RU2557982C2 - Композиции и способы ингибирования пути jak - Google Patents
Композиции и способы ингибирования пути jak Download PDFInfo
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- RU2557982C2 RU2557982C2 RU2012103538/15A RU2012103538A RU2557982C2 RU 2557982 C2 RU2557982 C2 RU 2557982C2 RU 2012103538/15 A RU2012103538/15 A RU 2012103538/15A RU 2012103538 A RU2012103538 A RU 2012103538A RU 2557982 C2 RU2557982 C2 RU 2557982C2
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US22919109P | 2009-07-28 | 2009-07-28 | |
| US61/229,191 | 2009-07-28 | ||
| PCT/US2010/043592 WO2011017178A1 (en) | 2009-07-28 | 2010-07-28 | Compositions and methods for inhibition of the jak pathway |
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| RU2012103538A RU2012103538A (ru) | 2013-09-10 |
| RU2557982C2 true RU2557982C2 (ru) | 2015-07-27 |
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| US (1) | US20110028503A1 (enExample) |
| EP (1) | EP2459195A1 (enExample) |
| JP (1) | JP5738292B2 (enExample) |
| KR (1) | KR101740076B1 (enExample) |
| CN (2) | CN106420756A (enExample) |
| AU (3) | AU2010281404A1 (enExample) |
| BR (1) | BR112012002001A2 (enExample) |
| CA (1) | CA2768543C (enExample) |
| MX (1) | MX337849B (enExample) |
| RU (1) | RU2557982C2 (enExample) |
| WO (1) | WO2011017178A1 (enExample) |
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| JP6247223B2 (ja) * | 2011-12-08 | 2017-12-13 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 化合物を投与するための局所用製剤 |
| AU2013214693B2 (en) * | 2012-02-02 | 2017-02-23 | Kenneth Gek-Jin OOI | Improvements in tear film stability |
| CA2884710A1 (en) | 2012-09-12 | 2014-03-20 | Rigel Pharmaceuticals, Inc. | Treatment for vitiligo |
| JP6351629B2 (ja) * | 2013-01-24 | 2018-07-04 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 点眼用組成物 |
| PT2974728T (pt) | 2013-03-13 | 2020-07-21 | Santen Pharmaceutical Co Ltd | Agente terapêutico para a disfunção meibomiana |
| HRP20170277T1 (hr) | 2013-08-07 | 2017-05-19 | Cadila Healthcare Limited | N-cijanometilamidi kao inhibitori janus kinaze |
| US20160367556A1 (en) * | 2013-10-21 | 2016-12-22 | Japan Tobacco Inc. | Therapeutic Agent for Ocular Disease or Prophylactic Agent for Ocular Disease |
| MY195427A (en) | 2015-11-03 | 2023-01-20 | Theravance Biopharma R&D Ip Llc | Jak Kinase Inhibitor Compounds for Treatment of Respiratory Disease |
| RU2764979C2 (ru) | 2017-05-01 | 2022-01-24 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | Способы лечения с использованием соединения-ингибитора jak |
| CN107805212B (zh) * | 2017-11-03 | 2021-08-20 | 宿迁德威化工股份有限公司 | 一种2-甲基-5-氨基苯磺酰胺的制备方法 |
| EP4009974A1 (en) | 2019-08-08 | 2022-06-15 | Rigel Pharmaceuticals, Inc. | Compounds and method for treating cytokine release syndrome |
| CN111973599A (zh) * | 2020-08-07 | 2020-11-24 | 杭州邦顺制药有限公司 | 用于眼部疾病治疗的化合物 |
| TW202317550A (zh) | 2021-06-25 | 2023-05-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 作為jak抑制劑之咪唑吲唑化合物 |
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| US723561A (en) * | 1902-03-28 | 1903-03-24 | Helen M Van Etten | Artificial fuel. |
| US4166452A (en) * | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
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- 2010-07-28 JP JP2012523011A patent/JP5738292B2/ja not_active Expired - Fee Related
- 2010-07-28 AU AU2010281404A patent/AU2010281404A1/en not_active Abandoned
- 2010-07-28 US US12/845,655 patent/US20110028503A1/en not_active Abandoned
- 2010-07-28 WO PCT/US2010/043592 patent/WO2011017178A1/en not_active Ceased
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- 2010-07-28 MX MX2012001134A patent/MX337849B/es active IP Right Grant
- 2010-07-28 CN CN2010800344786A patent/CN102470135A/zh active Pending
- 2010-07-28 KR KR1020127004991A patent/KR101740076B1/ko not_active Expired - Fee Related
- 2010-07-28 BR BR112012002001A patent/BR112012002001A2/pt active Search and Examination
- 2010-07-28 CA CA2768543A patent/CA2768543C/en not_active Expired - Fee Related
-
2016
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| US20110028503A1 (en) | 2011-02-03 |
| KR20120089449A (ko) | 2012-08-10 |
| MX337849B (es) | 2016-03-09 |
| AU2010281404A1 (en) | 2012-02-09 |
| KR101740076B1 (ko) | 2017-06-08 |
| CA2768543C (en) | 2017-06-20 |
| CN102470135A (zh) | 2012-05-23 |
| MX2012001134A (es) | 2012-02-28 |
| CN106420756A (zh) | 2017-02-22 |
| JP2013500977A (ja) | 2013-01-10 |
| JP5738292B2 (ja) | 2015-06-24 |
| CA2768543A1 (en) | 2011-02-10 |
| BR112012002001A2 (pt) | 2016-05-10 |
| AU2016225851A1 (en) | 2016-09-29 |
| WO2011017178A1 (en) | 2011-02-10 |
| EP2459195A1 (en) | 2012-06-06 |
| RU2012103538A (ru) | 2013-09-10 |
| AU2018217196A1 (en) | 2018-08-30 |
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