AU2016268153B2 - Therapeutic uses of L-4-chlorokynurenine - Google Patents

Therapeutic uses of L-4-chlorokynurenine Download PDF

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Publication number
AU2016268153B2
AU2016268153B2 AU2016268153A AU2016268153A AU2016268153B2 AU 2016268153 B2 AU2016268153 B2 AU 2016268153B2 AU 2016268153 A AU2016268153 A AU 2016268153A AU 2016268153 A AU2016268153 A AU 2016268153A AU 2016268153 B2 AU2016268153 B2 AU 2016268153B2
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AU
Australia
Prior art keywords
chlorokynurenine
depression
dose
tinnitus
treatment
Prior art date
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Active
Application number
AU2016268153A
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English (en)
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AU2016268153A1 (en
Inventor
Allen E Cato
Jack S Hicklin
H. Ralph Snodgrass
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vistagen Therapeutics Inc
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Vistagen Therapeutics Inc
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Filing date
Publication date
Application filed by Vistagen Therapeutics Inc filed Critical Vistagen Therapeutics Inc
Publication of AU2016268153A1 publication Critical patent/AU2016268153A1/en
Priority to AU2021209279A priority Critical patent/AU2021209279B2/en
Application granted granted Critical
Publication of AU2016268153B2 publication Critical patent/AU2016268153B2/en
Priority to AU2023282234A priority patent/AU2023282234A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016268153A 2015-05-22 2016-05-23 Therapeutic uses of L-4-chlorokynurenine Active AU2016268153B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021209279A AU2021209279B2 (en) 2015-05-22 2021-07-29 Therapeutic uses of L-4-chlorokynurenine
AU2023282234A AU2023282234A1 (en) 2015-05-22 2023-12-13 Therapeutic uses of L-4-chlorokynurenine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562179924P 2015-05-22 2015-05-22
US62/179,924 2015-05-22
PCT/US2016/033733 WO2016191351A1 (en) 2015-05-22 2016-05-23 Therapeutic uses of l-4-chlorokynurenine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021209279A Division AU2021209279B2 (en) 2015-05-22 2021-07-29 Therapeutic uses of L-4-chlorokynurenine

Publications (2)

Publication Number Publication Date
AU2016268153A1 AU2016268153A1 (en) 2017-12-14
AU2016268153B2 true AU2016268153B2 (en) 2021-08-12

Family

ID=57393671

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2016268153A Active AU2016268153B2 (en) 2015-05-22 2016-05-23 Therapeutic uses of L-4-chlorokynurenine
AU2021209279A Active AU2021209279B2 (en) 2015-05-22 2021-07-29 Therapeutic uses of L-4-chlorokynurenine
AU2023282234A Abandoned AU2023282234A1 (en) 2015-05-22 2023-12-13 Therapeutic uses of L-4-chlorokynurenine

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2021209279A Active AU2021209279B2 (en) 2015-05-22 2021-07-29 Therapeutic uses of L-4-chlorokynurenine
AU2023282234A Abandoned AU2023282234A1 (en) 2015-05-22 2023-12-13 Therapeutic uses of L-4-chlorokynurenine

Country Status (19)

