JP2020517703A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020517703A5 JP2020517703A5 JP2019558411A JP2019558411A JP2020517703A5 JP 2020517703 A5 JP2020517703 A5 JP 2020517703A5 JP 2019558411 A JP2019558411 A JP 2019558411A JP 2019558411 A JP2019558411 A JP 2019558411A JP 2020517703 A5 JP2020517703 A5 JP 2020517703A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- composition according
- free amino
- composition
- isoleucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 16
- 229940024606 amino acid Drugs 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 10
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 7
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 7
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 7
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 7
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 7
- 229960000310 isoleucine Drugs 0.000 claims 7
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 7
- 229960003136 leucine Drugs 0.000 claims 7
- 229960004295 valine Drugs 0.000 claims 7
- 239000004474 valine Substances 0.000 claims 7
- 239000004475 Arginine Substances 0.000 claims 6
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 6
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 6
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 6
- 239000004472 Lysine Substances 0.000 claims 6
- 229960004308 acetylcysteine Drugs 0.000 claims 6
- 229960003121 arginine Drugs 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- 229960002743 glutamine Drugs 0.000 claims 6
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 6
- 229960003646 lysine Drugs 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 4
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 4
- 239000000796 flavoring agent Substances 0.000 claims 4
- 235000013355 food flavoring agent Nutrition 0.000 claims 4
- 229960002449 glycine Drugs 0.000 claims 4
- 229930182817 methionine Natural products 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 229960002429 proline Drugs 0.000 claims 4
- 230000009529 traumatic brain injury Effects 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000003086 colorant Substances 0.000 claims 2
- -1 compressors Substances 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 235000003599 food sweetener Nutrition 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- 229960004452 methionine Drugs 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000003765 sweetening agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491796P | 2017-04-28 | 2017-04-28 | |
| US62/491,796 | 2017-04-28 | ||
| PCT/US2018/029908 WO2018201024A1 (en) | 2017-04-28 | 2018-04-27 | Amino acid compositions and their use for the treatment of traumatic brain injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020517703A JP2020517703A (ja) | 2020-06-18 |
| JP2020517703A5 true JP2020517703A5 (enExample) | 2021-06-17 |
Family
ID=62165694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558411A Pending JP2020517703A (ja) | 2017-04-28 | 2018-04-27 | アミノ酸組成物及び外傷性脳損傷の治療のためのそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11617731B2 (enExample) |
| EP (1) | EP3615018A1 (enExample) |
| JP (1) | JP2020517703A (enExample) |
| CN (1) | CN110678172A (enExample) |
| WO (1) | WO2018201024A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| WO2018201024A1 (en) | 2017-04-28 | 2018-11-01 | Axcella Health Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| IT201700087359A1 (it) | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
| US10682325B2 (en) | 2017-08-14 | 2020-06-16 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| JP2021527670A (ja) | 2018-06-20 | 2021-10-14 | アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． | 筋肉中の脂肪浸潤の治療のための組成物及び方法 |
| EP3810168A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Methods of manufacturing amino acid compositions |
| IT201800006725A1 (it) | 2018-06-27 | 2019-12-27 | Composizioni comprendenti aminoacidi per l'uso nella prevenzione e nel trattamento di malattie epatiche | |
| IT201900002109A1 (it) | 2019-02-13 | 2020-08-13 | Professional Dietetics Spa | Composizioni comprendenti amminoacidi per l'uso nel trattamento di lesioni del sistema nervoso centrale |
| IT202000000442A1 (it) | 2020-01-13 | 2021-07-13 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nella prevenzione e nel trattamento di effetti collaterali della chemioterapia |
| US20220218640A1 (en) * | 2021-01-14 | 2022-07-14 | Rob Dickerman | Amino acid delivery system |
| JP2024529966A (ja) | 2021-07-26 | 2024-08-14 | アクセラ（アサインメント フォ ザ ベネフィット オブ クレディターズ），エルエルシー | Ｃｏｖｉｄ－１９の急性期後後遺症の治療に使用するためのアミノ酸組成物及び方法 |
| CN119235838A (zh) * | 2024-11-04 | 2025-01-03 | 苏州市立医院 | 一种hmb在制备改善创伤性脑损伤药物中的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4438144A (en) | 1980-07-31 | 1984-03-20 | Blackburn George L | Amino acid preparation and therapy for treatment of stress and injury |
| WO1997025883A1 (de) * | 1996-01-17 | 1997-07-24 | Friedrich Kisters | Aminosäuren-präparat zur haarwuchsförderung |
| US6864242B2 (en) * | 2001-03-05 | 2005-03-08 | Stephen P. Ernest | Enteral formulation |
| JP2004123564A (ja) * | 2002-09-30 | 2004-04-22 | Inst Of Physical & Chemical Res | 中枢機能改善用アミノ酸組成物 |
| US20050107338A1 (en) | 2003-11-17 | 2005-05-19 | Seidman Michael D. | Nutritional supplement enhancing mitochondrial function |
| JP4815752B2 (ja) * | 2004-04-01 | 2011-11-16 | 味の素株式会社 | アミノ酸含有飲食品 |
