MX2009013197A - Derivados terapeuticos de pirazolonaftiridina. - Google Patents

Derivados terapeuticos de pirazolonaftiridina.

Info

Publication number
MX2009013197A
MX2009013197A MX2009013197A MX2009013197A MX2009013197A MX 2009013197 A MX2009013197 A MX 2009013197A MX 2009013197 A MX2009013197 A MX 2009013197A MX 2009013197 A MX2009013197 A MX 2009013197A MX 2009013197 A MX2009013197 A MX 2009013197A
Authority
MX
Mexico
Prior art keywords
gabaa
formula
therapeutic
animal
compound
Prior art date
Application number
MX2009013197A
Other languages
English (en)
Inventor
Jan W F Wasley
Alan P Kaplan
Varsha Gupta
Original Assignee
Helicon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helicon Therapeutics Inc filed Critical Helicon Therapeutics Inc
Publication of MX2009013197A publication Critical patent/MX2009013197A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invenci?n proporciona una nueva serie qu?mica de la f?rmula (I), as? como m?todos para su uso para enlazarse al sitio de benzodiazepina del receptor GABAA y para modular negativamente el subtipo a5 de GABAA, y el uso del compuesto de la f?rmula (I) en la elaboraci?n de un medicamento para el tratamiento de trastornos asociados al receptor GABAA. La invenci?n proporciona adem?s un m?todo para la modulaci?n de uno o m?s subtipos de GABAA en un animal, que comprende administrar al animal una cantidad efectiva de un compuesto de la f?rmula (I).
MX2009013197A 2007-06-08 2008-06-06 Derivados terapeuticos de pirazolonaftiridina. MX2009013197A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94300007P 2007-06-08 2007-06-08
PCT/US2008/066211 WO2008154447A1 (en) 2007-06-08 2008-06-06 Therapeutic pyrazolonaphthyridine derivatives

Publications (1)

Publication Number Publication Date
MX2009013197A true MX2009013197A (es) 2010-04-27

Family

ID=40130166

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013197A MX2009013197A (es) 2007-06-08 2008-06-06 Derivados terapeuticos de pirazolonaftiridina.

Country Status (13)

Country Link
US (2) US7858614B2 (es)
EP (1) EP2166853B1 (es)
JP (1) JP2010529145A (es)
KR (1) KR20100036306A (es)
CN (1) CN101754681A (es)
AU (1) AU2008261803A1 (es)
BR (1) BRPI0812369A2 (es)
CA (1) CA2689934A1 (es)
ES (1) ES2483728T3 (es)
HK (1) HK1142774A1 (es)
IL (1) IL202287A0 (es)
MX (1) MX2009013197A (es)
WO (1) WO2008154447A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100038189A (ko) * 2007-06-08 2010-04-13 헬리콘 테라퓨틱스 인코퍼레이티드 치료적 피라졸로퀴놀린 우레아 유도체
EP2627655B1 (en) * 2010-10-14 2015-09-16 Dart Neuroscience (Cayman) Ltd FUSED 3-OXO-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AS GABAA MODULATORS
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US10531200B2 (en) * 2015-10-23 2020-01-07 Harman International Industries, Incorporated Dual asymmetric compression driver
CN106810550A (zh) * 2017-01-10 2017-06-09 湖南华腾制药有限公司 一种萘啶衍生物的制备方法
KR20200020911A (ko) 2017-06-30 2020-02-26 바이엘 애니멀 헬스 게엠베하 새로운 아자퀴놀린 유도체

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204126A1 (de) 1982-02-06 1983-08-11 Bayer Ag, 5090 Leverkusen Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4479955A (en) * 1983-01-10 1984-10-30 Ciba-Geigy Corporation Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators
US4814450A (en) 1984-07-09 1989-03-21 Ciba-Geigy Corporation Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives
JPS61112075A (ja) 1984-11-05 1986-05-30 Shionogi & Co Ltd チエニルピラゾロキノリン誘導体
EP0214092A1 (en) 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
US4817450A (en) * 1987-11-30 1989-04-04 Spedco, Inc. Pressure/temperature test plug assembly
FR2695126B1 (fr) * 1992-08-27 1994-11-10 Sanofi Elf Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.
US5334595A (en) 1992-10-23 1994-08-02 Sterling Winthrop Inc. Pyrazoloquinolones as anticancer agents
RU2145606C1 (ru) * 1994-05-24 2000-02-20 Ф.Хоффманн-Ля Рош Аг Трициклические дикарбонильные производные и лекарственный препарат на их основе
GB9716345D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716344D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716347D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
TWI271406B (en) * 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
DE60326639D1 (de) 2002-12-16 2009-04-23 Active Biotech Ab Tetrazyklische immunmodulierende verbindungen
WO2005028474A2 (en) 2003-05-29 2005-03-31 Millennium Pharmaceuticals, Inc. Pyrazoloquinoline derivatives as chk-1 inhibitors
CN1893943A (zh) * 2003-10-03 2007-01-10 3M创新有限公司 吡唑并吡啶和其类似物
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
EP1937236A2 (en) * 2005-09-07 2008-07-02 Braincells, Inc. Modulation of neurogenesis by hdac inhibition
KR20100039331A (ko) * 2007-06-08 2010-04-15 헬리콘 테라퓨틱스 인코퍼레이티드 치료용 피라졸로퀴놀린 유도체

Also Published As

Publication number Publication date
ES2483728T3 (es) 2014-08-07
US8497262B2 (en) 2013-07-30
AU2008261803A1 (en) 2008-12-18
KR20100036306A (ko) 2010-04-07
JP2010529145A (ja) 2010-08-26
US20110065692A1 (en) 2011-03-17
EP2166853A4 (en) 2011-04-06
HK1142774A1 (en) 2010-12-17
IL202287A0 (en) 2010-06-16
EP2166853B1 (en) 2014-05-28
BRPI0812369A2 (pt) 2016-08-09
EP2166853A1 (en) 2010-03-31
CA2689934A1 (en) 2008-12-18
US20090005365A1 (en) 2009-01-01
US7858614B2 (en) 2010-12-28
CN101754681A (zh) 2010-06-23
WO2008154447A1 (en) 2008-12-18

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