JP2016540785A5 - - Google Patents

Download PDF

Info

Publication number
JP2016540785A5
JP2016540785A5 JP2016538656A JP2016538656A JP2016540785A5 JP 2016540785 A5 JP2016540785 A5 JP 2016540785A5 JP 2016538656 A JP2016538656 A JP 2016538656A JP 2016538656 A JP2016538656 A JP 2016538656A JP 2016540785 A5 JP2016540785 A5 JP 2016540785A5
Authority
JP
Japan
Prior art keywords
botulinum toxin
animal protein
composition
free
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016538656A
Other languages
English (en)
Japanese (ja)
Other versions
JP6895751B2 (ja
JP2016540785A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/070113 external-priority patent/WO2015089452A1/en
Publication of JP2016540785A publication Critical patent/JP2016540785A/ja
Publication of JP2016540785A5 publication Critical patent/JP2016540785A5/ja
Application granted granted Critical
Publication of JP6895751B2 publication Critical patent/JP6895751B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016538656A 2013-12-12 2014-12-12 新しいボツリヌス毒素製剤の長期持続作用 Active JP6895751B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361915476P 2013-12-12 2013-12-12
US61/915,476 2013-12-12
PCT/US2014/070113 WO2015089452A1 (en) 2013-12-12 2014-12-12 Long lasting effect of new botulinum toxin formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019217930A Division JP7121458B2 (ja) 2013-12-12 2019-12-02 新しいボツリヌス毒素製剤の長期持続作用

Publications (3)

Publication Number Publication Date
JP2016540785A JP2016540785A (ja) 2016-12-28
JP2016540785A5 true JP2016540785A5 (enExample) 2018-02-01
JP6895751B2 JP6895751B2 (ja) 2021-06-30

Family

ID=52118051

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016538656A Active JP6895751B2 (ja) 2013-12-12 2014-12-12 新しいボツリヌス毒素製剤の長期持続作用
JP2019217930A Active JP7121458B2 (ja) 2013-12-12 2019-12-02 新しいボツリヌス毒素製剤の長期持続作用
JP2022123668A Active JP7439187B2 (ja) 2013-12-12 2022-08-03 新しいボツリヌス毒素製剤の長期持続作用
JP2024021300A Pending JP2024059717A (ja) 2013-12-12 2024-02-15 新しいボツリヌス毒素製剤の長期持続作用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019217930A Active JP7121458B2 (ja) 2013-12-12 2019-12-02 新しいボツリヌス毒素製剤の長期持続作用
JP2022123668A Active JP7439187B2 (ja) 2013-12-12 2022-08-03 新しいボツリヌス毒素製剤の長期持続作用
JP2024021300A Pending JP2024059717A (ja) 2013-12-12 2024-02-15 新しいボツリヌス毒素製剤の長期持続作用

Country Status (9)

Country Link
US (6) US9480731B2 (enExample)
EP (2) EP3079714B1 (enExample)
JP (4) JP6895751B2 (enExample)
KR (4) KR20220071292A (enExample)
CN (2) CN116570567A (enExample)
AU (3) AU2014361859A1 (enExample)
CA (1) CA2933363C (enExample)
ES (1) ES2861509T3 (enExample)
WO (1) WO2015089452A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7758872B1 (en) 2003-02-07 2010-07-20 Eric Finzi Method of treating depression
CA2690773C (en) * 2007-07-10 2013-09-17 Medy-Tox, Inc. Pharmaceutical liquid composition of botulinum toxin with improved stability
US9480731B2 (en) 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
TW201718627A (zh) * 2015-06-11 2017-06-01 梅茲製藥有限兩合公司 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
CN109069609A (zh) * 2015-12-11 2018-12-21 雷文斯治疗公司 使用神经递质的用于原发性情绪和情感障碍的肉毒杆菌毒素
HUE046449T2 (hu) * 2016-09-13 2020-03-30 Allergan Inc Stabilizált, nem fehérje eredetû, clostridiális toxin készítmények
KR101744900B1 (ko) * 2017-01-20 2017-06-08 주식회사 대웅 보툴리눔 독소를 포함하는 안정한 액상 조성물
KR20240160669A (ko) * 2017-03-24 2024-11-11 메르츠 파마 게엠베하 운트 코. 카가아 타액과다증의 치료에서의 보툴리늄 신경독소의 개선된 용도
EP3641746B1 (en) 2017-06-19 2024-11-20 President And Fellows Of Harvard College Methods and compositions for treating a microbial infection
KR102531760B1 (ko) * 2017-11-13 2023-05-10 한동희 다기능성 생체적합실
MX2020005785A (es) * 2017-12-04 2020-10-28 Revance Therapeutics Inc Formulaciones inyectables de toxina botulínica y métodos de uso de las mismas que tienen una alta tasa de respuesta y una larga duración del efecto.
US10918586B2 (en) * 2017-12-07 2021-02-16 Ps Therapy Ltd. Topical compositions and methods of use thereof
CN112955166A (zh) 2018-09-13 2021-06-11 阿勒根公司 治疗咬肌肥大的方法
US20200108129A1 (en) * 2018-09-13 2020-04-09 Allergan, Inc. Clostridial toxin - hyaluronic acid compositions
SG11202112275VA (en) 2019-05-23 2021-12-30 Bolt Threads Inc A composite material, and methods for production thereof
UY38744A (es) * 2019-06-07 2020-12-31 Nestle Skin Health S A Tratamiento de líneas glabelares y líneas cantales laterales de moderadas a muy graves
WO2021206360A1 (ko) * 2020-04-08 2021-10-14 (주)메디톡스 토출 속도 조절이 용이하고 안정한 보툴리눔 독소 사전충전된 주사기 제형
KR102404217B1 (ko) * 2020-04-08 2022-06-02 (주)메디톡스 토출 속도 조절이 용이하고 안정한 보툴리눔 독소 사전충전된 주사기 제형
IL298399A (en) * 2020-06-05 2023-01-01 Merz Pharma Gmbh & Co Kgaa Treatment of facial wrinkles with the botulinum toxin in high dose and low volume
CN115666405B (zh) * 2020-08-05 2025-10-28 松下知识产权经营株式会社 脑卒中检查系统、脑卒中检查方法、以及程序记录介质
KR102414997B1 (ko) * 2020-09-29 2022-06-29 주식회사 엘지생활건강 안정성이 개선된 재조합 보툴리눔 독소 경쇄 단백질 조성물
WO2023085849A1 (ko) 2021-11-15 2023-05-19 (주)메디톡스 보툴리눔 독소 조성물
CN116440281A (zh) * 2022-01-07 2023-07-18 重庆誉颜制药有限公司 一种肉毒毒素蛋白组合物
JP2025500698A (ja) * 2022-01-14 2025-01-09 ガルデルマ・ホールディング・エスアー 中等度から最重度の眉間皺及び外眼角皺の治療
JP2025530928A (ja) 2022-09-02 2025-09-18 メディトックス インク. 耐性発現が減少したボツリヌス毒素製剤及びそれに係わる方法
DE102025101336A1 (de) * 2024-01-19 2025-07-24 Abbvie Inc. Zusammensetzungen von clostridium botulinum neurotoxin serotyp a und verbesserte trocknungsprozesse

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437291A (en) 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
US6974578B1 (en) 1993-12-28 2005-12-13 Allergan, Inc. Method for treating secretions and glands using botulinum toxin
US5766605A (en) 1994-04-15 1998-06-16 Mount Sinai School Of Medicine Of The City University Of New York Treatment of autonomic nerve dysfunction with botulinum toxin
US5670484A (en) 1994-05-09 1997-09-23 Binder; William J. Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders
DE69526340T2 (de) * 1994-05-09 2002-11-14 William J. Binder Botulinumtoxin ZUR REDUKTION VON Migraine -KOPFSCHMERZEN
US6063768A (en) 1997-09-04 2000-05-16 First; Eric R. Application of botulinum toxin to the management of neurogenic inflammatory disorders
US6265379B1 (en) 1999-10-13 2001-07-24 Allergan Sales, Inc. Method for treating otic disorders
US6139845A (en) 1999-12-07 2000-10-31 Allergan Sales, Inc. Method for treating cancer with a neurotoxin
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US7780967B2 (en) * 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US6464986B1 (en) 2000-04-14 2002-10-15 Allegan Sales, Inc. Method for treating pain by peripheral administration of a neurotoxin
US6299893B1 (en) 2000-04-17 2001-10-09 Marvin Schwartz Method to reduce hair loss and stimulate hair regrowth
US20040033241A1 (en) * 2000-06-02 2004-02-19 Allergan, Inc. Controlled release botulinum toxin system
US6423319B1 (en) 2000-10-04 2002-07-23 Allergan Sales, Inc. Methods for treating muscle injuries
US7226605B2 (en) 2001-07-27 2007-06-05 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Botulinum toxin in the treatment or prevention of acne
MXPA01011542A (es) * 2001-11-13 2003-05-22 Alcon Inc Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel.
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US7459164B2 (en) 2002-05-28 2008-12-02 Botulinum Toxin Research Associates, Inc. Composition for therapeutic and cosmetic botulinum toxin
WO2003101483A1 (en) 2002-05-31 2003-12-11 Solux Corporation Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use
MXPA05006690A (es) * 2002-12-20 2006-02-17 Botulinum Toxin Res Ass Inc Composiciones farmaceuticas de toxina botulinica mejoradas.
US7396535B2 (en) * 2003-04-25 2008-07-08 Ackerman Alan H Therapy for obsessive compulsive head banging
DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
US7160699B2 (en) * 2003-09-25 2007-01-09 Allergan, Inc. Media for clostridium bacterium and processes for obtaining a clostridial toxin
US9078892B2 (en) * 2004-02-26 2015-07-14 Allergan, Inc. Methods for treating pain and for treating a medication overuse disorder
US20100266638A1 (en) * 2004-02-26 2010-10-21 Allergan, Inc. Headache treatment method
US20050191321A1 (en) * 2004-02-26 2005-09-01 Allergan, Inc. Methods for treating headache
GB2416122A (en) 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
BRPI0513850A (pt) * 2004-07-26 2008-05-20 Merz Pharma Gmbh & Co Kgaa composição terapêutica com uma neurotoxina botulìnica
EP2813239B1 (en) * 2004-08-04 2017-03-22 Ipsen Biopharm Limited Pharmaceutical composition containing botulinum neurotoxin A2
US20060073208A1 (en) * 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
CN1930186A (zh) * 2005-03-03 2007-03-14 阿勒根公司 为获得梭菌毒素的梭菌细菌培养基及方法
US20090214466A1 (en) * 2005-05-09 2009-08-27 Levin Bruce H Methods of Alleviating Disorders and Their Associated Pain
US8926991B2 (en) * 2005-06-14 2015-01-06 Botulinum Toxin Research Associates, Inc. Botulinum toxin and the treatment of primary disorders of mood and affect
US8323666B2 (en) * 2005-08-01 2012-12-04 Allergan, Inc. Botulinum toxin compositions
US7744904B1 (en) * 2005-09-26 2010-06-29 B.B. Scientific L.L.C. Stabilization of Clostridium botulinum neurotoxin complex
US8168206B1 (en) * 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
US8137677B2 (en) * 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
WO2007044809A2 (en) * 2005-10-11 2007-04-19 Botulinum Toxin Research Associates, Inc. Albumin-free botulinum toxin based pharmaceutical compositions containing a hyaluronidase and methods of use
US9061025B2 (en) * 2006-08-31 2015-06-23 Allergan, Inc. Methods for selecting headache patients responsive to botulinum toxin therapy
FR2910327B1 (fr) 2006-12-22 2013-04-26 Scras Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
CA2690773C (en) * 2007-07-10 2013-09-17 Medy-Tox, Inc. Pharmaceutical liquid composition of botulinum toxin with improved stability
US9044477B2 (en) * 2007-12-12 2015-06-02 Allergan, Inc. Botulinum toxin formulation
US9161970B2 (en) * 2007-12-12 2015-10-20 Allergan, Inc. Dermal filler
EP2072039A1 (en) * 2007-12-21 2009-06-24 Merz Pharma GmbH & Co.KGaA Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects
US9107815B2 (en) * 2008-02-22 2015-08-18 Allergan, Inc. Sustained release poloxamer containing pharmaceutical compositions
US8617571B2 (en) * 2008-04-03 2013-12-31 Allergan, Inc. Suture line administration technique using botulinum toxin
KR20090120222A (ko) * 2008-05-19 2009-11-24 (주)메디톡스 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법
US8535276B2 (en) * 2008-06-26 2013-09-17 Bellanovus Development Company Llc Syringe-attached topical anesthetic dispenser
WO2010096134A1 (en) * 2008-12-04 2010-08-26 Botulinum Toxin Research Associates, Inc. Extended length botulinum toxin formulation for human or mammalian use
KR20160103551A (ko) 2008-12-10 2016-09-01 알러간, 인코포레이티드 클로스트리디움 독소 약제학적 조성물
HRP20180739T1 (hr) * 2008-12-31 2018-06-29 Revance Therapeutics, Inc. Injekcijske formulacije botulinskog toksina
ES2538835T3 (es) 2009-01-07 2015-06-24 Robert John Petrella Tratamiento de lesiones de tejidos blandos utilizando el ácido hialurónico y la toxina botulínica
EP2248518B1 (en) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
WO2010136594A2 (en) 2009-05-29 2010-12-02 Symatese Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection
CA2766521C (en) * 2009-06-25 2020-07-21 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
KR101736775B1 (ko) * 2009-06-30 2017-05-18 (주)아모레퍼시픽 복분자 추출물을 함유하는 피부 주름 개선용 화장료 조성물
US8129139B2 (en) * 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
JP5951490B2 (ja) 2009-10-21 2016-07-13 ルバンス セラピュティックス インク.Revance Therapeutics,Inc. 非複合ボツリヌス神経毒素を精製するための方法およびシステム
MX2012005115A (es) * 2009-10-30 2012-06-19 Revance Therapeutics Inc Dispositivo y metodo para la aplicacion topica de composiciones terapeuticas o cosmeticas.
WO2011075623A1 (en) * 2009-12-18 2011-06-23 Latitude Pharmaceuticals, Inc. One - phase gel compos ition compri s ing phos pholi pids
US8940308B2 (en) * 2010-03-30 2015-01-27 Allergan, Inc. Methods for treating depression
EP2627318B1 (en) * 2010-10-12 2017-08-16 Merz Pharma GmbH & Co. KGaA Formulation suitable for stabilizing proteins, which is free of mammalian excipients
BR112013025256B1 (pt) * 2011-03-31 2022-01-18 Medy-Tox Inc Preparação liofilizada farmacêutica
KR20130022923A (ko) * 2011-08-26 2013-03-07 삼성전자주식회사 가상 시점 합성 예측을 이용한 부호화/복호화 장치 및 부호화/복호화 방법
BR112014016195A2 (pt) * 2011-12-30 2020-10-27 Halozyme, Inc. variantes de polipeptídio ph20, formulações e usos das mesmas
DE18200782T1 (de) * 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9480731B2 (en) 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
CN106104240B (zh) 2014-03-18 2020-02-07 日立金属株式会社 导电性树脂组合物以及压力传感器
US9579502B2 (en) * 2014-04-19 2017-02-28 Medtronic, Inc. Implantable medical leads, systems, and related methods for creating a high impedance within a conduction path in the presence of a magnetic field of a given strength
CN108136038A (zh) * 2015-11-25 2018-06-08 乐高化学生物科学股份有限公司 包含肽基团的缀合物及其相关方法
EP4026532B1 (en) 2016-05-27 2025-11-26 Ipsen Biopharm Limited Liquid neurotoxin formulation stabilized with tryptophan or tyrosine
WO2018038301A1 (en) 2016-08-26 2018-03-01 Hugel Inc. Stabilized liquid formulation of botulinum toxin and preparation method thereof
KR102463881B1 (ko) * 2016-10-04 2022-11-07 (주)메디톡스 보툴리눔 독소 함유 용액으로부터 보툴리눔 독소를 분리하는 방법
KR102088104B1 (ko) * 2018-06-29 2020-03-11 호서대학교 산학협력단 개망초 꽃 에센셜 오일을 포함하는 신경 근육 관련 질환 예방 및 치료용 조성물
US20200108129A1 (en) * 2018-09-13 2020-04-09 Allergan, Inc. Clostridial toxin - hyaluronic acid compositions
KR101968873B1 (ko) * 2018-09-21 2019-04-29 아이큐어 주식회사 세포 침투 효과가 우수한 보툴리늄 유래 펩타이드를 포함하는 화장료 조성물
UY38744A (es) 2019-06-07 2020-12-31 Nestle Skin Health S A Tratamiento de líneas glabelares y líneas cantales laterales de moderadas a muy graves