Country Link
US (3) US20180140568A1 (enExample)
EP (2) EP4108239A1 (enExample)
JP (3) JP2018521007A (enExample)
KR (2) KR20240068766A (enExample)
CN (1) CN107949379A (enExample)
AU (3) AU2016268153B2 (enExample)
BR (1) BR112017024908A2 (enExample)
CA (1) CA3024783A1 (enExample)
DK (1) DK3297619T3 (enExample)
EA (1) EA201792571A1 (enExample)
ES (1) ES2925274T3 (enExample)
IL (3) IL296380A (enExample)
MX (1) MX395492B (enExample)
PL (1) PL3297619T3 (enExample)
PT (1) PT3297619T (enExample)
SG (1) SG10202007661XA (enExample)
SI (1) SI3297619T1 (enExample)
WO (1) WO2016191351A1 (enExample)
ZA (1) ZA201707874B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS59687B1 (sr) 2013-01-22 2020-01-31 Vistagen Therapeutics Inc Oblici doziranja i terapeutske primene l-4-hlorkinurenina
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
MX2021012383A (es) * 2019-04-09 2022-01-04 Vistagen Therapeutics Inc Variantes genéticas asociadas con la respuesta al tratamiento de trastornos neurológicos.
PH12022553441A1 (en) * 2020-06-24 2024-03-04 Biohaven Therapeutics Ltd Compositions and methods for treating obsessive-compulsive disorder
WO2022221423A1 (en) * 2021-04-13 2022-10-20 Vistagen Therapeutics, Inc. Treatment of autoimmune anti-nmda-receptor encephalitis
CN115677519A (zh) * 2021-07-22 2023-02-03 立科时代(武汉)生物科技有限公司 L-4-溴-犬尿氨酸及其在制备治疗抑郁症药物中的应用
WO2024011105A1 (en) * 2022-07-05 2024-01-11 Mahana Therapeutics, Inc. Methods and systems for treating tinnitus using digital therapeutics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014116739A1 (en) * 2013-01-22 2014-07-31 Vistagen Therapeutics, Inc. Dosage forms and therapeutic uses l-4-chlorokynurenine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484814A (en) 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
EP1061924A1 (en) * 1998-03-09 2000-12-27 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
TW518218B (en) * 1999-05-27 2003-01-21 Merck Patent Gmbh Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
CA2436311A1 (en) * 2000-12-07 2002-06-13 Neuromolecular Inc. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
US20060063802A1 (en) * 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
BRPI0709984A2 (pt) * 2006-04-12 2011-08-02 Probiodrug Ag inibidores de enzima
US8058243B2 (en) * 2006-10-13 2011-11-15 Hsc Research And Development Limited Partnership Method for treating a brain cancer with ifenprodil
JP2011503013A (ja) * 2007-11-06 2011-01-27 エモリー・ユニバーシテイ 安全なｎｍｄａ受容体拮抗薬を同定する方法
TW201026667A (en) * 2008-09-30 2010-07-16 Merz Pharma Gmbh & Co Kgaa Glycine b antagonists
KR20150096370A (ko) * 2012-08-23 2015-08-24 스튜어트 엘. 웨그 항불안제 조성물, 제형 및 사용방법
CA2941559A1 (en) 2013-03-14 2014-09-25 Vistagen Therapeutics, Inc. Methods for the synthesis of chiral kynurenine compounds
WO2014152835A1 (en) 2013-03-14 2014-09-25 Vistagen Therapeutics, Inc. Synthesis of chiral kynurenine compounds and intermediates
MX2016014581A (es) * 2014-05-06 2018-02-16 Univ Northwestern Composiciones de compuestos que modulan nmdar.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014116739A1 (en) * 2013-01-22 2014-07-31 Vistagen Therapeutics, Inc. Dosage forms and therapeutic uses l-4-chlorokynurenine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Guitton, MJ et al (2005) European Journal of Neuroscience 22: 2675-2678 *

Also Published As

Publication number Publication date
WO2016191351A1 (en) 2016-12-01
ES2925274T3 (es) 2022-10-14
ZA201707874B (en) 2020-01-29
US20180140568A1 (en) 2018-05-24
CA3024783A1 (en) 2016-12-01
MX395492B (es) 2025-03-25
MX2017014456A (es) 2018-03-16
IL255770B (en) 2021-09-30
HK1257800A1 (en) 2019-11-01
US20190321317A1 (en) 2019-10-24
BR112017024908A2 (pt) 2018-07-31
AU2023282234A1 (en) 2024-01-18
CN107949379A (zh) 2018-04-20
EP4108239A1 (en) 2022-12-28
PL3297619T3 (pl) 2023-02-13
IL285882A (en) 2021-09-30
KR20240068766A (ko) 2024-05-17
JP2022064908A (ja) 2022-04-26
EP3297619B1 (en) 2022-07-06
IL255770A (en) 2018-01-31
EP3297619A4 (en) 2019-01-02
AU2021209279A1 (en) 2021-08-19
KR20180015158A (ko) 2018-02-12
DK3297619T3 (da) 2022-08-15
IL296380A (en) 2022-11-01
EA201792571A1 (ru) 2018-06-29
JP2018521007A (ja) 2018-08-02
AU2016268153A1 (en) 2017-12-14
EP3297619A1 (en) 2018-03-28
PT3297619T (pt) 2022-08-05
AU2021209279B2 (en) 2023-09-14
SI3297619T1 (sl) 2023-02-28
US20240122887A1 (en) 2024-04-18
JP2024050575A (ja) 2024-04-10
SG10202007661XA (en) 2020-09-29

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ SNODGRASS, H. RALPH; CATO, ALLEN E AND HICKLIN, JACK S

FGA Letters patent sealed or granted (standard patent)