JP2018529666A5 - - Google Patents
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- Publication number
- JP2018529666A5 JP2018529666A5 JP2018511381A JP2018511381A JP2018529666A5 JP 2018529666 A5 JP2018529666 A5 JP 2018529666A5 JP 2018511381 A JP2018511381 A JP 2018511381A JP 2018511381 A JP2018511381 A JP 2018511381A JP 2018529666 A5 JP2018529666 A5 JP 2018529666A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hydroxyacetoxy
- cyclopentyl
- carboxymethyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 53
- KTCKPDPJTAUEPP-UHFFFAOYSA-N 2-[3-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy-1-methylpyrrolidin-1-ium-1-yl]acetate Chemical compound C1[N+](C)(CC([O-])=O)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 KTCKPDPJTAUEPP-UHFFFAOYSA-N 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 50
- 150000001875 compounds Chemical class 0.000 claims description 42
- 230000004379 myopia Effects 0.000 claims description 18
- 208000001491 myopia Diseases 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 230000004515 progressive myopia Effects 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 2
- 230000003442 weekly effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 description 12
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020134413A JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952342P | 2014-03-13 | 2014-03-13 | |
| US14/845,645 | 2015-09-04 | ||
| US14/845,645 US10632067B2 (en) | 2014-03-13 | 2015-09-04 | Use of selected anticholinergic zwitterions |
| PCT/US2016/049047 WO2017040307A1 (en) | 2014-03-13 | 2016-08-26 | Use of selected anticholinergic zwitterions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020134413A Division JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529666A JP2018529666A (ja) | 2018-10-11 |
| JP2018529666A5 true JP2018529666A5 (enExample) | 2019-10-03 |
| JP6750900B2 JP6750900B2 (ja) | 2020-09-02 |
Family
ID=54072392
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556253A Withdrawn JP2017507959A (ja) | 2014-03-13 | 2015-03-12 | 選択された抗コリン作動性両性イオンの使用 |
| JP2018511381A Active JP6750900B2 (ja) | 2014-03-13 | 2016-08-26 | 選択された抗コリン作用性双性イオンの使用 |
| JP2020050858A Expired - Fee Related JP6732356B2 (ja) | 2014-03-13 | 2020-03-23 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020115416A Active JP6968457B2 (ja) | 2014-03-13 | 2020-07-03 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020134413A Active JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556253A Withdrawn JP2017507959A (ja) | 2014-03-13 | 2015-03-12 | 選択された抗コリン作動性両性イオンの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020050858A Expired - Fee Related JP6732356B2 (ja) | 2014-03-13 | 2020-03-23 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020115416A Active JP6968457B2 (ja) | 2014-03-13 | 2020-07-03 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020134413A Active JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US10632067B2 (enExample) |
| JP (5) | JP2017507959A (enExample) |
| WO (2) | WO2015138700A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150259283A1 (en) | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| WO2015138700A1 (en) | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
| MY185814A (en) | 2015-07-21 | 2021-06-10 | Bodor Laboratories Inc | Formulation for soft anticholinergic analogs |
| CA3029621A1 (en) * | 2016-07-01 | 2018-01-04 | Bodor Laboratories, Inc. | Compositions and methods for treatment of copd |
| TWI719046B (zh) | 2016-07-21 | 2021-02-21 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
| WO2021252636A1 (en) * | 2020-06-11 | 2021-12-16 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for preventing and treating myopia with fingolimod, a sphingosine-1-phosphate receptor modulator, and derivatives thereof |
| CA3182397A1 (en) * | 2020-06-11 | 2021-12-16 | Andrei V. Tkatchenko | Methods and compositions for preventing and treating myopia with fenoterol hydrobromide, a .beta.2-adrenergic receptor agonist, and derivatives thereof |
| JP2023530677A (ja) * | 2020-06-11 | 2023-07-19 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | トリコスタチンａ、ヒストンデアセチラーゼ（ｈｄａｃ）阻害剤、及びその誘導体を用いて近視を予防及び治療するための方法及び組成物 |
| CN115966912B (zh) * | 2023-01-09 | 2025-08-22 | 西安电子科技大学 | 一种2比特高功率放大型非互易反射式超表面 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0786997A4 (en) * | 1994-10-27 | 1998-03-11 | Merck & Co Inc | MUSCARINE ANTAGONISTS |
| US6433003B1 (en) | 1999-04-23 | 2002-08-13 | Arthur M. Bobrove | Method for treating hyperhidrosis in mammals |
| AU2002340058A1 (en) | 2001-09-26 | 2003-04-07 | Alison B. Lukacsko | Compositions and methods for inhibiting eccrine perspiration in humans |
| US7417147B2 (en) | 2005-11-10 | 2008-08-26 | Bodor Nicholas S | Soft anticholinergic zwitterions |
| WO2007058971A2 (en) | 2005-11-10 | 2007-05-24 | Bodor Nicholas S | Soft anticholinergic esters |
| JP2007308398A (ja) * | 2006-05-17 | 2007-11-29 | Chang Gung Memorial Hospital | 目薬、及びその製造方法 |
| US20100114309A1 (en) * | 2006-12-26 | 2010-05-06 | De Juan Jr Eugene | Drug delivery implants for inhibition of optical defects |
| EP2200550B1 (en) | 2007-10-18 | 2018-04-18 | Rose U, LLC | Topical glycopyrrolate formulations |
| CN105050596A (zh) | 2013-03-15 | 2015-11-11 | 博多尔实验仪器公司 | 用于治疗多汗症的抗胆碱能格隆溴铵酯 |
| WO2015138700A1 (en) * | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
-
2015
- 2015-03-12 WO PCT/US2015/020137 patent/WO2015138700A1/en not_active Ceased
- 2015-03-12 JP JP2016556253A patent/JP2017507959A/ja not_active Withdrawn
- 2015-09-04 US US14/845,645 patent/US10632067B2/en active Active
-
2016
- 2016-08-26 US US15/757,534 patent/US10335367B2/en active Active
- 2016-08-26 WO PCT/US2016/049047 patent/WO2017040307A1/en not_active Ceased
- 2016-08-26 JP JP2018511381A patent/JP6750900B2/ja active Active
-
2020
- 2020-03-23 JP JP2020050858A patent/JP6732356B2/ja not_active Expired - Fee Related
- 2020-07-03 JP JP2020115416A patent/JP6968457B2/ja active Active
- 2020-08-07 JP JP2020134413A patent/JP6981694B2/ja active Active
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