JP2009500045A5 - - Google Patents
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- Publication number
- JP2009500045A5 JP2009500045A5 JP2008520699A JP2008520699A JP2009500045A5 JP 2009500045 A5 JP2009500045 A5 JP 2009500045A5 JP 2008520699 A JP2008520699 A JP 2008520699A JP 2008520699 A JP2008520699 A JP 2008520699A JP 2009500045 A5 JP2009500045 A5 JP 2009500045A5
- Authority
- JP
- Japan
- Prior art keywords
- damage
- thymosin
- derivative
- pharmaceutical composition
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UGPMCIBIHRSCBV-XNBOLLIBSA-N Thymosin beta 4 Chemical class N([C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O UGPMCIBIHRSCBV-XNBOLLIBSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000028006 Corneal injury Diseases 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 230000003683 cardiac damage Effects 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 230000037380 skin damage Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510083894.6 | 2005-07-15 | ||
| CN 200510083894 CN1896096A (zh) | 2005-07-15 | 2005-07-15 | 基因工程方法生产的高活性胸腺素β4衍生物 |
| CNB2005101032937A CN100484957C (zh) | 2005-09-23 | 2005-09-23 | 胸腺素β4衍生物及其应用 |
| CN200510103293.7 | 2005-09-23 | ||
| PCT/CN2006/001679 WO2007009359A1 (en) | 2005-07-15 | 2006-07-14 | Thymosin beta 4 derivatives and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500045A JP2009500045A (ja) | 2009-01-08 |
| JP2009500045A5 true JP2009500045A5 (enExample) | 2009-07-23 |
| JP5180074B2 JP5180074B2 (ja) | 2013-04-10 |
Family
ID=37668439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008520699A Active JP5180074B2 (ja) | 2005-07-15 | 2006-07-14 | サイモシンβ４誘導体及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7816321B2 (enExample) |
| EP (1) | EP1908779B1 (enExample) |
| JP (1) | JP5180074B2 (enExample) |
| KR (1) | KR100984635B1 (enExample) |
| CN (1) | CN100582121C (enExample) |
| PL (1) | PL1908779T3 (enExample) |
| WO (1) | WO2007009359A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007014253A2 (en) * | 2005-07-26 | 2007-02-01 | Regenerx Biopharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to congestive heart failure |
| GB2476789A (en) | 2009-11-10 | 2011-07-13 | Gl Holdings Inc Bv | Use of thymosin for treatment of type 2 diabetes |
| US9504730B2 (en) | 2010-09-30 | 2016-11-29 | Regenerx Biopharmaceuticals, Inc. | Method of achieving a thymosin beta 4 concentration in a human patient |
| WO2012126047A1 (en) * | 2011-03-18 | 2012-09-27 | Adistem Ltd | Agent and method for treating pain and reducing inflammation |
| CN103724422B (zh) * | 2014-01-13 | 2015-10-21 | 哈尔滨吉象隆生物技术有限公司 | 一种裂解胸腺素β4的方法 |
| CN104311672B (zh) * | 2014-10-21 | 2017-07-11 | 中国药科大学 | 一种具有肿瘤细胞靶向性的抑制剂多肽 |
| CN106692949B (zh) * | 2016-12-23 | 2022-03-15 | 北京诺思兰德生物技术股份有限公司 | 一种用于治疗眼部疾病的药物及其组合物 |
| KR101910908B1 (ko) * | 2017-06-14 | 2018-10-24 | (주)휴온스 | Gly-Tβ4 (Gly-티모신β4)을 함유하는 안구건조증 치료용 약학적 조성물 |
| KR101946789B1 (ko) * | 2018-01-26 | 2019-02-12 | (주)휴온스 | 이황화결합 이성질화효소 신호 펩타이드를 포함하는 재조합 벡터 및 이의 용도 |
| WO2019178059A1 (en) * | 2018-03-13 | 2019-09-19 | Georgetown University | ENHANCING CHEMOTHERAPY IN MEDULLOBLASTOMA AND GLIOBLASTOMA WITH HIGH BASAL p53 LEVELS |
| KR102140531B1 (ko) * | 2018-08-07 | 2020-08-04 | (주)휴온스 | Gly-Tβ4의 제조방법 |
| CN108853483B (zh) * | 2018-08-10 | 2022-03-15 | 北京诺思兰德生物技术股份有限公司 | 经修饰的胸腺素β4在治疗脑缺血再灌注损伤方面的用途 |
| CN110215513B (zh) * | 2018-11-15 | 2022-02-22 | 北京诺思兰德生物技术股份有限公司 | 经修饰的胸腺素β4在治疗放射性肠炎方面的用途 |
| CN109865127B (zh) * | 2018-11-22 | 2022-03-04 | 北京诺思兰德生物技术股份有限公司 | 经修饰的胸腺素β4在治疗糖尿病周围神经病变方面的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4297276A (en) * | 1979-03-23 | 1981-10-27 | Hoffman-La Roche Inc. | Thymosin beta 3 and beta 4 |
| US4395404A (en) * | 1982-05-14 | 1983-07-26 | George Washington University | Synthetic thymosin β3 and β4 analogues |
| EP1591128A1 (en) * | 1998-07-30 | 2005-11-02 | The Government of the United States of America, as repres. by the Secretary of Health and Human Services, Nat. Inst. of Health | Thymosin beta 4 promotes wound repair |
| ATE466868T1 (de) | 2005-04-20 | 2010-05-15 | Viromed Co Ltd | Zusammensetzungen und verfahren zur trennung von fusionsproteinen |
-
2006
- 2006-07-14 CN CN200680025339A patent/CN100582121C/zh active Active
- 2006-07-14 JP JP2008520699A patent/JP5180074B2/ja active Active
- 2006-07-14 US US11/995,817 patent/US7816321B2/en active Active
- 2006-07-14 PL PL06761426T patent/PL1908779T3/pl unknown
- 2006-07-14 KR KR1020087003496A patent/KR100984635B1/ko active Active
- 2006-07-14 EP EP06761426A patent/EP1908779B1/en active Active
- 2006-07-14 WO PCT/CN2006/001679 patent/WO2007009359A1/zh not_active Ceased
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