BR112012032033A2 - novas formas de dosagem de libertação modificada de inibidor de xantina oxidorredutase ou inibidores de xantina oxidase - Google Patents

novas formas de dosagem de libertação modificada de inibidor de xantina oxidorredutase ou inibidores de xantina oxidase

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Publication number
BR112012032033A2
BR112012032033A2 BR112012032033A BR112012032033A BR112012032033A2 BR 112012032033 A2 BR112012032033 A2 BR 112012032033A2 BR 112012032033 A BR112012032033 A BR 112012032033A BR 112012032033 A BR112012032033 A BR 112012032033A BR 112012032033 A2 BR112012032033 A2 BR 112012032033A2
Authority
BR
Brazil
Prior art keywords
xanthine
inhibitor
dosage forms
modified release
new modified
Prior art date
Application number
BR112012032033A
Other languages
English (en)
Inventor
Vakilynejad Majid
Taneja Rajneesh
Gupte Vijay
Original Assignee
Takeda Pharmaceuticals Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45328897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012032033(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Usa Inc filed Critical Takeda Pharmaceuticals Usa Inc
Publication of BR112012032033A2 publication Critical patent/BR112012032033A2/pt

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

novas formas de dosagem de libertação modificada de inibidor de xantina oxidorredutase ou inibidores de xantina oxidase. a presente descrição refere-se a novas formas de dosagem de inibidores sa xantina oxidorredutase.
BR112012032033A 2010-06-16 2011-06-15 novas formas de dosagem de libertação modificada de inibidor de xantina oxidorredutase ou inibidores de xantina oxidase BR112012032033A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35516410P 2010-06-16 2010-06-16
PCT/US2011/040418 WO2011159745A1 (en) 2010-06-16 2011-06-15 Novel modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors

Publications (1)

Publication Number Publication Date
BR112012032033A2 true BR112012032033A2 (pt) 2017-10-31

Family

ID=45328897

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012032033A BR112012032033A2 (pt) 2010-06-16 2011-06-15 novas formas de dosagem de libertação modificada de inibidor de xantina oxidorredutase ou inibidores de xantina oxidase

Country Status (25)

Country Link
US (2) US9248119B2 (pt)
EP (1) EP2582812B1 (pt)
JP (2) JP5865904B2 (pt)
KR (1) KR101872189B1 (pt)
CN (1) CN103210084B (pt)
AU (2) AU2011268445B9 (pt)
BR (1) BR112012032033A2 (pt)
CA (1) CA2801930A1 (pt)
CL (1) CL2012003548A1 (pt)
CO (1) CO6650415A2 (pt)
EC (1) ECSP13012394A (pt)
ES (1) ES2669184T3 (pt)
HK (1) HK1187371A1 (pt)
IL (2) IL223455B (pt)
JO (1) JO3450B1 (pt)
MX (2) MX361138B (pt)
MY (1) MY167126A (pt)
NZ (1) NZ604646A (pt)
PE (2) PE20170306A1 (pt)
RU (1) RU2602188C2 (pt)
SG (1) SG186301A1 (pt)
TW (1) TW201202249A (pt)
UA (1) UA112632C2 (pt)
WO (1) WO2011159745A1 (pt)
ZA (1) ZA201209386B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201206502A (en) * 2010-06-16 2012-02-16 Teijin Pharma Ltd Controlled release nucleated tablet
KR20130088755A (ko) * 2010-06-25 2013-08-08 데이진 화-마 가부시키가이샤 서방성 고혈압 및 신 기능 장애 치료제
NZ605562A (en) * 2010-07-09 2013-11-29 Teijin Pharma Ltd Deuterated benzylbenzene derivatives and methods of use
WO2012153313A1 (en) * 2011-05-11 2012-11-15 Ranbaxy Laboratories Limited Pharmaceutical composition of febuxostat
WO2012172461A1 (en) * 2011-06-13 2012-12-20 Ranbaxy Laboratories Limited Pharmaceutical compositions of febuxostat
US20150005506A1 (en) * 2012-01-27 2015-01-01 National University Corporation Tottori University Therapeutic agent for diabetes
EP2925306A1 (en) * 2012-07-12 2015-10-07 Alembic Pharmaceuticals Limited Pharmaceutical composition of febuxostat
CN102973530B (zh) * 2012-12-14 2016-08-03 贵州信邦制药股份有限公司 一种非布索坦双层肠溶片剂及其制备方法
WO2014125504A2 (en) * 2013-02-18 2014-08-21 Hetero Research Foundation Pharmaceutical compositions of febuxostat
SG11201509738RA (en) * 2013-05-31 2015-12-30 Takeda Pharmaceuticals Usa Inc Methods of treatment and compositions with xanthine oxidase inhibitors
EP2881116A1 (en) * 2013-12-05 2015-06-10 Ranbaxy Laboratories Limited Febuxostat composition
CA2983394A1 (en) * 2015-04-20 2016-10-27 Twi Biotechnology, Inc. Formulations containing diacerein and methods of lowering blood levels of uric acid using the same
TWI684465B (zh) * 2015-04-22 2020-02-11 安成生物科技股份有限公司 含雙醋瑞因之製劑及使用其於降低尿酸血中濃度的方法
WO2017100559A1 (en) * 2015-12-10 2017-06-15 Cogwellin Llc Controlled release formulations of salicylate-releasing actives
CN106279024B (zh) * 2016-07-19 2018-09-14 华南理工大学 一种黄嘌呤氧化还原酶抑制剂及其制备方法与应用
CN106146419A (zh) * 2016-08-01 2016-11-23 沈阳药科大学 黄嘌呤氧化酶抑制剂
CN109982697A (zh) * 2016-11-28 2019-07-05 帝人制药株式会社 糖尿病性肾病的治疗药或预防药
WO2018228440A1 (zh) * 2017-06-14 2018-12-20 江苏恒瑞医药股份有限公司 一种非布司他控释组合物及其制备方法
CN109721586B (zh) * 2017-10-27 2021-03-02 中国医科大学 一种5-苄基-3-吡啶基-1h-1,2,4-三唑类化合物及其制备方法和用途
CN108484494B (zh) * 2018-06-15 2021-07-30 沈阳药科大学 2-氧代-1,2-二氢吡啶-4-甲酸类化合物
CN108938591A (zh) * 2018-08-21 2018-12-07 天津双硕医药科技有限公司 一种含有非布司他的固体药物组合物
CN109157654B (zh) * 2018-11-06 2021-12-07 苏州大学 Tmx1的用途
CN111662239B (zh) * 2019-03-06 2023-07-28 中国医学科学院药物研究所 1,2,4-三唑类化合物及其制法和药物用途
US20220354855A1 (en) * 2019-10-09 2022-11-10 Mayo Foundation For Medical Education And Research Treatment for gastrointestinal disorders
CN113354616B (zh) * 2020-03-05 2024-03-26 中国医学科学院药物研究所 二芳基-1,2,4-三唑类化合物及其制法和药物用途