| KR20070112811A (ko) | 2005-03-21 | 2007-11-27 | 아보트 러보러터리즈 | 포도당내성을 개선시키기 위한 아미노산 조성물 |
| US20070286909A1 (en) * | 2006-06-07 | 2007-12-13 | Daniel S. Smith | Amino acid compositions |
| GB0624879D0 (en) | 2006-12-14 | 2007-01-24 | Shs Int Ltd | Treatment of pervasive development disorders |
| JP2009106217A (ja) * | 2007-10-31 | 2009-05-21 | Ajinomoto Co Inc | 増粘剤とアミノ酸を含有する食品組成物 |
| JPWO2010050168A1 (ja) * | 2008-10-27 | 2012-03-29 | 味の素株式会社 | バリン、イソロイシン、ロイシン固溶体およびその製造方法 |
| WO2012047800A1 (en) * | 2010-10-06 | 2012-04-12 | Abbott Laboratories | Methods for increasing muscle glucose uptake and decreasing muscle recovery time using amino acid blend |
| CA2826602C (en) | 2011-02-04 | 2019-06-11 | Hough Ear Institute | Methods for treating brain injury |
| US20130090356A1 (en) | 2011-06-24 | 2013-04-11 | Jon D. Kaiser | Compositions and methods for treatment of neuropsychological deficits |
| EP2580967A1 (en) | 2011-10-11 | 2013-04-17 | Nestec S.A. | Accelerating muscle recovery after immobilization-induced muscle atrophy |
| US9101580B2 (en) | 2012-12-18 | 2015-08-11 | Matthew Bennett | Compositions and methods for treating traumatic brain injury |
| ES2844199T3 (es) | 2013-04-16 | 2021-07-21 | Childrens Hospital Philadelphia | Composiciones y métodos para el tratamiento de lesiones cerebrales |
| EP3048904A2 (en) | 2013-09-25 | 2016-08-03 | Pronutria Biosciences, Inc. | Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof |
| US20180125926A1 (en) | 2013-09-25 | 2018-05-10 | Axcella Health Inc. | Compositions and Formulations and Methods of Production and Use Thereof |
| US20180133185A1 (en) | 2016-11-11 | 2018-05-17 | The Children's Hospital Of Philadelphia | Compositions and Methods for the Improvement of Memory |
| JOP20190147A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض واضطرابات العضلات |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| WO2018201024A1 (en) | 2017-04-28 | 2018-11-01 | Axcella Health Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| US10682325B2 (en) | 2017-08-14 | 2020-06-16 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting |
| EP3684350A1 (en) | 2017-08-14 | 2020-07-29 | Axcella Health Inc. | Amino acids compositions for the treatment of neuronal injury |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| EP3810168A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Methods of manufacturing amino acid compositions |
| AR115583A1 (es) | 2018-06-20 | 2021-02-03 | Axcella Health Inc | Composiciones y métodos para el tratamiento de las enfermedades y trastornos del hígado |
| JP2021527670A (ja) | 2018-06-20 | 2021-10-14 | アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． | 筋肉中の脂肪浸潤の治療のための組成物及び方法 |
| MX2020013731A (es) | 2018-06-20 | 2021-02-26 | Axcella Health Inc | Composiciones para terapia y salud que contienen aminoacidos con sabor amargo. |
-
2018
- 2018-04-27 WO PCT/US2018/029908 patent/WO2018201024A1/en not_active Ceased
- 2018-04-27 US US16/608,349 patent/US11617731B2/en active Active
- 2018-04-27 CN CN201880035067.5A patent/CN110678172A/zh active Pending
- 2018-04-27 EP EP18724718.4A patent/EP3615018A1/en not_active Withdrawn
- 2018-04-27 JP JP2019558411A patent/JP2020517703A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020517703A5 (enExample) | ||
| CY1124432T1 (el) | Φαρμακευτικες συνθεσεις που αποτελουν ν-(3,5-διμεθοδυφαινυλ)-ν'-(1-μεθυλαιθυλ)-ν-[3-(1--μεθυλ-1η-πυραζολ-4-υλ)κινοοξαλιν-6-υλ]αιθανο-1,2-διαμινη | |
| JP2017532343A5 (enExample) | ||
| MX393855B (es) | Terapia de combinación que comprende un inhibidor de raf y trametinib | |
| JP2018012722A5 (enExample) | ||
| JP2019533722A5 (enExample) | ||
| EP2444082A3 (en) | Hydroxymethylbutyrate compositions and uses thereof | |
| ZA202201828B (en) | Therapeutic fusion proteins | |
| WO2018053029A8 (en) | Methods for treating pulmonary disease using inter-alpha inhibitor proteins | |
| WO2014039987A3 (en) | Treatment of disease using inter-alpha inhibitor proteins | |
| MX2020010302A (es) | Uso de ácido (1s,3s)-3-amino-4-(difluorometilideno)ciclopentano-1- carboxílico y ácido (s)-3-amino-4-(difluorometilenil)ciclopent-1-e no-1-carboxílico en eltratamiento contra trastornos oculares. | |
| JP2018531929A5 (enExample) | ||
| LT3586837T (lt) | Kompozicijos, apimančios aminorūgštis, skirtos panaudoti kepenų ligų prevencijai ir gydymui | |
| JP2018529666A5 (enExample) | ||
| WO2016191458A3 (en) | Pharmaceutical compositions affecting mitochondrial redox state and methods of treatment | |
| ZA201901370B (en) | Formulations for oral administration of active agents | |
| EA201792237A1 (ru) | Фармацевтические составы | |
| JP2017519763A5 (enExample) | ||
| WO2020023094A3 (en) | Treatment of lysosomal storage disorders | |
| RU2015134356A (ru) | Пептид | |
| WO2014142760A3 (en) | Re-trafficking of herg reverses long qt syndrome 2 phenotype in human ips-derived cardiomyocytes | |
| JP2019519466A5 (enExample) | ||
| RU2019135294A (ru) | Полипептид, композиция, фармацевтическая композиция, лекарственное средство, диетическая добавка, пищевая композиция, применения полипептида, фармацевтической композиции, лекарственного средства, диетической добавки, пищевой композиции для лечения ожирения и снижения веса | |
| JP2018043942A5 (enExample) | ||
| Yaremko et al. | Features of the laparoscopic cholecystectomy in patients with pneumoconiosis |