JP2017532343A - 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 - Google Patents

駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 Download PDF

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JP2017532343A
JP2017532343A JP2017520447A JP2017520447A JP2017532343A JP 2017532343 A JP2017532343 A JP 2017532343A JP 2017520447 A JP2017520447 A JP 2017520447A JP 2017520447 A JP2017520447 A JP 2017520447A JP 2017532343 A JP2017532343 A JP 2017532343A
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heart failure
ejection fraction
neuregulin
nrg
treating
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JP2017532343A5 (enExample
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ズホウ ミングドング
ズホウ ミングドング
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ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー．
ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー．
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Publication of JP2017532343A publication Critical patent/JP2017532343A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2017520447A 2014-10-17 2015-10-08 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物 Pending JP2017532343A (ja)

Applications Claiming Priority (3)

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CN201410550212.7A CN105561298A (zh) 2014-10-17 2014-10-17 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
CN201410550212.7 2014-10-17
PCT/CN2015/091459 WO2016058493A1 (zh) 2014-10-17 2015-10-08 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物

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JP2020139931A Division JP2020193217A (ja) 2014-10-17 2020-08-21 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物

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JP2017532343A5 JP2017532343A5 (enExample) 2018-10-18

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JP2017520447A Pending JP2017532343A (ja) 2014-10-17 2015-10-08 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物
JP2020139931A Pending JP2020193217A (ja) 2014-10-17 2020-08-21 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物
JP2022108771A Pending JP2022153417A (ja) 2014-10-17 2022-07-06 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物
JP2024135192A Pending JP2024164068A (ja) 2014-10-17 2024-08-14 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物

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JP2020139931A Pending JP2020193217A (ja) 2014-10-17 2020-08-21 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物
JP2022108771A Pending JP2022153417A (ja) 2014-10-17 2022-07-06 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物
JP2024135192A Pending JP2024164068A (ja) 2014-10-17 2024-08-14 駆出率が保たれた心不全を予防し、治療し、又は遅延させるための方法及びニューレグリン組成物

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US (3) US10561709B2 (enExample)
EP (2) EP3207940B1 (enExample)
JP (4) JP2017532343A (enExample)
KR (2) KR102603711B1 (enExample)
CN (3) CN105561298A (enExample)
AU (2) AU2015333335B2 (enExample)
CA (1) CA2963322A1 (enExample)
ES (1) ES2924395T3 (enExample)
RU (1) RU2017116973A (enExample)
WO (1) WO2016058493A1 (enExample)

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JP6096262B2 (ja) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． ニューレグリンに基づく心不全の治療方法
CN102139095A (zh) 2010-01-29 2011-08-03 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
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JP6475623B2 (ja) 2012-10-08 2019-02-27 ゼンスン（シャンハイ）サイエンス アンド テクノロジー カンパニー リミテッド 糖尿病患者における心不全の治療用組成物
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CN105497876B (zh) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
JP7575272B2 (ja) * 2018-04-11 2024-10-29 サルブリス バイオセラピューティクス，インコーポレイティド ヒトニューレグリン－１（ｎｒｇ－１）組換え型融合タンパク質組成物及びその使用方法
CN111407881A (zh) * 2019-01-07 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物
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CN113289002A (zh) * 2020-02-24 2021-08-24 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物
CN116710139A (zh) * 2020-11-12 2023-09-05 安进股份有限公司 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法
CN117797243A (zh) * 2022-09-30 2024-04-02 上海泽生科技开发股份有限公司 神经调节蛋白及其应用

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CN108064164A (zh) 2018-05-22
US20200368317A1 (en) 2020-11-26
CN105561298A (zh) 2016-05-11
US20220354928A1 (en) 2022-11-10
AU2015333335B2 (en) 2021-08-05
CA2963322A1 (en) 2016-04-21
JP2022153417A (ja) 2022-10-12
EP4112068A1 (en) 2023-01-04
KR20230159650A (ko) 2023-11-21
JP2020193217A (ja) 2020-12-03
RU2017116973A3 (enExample) 2019-05-06
CN111407882A (zh) 2020-07-14
US20170232068A1 (en) 2017-08-17
ES2924395T3 (es) 2022-10-06
EP3207940B1 (en) 2022-06-01
US10561709B2 (en) 2020-02-18
KR20170066440A (ko) 2017-06-14
EP3207940A1 (en) 2017-08-23
WO2016058493A1 (zh) 2016-04-21
AU2015333335A1 (en) 2017-04-20
KR102603711B1 (ko) 2023-11-20
JP2024164068A (ja) 2024-11-26
EP3207940A4 (en) 2018-06-06
AU2021258063A1 (en) 2021-11-25
RU2017116973A (ru) 2018-11-19
AU2021258063B2 (en) 2025-02-27

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