JP2017532343A5 - - Google Patents
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- Publication number
- JP2017532343A5 JP2017532343A5 JP2017520447A JP2017520447A JP2017532343A5 JP 2017532343 A5 JP2017532343 A5 JP 2017532343A5 JP 2017520447 A JP2017520447 A JP 2017520447A JP 2017520447 A JP2017520447 A JP 2017520447A JP 2017532343 A5 JP2017532343 A5 JP 2017532343A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical preparation
- mammal
- heart failure
- neuregulin
- ejection fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 102000014413 Neuregulin Human genes 0.000 claims 5
- 108050003475 Neuregulin Proteins 0.000 claims 5
- 206010019280 Heart failures Diseases 0.000 claims 3
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 2
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 2
- 101000653754 Rattus norvegicus Sphingosine 1-phosphate receptor 5 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000038003 heart failure with preserved ejection fraction Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410550212.7A CN105561298A (zh) | 2014-10-17 | 2014-10-17 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
| CN201410550212.7 | 2014-10-17 | ||
| PCT/CN2015/091459 WO2016058493A1 (zh) | 2014-10-17 | 2015-10-08 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139931A Division JP2020193217A (ja) | 2014-10-17 | 2020-08-21 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017532343A JP2017532343A (ja) | 2017-11-02 |
| JP2017532343A5 true JP2017532343A5 (enExample) | 2018-10-18 |
Family
ID=55746124
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520447A Pending JP2017532343A (ja) | 2014-10-17 | 2015-10-08 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2020139931A Pending JP2020193217A (ja) | 2014-10-17 | 2020-08-21 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2022108771A Pending JP2022153417A (ja) | 2014-10-17 | 2022-07-06 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2024135192A Pending JP2024164068A (ja) | 2014-10-17 | 2024-08-14 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139931A Pending JP2020193217A (ja) | 2014-10-17 | 2020-08-21 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2022108771A Pending JP2022153417A (ja) | 2014-10-17 | 2022-07-06 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
| JP2024135192A Pending JP2024164068A (ja) | 2014-10-17 | 2024-08-14 | 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10561709B2 (enExample) |
| EP (2) | EP3207940B1 (enExample) |
| JP (4) | JP2017532343A (enExample) |
| KR (2) | KR102603711B1 (enExample) |
| CN (3) | CN105561298A (enExample) |
| AU (2) | AU2015333335B2 (enExample) |
| CA (1) | CA2963322A1 (enExample) |
| ES (1) | ES2924395T3 (enExample) |
| RU (1) | RU2017116973A (enExample) |
| WO (1) | WO2016058493A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0620819A2 (pt) | 2005-12-30 | 2011-11-22 | Zensun Shangai Science & Technology Ltd | uso de uma neuregulina (nrg) de liberação prolongada, nrg em uma liberação prolongada de uma dosagem baixa constante, e, composição de liberação prolongada para prevenir, tratar ou retardar uma doença ou distúrbio em um mamìfero |
| JP6096262B2 (ja) | 2009-08-25 | 2017-03-15 | ゼンサン (シャンハイ) サイエンス アンド テクノロジー,シーオー.,エルティーディー. | ニューレグリンに基づく心不全の治療方法 |
| CN102139095A (zh) | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions and methods for treating heart failure |
| JP6475623B2 (ja) | 2012-10-08 | 2019-02-27 | ゼンスン(シャンハイ)サイエンス アンド テクノロジー カンパニー リミテッド | 糖尿病患者における心不全の治療用組成物 |
| CA2911848A1 (en) | 2013-05-22 | 2014-11-27 | Zensun (Shanghai) Science & Technology, Ltd. | Extended release of neuregulin for treating heart failure |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| CN105497876B (zh) | 2014-09-24 | 2021-01-15 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
| JP7575272B2 (ja) * | 2018-04-11 | 2024-10-29 | サルブリス バイオセラピューティクス,インコーポレイティド | ヒトニューレグリン-1(nrg-1)組換え型融合タンパク質組成物及びその使用方法 |
| CN111407881A (zh) * | 2019-01-07 | 2020-07-14 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物 |
| AR121035A1 (es) | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
| CN113289002A (zh) * | 2020-02-24 | 2021-08-24 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物 |
| CN116710139A (zh) * | 2020-11-12 | 2023-09-05 | 安进股份有限公司 | 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法 |
| CN117797243A (zh) * | 2022-09-30 | 2024-04-02 | 上海泽生科技开发股份有限公司 | 神经调节蛋白及其应用 |
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| WO1989001489A1 (en) | 1987-08-10 | 1989-02-23 | Commonwealth Scientific And Industrial Research Or | Control of angiogenesis and compositions and methods therefor |
| US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US5716930A (en) | 1991-04-10 | 1998-02-10 | Ludwig Institute For Cancer Research | Glial growth factors |
| US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US6750196B1 (en) | 1995-03-27 | 2004-06-15 | Acorda Therapeutics | Methods of treating disorders of the eye |
| US5912326A (en) | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
| IL130827A0 (en) | 1997-02-10 | 2001-01-28 | Genentech Inc | Heregulin variants |
| CA2306228A1 (en) | 1997-10-14 | 1999-04-22 | Cambridge Neuroscience, Inc. | Therapeutic methods comprising use of a neuregulin |
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| AUPP785098A0 (en) | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
| US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| CN1138785C (zh) | 1999-06-04 | 2004-02-18 | 周明东 | 生长因子神经调节蛋白及其类似物的新应用 |
| AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
| WO2001064877A2 (en) | 2000-02-28 | 2001-09-07 | Decode Genetics Ehf | Human schizophrenia gene |
| AU2001274947B2 (en) | 2000-05-23 | 2006-08-17 | Acorda Therapeutics, Inc. | Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods |
| WO2002024889A2 (en) | 2000-09-12 | 2002-03-28 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Optimized cardiac contraction through differential phosphorylation of myosin |
| US6482624B2 (en) | 2000-11-14 | 2002-11-19 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| RU2180843C1 (ru) | 2001-02-19 | 2002-03-27 | Новокузнецкий государственный институт усовершенствования врачей | Способ профилактики повторного инфаркта миокарда |
| CN1498656A (zh) | 2002-11-08 | 2004-05-26 | 上海泽生科技开发有限公司 | 神经调节蛋白用于心肌梗死治疗的方法和组合物 |
| WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| US20060275770A1 (en) | 2002-11-27 | 2006-12-07 | Daniel Bednarik | Heart failure gene determination and therapeutic screening |
| MXPA05012619A (es) | 2003-05-21 | 2006-02-08 | Univ Texas | Inhibicion de la proteina cinasa c-mu como un tratamiento para la hipertrofia cardiaca y la falla cardiaca. |
| CN1715926B (zh) | 2004-07-02 | 2011-08-17 | 上海泽生科技开发有限公司 | 神经调节蛋白突变体的应用 |
| US20080213395A1 (en) | 2004-10-14 | 2008-09-04 | Adventures Plus Pty Ltd | Method for the Treatment of Gastrointestinal and Other Disorders with an Admixture of Vitamins |
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| US20070141548A1 (en) | 2005-03-11 | 2007-06-21 | Jorg Kohl | Organ transplant solutions and method for transplanting organs |
| CN100361709C (zh) | 2005-08-30 | 2008-01-16 | 山东省生物药物研究院 | 一种对生命活性物质有保护作用的糖类组合 |
| CN1768859A (zh) | 2005-10-24 | 2006-05-10 | 天津大学 | 基于醛基的微粒表面多重生物功能因子组装方法 |
| US20070213264A1 (en) | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
| CN101394861A (zh) * | 2005-12-30 | 2009-03-25 | 上海泽生科技开发有限公司 | 纽兰格林持续给药能改善心脏功能 |
| BRPI0620819A2 (pt) | 2005-12-30 | 2011-11-22 | Zensun Shangai Science & Technology Ltd | uso de uma neuregulina (nrg) de liberação prolongada, nrg em uma liberação prolongada de uma dosagem baixa constante, e, composição de liberação prolongada para prevenir, tratar ou retardar uma doença ou distúrbio em um mamìfero |
| US9580515B2 (en) | 2006-08-21 | 2017-02-28 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neukinase, a downstream protein of neuregulin |
| CN101636656A (zh) | 2007-01-25 | 2010-01-27 | 霍夫曼-拉罗奇有限公司 | Igfbp-7在心力衰竭评估中的用途 |
