JP2005537234A5 - - Google Patents
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- Publication number
- JP2005537234A5 JP2005537234A5 JP2004508829A JP2004508829A JP2005537234A5 JP 2005537234 A5 JP2005537234 A5 JP 2005537234A5 JP 2004508829 A JP2004508829 A JP 2004508829A JP 2004508829 A JP2004508829 A JP 2004508829A JP 2005537234 A5 JP2005537234 A5 JP 2005537234A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorotoxin
- temozolomide
- derivative
- therapeutic agent
- cancer therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QPAKKWCQMHUHNI-GQIQPHNSSA-N chlorotoxin Chemical compound C([C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]4CSSC[C@@H](C(N[C@@H](CCSC)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC4=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)=O)NC(=O)[C@@H](N)CCSC)C1=CC=C(O)C=C1 QPAKKWCQMHUHNI-GQIQPHNSSA-N 0.000 claims 7
- 101710164760 Chlorotoxin Proteins 0.000 claims 3
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 3
- 239000012830 cancer therapeutic Substances 0.000 claims 3
- 229960005534 chlorotoxin Drugs 0.000 claims 3
- 229960004964 temozolomide Drugs 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38417102P | 2002-05-31 | 2002-05-31 | |
| US40603302P | 2002-08-27 | 2002-08-27 | |
| PCT/US2003/017410 WO2003101474A1 (en) | 2002-05-31 | 2003-06-02 | Combination chemotherapy with chlorotoxin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011052039A Division JP5856744B2 (ja) | 2002-05-31 | 2011-03-09 | クロロトキシンとの併用化学療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005537234A JP2005537234A (ja) | 2005-12-08 |
| JP2005537234A5 true JP2005537234A5 (enExample) | 2010-02-04 |
Family
ID=29715313
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508829A Pending JP2005537234A (ja) | 2002-05-31 | 2003-06-02 | クロロトキシンとの併用化学療法 |
| JP2011052039A Expired - Lifetime JP5856744B2 (ja) | 2002-05-31 | 2011-03-09 | クロロトキシンとの併用化学療法 |
| JP2015134259A Pending JP2015214562A (ja) | 2002-05-31 | 2015-07-03 | クロロトキシンとの併用化学療法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011052039A Expired - Lifetime JP5856744B2 (ja) | 2002-05-31 | 2011-03-09 | クロロトキシンとの併用化学療法 |
| JP2015134259A Pending JP2015214562A (ja) | 2002-05-31 | 2015-07-03 | クロロトキシンとの併用化学療法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060166892A1 (enExample) |
| EP (4) | EP2431385A3 (enExample) |
| JP (3) | JP2005537234A (enExample) |
| AT (1) | ATE458751T1 (enExample) |
| AU (2) | AU2003240496B2 (enExample) |
| CA (2) | CA2487425A1 (enExample) |
| DE (1) | DE60331458D1 (enExample) |
| ES (1) | ES2341767T3 (enExample) |
| MX (1) | MXPA04011871A (enExample) |
| WO (2) | WO2003101474A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060088899A1 (en) * | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
| WO2005099774A2 (en) * | 2004-04-06 | 2005-10-27 | Transmolecular, Inc. | Diagnosis and treatment of myeloid and lymphoid cell cancers |
| US20070275902A1 (en) * | 2003-11-26 | 2007-11-29 | Transmolecular, Inc. | Treatment of Phosphatidylinositol Phospholipid Disorders |
| EP1877428B1 (en) * | 2005-04-22 | 2011-03-16 | University of Washington | Cyanine- chlorotoxin conjugate and method for intra-operative visualization of cancer |
| US20070237714A1 (en) * | 2006-03-31 | 2007-10-11 | Alvarez Vernon L | Diagnosis and treatment of tumors |
| WO2007137163A2 (en) * | 2006-05-19 | 2007-11-29 | Georgia Tech Research Corporation | Abc transporter ligand |
| CN100590130C (zh) * | 2007-07-31 | 2010-02-17 | 厦门北大之路生物工程有限公司 | 抗癌活性肽 |
| WO2009021136A1 (en) * | 2007-08-07 | 2009-02-12 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
| CN101918041A (zh) * | 2007-10-12 | 2010-12-15 | 超分子有限公司 | 用于肿瘤诊断和治疗的氯毒素剂的系统性给药 |
| CN102438646A (zh) * | 2008-05-15 | 2012-05-02 | 特兰斯莫莱库拉公司 | 转移性肿瘤的治疗 |
| BRPI0912683A2 (pt) | 2008-05-15 | 2016-01-26 | Transmolecular Inc | tratamento de tumores metastáticos |
| WO2010086964A1 (ja) * | 2009-01-28 | 2010-08-05 | 株式会社 静岡カフェイン工業所 | がん治療のための併用療法 |
| HRP20171291T1 (hr) | 2010-02-04 | 2017-10-20 | Morphotek, Inc. | Polipeptidi i konjugati klorotoksina i njihove uporabe |
| EP3165533B1 (en) * | 2010-05-11 | 2020-04-08 | Fred Hutchinson Cancer Research Center | Chlorotoxin variants, conjugates and methods for their use |
| CU24055B1 (es) * | 2010-09-27 | 2014-12-26 | Grupo Empresarial De Producciones Biofarmacéuticas Y Químicas Labiofam | Composiciones farmacéuticas de veneno de escorpión rhopalurus junceus |
| GB201106004D0 (en) | 2011-04-08 | 2011-05-25 | Univ Edinburgh | Optical imaging probes |
| WO2013003507A1 (en) | 2011-06-27 | 2013-01-03 | Morphotek, Inc. | Multifunctional agents |
| AU2013249307B2 (en) | 2012-04-17 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for non-invasive imaging |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| CA2913029A1 (en) | 2012-12-10 | 2014-06-19 | Fred Hutchinson Cancer Research Center | Lipocalin fusion partners |
| JP2016523818A (ja) * | 2013-04-18 | 2016-08-12 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | それを必要とする被験体におけるｔ細胞増殖を阻害するための方法及び医薬組成物（ｃｔｐｓ１阻害剤、例えばノルロイシン） |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| WO2015061592A1 (en) * | 2013-10-23 | 2015-04-30 | Merrimack Pharmaceuticals, Inc. | Liposomes for non-invasive imaging and drug delivery |
| US9522114B1 (en) * | 2014-03-27 | 2016-12-20 | University Of South Florida | Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| ES2848118T3 (es) | 2015-08-20 | 2021-08-05 | Ipsen Biopharm Ltd | Terapia de combinación que usa irinotecán liposomal y un inhibidor de PARP para el tratamiento del cáncer |
| KR102714060B1 (ko) | 2015-08-21 | 2024-10-08 | 입센 바이오팜 리미티드 | 리포솜 이리노테칸 및 옥살리플라틴을 포함하는 병용 치료를 이용하여 전이성 췌장암을 치료하는 방법 |
| US10745478B2 (en) * | 2016-02-19 | 2020-08-18 | Dignity Health | Antibody fusion protein and related compositions for targeting cancer |
| AU2017250359B2 (en) | 2016-04-15 | 2022-06-16 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| KR101678393B1 (ko) | 2016-08-25 | 2016-12-06 | (주)넥스젠바이오텍 | 피부 세포 증식 효과가 증가한 전갈독 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선, 피부 탄력 증대 및 항노화 화장료 조성물 |
| BR112019007844A2 (pt) | 2016-11-02 | 2019-07-16 | Ipsen Biopharm Ltd | tratamento de câncer gástrico usando terapias de combinação compreendendo irinotecano lipossômico, oxaliplatina, 5-fluoroacila (e leucovorina) |
| EP3681540A4 (en) | 2017-09-15 | 2021-05-19 | Eisai, Inc. | CHLOROTOXIN AGENT AND USES THEREOF |
| CA3086040A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE135373T1 (de) * | 1989-09-08 | 1996-03-15 | Univ Johns Hopkins | Modifikationen der struktur des egf-rezeptor-gens in menschlichen glioma |
| US5223253A (en) * | 1989-09-28 | 1993-06-29 | American Home Products Corporation | Bovine vaccine compositions and method for preventing trichomonas infections using same |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| RU2148401C1 (ru) * | 1993-01-13 | 2000-05-10 | Канзер Рисерч Кампейн Технолоджи, Лтд. | Фармацевтическая композиция с антиопухолевой активностью и способ ее получения |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5756340A (en) * | 1995-05-08 | 1998-05-26 | The Regents Of The University Of California | Insect control with multiple toxins |
| JP3809502B2 (ja) * | 1995-05-30 | 2006-08-16 | 二郎 有川 | ハンタウィルス抗原蛋白質およびモノクローナル抗体 |
| JPH0971599A (ja) * | 1995-09-06 | 1997-03-18 | Nippon Seibutsu Kagaku Kenkyusho | 鶏貧血ウイルス（ｃａｖ）感染鶏血清と高い反応性を示すポリペプチド及びこのポリペプチドに対する抗体、鶏貧血ウイルス感染の診断法及びワクチン |
| US5905027A (en) * | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
| US6667156B2 (en) * | 1995-12-27 | 2003-12-23 | Uab Research Foundation | Diagnosis and treatment of neuroectodermal tumors |
| EP1055684A4 (en) * | 1997-12-05 | 2002-12-04 | Kyogo Itoh | TUMORANTIGENS IN THE FORM OF PEPTIDE DERIVATIVES |
-
2003
- 2003-06-02 MX MXPA04011871A patent/MXPA04011871A/es active IP Right Grant
- 2003-06-02 EP EP10178613A patent/EP2431385A3/en not_active Withdrawn
- 2003-06-02 AU AU2003240496A patent/AU2003240496B2/en not_active Expired
- 2003-06-02 WO PCT/US2003/017410 patent/WO2003101474A1/en not_active Ceased
- 2003-06-02 WO PCT/US2003/017411 patent/WO2003101475A1/en not_active Ceased
- 2003-06-02 DE DE60331458T patent/DE60331458D1/de not_active Expired - Lifetime
- 2003-06-02 AT AT03731504T patent/ATE458751T1/de not_active IP Right Cessation
- 2003-06-02 JP JP2004508829A patent/JP2005537234A/ja active Pending
- 2003-06-02 EP EP09176234A patent/EP2182004A1/en not_active Withdrawn
- 2003-06-02 EP EP03731504A patent/EP1553962B1/en not_active Expired - Lifetime
- 2003-06-02 CA CA002487425A patent/CA2487425A1/en not_active Abandoned
- 2003-06-02 ES ES03731504T patent/ES2341767T3/es not_active Expired - Lifetime
- 2003-06-02 CA CA002494451A patent/CA2494451A1/en not_active Abandoned
- 2003-06-02 US US10/522,810 patent/US20060166892A1/en not_active Abandoned
- 2003-06-02 EP EP03736810A patent/EP1539207A4/en not_active Withdrawn
- 2003-06-02 AU AU2003237347A patent/AU2003237347B2/en not_active Ceased
-
2011
- 2011-03-09 JP JP2011052039A patent/JP5856744B2/ja not_active Expired - Lifetime
-
2015
- 2015-07-03 JP JP2015134259A patent/JP2015214562A/ja active Pending
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