DK1778680T3 - Spirocykliske cyclohexaderivater - Google Patents

Spirocykliske cyclohexaderivater

Info

Publication number
DK1778680T3
DK1778680T3 DK05776804T DK05776804T DK1778680T3 DK 1778680 T3 DK1778680 T3 DK 1778680T3 DK 05776804 T DK05776804 T DK 05776804T DK 05776804 T DK05776804 T DK 05776804T DK 1778680 T3 DK1778680 T3 DK 1778680T3
Authority
DK
Denmark
Prior art keywords
spirocyclic
compounds
cyclohexa
derivatives
cyclohexa derivatives
Prior art date
Application number
DK05776804T
Other languages
English (en)
Inventor
Bernd Sundermann
Claudia Hinze
Helmut Sonnenschein
Hans Schick
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK1778680T3 publication Critical patent/DK1778680T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK05776804T 2004-08-13 2005-08-09 Spirocykliske cyclohexaderivater DK1778680T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004039382A DE102004039382A1 (de) 2004-08-13 2004-08-13 Spirocyclische Cyclohexan-Derivate
PCT/EP2005/008625 WO2006018184A2 (de) 2004-08-13 2005-08-09 Spirocyclische cyclohexan-derivate

Publications (1)

Publication Number Publication Date
DK1778680T3 true DK1778680T3 (da) 2008-12-15

Family

ID=35457057

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05776804T DK1778680T3 (da) 2004-08-13 2005-08-09 Spirocykliske cyclohexaderivater

Country Status (11)

Country Link
US (1) US7776848B2 (da)
EP (1) EP1778680B1 (da)
AT (1) ATE410424T1 (da)
CY (1) CY1108794T1 (da)
DE (2) DE102004039382A1 (da)
DK (1) DK1778680T3 (da)
ES (1) ES2314695T3 (da)
PL (1) PL1778680T3 (da)
PT (1) PT1778680E (da)
SI (1) SI1778680T1 (da)
WO (1) WO2006018184A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006019597A1 (de) 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
BRPI0907122B8 (pt) 2008-01-11 2021-05-25 Albany Molecular Res Inc compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
BR122013017387A2 (pt) 2008-03-27 2019-10-15 Grünenthal GmbH Compostos derivados substituídos de 4-aminociclohexano, composição farmacêutica e uso dos referidos compostos
DK2257526T3 (da) 2008-03-27 2012-02-06 Gruenenthal Gmbh Spiro(5,5)undecan-derivater
PL2271613T3 (pl) 2008-03-27 2014-09-30 Gruenenthal Gmbh Hydroksymetylocykloheksyloaminy
TWI450899B (zh) 2008-03-27 2014-09-01 被取代之螺環環已烷衍生物
CL2009000735A1 (es) 2008-03-27 2009-05-15 Gruenenthal Gmbh Compuestos derivados de 1,4 di-amino-ciclohexil sustituido, moduladores del receptor de opioides y el receptor orl-1; composicion farmaceutica que comprende dichos compuestos; y uso para el tratamiento del dolor, estados de ansiedad, depresion, epilepsia, disfuncion sexual, enfermedades cardiovasculares.
PL2280941T3 (pl) 2008-03-27 2015-10-30 Gruenenthal Gmbh (Hetero-)arylowe pochodne cykloheksanu
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
RS53017B (en) * 2009-11-16 2014-04-30 Eli Lilly And Company SPIROPIPERIDINE COMPOUNDS AS ANTAGONISTS OF ORL 1 RECEPTORS
UA107943C2 (en) * 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
PT3169666T (pt) 2014-07-15 2018-10-19 Gruenenthal Gmbh Derivados sbstituidos de azaspiro(4,5)decano
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1055203A (en) * 1964-09-16 1967-01-18 Ici Ltd -ß-carboline derivatives, a process for their manufacture, and compositions containing them
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
PL345589A1 (en) * 1998-06-12 2001-12-17 Sod Conseils Rech Applic β-CARBOLINE COMPOUNDS
AU1691500A (en) * 1998-12-24 2000-07-31 Meiji Seika Kaisha Ltd. Remedies for pain
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
WO2004113336A1 (en) * 2003-06-16 2004-12-29 Chroma Therapeutics Limited Carboline and betacarboline derivatives for use as hdac enzyme inhibitors
US7314886B2 (en) * 2003-10-02 2008-01-01 Cephalon, Inc. Tetrahydropyrano-indole derivatives

Also Published As

Publication number Publication date
WO2006018184A3 (de) 2006-05-18
PT1778680E (pt) 2008-12-12
WO2006018184A2 (de) 2006-02-23
ATE410424T1 (de) 2008-10-15
EP1778680A2 (de) 2007-05-02
DE502005005636D1 (en) 2008-11-20
DE102004039382A1 (de) 2006-02-23
ES2314695T3 (es) 2009-03-16
SI1778680T1 (sl) 2009-02-28
EP1778680B1 (de) 2008-10-08
PL1778680T3 (pl) 2009-04-30
US7776848B2 (en) 2010-08-17
CY1108794T1 (el) 2014-04-09
US20070213351A1 (en) 2007-09-13

Similar Documents

Publication Publication Date Title
DK1778680T3 (da) Spirocykliske cyclohexaderivater
ATE457027T1 (de) Substituierte 1,4,8-triazaspiroä4.5 decan-2-on- verbindungen zur behandlung von fettsucht
NO20064201L (no) Glukopyranosylsubstituerte benzolderivater, medikamenter inneholdende slike forbindelser, deres anvendelse og fremstilling
WO2005013892A3 (en) Hydrolytically-resistant boron-containing therapeutics and methods of use
CY1109366T1 (el) Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης
ATE470443T1 (de) Indol-1-yl-essigsäurederivate
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
DE602006006712D1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
TW200716628A (en) Novel compounds
TW200626158A (en) Naphthaline derivatives
ATE554089T1 (de) Spirocyclische cyclohexan-derivate
EA201201658A1 (ru) Производные пиперидина и их применение для лечения метаболических нарушений
ATE412636T1 (de) Piperazinylpyridinderivate als mittel gegen adipositas
TW200626581A (en) Compounds, compositions containing them, preparation thereof and uses thereof
NO20063619L (no) Diarylmetylpiperazinderivater, fremstilling og anvendelse derav
MX2009013197A (es) Derivados terapeuticos de pirazolonaftiridina.
IL191670A0 (en) Compounds for the inhibition of apoptosis
WO2008130321A3 (en) Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain
NO20063617L (no) Diarylmetylidenpiperidinderivater, fremstilling og anvendelse derav
NO20063618L (no) Diarylmetylpiperidinderivater, fremstilling og anvendelse derav
NO20072091L (no) Forbindelser, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav III
NO20072090L (no) Forbindelser, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav II
UA87327C2 (ru) Производные бензимидазола, композиция, которая их содержит, их получение и применение
TW200616970A (en) Compounds, compositions containing them, preparation thereof and uses thereof
TW200626582A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof