JP2012520882A5 - - Google Patents
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- Publication number
- JP2012520882A5 JP2012520882A5 JP2012500851A JP2012500851A JP2012520882A5 JP 2012520882 A5 JP2012520882 A5 JP 2012520882A5 JP 2012500851 A JP2012500851 A JP 2012500851A JP 2012500851 A JP2012500851 A JP 2012500851A JP 2012520882 A5 JP2012520882 A5 JP 2012520882A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- ophthalmic
- cetirizine
- concentration
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 57
- 238000009472 formulation Methods 0.000 claims description 36
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims description 23
- 238000002360 preparation method Methods 0.000 claims description 22
- 229960001803 cetirizine Drugs 0.000 claims description 21
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims description 14
- 229960002714 fluticasone Drugs 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 10
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical group C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims description 8
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 229920000858 Cyclodextrin Polymers 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 6
- 208000002205 allergic conjunctivitis Diseases 0.000 claims description 6
- 208000024998 atopic conjunctivitis Diseases 0.000 claims description 6
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 6
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 6
- 230000003381 solubilizing effect Effects 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 229960005016 naphazoline Drugs 0.000 claims description 4
- 229960001528 oxymetazoline Drugs 0.000 claims description 4
- 150000003431 steroids Chemical class 0.000 claims description 4
- 239000005526 vasoconstrictor agent Substances 0.000 claims description 4
- 239000013011 aqueous formulation Substances 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 229960004342 cetirizine hydrochloride Drugs 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 229960003943 hypromellose Drugs 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 125000005430 oxychloro group Chemical group 0.000 claims description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 2
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010052140 Eye pruritus Diseases 0.000 description 1
- 206010028735 Nasal congestion Diseases 0.000 description 1
- 206010052437 Nasal discomfort Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010040742 Sinus congestion Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16100609P | 2009-03-17 | 2009-03-17 | |
| US61/161,006 | 2009-03-17 | ||
| US17485009P | 2009-05-01 | 2009-05-01 | |
| US61/174,850 | 2009-05-01 | ||
| PCT/US2010/027295 WO2010107689A1 (en) | 2009-03-17 | 2010-03-15 | Ophthalmic formulations of cetirizine and methods of use |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014209682A Division JP2015007136A (ja) | 2009-03-17 | 2014-10-14 | セチリジンの眼科用製剤および使用方法 |
| JP2016158650A Division JP6144393B2 (ja) | 2009-03-17 | 2016-08-12 | セチリジンの眼科用製剤および使用方法 |
| JP2016158651A Division JP6449202B2 (ja) | 2009-03-17 | 2016-08-12 | セチリジンの眼科用製剤および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520882A JP2012520882A (ja) | 2012-09-10 |
| JP2012520882A5 true JP2012520882A5 (enExample) | 2013-05-02 |
| JP6033677B2 JP6033677B2 (ja) | 2016-11-30 |
Family
ID=42738180
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500851A Active JP6033677B2 (ja) | 2009-03-17 | 2010-03-15 | セチリジンの眼科用製剤および使用方法 |
| JP2014209682A Pending JP2015007136A (ja) | 2009-03-17 | 2014-10-14 | セチリジンの眼科用製剤および使用方法 |
| JP2016158651A Active JP6449202B2 (ja) | 2009-03-17 | 2016-08-12 | セチリジンの眼科用製剤および使用方法 |
| JP2016158650A Active JP6144393B2 (ja) | 2009-03-17 | 2016-08-12 | セチリジンの眼科用製剤および使用方法 |
| JP2018118671A Withdrawn JP2018141022A (ja) | 2009-03-17 | 2018-06-22 | セチリジンの眼科用製剤および使用方法 |
| JP2020084425A Active JP7088980B2 (ja) | 2009-03-17 | 2020-05-13 | セチリジンの眼科用製剤および使用方法 |
| JP2020084424A Active JP6893573B2 (ja) | 2009-03-17 | 2020-05-13 | セチリジンの眼科用製剤および使用方法 |
| JP2021099424A Withdrawn JP2021138760A (ja) | 2009-03-17 | 2021-06-15 | セチリジンの眼科用製剤および使用方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014209682A Pending JP2015007136A (ja) | 2009-03-17 | 2014-10-14 | セチリジンの眼科用製剤および使用方法 |
