ATE384529T1 - Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen - Google Patents
Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungenInfo
- Publication number
- ATE384529T1 ATE384529T1 AT04723608T AT04723608T ATE384529T1 AT E384529 T1 ATE384529 T1 AT E384529T1 AT 04723608 T AT04723608 T AT 04723608T AT 04723608 T AT04723608 T AT 04723608T AT E384529 T1 ATE384529 T1 AT E384529T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- respiratory diseases
- active ingredients
- synergistic combination
- ingredients selected
- Prior art date
Links
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002586 roflumilast Drugs 0.000 title abstract 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 230000001078 anti-cholinergic effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 title 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 abstract 1
- 229960001888 ipratropium Drugs 0.000 abstract 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 abstract 1
- 229960000797 oxitropium Drugs 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03007104 | 2003-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE384529T1 true ATE384529T1 (de) | 2008-02-15 |
Family
ID=33040925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04723608T ATE384529T1 (de) | 2003-03-28 | 2004-03-26 | Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060147382A1 (de) |
| EP (1) | EP1610787B1 (de) |
| AT (1) | ATE384529T1 (de) |
| CA (1) | CA2519679C (de) |
| CY (1) | CY1110373T1 (de) |
| DE (1) | DE602004011494T2 (de) |
| DK (1) | DK1610787T3 (de) |
| ES (1) | ES2300755T3 (de) |
| MX (1) | MXPA05010160A (de) |
| PL (1) | PL1610787T3 (de) |
| PT (1) | PT1610787E (de) |
| SI (1) | SI1610787T1 (de) |
| WO (1) | WO2004084896A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| SI1606261T1 (sl) | 2003-03-10 | 2010-03-31 | Nycomed Gmbh | Novi postopek za pripravo roflumilasta |
| US20050026887A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a steroid |
| HRP20120286T1 (hr) * | 2004-02-06 | 2012-04-30 | Meda Pharma Gmbh & Co. Kg | Kombinacija antikolinergika i inhibitora fosfodiesteraze tip 4 za liječenje respiratornih bolesti |
| JP4819699B2 (ja) * | 2004-02-06 | 2011-11-24 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト | 喘息及びｃｏｐｄの長期間の治療のための抗コリン作用薬及びグルココルチコイドの組合せ剤 |
| RU2379033C2 (ru) * | 2004-05-31 | 2010-01-20 | Лабораториос Альмираль, С.А. | Комбинации, содержащие антимускариновые средства и бета-адренергические агонисты |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| CN101128196B (zh) * | 2005-03-16 | 2013-01-02 | Meda制药有限及两合公司 | 用于治疗呼吸系统疾病的抗胆碱能药和白三烯受体拮抗剂的组合 |
| US8663694B2 (en) * | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| US20060219242A1 (en) * | 2005-03-30 | 2006-10-05 | Boehringer Ingelheim International | Method for the Administration of an Anticholinergic by Inhalation |
| CA2623882A1 (en) * | 2005-09-28 | 2007-04-05 | Merck Frosst Canada Ltd. | Aerosol powder formulation comprising sieved lactose |
| DE602006008665D1 (de) | 2005-12-21 | 2009-10-01 | Meda Pharma Gmbh & Co Kg | Kombination von r,r-glycopyrrolat, rolipram und budesonid zur behandlung von entzündungskrankheiten |
| EP2100599A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2100598A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2510928A1 (de) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6585958B1 (en) * | 1998-07-24 | 2003-07-01 | Jago Research Ag | Medicinal aerosol formulations |
| US20020052312A1 (en) * | 2000-05-30 | 2002-05-02 | Reiss Theodore F. | Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists |
| DE10110772A1 (de) * | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| US20020193393A1 (en) * | 2001-03-07 | 2002-12-19 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| SK14312003A3 (sk) * | 2001-05-25 | 2004-08-03 | Pfizer Inc. | Inhibítor PDE4 a anticholinergné činidlo v kombinácii na liečbu obštrukčných chorôb dýchacích ciest |
| DE60216588T2 (de) * | 2001-05-25 | 2007-09-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kombination eines pde4-inhibitors mit tiotropium zur behandlung obstruktiver atemwegserkrankungen |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| US20050107420A1 (en) * | 2002-05-23 | 2005-05-19 | Boehringe Ingelheim Pharma Gmbh & Co. Kg | Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases |
-
2004
- 2004-03-26 CA CA2519679A patent/CA2519679C/en not_active Expired - Fee Related
- 2004-03-26 EP EP04723608A patent/EP1610787B1/de not_active Expired - Lifetime
- 2004-03-26 AT AT04723608T patent/ATE384529T1/de active
- 2004-03-26 US US10/550,192 patent/US20060147382A1/en not_active Abandoned
- 2004-03-26 DK DK04723608T patent/DK1610787T3/da active
- 2004-03-26 ES ES04723608T patent/ES2300755T3/es not_active Expired - Lifetime
- 2004-03-26 PT PT04723608T patent/PT1610787E/pt unknown
- 2004-03-26 PL PL04723608T patent/PL1610787T3/pl unknown
- 2004-03-26 MX MXPA05010160A patent/MXPA05010160A/es active IP Right Grant
- 2004-03-26 DE DE602004011494T patent/DE602004011494T2/de not_active Expired - Lifetime
- 2004-03-26 WO PCT/EP2004/050376 patent/WO2004084896A1/en not_active Ceased
- 2004-03-26 SI SI200430665T patent/SI1610787T1/sl unknown
-
2008
- 2008-03-27 CY CY20081100350T patent/CY1110373T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1610787A1 (de) | 2006-01-04 |
| SI1610787T1 (sl) | 2008-06-30 |
| CY1110373T1 (el) | 2015-04-29 |
| EP1610787B1 (de) | 2008-01-23 |
| PT1610787E (pt) | 2008-04-23 |
| CA2519679C (en) | 2012-08-28 |
| PL1610787T3 (pl) | 2008-07-31 |
| CA2519679A1 (en) | 2004-10-07 |
| ES2300755T3 (es) | 2008-06-16 |
| WO2004084896A1 (en) | 2004-10-07 |
| DE602004011494D1 (de) | 2008-03-13 |
| MXPA05010160A (es) | 2005-11-16 |
| DK1610787T3 (da) | 2008-06-02 |
| US20060147382A1 (en) | 2006-07-06 |
| DE602004011494T2 (de) | 2009-01-22 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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