CY1108794T1 - Σπειροκυκλικα παραγωγα κυκλοεξανιου - Google Patents

Σπειροκυκλικα παραγωγα κυκλοεξανιου

Info

Publication number
CY1108794T1
CY1108794T1 CY20081101451T CY081101451T CY1108794T1 CY 1108794 T1 CY1108794 T1 CY 1108794T1 CY 20081101451 T CY20081101451 T CY 20081101451T CY 081101451 T CY081101451 T CY 081101451T CY 1108794 T1 CY1108794 T1 CY 1108794T1
Authority
CY
Cyprus
Prior art keywords
spiracyclical
cycloexane
derivatives
compounds
treat
Prior art date
Application number
CY20081101451T
Other languages
English (en)
Inventor
Bernd Sundermann
Claudia Hinze
Hans Schick
Helmut Sonnenschein
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1108794T1 publication Critical patent/CY1108794T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σπειροκυκλικά παράγωγα κυκλοεξανίου, μεθόδους για την παρασκεύη τους, φάρμακα που περιέχουν τις ενώσεις αυτές και τη χρησιμοποίηση σπειροκυκλικών παραγώγων κυκλοεξανίου για την παρασκευή φαρμάκων.
CY20081101451T 2004-08-13 2008-12-16 Σπειροκυκλικα παραγωγα κυκλοεξανιου CY1108794T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004039382A DE102004039382A1 (de) 2004-08-13 2004-08-13 Spirocyclische Cyclohexan-Derivate
EP05776804A EP1778680B1 (de) 2004-08-13 2005-08-09 Spirocyclische cyclohexan-derivate

Publications (1)

Publication Number Publication Date
CY1108794T1 true CY1108794T1 (el) 2014-04-09

Family

ID=35457057

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101451T CY1108794T1 (el) 2004-08-13 2008-12-16 Σπειροκυκλικα παραγωγα κυκλοεξανιου

Country Status (11)

Country Link
US (1) US7776848B2 (el)
EP (1) EP1778680B1 (el)
AT (1) ATE410424T1 (el)
CY (1) CY1108794T1 (el)
DE (2) DE102004039382A1 (el)
DK (1) DK1778680T3 (el)
ES (1) ES2314695T3 (el)
PL (1) PL1778680T3 (el)
PT (1) PT1778680E (el)
SI (1) SI1778680T1 (el)
WO (1) WO2006018184A2 (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006019597A1 (de) 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
MX2010010446A (es) 2008-03-27 2010-11-05 Gruenenthal Gmbh Derivados de (hetero)arilo ciclohexano.
TWI466866B (zh) 2008-03-27 2015-01-01 被取代之環己基二胺
ATE537143T1 (de) 2008-03-27 2011-12-15 Gruenenthal Gmbh Spiro(5.5)undecan derivate
SI2271613T1 (sl) 2008-03-27 2014-08-29 Grunenthal Gmbh Hidroksimetilcikloheksilamini
RU2503660C2 (ru) 2008-03-27 2014-01-10 Грюненталь Гмбх Замещенные производные 4-аминоциклогексана
PT2260042E (pt) 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos
WO2011003005A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8618299B2 (en) 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
UA107943C2 (en) * 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors
SI2501704T1 (sl) * 2009-11-16 2013-11-29 Eli Lilly Company Spojine spiropiperidina kot antagonisti oral-1 receptorja
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
JP6509321B2 (ja) 2014-07-15 2019-05-08 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換アザスピロ（４．５）デカン誘導体
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1055203A (en) * 1964-09-16 1967-01-18 Ici Ltd -ß-carboline derivatives, a process for their manufacture, and compositions containing them
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
RU2233841C2 (ru) * 1998-06-12 2004-08-10 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик Сас Бета-карболиновые соединения, фармацевтические композиции на их основе и способы связывания, достижения агонистического/антагонистического эффекта
AU1691500A (en) * 1998-12-24 2000-07-31 Meiji Seika Kaisha Ltd. Remedies for pain
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US20060235012A1 (en) * 2003-06-16 2006-10-19 Chroma Therapeutics Limited Carboline and betacarboline derivatives for use as hdac enzyme inhibitors
CA2540289A1 (en) * 2003-10-02 2005-04-14 Cephalon, Inc. Substituted indole derivatives

Also Published As

Publication number Publication date
WO2006018184A3 (de) 2006-05-18
EP1778680B1 (de) 2008-10-08
ES2314695T3 (es) 2009-03-16
DE102004039382A1 (de) 2006-02-23
SI1778680T1 (sl) 2009-02-28
US7776848B2 (en) 2010-08-17
US20070213351A1 (en) 2007-09-13
ATE410424T1 (de) 2008-10-15
DE502005005636D1 (en) 2008-11-20
PT1778680E (pt) 2008-12-12
EP1778680A2 (de) 2007-05-02
DK1778680T3 (da) 2008-12-15
WO2006018184A2 (de) 2006-02-23
PL1778680T3 (pl) 2009-04-30

Similar Documents

Publication Publication Date Title
ATE410424T1 (de) Spirocyclische cyclohexan-derivate
ATE457027T1 (de) Substituierte 1,4,8-triazaspiroä4.5 decan-2-on- verbindungen zur behandlung von fettsucht
ATE470443T1 (de) Indol-1-yl-essigsäurederivate
AR047928A1 (es) Derivados de tetrahidropiridoindol
WO2005013892A3 (en) Hydrolytically-resistant boron-containing therapeutics and methods of use
CY1109366T1 (el) Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης
DE602006006712D1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
TW200626158A (en) Naphthaline derivatives
EA201070327A1 (ru) Катехоламиновые производные и их пролекарства
TW200611695A (en) Pyrrolopyridine derivatives
TW200745122A (en) New compounds I
MX2007007027A (es) Derivados piperazinilpiridina como agentes anti-obesidad.
ATE507214T1 (de) Neuartige serotonin-wiederaufnahmehemmer als arzneimittel mit peripheriesystem-beschränkter aktivität
TW200626581A (en) Compounds, compositions containing them, preparation thereof and uses thereof
TW200745133A (en) New compounds II
ECSP088464A (es) Compuesto para la inhibición de la apoptosis
ATE496899T1 (de) Tetrahydro- und dihydrochinazolinone
WO2008130321A3 (en) Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain
NO20063617L (no) Diarylmetylidenpiperidinderivater, fremstilling og anvendelse derav
NO20072091L (no) Forbindelser, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav III
TNSN06068A1 (en) Pharmaceutical composition containing in association ubidecarenone, dexpanthenol and chlorhexidine or a pharmaceutically acceptable salt thereof for cutaneous application
TW200616970A (en) Compounds, compositions containing them, preparation thereof and uses thereof
UA87327C2 (ru) Производные бензимидазола, композиция, которая их содержит, их получение и применение