| JP2016158651A Active JP6449202B2 (ja) | 2009-03-17 | 2016-08-12 | セチリジンの眼科用製剤および使用方法 |
| JP2016158650A Active JP6144393B2 (ja) | 2009-03-17 | 2016-08-12 | セチリジンの眼科用製剤および使用方法 |
| JP2018118671A Withdrawn JP2018141022A (ja) | 2009-03-17 | 2018-06-22 | セチリジンの眼科用製剤および使用方法 |
| JP2020084425A Active JP7088980B2 (ja) | 2009-03-17 | 2020-05-13 | セチリジンの眼科用製剤および使用方法 |
| JP2020084424A Active JP6893573B2 (ja) | 2009-03-17 | 2020-05-13 | セチリジンの眼科用製剤および使用方法 |
| JP2021099424A Withdrawn JP2021138760A (ja) | 2009-03-17 | 2021-06-15 | セチリジンの眼科用製剤および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US9254286B2 (enExample) |
| EP (2) | EP3943069B1 (enExample) |
| JP (8) | JP6033677B2 (enExample) |
| CA (1) | CA2755679C (enExample) |
| ES (2) | ES2910374T3 (enExample) |
| MX (1) | MX2011009802A (enExample) |
| PT (2) | PT3943069T (enExample) |
| WO (1) | WO2010107689A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3943069T (pt) * | 2009-03-17 | 2025-02-21 | Nicox Ophthalmics Inc | Formulações oftálmicas de cetirizina e métodos de utilização |
| US8569273B2 (en) * | 2009-03-17 | 2013-10-29 | Aciex Therapeutics, Inc. | Ophthalmic formulations of cetirizine and methods of use |
| US20110105450A1 (en) * | 2009-06-05 | 2011-05-05 | Aciex Therapeutics, Inc. | Ophthalmic formulations of fluticasone and methods of use |
| CN102918336B (zh) | 2010-05-12 | 2016-08-03 | 布鲁克机械公司 | 用于低温冷却的系统及方法 |
| US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| PL3517541T3 (pl) | 2012-05-08 | 2020-12-28 | Nicox Ophthalmics, Inc. | Postać polimorficzna propionianu flutykazonu |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US11241426B2 (en) | 2017-02-13 | 2022-02-08 | Nitto Medic Co., Ltd. | Aqueous composition for ophthalmic or nasal administration |
| MX2019014748A (es) * | 2017-06-08 | 2020-08-03 | Eye Therapies Llc | Combinaciones de brimonidina de dosis baja y usos de las mismas. |
| CN119970625A (zh) * | 2018-01-15 | 2025-05-13 | 西雅图咖米公司 | 半固态抗组胺组合物及其制备和使用方法 |
| CN113712908A (zh) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | 一种用于治疗过敏性结膜炎的组合物其制备方法 |
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| US518882A (en) | 1894-04-24 | Mary p | ||
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| JP2010531898A (ja) * | 2007-06-28 | 2010-09-30 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | 鼻および眼へのコルチコステロイド水溶液送達 |
| PT3943069T (pt) * | 2009-03-17 | 2025-02-21 | Nicox Ophthalmics Inc | Formulações oftálmicas de cetirizina e métodos de utilização |
-
2010
- 2010-03-15 PT PT211797519T patent/PT3943069T/pt unknown
- 2010-03-15 US US12/724,128 patent/US9254286B2/en active Active
- 2010-03-15 WO PCT/US2010/027295 patent/WO2010107689A1/en not_active Ceased
- 2010-03-15 JP JP2012500851A patent/JP6033677B2/ja active Active
- 2010-03-15 CA CA2755679A patent/CA2755679C/en active Active
- 2010-03-15 EP EP21179751.9A patent/EP3943069B1/en active Active
- 2010-03-15 ES ES10753927T patent/ES2910374T3/es active Active
- 2010-03-15 PT PT107539272T patent/PT2408453T/pt unknown
- 2010-03-15 EP EP10753927.2A patent/EP2408453B1/en active Active
- 2010-03-15 ES ES21179751T patent/ES3014823T3/es active Active
- 2010-03-15 MX MX2011009802A patent/MX2011009802A/es not_active Application Discontinuation
-
2013
- 2013-05-21 US US13/899,321 patent/US8829005B2/en active Active
-
2014
- 2014-10-14 JP JP2014209682A patent/JP2015007136A/ja active Pending
-
2015
- 2015-12-29 US US14/982,258 patent/US9750684B2/en active Active
-
2016
- 2016-08-12 JP JP2016158651A patent/JP6449202B2/ja active Active
- 2016-08-12 JP JP2016158650A patent/JP6144393B2/ja active Active
-
2017
- 2017-03-10 US US15/456,249 patent/US9993471B2/en active Active
-
2018
- 2018-06-06 US US16/001,679 patent/US10675279B2/en active Active
- 2018-06-22 JP JP2018118671A patent/JP2018141022A/ja not_active Withdrawn
-
2020
- 2020-04-03 US US16/839,954 patent/US10987352B2/en active Active
- 2020-05-13 JP JP2020084425A patent/JP7088980B2/ja active Active
- 2020-05-13 JP JP2020084424A patent/JP6893573B2/ja active Active
- 2020-09-11 US US17/018,865 patent/US11617749B2/en active Active
-
2021
- 2021-05-27 US US17/332,814 patent/US11918573B2/en active Active
- 2021-06-15 JP JP2021099424A patent/JP2021138760A/ja not_active Withdrawn
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