテッド |
局所的眼薬組成物
|
|
US5728536A
(en)
*
|
1993-07-29 |
1998-03-17 |
St. Jude Children's Research Hospital |
Jak kinases and regulation of Cytokine signal transduction
|
|
BR9407799A
(pt)
*
|
1993-10-12 |
1997-05-06 |
Du Pont Merck Pharma |
Composição de matéria método de tratamento e composição farmaceutica
|
|
IL114193A
(en)
|
1994-06-20 |
2000-02-29 |
Teva Pharma |
Ophthalmic pharmaceutical compositions based on sodium alginate
|
|
ES2094688B1
(es)
|
1994-08-08 |
1997-08-01 |
Cusi Lab |
Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
|
|
US6316635B1
(en)
*
|
1995-06-07 |
2001-11-13 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
GB9523675D0
(en)
*
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
IT1283911B1
(it)
|
1996-02-05 |
1998-05-07 |
Farmigea Spa |
Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
|
|
US6696448B2
(en)
*
|
1996-06-05 |
2004-02-24 |
Sugen, Inc. |
3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
|
|
US6784194B2
(en)
*
|
1996-12-06 |
2004-08-31 |
Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) |
Therapeutic use of a thienylcyclohexylamine derivative
|
|
US5800807A
(en)
|
1997-01-29 |
1998-09-01 |
Bausch & Lomb Incorporated |
Ophthalmic compositions including glycerin and propylene glycol
|
|
US6486185B1
(en)
*
|
1997-05-07 |
2002-11-26 |
Sugen, Inc. |
3-heteroarylidene-2-indolinone protein kinase inhibitors
|
|
US6316429B1
(en)
*
|
1997-05-07 |
2001-11-13 |
Sugen, Inc. |
Bicyclic protein kinase inhibitors
|
|
GB9718913D0
(en)
*
|
1997-09-05 |
1997-11-12 |
Glaxo Group Ltd |
Substituted oxindole derivatives
|
|
US6133305A
(en)
*
|
1997-09-26 |
2000-10-17 |
Sugen, Inc. |
3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
|
|
US6261547B1
(en)
|
1998-04-07 |
2001-07-17 |
Alcon Manufacturing, Ltd. |
Gelling ophthalmic compositions containing xanthan gum
|
|
US6197934B1
(en)
|
1998-05-22 |
2001-03-06 |
Collagenesis, Inc. |
Compound delivery using rapidly dissolving collagen film
|
|
GB9828511D0
(en)
*
|
1998-12-24 |
1999-02-17 |
Zeneca Ltd |
Chemical compounds
|
|
US6841567B1
(en)
*
|
1999-02-12 |
2005-01-11 |
Cephalon, Inc. |
Cyclic substituted fused pyrrolocarbazoles and isoindolones
|
|
US6624171B1
(en)
*
|
1999-03-04 |
2003-09-23 |
Smithkline Beecham Corporation |
Substituted aza-oxindole derivatives
|
|
US6080747A
(en)
*
|
1999-03-05 |
2000-06-27 |
Hughes Institute |
JAK-3 inhibitors for treating allergic disorders
|
|
GB9914258D0
(en)
*
|
1999-06-18 |
1999-08-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
CA2392554A1
(en)
*
|
1999-11-30 |
2001-06-28 |
Parker Hughes Institute |
Inhibitors of thrombin induced platelet aggregation
|
|
CO5271715A1
(es)
*
|
1999-12-21 |
2003-04-30 |
Sugen Inc |
7-aza-indolin-2-onas sustituidas en 4 y su uso como inhibidores de proteiuna quinasa
|
|
KR20010111298A
(ko)
*
|
2000-02-05 |
2001-12-17 |
버텍스 파마슈티칼스 인코포레이티드 |
Ｅｒｋ의 억제제로서 유용한 피라졸 조성물
|
|
JP4739632B2
(ja)
*
|
2000-02-05 |
2011-08-03 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ｅｒｋのインヒビターとして有用なピラゾール組成物
|
|
GB0004886D0
(en)
*
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
US6608048B2
(en)
*
|
2000-03-28 |
2003-08-19 |
Wyeth Holdings |
Tricyclic protein kinase inhibitors
|
|
GB0016877D0
(en)
*
|
2000-07-11 |
2000-08-30 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2002055517A2
(en)
*
|
2000-12-20 |
2002-07-18 |
Jingrong Cui |
4-(hetero)aryl substituted indolinones
|
|
AUPR279101A0
(en)
*
|
2001-01-30 |
2001-02-22 |
Cytopia Pty Ltd |
Protein kinase signalling
|
|
CA2450769A1
(en)
*
|
2001-06-15 |
2002-12-27 |
Vertex Pharmaceuticals Incorporated |
5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors
|
|
US6939874B2
(en)
*
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
US7115617B2
(en)
*
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
US6433018B1
(en)
*
|
2001-08-31 |
2002-08-13 |
The Research Foundation Of State University Of New York |
Method for reducing hypertrophy and ischemia
