JP2017532343A5 - - Google Patents
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- Publication number
- JP2017532343A5 JP2017532343A5 JP2017520447A JP2017520447A JP2017532343A5 JP 2017532343 A5 JP2017532343 A5 JP 2017532343A5 JP 2017520447 A JP2017520447 A JP 2017520447A JP 2017520447 A JP2017520447 A JP 2017520447A JP 2017532343 A5 JP2017532343 A5 JP 2017532343A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical preparation
- mammal
- heart failure
- neuregulin
- ejection fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 102000014413 Neuregulin Human genes 0.000 claims 5
- 108050003475 Neuregulin Proteins 0.000 claims 5
- 206010019280 Heart failures Diseases 0.000 claims 3
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 2
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 2
- 101000653754 Rattus norvegicus Sphingosine 1-phosphate receptor 5 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000038003 heart failure with preserved ejection fraction Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410550212.7 | 2014-10-17 | ||
| CN201410550212.7A CN105561298A (zh) | 2014-10-17 | 2014-10-17 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
| PCT/CN2015/091459 WO2016058493A1 (zh) | 2014-10-17 | 2015-10-08 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139931A Division JP2020193217A (ja) | 2014-10-17 | 2020-08-21 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017532343A JP2017532343A (ja) | 2017-11-02 |
| JP2017532343A5 true JP2017532343A5 (enExample) | 2018-10-18 |
Family
ID=55746124
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520447A Pending JP2017532343A (ja) | 2014-10-17 | 2015-10-08 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2020139931A Pending JP2020193217A (ja) | 2014-10-17 | 2020-08-21 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2022108771A Pending JP2022153417A (ja) | 2014-10-17 | 2022-07-06 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2024135192A Pending JP2024164068A (ja) | 2014-10-17 | 2024-08-14 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139931A Pending JP2020193217A (ja) | 2014-10-17 | 2020-08-21 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2022108771A Pending JP2022153417A (ja) | 2014-10-17 | 2022-07-06 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2024135192A Pending JP2024164068A (ja) | 2014-10-17 | 2024-08-14 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10561709B2 (enExample) |
| EP (2) | EP3207940B1 (enExample) |
| JP (4) | JP2017532343A (enExample) |
| KR (2) | KR102603711B1 (enExample) |
| CN (3) | CN111407882A (enExample) |
| AU (2) | AU2015333335B2 (enExample) |
| CA (1) | CA2963322A1 (enExample) |
| ES (1) | ES2924395T3 (enExample) |
| RU (1) | RU2017116973A (enExample) |
| WO (1) | WO2016058493A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006332340B2 (en) | 2005-12-30 | 2013-09-26 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for improved cardiac function |
| JP6096262B2 (ja) | 2009-08-25 | 2017-03-15 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． | ニューレグリンに基づく心不全の治療方法 |
| CN102139095A (zh) | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| CN109276705B (zh) | 2012-10-08 | 2023-10-20 | 上海泽生科技开发股份有限公司 | 治疗糖尿病患者心力衰竭的组份和方法 |
| EP3610905B1 (en) | 2013-05-22 | 2021-03-31 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for treating heart failure |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| CN105497876B (zh) | 2014-09-24 | 2021-01-15 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
| EP3774859B1 (en) | 2018-04-11 | 2024-03-13 | Salubris Biotherapeutics, Inc. | Human neuregulin-1 (nrg-1) recombinant fusion protein compositions and methods of use thereof |
| CN111407881A (zh) * | 2019-01-07 | 2020-07-14 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物 |
| AR121035A1 (es) * | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
| CN113289002A (zh) * | 2020-02-24 | 2021-08-24 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物 |
| CN116710139A (zh) * | 2020-11-12 | 2023-09-05 | 安进股份有限公司 | 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法 |
| CN117797243A (zh) * | 2022-09-30 | 2024-04-02 | 上海泽生科技开发股份有限公司 | 神经调节蛋白及其应用 |
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| WO1989001489A1 (en) | 1987-08-10 | 1989-02-23 | Commonwealth Scientific And Industrial Research Or | Control of angiogenesis and compositions and methods therefor |
| US5716930A (en) | 1991-04-10 | 1998-02-10 | Ludwig Institute For Cancer Research | Glial growth factors |
| US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
| US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US6750196B1 (en) | 1995-03-27 | 2004-06-15 | Acorda Therapeutics | Methods of treating disorders of the eye |
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| CA2278151C (en) | 1997-02-10 | 2010-11-16 | Genentech, Inc. | Heregulin variants |
| WO1999018976A1 (en) | 1997-10-14 | 1999-04-22 | Cambridge Neuroscience, Inc. | Therapeutic methods comprising use of a neuregulin |
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| CN1138785C (zh) | 1999-06-04 | 2004-02-18 | 周明东 | 生长因子神经调节蛋白及其类似物的新应用 |
| AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
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| AU2001290864A1 (en) | 2000-09-12 | 2002-04-02 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Optimized cardiac contraction through differential phosphorylation of myosin |