Similar Documents

Publication Publication Date Title
JP2016540785A5 (enExample)
JP2018531984A5 (enExample)
JP2014505733A5 (enExample)
RU2018110647A (ru) Арильные, гетероарильные и гетероциклические соединения для лечения заболеваний
JP2018111728A5 (enExample)
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
RU2017116973A (ru) Способы применения и композиции нейрегулинов для предотвращения, лечения или замедления сердечной недостаточности с сохраненной фракцией выброса
WO2015085143A3 (en) Therapeutic agents for skin diseases and conditions
RU2013141845A (ru) Фармацевтическая композиция в виде крема, содержащая оксиметазолин, для лечения симптомов розацеа
JP2020530857A5 (enExample)
WO2017022962A8 (ko) Ripk 억제제를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물
RU2018124487A (ru) Лечение внутрипеченочного холестаза и родственных заболеваний печени
IL307992A (en) Parasitic formulations containing isoxazoline and methods for treating blepharitis
CA2986891C (en) Compositions for use in treating parkinson's disease and related disorders
JP2018529666A5 (enExample)
EA202091446A1 (ru) Способы лечения хронических воспалительных заболеваний
RU2017145271A (ru) Терапевтическое средство для фиброза
RU2019132648A (ru) Применение ботулинических нейротоксинов в лечении
JP2017523974A5 (enExample)
JP2014520892A5 (enExample)
JP2016521754A5 (enExample)
CL2020001426A1 (es) Composición tópica oftálmica que comprende ácido dobesilico para tratar enfermedades del segmento posterior del ojo.
JP2013520447A5 (enExample)
EA201690903A1 (ru) Лечение глаукомы с использованием лаквинимода
WO2019004788A3 (ko) 브라우쏘칼콘 a를 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 약학 조성물