JP2018521007A5 - - Google Patents
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- Publication number
- JP2018521007A5 JP2018521007A5 JP2017560663A JP2017560663A JP2018521007A5 JP 2018521007 A5 JP2018521007 A5 JP 2018521007A5 JP 2017560663 A JP2017560663 A JP 2017560663A JP 2017560663 A JP2017560663 A JP 2017560663A JP 2018521007 A5 JP2018521007 A5 JP 2018521007A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorokynurenine
- daily
- pharmaceutical composition
- treatment
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- HQLHZNDJQSRKDT-QMMMGPOBSA-N (2s)-2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid Chemical compound OC(=O)[C@@H](N)CC(=O)C1=CC=C(Cl)C=C1N HQLHZNDJQSRKDT-QMMMGPOBSA-N 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 5
- 208000009205 Tinnitus Diseases 0.000 claims description 5
- 231100000886 tinnitus Toxicity 0.000 claims description 5
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- 239000000654 additive Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022004811A JP2022064908A (ja) | 2015-05-22 | 2022-01-17 | Ｌ－４－クロロキヌレニンの治療的使用 |
| JP2024000227A JP2024050575A (ja) | 2015-05-22 | 2024-01-04 | Ｌ－４－クロロキヌレニンの治療的使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562179924P | 2015-05-22 | 2015-05-22 | |
| US62/179,924 | 2015-05-22 | ||
| PCT/US2016/033733 WO2016191351A1 (en) | 2015-05-22 | 2016-05-23 | Therapeutic uses of l-4-chlorokynurenine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022004811A Division JP2022064908A (ja) | 2015-05-22 | 2022-01-17 | Ｌ－４－クロロキヌレニンの治療的使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018521007A JP2018521007A (ja) | 2018-08-02 |
| JP2018521007A5 true JP2018521007A5 (enExample) | 2019-06-20 |
Family
ID=57393671
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560663A Pending JP2018521007A (ja) | 2015-05-22 | 2016-05-23 | Ｌ−４−クロロキヌレニンの治療的使用 |
| JP2022004811A Pending JP2022064908A (ja) | 2015-05-22 | 2022-01-17 | Ｌ－４－クロロキヌレニンの治療的使用 |
| JP2024000227A Pending JP2024050575A (ja) | 2015-05-22 | 2024-01-04 | Ｌ－４－クロロキヌレニンの治療的使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022004811A Pending JP2022064908A (ja) | 2015-05-22 | 2022-01-17 | Ｌ－４－クロロキヌレニンの治療的使用 |
| JP2024000227A Pending JP2024050575A (ja) | 2015-05-22 | 2024-01-04 | Ｌ－４－クロロキヌレニンの治療的使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20180140568A1 (enExample) |
| EP (2) | EP4108239A1 (enExample) |
| JP (3) | JP2018521007A (enExample) |
| KR (2) | KR20180015158A (enExample) |
| CN (1) | CN107949379A (enExample) |
| AU (3) | AU2016268153B2 (enExample) |
| BR (1) | BR112017024908A2 (enExample) |
| CA (1) | CA3024783A1 (enExample) |
| DK (1) | DK3297619T3 (enExample) |
| EA (1) | EA201792571A1 (enExample) |
| ES (1) | ES2925274T3 (enExample) |
| IL (3) | IL296380A (enExample) |
| MX (1) | MX395492B (enExample) |
| PL (1) | PL3297619T3 (enExample) |
| PT (1) | PT3297619T (enExample) |
| SG (1) | SG10202007661XA (enExample) |
| SI (1) | SI3297619T1 (enExample) |
| WO (1) | WO2016191351A1 (enExample) |
| ZA (1) | ZA201707874B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS59687B1 (sr) | 2013-01-22 | 2020-01-31 | Vistagen Therapeutics Inc | Oblici doziranja i terapeutske primene l-4-hlorkinurenina |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| US20220202756A1 (en) * | 2019-04-09 | 2022-06-30 | Vistagen Therapeutics, Inc. | Genetic variants associated with response to treatment of neurological disorders |
| CA3187323A1 (en) * | 2020-06-24 | 2021-12-30 | Biohaven Therapeutics Ltd. | Compositions and methods for treating obsessive-compulsive disorder |
| WO2022221423A1 (en) * | 2021-04-13 | 2022-10-20 | Vistagen Therapeutics, Inc. | Treatment of autoimmune anti-nmda-receptor encephalitis |
| CN115677519A (zh) * | 2021-07-22 | 2023-02-03 | 立科时代(武汉)生物科技有限公司 | L-4-溴-犬尿氨酸及其在制备治疗抑郁症药物中的应用 |