| US6482624B2 (en) | 2000-11-14 | 2002-11-19 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| RU2180843C1 (ru) | 2001-02-19 | 2002-03-27 | Новокузнецкий государственный институт усовершенствования врачей | Способ профилактики повторного инфаркта миокарда |
| CN1498656A (zh) | 2002-11-08 | 2004-05-26 | 上海泽生科技开发有限公司 | 神经调节蛋白用于心肌梗死治疗的方法和组合物 |
| WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| WO2004050894A2 (en) | 2002-11-27 | 2004-06-17 | Artesian Therapeutics, Inc. | Heart failure gene determination and therapeutic screening |
| EP1631268A2 (en) | 2003-05-21 | 2006-03-08 | Board Of Regents The University Of Texas System | Inhibition of protein kinase c-mu (pkd) as a treatment for cardiac hypertrophy and heart failure |
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| CA2583972A1 (en) | 2004-10-14 | 2006-10-19 | Adventures Plus Pty Ltd | A method for the treatment of gastrointestinal and other disorders with an admixture of vitamins and minerals |
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| AU2006332340B2 (en) | 2005-12-30 | 2013-09-26 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for improved cardiac function |
| CN101394861A (zh) * | 2005-12-30 | 2009-03-25 | 上海泽生科技开发有限公司 | 纽兰格林持续给药能改善心脏功能 |
| US9580515B2 (en) | 2006-08-21 | 2017-02-28 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neukinase, a downstream protein of neuregulin |
| JP2010517023A (ja) | 2007-01-25 | 2010-05-20 | エフ．ホフマン−ラ ロシュ アーゲー | 心不全の評価におけるｉｇｆｂｐ−７の使用 |
| CN101310779A (zh) | 2007-05-25 | 2008-11-26 | 上海泽生科技开发有限公司 | 包含神经调节蛋白的装置及药物制剂 |
| CN101310766B (zh) | 2007-05-25 | 2014-04-16 | 上海泽生科技开发有限公司 | 神经调节蛋白的新用途 |
| US20090156488A1 (en) | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
| JP5797112B2 (ja) * | 2008-07-17 | 2015-10-21 | アコーダ セラピューティクス インコーポレイテッド | 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法 |
| EP2808339B1 (en) | 2008-11-28 | 2017-02-15 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neuregulin peptides and their use |
| US20110229444A1 (en) | 2008-11-28 | 2011-09-22 | Zensun (Shanghai) Science & Technology Limited | Neuregulin And Cardiac Stem Cells |
| EP2440236B1 (en) * | 2009-06-09 | 2016-05-04 | Zensun (Shanghai) Science and Technology Limited | Neuregulin based methods for treating heart failure |
| ES2748886T3 (es) * | 2009-06-09 | 2020-03-18 | Zensun Shanghai Science & Tech Co Ltd | Métodos basados en Neuregulina para el tratamiento de la insuficiencia cardíaca |
| JP6096262B2 (ja) | 2009-08-25 | 2017-03-15 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． | ニューレグリンに基づく心不全の治療方法 |
| CN102139095A (zh) | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| JP5890785B2 (ja) | 2010-03-10 | 2016-03-22 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド抗生物質の非経口製剤 |
| WO2011119836A1 (en) * | 2010-03-24 | 2011-09-29 | Massachusetts Institute Of Technology | Methods and compositions for cardioprotection and cardioregeneration |
| CN108420827A (zh) | 2010-07-22 | 2018-08-21 | 雷文制药有限公司 | 包含磁偶极子稳定化溶液的组合物及其用途 |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| CN109276705B (zh) | 2012-10-08 | 2023-10-20 | 上海泽生科技开发股份有限公司 | 治疗糖尿病患者心力衰竭的组份和方法 |
| US20160129084A1 (en) * | 2013-03-06 | 2016-05-12 | Acorda Therapeutics, Inc. | Therapeutic Dosing of a Neuregulin or a Fragment Thereof for Treatment or Prophylaxis of Heart Failure |
| EP3610905B1 (en) | 2013-05-22 | 2021-03-31 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for treating heart failure |
| CN104758300A (zh) | 2014-01-02 | 2015-07-08 | 上海泽生科技开发有限公司 | 维生素d及其组合物的抗菌用途 |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| CN105497876B (zh) | 2014-09-24 | 2021-01-15 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
-
2014
- 2014-10-17 CN CN202010283482.1A patent/CN111407882A/zh active Pending
- 2014-10-17 CN CN201410550212.7A patent/CN105561298A/zh active Pending
-
2015
- 2015-10-08 ES ES15850529T patent/ES2924395T3/es active Active
- 2015-10-08 CN CN201580054201.2A patent/CN108064164A/zh active Pending
- 2015-10-08 AU AU2015333335A patent/AU2015333335B2/en active Active
- 2015-10-08 KR KR1020177010326A patent/KR102603711B1/ko active Active
- 2015-10-08 US US15/518,730 patent/US10561709B2/en active Active
- 2015-10-08 WO PCT/CN2015/091459 patent/WO2016058493A1/zh not_active Ceased
- 2015-10-08 JP JP2017520447A patent/JP2017532343A/ja active Pending
- 2015-10-08 EP EP15850529.7A patent/EP3207940B1/en active Active
- 2015-10-08 CA CA2963322A patent/CA2963322A1/en not_active Abandoned
- 2015-10-08 RU RU2017116973A patent/RU2017116973A/ru not_active Application Discontinuation
- 2015-10-08 KR KR1020237039263A patent/KR20230159650A/ko not_active Ceased
- 2015-10-08 EP EP22174662.1A patent/EP4112068A1/en active Pending
-
2019
- 2019-12-13 US US16/714,397 patent/US20200368317A1/en not_active Abandoned
-
2020
- 2020-08-21 JP JP2020139931A patent/JP2020193217A/ja active Pending
-
2021
- 2021-10-29 AU AU2021258063A patent/AU2021258063B2/en active Active
- 2021-12-21 US US17/558,451 patent/US20220354928A1/en not_active Abandoned
-
2022
- 2022-07-06 JP JP2022108771A patent/JP2022153417A/ja active Pending
-
2024
- 2024-08-14 JP JP2024135192A patent/JP2024164068A/ja active Pending
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