MX2013005994A - Monobactamas. - Google Patents

Monobactamas.

Info

Publication number
MX2013005994A
MX2013005994A MX2013005994A MX2013005994A MX2013005994A MX 2013005994 A MX2013005994 A MX 2013005994A MX 2013005994 A MX2013005994 A MX 2013005994A MX 2013005994 A MX2013005994 A MX 2013005994A MX 2013005994 A MX2013005994 A MX 2013005994A
Authority
MX
Mexico
Prior art keywords
monobactams
directed
present
bacterial infections
new class
Prior art date
Application number
MX2013005994A
Other languages
English (en)
Inventor
Matthew Frank Brown
Mark Stephen Plummer
Veerabahu Shanmugasundaram
Hud Lawrence Risley
Mark J Mitton-Fry
Seungil Han
Manjinder Lall
Jeremy T Starr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2013005994A publication Critical patent/MX2013005994A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a una nueva clase de derivados de monobactama y su uso para tratar infecciones bacterianas.
MX2013005994A 2010-11-29 2011-11-15 Monobactamas. MX2013005994A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41757510P 2010-11-29 2010-11-29
PCT/IB2011/055104 WO2012073138A1 (en) 2010-11-29 2011-11-15 Monobactams

Publications (1)

Publication Number Publication Date
MX2013005994A true MX2013005994A (es) 2013-07-15

Family

ID=45315854

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005994A MX2013005994A (es) 2010-11-29 2011-11-15 Monobactamas.

Country Status (18)

Country Link
US (3) US20120302542A1 (es)
EP (1) EP2646436B1 (es)
JP (1) JP5777725B2 (es)
KR (1) KR101514587B1 (es)
CN (1) CN103228652B (es)
AR (1) AR084001A1 (es)
AU (1) AU2011336209B2 (es)
CA (1) CA2815821C (es)
DK (1) DK2646436T3 (es)
ES (1) ES2542431T3 (es)
HK (1) HK1184462A1 (es)
IL (1) IL226052A0 (es)
MX (1) MX2013005994A (es)
SG (1) SG190007A1 (es)
TW (1) TW201247661A (es)
UY (1) UY33754A (es)
WO (1) WO2012073138A1 (es)
ZA (1) ZA201304479B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6422164B2 (ja) 2013-12-26 2018-11-14 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物
CN106164072B (zh) 2014-03-24 2019-10-01 诺华股份有限公司 用于治疗细菌感染的单环内酰胺有机化合物
EA037569B1 (ru) * 2015-09-23 2021-04-15 Новартис Аг Соли монобактамного антибиотика и их применение
CN105481812B (zh) * 2015-11-30 2020-04-21 重庆天奕恒化科技有限公司 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法
US20180339983A1 (en) 2015-12-15 2018-11-29 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
MA43811A (fr) 2016-03-07 2018-11-28 Merck Sharp & Dohme Composés d'arylmonobactame bicycliques et leurs méthodes d'utilisation pour le traitement des infections bactériennes
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
CN111094281B (zh) 2017-08-02 2023-08-29 诺华股份有限公司 用于制备单内酰胺抗生素的化学方法及其中间体
JP7252948B2 (ja) 2017-10-02 2023-04-05 メルク・シャープ・アンド・ドーム・エルエルシー 細菌感染症を治療するためのクロマンモノバクタム化合物
US10513504B2 (en) 2018-03-08 2019-12-24 Apotex Inc. Processes for the preparation of apalutamide and intermediates thereof
CN114787158B (zh) * 2019-11-22 2023-10-24 苏州二叶制药有限公司 磺酰脲环取代的单环β-内酰胺类抗生素
AU2020397059A1 (en) 2019-12-06 2022-07-21 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
CN111303144B (zh) * 2019-12-13 2020-11-27 苏州信诺维医药科技有限公司 一种治疗细菌感染的化合物
WO2022235077A1 (ko) * 2021-05-07 2022-11-10 한국생명공학연구원 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체
IL308953A (en) 2021-06-04 2024-01-01 Vertex Pharma N-Hydroalkyl(Hetero)Aryl)Tetrahydrofuran Carboxamides as Natrene Channel Modulators
WO2023091438A1 (en) 2021-11-18 2023-05-25 Merck Sharp & Dohme Llc Chromane amidine monobactam antibiotics
CN115304594B (zh) * 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007273A2 (en) * 1986-05-23 1987-12-03 The Upjohn Company N-1 substituted sulfonylaminocarbonyl, c-4 substituted monobactams
RS52068B (en) 2005-12-07 2012-06-30 Basilea Pharmaceutica Ag. USEFUL MANOBACTAM ANTIBIOTICS
CA2627529A1 (en) 2007-03-28 2008-09-28 Apotex Technologies Inc. Fluorinated derivatives of deferiprone
CN102325769A (zh) 2008-12-19 2012-01-18 美国辉瑞有限公司 单卡波姆

Also Published As

Publication number Publication date
WO2012073138A1 (en) 2012-06-07
EP2646436B1 (en) 2015-05-27
KR101514587B1 (ko) 2015-04-22
TW201247661A (en) 2012-12-01
US20150148326A1 (en) 2015-05-28
UY33754A (es) 2012-06-29
KR20130112054A (ko) 2013-10-11
CA2815821A1 (en) 2012-06-07
JP5777725B2 (ja) 2015-09-09
ZA201304479B (en) 2014-03-26
US20130252935A1 (en) 2013-09-26
CN103228652A (zh) 2013-07-31
CA2815821C (en) 2015-07-07
ES2542431T3 (es) 2015-08-05
AU2011336209A1 (en) 2013-05-30
EP2646436A1 (en) 2013-10-09
IL226052A0 (en) 2013-06-27
AU2011336209B2 (en) 2015-03-19
AR084001A1 (es) 2013-04-17
SG190007A1 (en) 2013-06-28
HK1184462A1 (en) 2014-01-24
US20120302542A1 (en) 2012-11-29
JP2013544276A (ja) 2013-12-12
DK2646436T3 (en) 2015-06-29
CN103228652B (zh) 2015-02-18

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