JP2017039729A5 - - Google Patents
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- Publication number
- JP2017039729A5 JP2017039729A5 JP2016177327A JP2016177327A JP2017039729A5 JP 2017039729 A5 JP2017039729 A5 JP 2017039729A5 JP 2016177327 A JP2016177327 A JP 2016177327A JP 2016177327 A JP2016177327 A JP 2016177327A JP 2017039729 A5 JP2017039729 A5 JP 2017039729A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- recombinant protein
- slit3
- lrr2
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101100455506 Arabidopsis thaliana LRR2 gene Proteins 0.000 claims 6
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 6
- 102100027339 Slit homolog 3 protein Human genes 0.000 claims 6
- 101700004678 SLIT3 Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 101150018985 SLIT3 gene Proteins 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000001009 osteoporotic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20120064302 | 2012-06-15 | ||
| KR10-2012-0064302 | 2012-06-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517190A Division JP6100367B2 (ja) | 2012-06-15 | 2013-06-14 | Ｓｌｉｔ−Ｒｏｂｏシステムを用いた骨折又は骨粗鬆症の予防或いは治療用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017039729A JP2017039729A (ja) | 2017-02-23 |
| JP2017039729A5 true JP2017039729A5 (enExample) | 2017-04-13 |
| JP6216849B2 JP6216849B2 (ja) | 2017-10-18 |
Family
ID=49758487
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517190A Active JP6100367B2 (ja) | 2012-06-15 | 2013-06-14 | Ｓｌｉｔ−Ｒｏｂｏシステムを用いた骨折又は骨粗鬆症の予防或いは治療用組成物 |
| JP2016177327A Active JP6216849B2 (ja) | 2012-06-15 | 2016-09-12 | Ｓｌｉｔ−Ｒｏｂｏシステムを用いた骨折又は骨粗鬆症の予防或いは治療用組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517190A Active JP6100367B2 (ja) | 2012-06-15 | 2013-06-14 | Ｓｌｉｔ−Ｒｏｂｏシステムを用いた骨折又は骨粗鬆症の予防或いは治療用組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9802994B2 (enExample) |
| EP (2) | EP2862580A4 (enExample) |
| JP (2) | JP6100367B2 (enExample) |
| KR (2) | KR101617497B1 (enExample) |
| CN (1) | CN104582727B (enExample) |
| WO (1) | WO2013187730A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3116521T3 (da) | 2014-03-14 | 2024-10-21 | Univ New York State Res Found | Neurogen regulering af knoglevækst og knoglenedbrydning |
| KR101897322B1 (ko) * | 2015-01-21 | 2018-09-10 | 재단법인 아산사회복지재단 | 원발성 갑상선암 전이의 진단방법 및 이를 이용한 진단키트 |
| WO2017213435A1 (ko) * | 2016-06-08 | 2017-12-14 | 재단법인 아산사회복지재단 | Slit-robo 시스템을 이용한 근감소증 예방 또는 치료용 조성물 |
| KR102011957B1 (ko) | 2016-06-08 | 2019-08-19 | 재단법인 아산사회복지재단 | Slit-robo 시스템을 이용한 근감소증 예방 또는 치료용 조성물 |
| BR112019024742A2 (pt) | 2017-06-02 | 2020-06-16 | Pfizer Inc. | Proteínas robo2 recombinantes, composições, métodos e usos das mesmas |
| US20200397860A1 (en) * | 2018-02-14 | 2020-12-24 | Cornell University | Slit and bone growth modulation |
| PH12021552079A1 (en) * | 2019-02-27 | 2022-07-18 | Daewoong Pharmaceutical Co Ltd | Albumin-bound composition including lrrd2 of slit3 protein for prevention or treatment of bone-related diseases |
| WO2024061158A1 (en) * | 2022-09-20 | 2024-03-28 | Everest Medicines (China) Co., Ltd. | Slit2 related compositions and methods |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US20040265808A1 (en) | 2001-04-05 | 2004-12-30 | Teresa Garcia | Genes involved in osteogenesis, and methods of use |
| US20090028831A1 (en) * | 2007-07-23 | 2009-01-29 | University Of Kentucky Research Foundation | Stem cell regulator, compositions and methods of use |
| US20110002972A1 (en) | 2007-09-14 | 2011-01-06 | Scil Technology Gmbh | Neuroendocrine factors for treatment of degenerative diseases |
| EP2036921A1 (en) * | 2007-09-14 | 2009-03-18 | Scil Technology GmbH | Use of Slit, nephrin, ephrin or semaphorin for treatment of cartilage diseases |
| EP2621511A1 (en) * | 2010-09-28 | 2013-08-07 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of bone density related diseases |
-
2013
- 2013-06-14 EP EP13804527.3A patent/EP2862580A4/en not_active Withdrawn
- 2013-06-14 CN CN201380031616.9A patent/CN104582727B/zh active Active
- 2013-06-14 KR KR1020130068411A patent/KR101617497B1/ko active Active
- 2013-06-14 WO PCT/KR2013/005282 patent/WO2013187730A1/ko not_active Ceased
- 2013-06-14 EP EP16200411.3A patent/EP3156074B1/en active Active
- 2013-06-14 US US14/408,275 patent/US9802994B2/en active Active
- 2013-06-14 JP JP2015517190A patent/JP6100367B2/ja active Active
-
2016
- 2016-03-11 KR KR1020160029525A patent/KR20160032077A/ko not_active Withdrawn
- 2016-09-12 JP JP2016177327A patent/JP6216849B2/ja active Active
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