| WO2024011105A1 (en) * | 2022-07-05 | 2024-01-11 | Mahana Therapeutics, Inc. | Methods and systems for treating tinnitus using digital therapeutics |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484814A (en) | 1991-02-28 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
| EP1061924A1 (en) * | 1998-03-09 | 2000-12-27 | Trustees Of Tufts College | Treatment of compulsive behaviours in man and animals |
| TW518218B (en) * | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| MXPA03005130A (es) * | 2000-12-07 | 2004-12-06 | Neuromolecular Inc | Metodos para tratar trastornos neurosiquiatricos con antagonistas del receptor del nmda. |
| US20060063802A1 (en) * | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| MX2008013130A (es) * | 2006-04-12 | 2008-11-19 | Probiodrug Ag | Inhibidores de enzima. |
| CA2606658A1 (en) * | 2006-10-13 | 2008-04-13 | Mike Tyers | Compositions and methods for treating neurological disorders or damage |
| MX2010004971A (es) * | 2007-11-06 | 2010-07-28 | Univ Emory | Metodos de identificacion de antagonistas seguros del receptor nmda. |
| TW201026667A (en) * | 2008-09-30 | 2010-07-16 | Merz Pharma Gmbh & Co Kgaa | Glycine b antagonists |
| US20140057988A1 (en) * | 2012-08-23 | 2014-02-27 | Stuart WEG | Anxiolytic composition, formulation and method of use |
| RS59687B1 (sr) * | 2013-01-22 | 2020-01-31 | Vistagen Therapeutics Inc | Oblici doziranja i terapeutske primene l-4-hlorkinurenina |
| CN105164096A (zh) | 2013-03-14 | 2015-12-16 | 维斯塔津治疗公司 | 手性犬尿氨酸化合物和中间体的合成 |
| WO2014152752A1 (en) | 2013-03-14 | 2014-09-25 | Vistagen Therapeutics, Inc. | Methods for the synthesis of chiral kynurenine compounds |
| MX2016014581A (es) * | 2014-05-06 | 2018-02-16 | Univ Northwestern | Composiciones de compuestos que modulan nmdar. |
-
2016
- 2016-05-23 IL IL296380A patent/IL296380A/en unknown
- 2016-05-23 PL PL16800590.8T patent/PL3297619T3/pl unknown
- 2016-05-23 KR KR1020177036471A patent/KR20180015158A/ko not_active Ceased
- 2016-05-23 SI SI201631606T patent/SI3297619T1/sl unknown
- 2016-05-23 EP EP22183035.9A patent/EP4108239A1/en not_active Withdrawn
- 2016-05-23 AU AU2016268153A patent/AU2016268153B2/en active Active
- 2016-05-23 EA EA201792571A patent/EA201792571A1/ru unknown
- 2016-05-23 WO PCT/US2016/033733 patent/WO2016191351A1/en not_active Ceased
- 2016-05-23 SG SG10202007661XA patent/SG10202007661XA/en unknown
- 2016-05-23 US US15/576,319 patent/US20180140568A1/en not_active Abandoned
- 2016-05-23 DK DK16800590.8T patent/DK3297619T3/da active
- 2016-05-23 CN CN201680042400.6A patent/CN107949379A/zh active Pending
- 2016-05-23 ES ES16800590T patent/ES2925274T3/es active Active
- 2016-05-23 EP EP16800590.8A patent/EP3297619B1/en active Active
- 2016-05-23 MX MX2017014456A patent/MX395492B/es unknown
- 2016-05-23 KR KR1020247014693A patent/KR20240068766A/ko not_active Ceased
- 2016-05-23 JP JP2017560663A patent/JP2018521007A/ja active Pending
- 2016-05-23 BR BR112017024908A patent/BR112017024908A2/pt not_active Application Discontinuation
- 2016-05-23 PT PT168005908T patent/PT3297619T/pt unknown
- 2016-05-23 CA CA3024783A patent/CA3024783A1/en active Pending
-
2017
- 2017-11-20 ZA ZA2017/07874A patent/ZA201707874B/en unknown
- 2017-11-20 IL IL255770A patent/IL255770B/en unknown
-
2019
- 2019-05-06 US US16/403,974 patent/US20190321317A1/en not_active Abandoned
-
2021
- 2021-07-29 AU AU2021209279A patent/AU2021209279B2/en active Active
- 2021-08-25 IL IL285882A patent/IL285882A/en unknown
-
2022
- 2022-01-17 JP JP2022004811A patent/JP2022064908A/ja active Pending
- 2022-09-30 US US17/958,169 patent/US20240122887A1/en not_active Abandoned
-
2023
- 2023-12-13 AU AU2023282234A patent/AU2023282234A1/en not_active Abandoned
-
2024
- 2024-01-04 JP JP2024000227A patent/JP2024050575A/ja active Pending
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