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218942B (hu) * 1990-11-30 2001-01-29 Teijin Ltd. 2-Fenil-tiazol-származékok, az ezeket tartalmazó gyógyászati készítmények, valamint eljárás a vegyületek előállítására
US5843969A (en) 1995-04-07 1998-12-01 Teijin Limited Protecting agent for organ or tissue
US20010055613A1 (en) * 1998-10-21 2001-12-27 Beth A. Burnside Oral pulsed dose drug delivery system
KR20070051953A (ko) 1998-11-02 2007-05-18 엘란 코포레이션, 피엘씨 다입자 변형 방출 조성물
ECSP993280A (es) 1999-12-17 2001-07-27 Polimorfos de acido 2- (3- ciano -4 -isobutiloxi fenil) -4 -metil -5-tiazol carboxilico y metodo de produccion de los mismos
RU2219957C2 (ru) * 2001-11-19 2003-12-27 Пихлак Андрей Эдуардович Способ лечения подагры с помощью плазмосорбции
SI21301A (sl) * 2002-09-11 2004-04-30 LEK farmacevtska družba d.d. Farmacevtska oblika z nadzorovanim sproščanjem
ZA200502318B (en) * 2002-10-16 2006-11-29 Takeda Pharmaceutical Controlled release preparation
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
FR2878159B1 (fr) * 2004-11-24 2008-10-17 Flamel Technologies Sa Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire
EP1854463A4 (en) * 2005-03-03 2011-03-23 Takeda Pharmaceutical COMPOSITION WITH CONTROLLED RELEASE
JP2008545627A (ja) 2005-05-09 2008-12-18 タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド 腎結石症を治療する方法
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
CA2635313C (en) * 2005-12-29 2013-12-31 Osmotica Corp. Triple combination release multi-layered tablet
KR20090103879A (ko) * 2006-11-13 2009-10-01 다케다 파마슈티칼스 노쓰 어메리카, 인코포레이티드 크산틴 옥시도리덕타아제 억제제를 사용하여 신장 기능을 보존하는 방법
US8110226B2 (en) 2007-07-20 2012-02-07 Mylan Pharmaceuticals Inc. Drug formulations having inert sealed cores
CN102105153B (zh) 2008-05-22 2014-03-05 百时美施贵宝公司 Sglt2抑制剂的医药用途和含该抑制剂的组合物
CN101716132B (zh) * 2008-10-09 2012-01-11 北京方策方程医药科技有限公司 非布索坦肠溶制剂
CN101474175B (zh) 2009-01-20 2014-07-02 重庆医药工业研究院有限责任公司 一种高生物利用度非布司他口服固体制剂及其制备方法
CN101658505A (zh) * 2009-09-29 2010-03-03 北京华禧联合科技发展有限公司 非布索坦的缓释制剂及其制备方法
CN101711751A (zh) 2009-12-04 2010-05-26 山东淄博新达制药有限公司 非布索坦分散片及其制备方法
CN101711743B (zh) 2009-12-04 2011-08-24 山东淄博新达制药有限公司 非布索坦干混悬剂及其制备方法
CN101773498B (zh) 2009-12-30 2012-06-20 青岛黄海制药有限责任公司 一种含有非布司他的口服缓控释制剂的制备方法
KR20130088755A (ko) 2010-06-25 2013-08-08 데이진 화-마 가부시키가이샤 서방성 고혈압 및 신 기능 장애 치료제
NZ605562A (en) 2010-07-09 2013-11-29 Teijin Pharma Ltd Deuterated benzylbenzene derivatives and methods of use

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