| CN101310766B (zh) * | 2007-05-25 | 2014-04-16 | 上海泽生科技开发有限公司 | 神经调节蛋白的新用途 |
| CN101310779A (zh) | 2007-05-25 | 2008-11-26 | 上海泽生科技开发有限公司 | 包含神经调节蛋白的装置及药物制剂 |
| US20090156488A1 (en) | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
| DK2320933T3 (en) * | 2008-07-17 | 2018-04-16 | Acorda Therapeutics Inc | THERAPEUTIC DOSAGE OF A NEUREGULIN OR A SUBSEQUENT THEREOF FOR TREATMENT OR PROPHYLAXY OF HEART FAILURE |
| EP2808339B1 (en) | 2008-11-28 | 2017-02-15 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neuregulin peptides and their use |
| WO2010060266A1 (en) | 2008-11-28 | 2010-06-03 | Zensun (Shanghai) Science & Technology Limited | Neuregulin and cardiac stem cells |
| WO2010142141A1 (en) | 2009-06-09 | 2010-12-16 | Zensun (Shanghai) Science & Technology Limited | Neuregulin based methods for treating heart failure |
| CN102470161A (zh) | 2009-06-09 | 2012-05-23 | 上海泽生科技开发有限公司 | 神经调节蛋白用于治疗心力衰竭的有效剂量 |
| JP6096262B2 (ja) | 2009-08-25 | 2017-03-15 | ゼンサン (シャンハイ) サイエンス アンド テクノロジー,シーオー.,エルティーディー. | ニューレグリンに基づく心不全の治療方法 |
| CN102139095A (zh) | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| JP5890785B2 (ja) | 2010-03-10 | 2016-03-22 | センプラ ファーマシューティカルズ,インコーポレイテッド | マクロライド抗生物質の非経口製剤 |
| EP2555788B1 (en) * | 2010-03-24 | 2017-10-11 | Massachusetts Institute of Technology | NEUREGULIN DIMER FOR AN ErbB/HER RECEPTOR FOR USE IN REDUCING CARDIOTOXICITY. |
| BR112013001594A2 (pt) | 2010-07-22 | 2016-05-17 | Reven Pharmaceuticals Inc | métodos de tratamento ou melhoria de doenças e para melhorar o desempenho compreendendo o uso de uma solução dipolo magnético estabilizada |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions and methods for treating heart failure |
| AU2013243955B2 (en) | 2012-04-02 | 2018-02-22 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| JP6475623B2 (ja) | 2012-10-08 | 2019-02-27 | ゼンスン(シャンハイ)サイエンス アンド テクノロジー カンパニー リミテッド | 糖尿病患者における心不全の治療用組成物 |
| CA2904055A1 (en) * | 2013-03-06 | 2014-09-12 | Acorda Therapeutics, Inc. | Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure |
| CA2911848A1 (en) | 2013-05-22 | 2014-11-27 | Zensun (Shanghai) Science & Technology, Ltd. | Extended release of neuregulin for treating heart failure |
| CN104758300A (zh) | 2014-01-02 | 2015-07-08 | 上海泽生科技开发有限公司 | 维生素d及其组合物的抗菌用途 |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| CN105497876B (zh) | 2014-09-24 | 2021-01-15 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
-
2014
- 2014-10-17 CN CN201410550212.7A patent/CN105561298A/zh active Pending
- 2014-10-17 CN CN202010283482.1A patent/CN111407882A/zh active Pending
-
2015
- 2015-10-08 WO PCT/CN2015/091459 patent/WO2016058493A1/zh not_active Ceased
- 2015-10-08 CN CN201580054201.2A patent/CN108064164A/zh active Pending
- 2015-10-08 EP EP15850529.7A patent/EP3207940B1/en active Active
- 2015-10-08 AU AU2015333335A patent/AU2015333335B2/en active Active
- 2015-10-08 EP EP22174662.1A patent/EP4112068A1/en active Pending
- 2015-10-08 US US15/518,730 patent/US10561709B2/en active Active
- 2015-10-08 ES ES15850529T patent/ES2924395T3/es active Active
- 2015-10-08 JP JP2017520447A patent/JP2017532343A/ja active Pending
- 2015-10-08 CA CA2963322A patent/CA2963322A1/en not_active Abandoned
- 2015-10-08 KR KR1020177010326A patent/KR102603711B1/ko active Active
- 2015-10-08 RU RU2017116973A patent/RU2017116973A/ru not_active Application Discontinuation
- 2015-10-08 KR KR1020237039263A patent/KR20230159650A/ko not_active Ceased
-
2019
- 2019-12-13 US US16/714,397 patent/US20200368317A1/en not_active Abandoned
-
2020
- 2020-08-21 JP JP2020139931A patent/JP2020193217A/ja active Pending
-
2021
- 2021-10-29 AU AU2021258063A patent/AU2021258063B2/en active Active
- 2021-12-21 US US17/558,451 patent/US20220354928A1/en not_active Abandoned
-
2022
- 2022-07-06 JP JP2022108771A patent/JP2022153417A/ja active Pending
-
2024
- 2024-08-14 JP JP2024135192A patent/JP2024164068A/ja active Pending
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