CA2725047A1 - Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same - Google Patents
Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same Download PDFInfo
- Publication number
- CA2725047A1 CA2725047A1 CA2725047A CA2725047A CA2725047A1 CA 2725047 A1 CA2725047 A1 CA 2725047A1 CA 2725047 A CA2725047 A CA 2725047A CA 2725047 A CA2725047 A CA 2725047A CA 2725047 A1 CA2725047 A1 CA 2725047A1
- Authority
- CA
- Canada
- Prior art keywords
- inhibitor
- sglt2
- sglt2 inhibitor
- uric acid
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000000034 method Methods 0.000 title claims abstract description 70
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- NAFSTSRULRIERK-UHFFFAOYSA-M monosodium urate Chemical compound [Na+].N1C([O-])=NC(=O)C2=C1NC(=O)N2 NAFSTSRULRIERK-UHFFFAOYSA-M 0.000 description 1
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5535208P | 2008-05-22 | 2008-05-22 | |
| US61/055,352 | 2008-05-22 | ||
| PCT/US2009/044156 WO2009143020A1 (en) | 2008-05-22 | 2009-05-15 | Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same |
Publications (1)
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|---|---|
| CA2725047A1 true CA2725047A1 (en) | 2009-11-26 |
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| CA2725047A Abandoned CA2725047A1 (en) | 2008-05-22 | 2009-05-15 | Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same |
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| EP (2) | EP2291189B1 (enExample) |
| JP (2) | JP5820269B2 (enExample) |
| CN (1) | CN102105153B (enExample) |
| BR (1) | BRPI0913129A2 (enExample) |
| CA (1) | CA2725047A1 (enExample) |
| ES (1) | ES2526930T3 (enExample) |
| MX (1) | MX2010012656A (enExample) |
| WO (1) | WO2009143020A1 (enExample) |
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| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| ES2669184T3 (es) | 2010-06-16 | 2018-05-24 | Takeda Pharmaceuticals U.S.A., Inc. | Nuevas formas de dosificación de liberación modificada de inhibidor de xantina oxidorreductasa o inhibidores de xantina oxidasa |
| US20140093563A1 (en) * | 2011-06-13 | 2014-04-03 | Ranbaxy Laboratories Limited | Febuxostat compositions |
| CN104066430A (zh) * | 2012-01-27 | 2014-09-24 | 帝人制药株式会社 | 糖尿病的治疗药 |
| EP2968235B1 (en) * | 2013-03-15 | 2017-09-13 | Janssen Pharmaceutica NV | Combination of canagliflozin and probenecid for the treatment of hyperuricemia |
| EP2981269B9 (en) | 2013-04-04 | 2023-12-06 | Boehringer Ingelheim Vetmedica GmbH | Treatment of metabolic disorders in equine animals |
| ES2859905T3 (es) | 2013-12-17 | 2021-10-04 | Boehringer Ingelheim Vetmedica Gmbh | Inhibidores de SGLT2 para el tratamiento de trastornos metabólicos en animales felinos |
| KR20220097538A (ko) | 2014-01-23 | 2022-07-07 | 베링거잉겔하임베트메디카게엠베하 | 개과 동물에서 대사 장애의 치료 |
| PL3125882T3 (pl) | 2014-04-01 | 2020-10-19 | Boehringer Ingelheim Vetmedica Gmbh | Leczenie zaburzeń metabolicznych u zwierząt koniowatych |
| DK3197429T3 (da) | 2014-09-25 | 2024-08-26 | Boehringer Ingelheim Vetmedica Gmbh | Kombinationsbehandling med sglt2-hæmmere og dopaminagonister til forebyggelse af metaboliske lidelser af dyr i hestefamilien |
| HUE069575T2 (hu) | 2015-08-27 | 2025-03-28 | Boehringer Ingelheim Vetmedica Gmbh | Folyékony gyógyászati készítmények, amelyek SGLT-2-inhibitorokat tartalmaznak |
| KR101863604B1 (ko) * | 2016-04-08 | 2018-06-04 | 한국 한의학 연구원 | 익지 추출물을 유효성분으로 함유하는 고요산혈증 또는 고요산혈증 관련 대사 장애의 예방, 개선 또는 치료용 조성물 |
| WO2018167589A1 (en) | 2017-03-16 | 2018-09-20 | Inventia Healthcare Private Limited | Pharmaceutical composition comprising dapagliflozin |
| WO2019087239A1 (ja) * | 2017-10-30 | 2019-05-09 | 合同会社カルナヘルスサポート | 腎症治療剤 |
| JPWO2019092770A1 (ja) * | 2017-11-07 | 2019-11-14 | 合同会社カルナヘルスサポート | 網膜疾患治療剤 |
| BR112021006002A2 (pt) * | 2018-10-01 | 2021-06-29 | Astrazeneca Ab | composições para a redução de ácido úrico sérico |
| KR20210100677A (ko) | 2018-12-06 | 2021-08-17 | 아쓰로시 테라퓨틱스, 인크. | 통풍 또는 고뇨산혈증의 치료 또는 예방을 위한 화합물의 결정형 |
| CA3121624A1 (en) | 2018-12-06 | 2020-06-11 | Arthrosi Therapeutics, Inc. | Methods for treating or preventing gout or hyperuricemia |
| WO2020178821A1 (en) * | 2019-03-03 | 2020-09-10 | Algatechnologies Ltd. | Compositions comprising algae powder and uses thereof |
| JP6831961B2 (ja) * | 2019-10-23 | 2021-02-24 | 株式会社カルナヘルスサポート | 網膜疾患治療剤 |
| UY38969A (es) | 2019-11-28 | 2021-05-31 | Boehringer Ingelheim Vetmedica Gmbh | Uso de inhibidores de sglt-2 en el secado de mamíferos no humanos |
| JP2023529691A (ja) * | 2020-06-10 | 2023-07-11 | アースローシ セラピューティクス，インク． | 慢性腎疾患を処置または防止するための方法 |
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| JP2814950B2 (ja) | 1994-05-11 | 1998-10-27 | 田辺製薬株式会社 | 血糖降下剤 |
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| JP3034192B2 (ja) | 1995-11-07 | 2000-04-17 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
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| DE102004034690A1 (de) | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
| WO2006010557A1 (de) | 2004-07-27 | 2006-02-02 | Boehringer Ingelheim International Gmbh | D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| WO2006018150A1 (de) | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| AR051446A1 (es) | 2004-09-23 | 2007-01-17 | Bristol Myers Squibb Co | Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2) |
| JP2006117651A (ja) | 2004-09-27 | 2006-05-11 | Taisho Pharmaceut Co Ltd | Ｓｇｌｔ２の活性阻害剤 |
| CA2581922A1 (en) | 2004-09-29 | 2006-04-06 | Kissei Pharmaceutical Co., Ltd. | 1-(.beta.-d-glycopyranosyl)-3-substituted nitrogenous heterocyclic compound, medicinal composition containing the same, and medicinal use thereof |
| DE102004048388A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| CN100457143C (zh) * | 2004-11-29 | 2009-02-04 | 成都华西天然药物有限公司 | 一种治疗痛风的药物 |
| DE102004058449A1 (de) | 2004-12-03 | 2006-06-14 | Merck Patent Gmbh | Tetrahydropyranderivate |
| TW200637839A (en) * | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| ATE484499T1 (de) | 2005-08-30 | 2010-10-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür |
| ATE517099T1 (de) | 2006-02-15 | 2011-08-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte benzonitril-derivate,pharmazeutische zusammensetzungen mit derartigen verbindungen, ihre verwendung und herstellungsverfahren dafür |
| BRPI0711949A2 (pt) | 2006-05-19 | 2012-01-17 | Taisho Pharmaceutical Co., Ltd. | composto c-fenil glicitol |
| WO2007140191A2 (en) * | 2006-05-23 | 2007-12-06 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
| US7919598B2 (en) | 2006-06-28 | 2011-04-05 | Bristol-Myers Squibb Company | Crystal structures of SGLT2 inhibitors and processes for preparing same |
| AR063627A1 (es) * | 2006-11-09 | 2009-02-04 | Boehringer Ingelheim Int | Terapia combinada con inhibidores de sgl t-2 y sus composiciones farmaceuticas |
| TW200904405A (en) * | 2007-03-22 | 2009-02-01 | Bristol Myers Squibb Co | Pharmaceutical formulations containing an SGLT2 inhibitor |
| US8603989B2 (en) * | 2008-05-22 | 2013-12-10 | Bristol-Myers Squibb Company | Method for treating and preventing kidney stones employing an SGLT2 inhibitor and composition containing same |
-
2009
- 2009-05-15 MX MX2010012656A patent/MX2010012656A/es active IP Right Grant
- 2009-05-15 BR BRPI0913129A patent/BRPI0913129A2/pt not_active IP Right Cessation
- 2009-05-15 EP EP09751249.5A patent/EP2291189B1/en not_active Not-in-force
- 2009-05-15 ES ES09751249.5T patent/ES2526930T3/es active Active
- 2009-05-15 CA CA2725047A patent/CA2725047A1/en not_active Abandoned
- 2009-05-15 JP JP2011510594A patent/JP5820269B2/ja not_active Expired - Fee Related
- 2009-05-15 US US12/993,750 patent/US8791077B2/en not_active Expired - Fee Related
- 2009-05-15 WO PCT/US2009/044156 patent/WO2009143020A1/en not_active Ceased
- 2009-05-15 EP EP13181659.7A patent/EP2668953A1/en not_active Withdrawn
- 2009-05-15 CN CN200980128978.3A patent/CN102105153B/zh not_active Expired - Fee Related
-
2014
- 2014-06-23 JP JP2014128550A patent/JP2014205700A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN102105153B (zh) | 2014-03-05 |
| MX2010012656A (es) | 2010-12-20 |
| BRPI0913129A2 (pt) | 2016-01-05 |
| EP2291189A1 (en) | 2011-03-09 |
| ES2526930T3 (es) | 2015-01-16 |
| EP2291189B1 (en) | 2014-10-01 |
| US8791077B2 (en) | 2014-07-29 |
| JP2014205700A (ja) | 2014-10-30 |
| US20110065658A1 (en) | 2011-03-17 |
| JP2011520965A (ja) | 2011-07-21 |
| CN102105153A (zh) | 2011-06-22 |
| WO2009143020A1 (en) | 2009-11-26 |
| EP2668953A1 (en) | 2013-12-04 |
| JP5820269B2 (ja) | 2015-11-24 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20140425 |
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| FZDE | Discontinued |
Effective date: 20171221 |