AU2015333335B2 - Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure - Google Patents

Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure Download PDF

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Publication number
AU2015333335B2
AU2015333335B2 AU2015333335A AU2015333335A AU2015333335B2 AU 2015333335 B2 AU2015333335 B2 AU 2015333335B2 AU 2015333335 A AU2015333335 A AU 2015333335A AU 2015333335 A AU2015333335 A AU 2015333335A AU 2015333335 B2 AU2015333335 B2 AU 2015333335B2
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heart failure
ejection fraction
neuregulin
treating
preserved ejection
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AU2015333335A1 (en
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Mingdong Zhou
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Zensun Shanghai Science and Technology Ltd
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Zensun Shanghai Science and Technology Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2015333335A 2014-10-17 2015-10-08 Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure Active AU2015333335B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021258063A AU2021258063B2 (en) 2014-10-17 2021-10-29 Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410550212.7A CN105561298A (zh) 2014-10-17 2014-10-17 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
CN201410550212.7 2014-10-17
PCT/CN2015/091459 WO2016058493A1 (zh) 2014-10-17 2015-10-08 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物

Related Child Applications (1)

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AU2021258063A Division AU2021258063B2 (en) 2014-10-17 2021-10-29 Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure

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AU2015333335A1 AU2015333335A1 (en) 2017-04-20
AU2015333335B2 true AU2015333335B2 (en) 2021-08-05

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AU2015333335A Active AU2015333335B2 (en) 2014-10-17 2015-10-08 Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure
AU2021258063A Active AU2021258063B2 (en) 2014-10-17 2021-10-29 Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure

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US (3) US10561709B2 (enExample)
EP (2) EP3207940B1 (enExample)
JP (4) JP2017532343A (enExample)
KR (2) KR20230159650A (enExample)
CN (3) CN111407882A (enExample)
AU (2) AU2015333335B2 (enExample)
CA (1) CA2963322A1 (enExample)
ES (1) ES2924395T3 (enExample)
RU (1) RU2017116973A (enExample)
WO (1) WO2016058493A1 (enExample)

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BRPI0620819A2 (pt) 2005-12-30 2011-11-22 Zensun Shangai Science & Technology Ltd uso de uma neuregulina (nrg) de liberação prolongada, nrg em uma liberação prolongada de uma dosagem baixa constante, e, composição de liberação prolongada para prevenir, tratar ou retardar uma doença ou distúrbio em um mamìfero
JP6096262B2 (ja) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． ニューレグリンに基づく心不全の治療方法
CN102139095A (zh) 2010-01-29 2011-08-03 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
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JP6568052B2 (ja) 2013-05-22 2019-09-04 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． 心不全を治療するためのニューレグリンの徐放
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CN105497876B (zh) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
EP3774859B1 (en) * 2018-04-11 2024-03-13 Salubris Biotherapeutics, Inc. Human neuregulin-1 (nrg-1) recombinant fusion protein compositions and methods of use thereof
CN111407881A (zh) * 2019-01-07 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物
AR121035A1 (es) * 2019-04-01 2022-04-13 Lilly Co Eli Compuestos de neuregulina-4 y métodos de uso
CN113289002A (zh) * 2020-02-24 2021-08-24 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物
CN116710139A (zh) * 2020-11-12 2023-09-05 安进股份有限公司 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法
CN117797243A (zh) * 2022-09-30 2024-04-02 上海泽生科技开发股份有限公司 神经调节蛋白及其应用

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EP3207940B1 (en) 2022-06-01
AU2021258063A1 (en) 2021-11-25
CN108064164A (zh) 2018-05-22
EP3207940A4 (en) 2018-06-06
KR20170066440A (ko) 2017-06-14
JP2024164068A (ja) 2024-11-26
US20170232068A1 (en) 2017-08-17
EP4112068A1 (en) 2023-01-04
US20200368317A1 (en) 2020-11-26
CA2963322A1 (en) 2016-04-21
WO2016058493A1 (zh) 2016-04-21
CN105561298A (zh) 2016-05-11
RU2017116973A (ru) 2018-11-19
JP2020193217A (ja) 2020-12-03
KR20230159650A (ko) 2023-11-21
AU2021258063B2 (en) 2025-02-27
EP3207940A1 (en) 2017-08-23
KR102603711B1 (ko) 2023-11-20
JP2022153417A (ja) 2022-10-12
ES2924395T3 (es) 2022-10-06
AU2015333335A1 (en) 2017-04-20
US20220354928A1 (en) 2022-11-10
RU2017116973A3 (enExample) 2019-05-06
CN111407882A (zh) 2020-07-14
US10561709B2 (en) 2020-02-18
JP2017532343A (ja) 2017-11-02

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HB Alteration of name in register

Owner name: ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY, CO., LTD.

Free format text: FORMER NAME(S): ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY LIMITED

FGA Letters patent sealed or granted (standard patent)