CA2768543C - Compositions and methods for inhibition of the jak pathway - Google Patents
Compositions and methods for inhibition of the jak pathway Download PDFInfo
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- CA2768543C CA2768543C CA2768543A CA2768543A CA2768543C CA 2768543 C CA2768543 C CA 2768543C CA 2768543 A CA2768543 A CA 2768543A CA 2768543 A CA2768543 A CA 2768543A CA 2768543 C CA2768543 C CA 2768543C
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22919109P | 2009-07-28 | 2009-07-28 | |
| US61/229,191 | 2009-07-28 | ||
| PCT/US2010/043592 WO2011017178A1 (en) | 2009-07-28 | 2010-07-28 | Compositions and methods for inhibition of the jak pathway |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2768543A1 CA2768543A1 (en) | 2011-02-10 |
| CA2768543C true CA2768543C (en) | 2017-06-20 |
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| CA2768543A Expired - Fee Related CA2768543C (en) | 2009-07-28 | 2010-07-28 | Compositions and methods for inhibition of the jak pathway |
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| Country | Link |
|---|---|
| US (1) | US20110028503A1 (enExample) |
| EP (1) | EP2459195A1 (enExample) |
| JP (1) | JP5738292B2 (enExample) |
| KR (1) | KR101740076B1 (enExample) |
| CN (2) | CN102470135A (enExample) |
| AU (3) | AU2010281404A1 (enExample) |
| BR (1) | BR112012002001A2 (enExample) |
| CA (1) | CA2768543C (enExample) |
| MX (1) | MX337849B (enExample) |
| RU (1) | RU2557982C2 (enExample) |
| WO (1) | WO2011017178A1 (enExample) |
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| JP6247223B2 (ja) * | 2011-12-08 | 2017-12-13 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 化合物を投与するための局所用製剤 |
| WO2013113067A1 (en) * | 2012-02-02 | 2013-08-08 | The University Of Sydney | Improvements in tear film stability |
| JP2015528501A (ja) * | 2012-09-12 | 2015-09-28 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 白斑の治療法 |
| WO2014117010A2 (en) * | 2013-01-24 | 2014-07-31 | Rigel Pharmaceuticals, Inc. | Composition for ophthalmic administration |
| TWI623313B (zh) * | 2013-03-13 | 2018-05-11 | Santen Pharmaceutical Co Ltd | 瞼板腺功能障礙之治療劑 |
| KR101665301B1 (ko) | 2013-08-07 | 2016-10-11 | 카딜라 핼쓰캐어 리미티드 | 야누스 키나제의 억제제로서 n-시아노메틸아미드 |
| WO2015060208A1 (ja) * | 2013-10-21 | 2015-04-30 | 日本たばこ産業株式会社 | 眼疾患の治療剤又は予防剤 |
| TWI710560B (zh) | 2015-11-03 | 2020-11-21 | 美商施萬生物製藥研發Ｉｐ有限責任公司 | 用於治療呼吸疾病之jak激酶抑制劑化合物 |
| AU2018261588A1 (en) * | 2017-05-01 | 2019-10-31 | Theravance Biopharma R&D Ip, Llc | Methods of treatment using a JAK inhibitor compound |
| CN107805212B (zh) * | 2017-11-03 | 2021-08-20 | 宿迁德威化工股份有限公司 | 一种2-甲基-5-氨基苯磺酰胺的制备方法 |
| EP4009974A1 (en) | 2019-08-08 | 2022-06-15 | Rigel Pharmaceuticals, Inc. | Compounds and method for treating cytokine release syndrome |
| CN111973599A (zh) * | 2020-08-07 | 2020-11-24 | 杭州邦顺制药有限公司 | 用于眼部疾病治疗的化合物 |
| TW202317550A (zh) | 2021-06-25 | 2023-05-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 作為jak抑制劑之咪唑吲唑化合物 |
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-
2010
- 2010-07-28 MX MX2012001134A patent/MX337849B/es active IP Right Grant
- 2010-07-28 RU RU2012103538/15A patent/RU2557982C2/ru active
- 2010-07-28 CN CN2010800344786A patent/CN102470135A/zh active Pending
- 2010-07-28 CN CN201610848344.7A patent/CN106420756A/zh active Pending
- 2010-07-28 EP EP10738139A patent/EP2459195A1/en not_active Withdrawn
- 2010-07-28 KR KR1020127004991A patent/KR101740076B1/ko not_active Expired - Fee Related
- 2010-07-28 BR BR112012002001A patent/BR112012002001A2/pt active Search and Examination
- 2010-07-28 AU AU2010281404A patent/AU2010281404A1/en not_active Abandoned
- 2010-07-28 US US12/845,655 patent/US20110028503A1/en not_active Abandoned
- 2010-07-28 JP JP2012523011A patent/JP5738292B2/ja not_active Expired - Fee Related
- 2010-07-28 WO PCT/US2010/043592 patent/WO2011017178A1/en not_active Ceased
- 2010-07-28 CA CA2768543A patent/CA2768543C/en not_active Expired - Fee Related
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2016
- 2016-09-08 AU AU2016225851A patent/AU2016225851A1/en not_active Abandoned
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2018
- 2018-08-13 AU AU2018217196A patent/AU2018217196A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5738292B2 (ja) | 2015-06-24 |
| CA2768543A1 (en) | 2011-02-10 |
| US20110028503A1 (en) | 2011-02-03 |
| MX2012001134A (es) | 2012-02-28 |
| RU2012103538A (ru) | 2013-09-10 |
| MX337849B (es) | 2016-03-09 |
| JP2013500977A (ja) | 2013-01-10 |
| KR20120089449A (ko) | 2012-08-10 |
| EP2459195A1 (en) | 2012-06-06 |
| RU2557982C2 (ru) | 2015-07-27 |
| CN102470135A (zh) | 2012-05-23 |
| CN106420756A (zh) | 2017-02-22 |
| WO2011017178A1 (en) | 2011-02-10 |
| BR112012002001A2 (pt) | 2016-05-10 |
| AU2010281404A1 (en) | 2012-02-09 |
| AU2016225851A1 (en) | 2016-09-29 |
| AU2018217196A1 (en) | 2018-08-30 |
| KR101740076B1 (ko) | 2017-06-08 |
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