|
|
US6777417B2
(en)
*
|
2001-09-10 |
2004-08-17 |
Sugen, Inc. |
3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors
|
|
ATE407678T1
(de)
*
|
2001-10-17 |
2008-09-15 |
Boehringer Ingelheim Pharma |
Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
|
|
WO2003032994A2
(de)
*
|
2001-10-17 |
2003-04-24 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren
|
|
TWI329105B
(en)
*
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
US6998391B2
(en)
*
|
2002-02-07 |
2006-02-14 |
Supergen.Inc. |
Method for treating diseases associated with abnormal kinase activity
|
|
US7288547B2
(en)
*
|
2002-03-11 |
2007-10-30 |
Schering Ag |
CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents
|
|
JP2005528443A
(ja)
*
|
2002-05-30 |
2005-09-22 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ｊａｋキナーゼおよびｃｄｋ２プロテインキナーゼのインヒビター
|
|
HRP20050089B1
(hr)
*
|
2002-07-29 |
2015-06-19 |
Rigel Pharmaceuticals |
Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
|
|
EP1542768A1
(en)
*
|
2002-09-20 |
2005-06-22 |
Alcon, Inc. |
Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
|
|
AU2003286876A1
(en)
*
|
2002-11-01 |
2004-06-07 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of jak and other protein kinases
|
|
TWI335913B
(en)
*
|
2002-11-15 |
2011-01-11 |
Vertex Pharma |
Diaminotriazoles useful as inhibitors of protein kinases
|
|
WO2005012294A1
(en)
*
|
2003-07-30 |
2005-02-10 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
|
|
ATE506953T1
(de)
*
|
2003-08-07 |
2011-05-15 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel
|
|
DE10349423A1
(de)
*
|
2003-10-16 |
2005-06-16 |
Schering Ag |
Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
|
|
WO2005063722A1
(en)
*
|
2003-12-19 |
2005-07-14 |
Rigel Pharmaceuticals, Inc. |
Stereoisomers and stereoisomeric mixtures of 1-(2,4-pyrimidinediamino)-2-cyclopentanecarboxamide synthetic intermediates
|
|
US7754714B2
(en)
*
|
2004-05-18 |
2010-07-13 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
|
JP2008511659A
(ja)
*
|
2004-09-01 |
2008-04-17 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
２，４−ピリミジンジアミン化合物の合成
|
|
EP1794134A1
(de)
*
|
2004-09-29 |
2007-06-13 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 2-anilinopyrimidine als zellzyklus -kinase oder rezeptortyrosin-kinase inhibitoren, deren herstellung und verwendung als arzneimittel
|
|
SI1814878T1
(sl)
*
|
2004-11-24 |
2012-06-29 |
Rigel Pharmaceuticals Inc |
Spojine spiro-2,4-pirimidindiamina in njihova uporaba
|
|
AU2006206458B2
(en)
*
|
2005-01-19 |
2012-10-25 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
BRPI0610876B8
(pt)
*
|
2005-06-08 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel
|
|
US20070203161A1
(en)
*
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
JP2008543855A
(ja)
*
|
2005-06-13 |
2008-12-04 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
変形性骨疾患を処置するための方法および組成物
|
|
WO2007053844A2
(en)
*
|
2005-10-31 |
2007-05-10 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for treating inflammatory disorders
|
|
US7713987B2
(en)
*
|
2005-12-06 |
2010-05-11 |
Rigel Pharmaceuticals, Inc. |
Pyrimidine-2,4-diamines and their uses
|
|
US7659280B2
(en)
*
|
2006-02-17 |
2010-02-09 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases
|
|
ES2622493T3
(es)
*
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
|
GB0605691D0
(en)
*
|
2006-03-21 |
2006-05-03 |
Novartis Ag |
Organic Compounds
|
|
JP5161233B2
(ja)
*
|
2006-10-19 |
2013-03-13 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
自己免疫疾患の処置のためのｊａｋキナーゼの阻害剤としての２，４−ピリミジンアミン誘導体
|
|
WO2009003136A1
(en)
*
|
2007-06-26 |
2008-12-31 |
Rigel Pharmaceuticals, Inc. |
Substituted pyrimidine-2, 4 -diamines for treating cell proliferative disorders
|
|
NZ582188A
(en)
*
|
2007-07-11 |
2012-03-30 |
Pfizer |
Pharmaceutical compositions and methods of treating dry eye disorders
|
|
CN101903357A
(zh)
*
|
2007-07-17 |
2010-12-01 |
里格尔药品股份有限公司 |
作为pkc抑制剂的环状胺取代的嘧啶二胺
|