JP2020509072A5 - - Google Patents
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- Publication number
- JP2020509072A5 JP2020509072A5 JP2019548652A JP2019548652A JP2020509072A5 JP 2020509072 A5 JP2020509072 A5 JP 2020509072A5 JP 2019548652 A JP2019548652 A JP 2019548652A JP 2019548652 A JP2019548652 A JP 2019548652A JP 2020509072 A5 JP2020509072 A5 JP 2020509072A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- composition
- use according
- parts
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 14
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 7
- 229930003268 Vitamin C Natural products 0.000 description 7
- 229930003231 vitamin Natural products 0.000 description 7
- 235000013343 vitamin Nutrition 0.000 description 7
- 239000011782 vitamin Substances 0.000 description 7
- 229940088594 vitamin Drugs 0.000 description 7
- 235000019154 vitamin C Nutrition 0.000 description 7
- 239000011718 vitamin C Substances 0.000 description 7
- 235000019156 vitamin B Nutrition 0.000 description 6
- 239000011720 vitamin B Substances 0.000 description 6
- 150000003722 vitamin derivatives Chemical class 0.000 description 6
- 229930003270 Vitamin B Natural products 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 229940127557 pharmaceutical product Drugs 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 1
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 229930003571 Vitamin B5 Natural products 0.000 description 1
- 229930003756 Vitamin B7 Natural products 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000009492 vitamin B5 Nutrition 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022172956A JP2023011769A (ja) | 2017-03-07 | 2022-10-28 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
| JP2024198677A JP2025024089A (ja) | 2017-03-07 | 2024-11-14 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710131111.X | 2017-03-07 | ||
| CN201710131111.XA CN108567792A (zh) | 2017-03-07 | 2017-03-07 | 一种治疗阿尔茨海默病的复合维生素组合物 |
| PCT/CN2018/077107 WO2018161808A1 (zh) | 2017-03-07 | 2018-02-24 | 维生素组合物在制备用于预防、治疗或延迟阿尔茨海默病的药物中的用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172956A Division JP2023011769A (ja) | 2017-03-07 | 2022-10-28 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020509072A JP2020509072A (ja) | 2020-03-26 |
| JP2020509072A5 true JP2020509072A5 (enExample) | 2021-04-08 |
| JP7169285B2 JP7169285B2 (ja) | 2022-11-10 |
Family
ID=63448062
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548652A Active JP7169285B2 (ja) | 2017-03-07 | 2018-02-24 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
| JP2022172956A Pending JP2023011769A (ja) | 2017-03-07 | 2022-10-28 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
| JP2024198677A Pending JP2025024089A (ja) | 2017-03-07 | 2024-11-14 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172956A Pending JP2023011769A (ja) | 2017-03-07 | 2022-10-28 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
| JP2024198677A Pending JP2025024089A (ja) | 2017-03-07 | 2024-11-14 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11464797B2 (enExample) |
| EP (2) | EP4461361A3 (enExample) |
| JP (3) | JP7169285B2 (enExample) |
| CN (2) | CN108567792A (enExample) |
| AU (2) | AU2018229920B2 (enExample) |
| BR (1) | BR112019018652A2 (enExample) |
| CA (1) | CA3054972A1 (enExample) |
| ES (1) | ES2989651T3 (enExample) |
| WO (1) | WO2018161808A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7442874B2 (ja) * | 2019-08-02 | 2024-03-05 | シャンハイ、レイジング、ファーマシューティカル、カンパニー、リミテッド | アルツハイマー病における標的としてのｔｐｋの使用 |
| KR102275981B1 (ko) * | 2020-03-31 | 2021-07-13 | 고려은단주식회사 | 섬쑥부쟁이 추출물과 비타민 b 복합체의 혼합물을 포함하는 인지기능 개선용 조성물 |
| AU2022464309A1 (en) * | 2022-06-22 | 2025-01-23 | Biomedical Research Group Inc. | Prophylactic drug and therapeutic drug for diabetes-associated dementia |
| CN119055674B (zh) * | 2024-11-06 | 2025-02-18 | 中国医学科学院北京协和医院 | 一种可改善认知的组合物及其在阿尔茨海默病防治中的应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5626884A (en) | 1995-08-18 | 1997-05-06 | Lockett; Curtis G. | Treatment of sickle cell disease |
| DE69930746T2 (de) | 1998-06-10 | 2007-03-15 | Crum, Albert B. | Vorbeugender und therapeutischer nahrungsmittelzusatz zur schaffung/erhaltung einer die gesundheit schützenden darmmikroflora und zur stärkung des immunsystems |
| WO2003082339A1 (en) | 2002-03-22 | 2003-10-09 | Doc's Guide, Inc. | Multivitamin and mineral nutritional supplement |
| CA2583972A1 (en) | 2004-10-14 | 2006-10-19 | Adventures Plus Pty Ltd | A method for the treatment of gastrointestinal and other disorders with an admixture of vitamins and minerals |
| US20110275591A1 (en) * | 2004-12-01 | 2011-11-10 | Concourse Health Sciences Llc | Cocktail for modulation of alzheimer's disease |
| US20060148727A1 (en) * | 2004-12-01 | 2006-07-06 | Curt Hendrix | Folate based composition for neurological and cognitive applications |
| NZ582329A (en) * | 2007-06-26 | 2012-09-28 | Nutricia Nv | Improving memory in subjects with mini-mental state examination of 24-26 |
| US9763989B2 (en) * | 2007-08-03 | 2017-09-19 | Shaklee Corporation | Nutritional supplement system |
| JP4206428B1 (ja) * | 2008-06-09 | 2009-01-14 | 正樹 今川 | 認知症を処置するための組成物及びその利用 |
| KR20110004691A (ko) * | 2009-07-08 | 2011-01-14 | 대한민국(농촌진흥청장) | 뇌기능 개선효과를 가지는 붉나무 추출물을 포함하는 약학조성물 및 건강식품조성물 |
| EP2554057A4 (en) * | 2010-03-31 | 2013-12-18 | Vegenat S A | ENERAL OR ORAL FOOD PRODUCT SPECIALLY FOR NUTRITION, PREVENTION AND MITIGATION OF NEUROLOGICAL OR NEURODEGENERATIVE ALTERATIONS OR COGNITIVE DISORDERS |
| US8563609B2 (en) * | 2010-05-13 | 2013-10-22 | Nitromega Corp. | Nitro fatty acids - neuroprotection and/or inhibition of cognitive decline |
| WO2012012682A2 (en) | 2010-07-22 | 2012-01-26 | Zishan Haroon | Methods of treating or ameliorating diseases and enhancing performance comprising the use of a magnetic dipole stabilized solution |
| KR20130015932A (ko) * | 2011-08-05 | 2013-02-14 | 연세대학교 산학협력단 | 저용량의 치아졸리딘다이온을 포함하는 알츠하이머 병 치료용 약학조성물 |
| WO2013066151A1 (en) * | 2011-10-31 | 2013-05-10 | N.V. Nutricia | Improving recognition |
| BR112014020177A8 (pt) * | 2012-03-02 | 2021-10-19 | Nutricia Nv | Uso de uma composição para a fabricação de um produto para diminuir, prevenir ou reverter a conectividade cerebral funcional prejudicada e/ou organização da rede cerebral prejudicada |
| EP2882304A1 (en) * | 2012-08-07 | 2015-06-17 | Buck Institute For Research On Aging | Multi-component formulation for improving neurological function |
| WO2014026161A1 (en) * | 2012-08-10 | 2014-02-13 | Aquavit Pharmaceuticals, Inc. | Vitamin supplement compositions for injection |
| CN104337813A (zh) | 2013-07-23 | 2015-02-11 | 上海泽生科技开发有限公司 | 使用维生素b组合物促进胃肠系统动力的方法 |
| CN104256652A (zh) | 2014-10-08 | 2015-01-07 | 李明刚 | 一种口服复合维生素纳米脂质体 |
| CN104922164B (zh) * | 2014-12-12 | 2020-06-02 | 中国医科大学 | 一种治疗阿尔茨海默病的药物复合制剂 |
| CN111803514A (zh) * | 2015-06-12 | 2020-10-23 | 上海泽生科技开发股份有限公司 | 使用复合维生素b、c组合物促进胃肠系统动力的方法 |
| CN104856048A (zh) | 2015-06-18 | 2015-08-26 | 安徽医联大成医药科技有限公司 | 一种促进肠胃蠕动的食品配方及其制备方法 |
| CN108079008A (zh) * | 2016-11-23 | 2018-05-29 | 上海泽生科技开发股份有限公司 | 促进胃肠系统动力的复合维生素组合物 |
-
2017
- 2017-03-07 CN CN201710131111.XA patent/CN108567792A/zh active Pending
-
2018
- 2018-02-24 EP EP24189913.7A patent/EP4461361A3/en not_active Withdrawn
- 2018-02-24 CA CA3054972A patent/CA3054972A1/en not_active Abandoned
- 2018-02-24 CN CN201880015481.XA patent/CN110520135A/zh active Pending
- 2018-02-24 JP JP2019548652A patent/JP7169285B2/ja active Active
- 2018-02-24 WO PCT/CN2018/077107 patent/WO2018161808A1/zh not_active Ceased
- 2018-02-24 AU AU2018229920A patent/AU2018229920B2/en active Active
- 2018-02-24 BR BR112019018652A patent/BR112019018652A2/pt not_active Application Discontinuation
- 2018-02-24 ES ES18763903T patent/ES2989651T3/es active Active
- 2018-02-24 US US16/491,560 patent/US11464797B2/en active Active
- 2018-02-24 EP EP18763903.4A patent/EP3593805B1/en active Active
-
2022
- 2022-09-15 US US17/945,684 patent/US20230248756A1/en not_active Abandoned
- 2022-10-28 JP JP2022172956A patent/JP2023011769A/ja active Pending
-
2024
- 2024-04-24 AU AU2024202678A patent/AU2024202678A1/en active Pending
- 2024-11-14 JP JP2024198677A patent/JP2025024089A/ja active Pending
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