ATE458751T1 - Kombinationschemotherapie mit chlorotoxin - Google Patents
Kombinationschemotherapie mit chlorotoxinInfo
- Publication number
- ATE458751T1 ATE458751T1 AT03731504T AT03731504T ATE458751T1 AT E458751 T1 ATE458751 T1 AT E458751T1 AT 03731504 T AT03731504 T AT 03731504T AT 03731504 T AT03731504 T AT 03731504T AT E458751 T1 ATE458751 T1 AT E458751T1
- Authority
- AT
- Austria
- Prior art keywords
- chlorotoxin
- combination chemotherapy
- combination
- derivative
- chemotherapy
- Prior art date
Links
- 101710164760 Chlorotoxin Proteins 0.000 title abstract 2
- QPAKKWCQMHUHNI-GQIQPHNSSA-N chlorotoxin Chemical compound C([C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]4CSSC[C@@H](C(N[C@@H](CCSC)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC4=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)=O)NC(=O)[C@@H](N)CCSC)C1=CC=C(O)C=C1 QPAKKWCQMHUHNI-GQIQPHNSSA-N 0.000 title abstract 2
- 229960005534 chlorotoxin Drugs 0.000 title abstract 2
- 238000009096 combination chemotherapy Methods 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38417102P | 2002-05-31 | 2002-05-31 | |
| US40603302P | 2002-08-27 | 2002-08-27 | |
| PCT/US2003/017410 WO2003101474A1 (en) | 2002-05-31 | 2003-06-02 | Combination chemotherapy with chlorotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE458751T1 true ATE458751T1 (de) | 2010-03-15 |
Family
ID=29715313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03731504T ATE458751T1 (de) | 2002-05-31 | 2003-06-02 | Kombinationschemotherapie mit chlorotoxin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060166892A1 (de) |
| EP (4) | EP1553962B1 (de) |
| JP (3) | JP2005537234A (de) |
| AT (1) | ATE458751T1 (de) |
| AU (2) | AU2003237347B2 (de) |
| CA (2) | CA2487425A1 (de) |
| DE (1) | DE60331458D1 (de) |
| ES (1) | ES2341767T3 (de) |
| MX (1) | MXPA04011871A (de) |
| WO (2) | WO2003101474A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060088899A1 (en) * | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
| WO2005053611A2 (en) * | 2003-11-26 | 2005-06-16 | Transmolecular, Inc. | Treatment of phosphatidylinositol phospholipid disorders |
| DE602005019728D1 (de) * | 2004-04-06 | 2010-04-15 | Transmolecular Inc | Diagnose und behandlung von myeloid- und lymphoidzellenkrebs mit chlorotoxin oder derivat |
| ATE502048T1 (de) | 2005-04-22 | 2011-04-15 | Univ Washington | Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs |
| EP2147927A3 (de) * | 2006-03-31 | 2010-09-01 | Transmolecular, Inc. | Verwendung von 131I-TM-601 für die Diagnose und Behandlung von Gliomas |
| EP2029157A4 (de) * | 2006-05-19 | 2009-11-18 | Georgia Tech Res Inst | Abc-transporterligand |
| CN100590130C (zh) * | 2007-07-31 | 2010-02-17 | 厦门北大之路生物工程有限公司 | 抗癌活性肽 |
| CA2696303A1 (en) * | 2007-08-07 | 2009-02-12 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
| EP2211913A4 (de) * | 2007-10-12 | 2010-12-22 | Transmolecular Inc | Systemische verabreichung von chlorotoxin-mitteln zur diagnose und behandlung von tumoren |
| CN102438646A (zh) * | 2008-05-15 | 2012-05-02 | 特兰斯莫莱库拉公司 | 转移性肿瘤的治疗 |
| US8227439B2 (en) * | 2008-05-15 | 2012-07-24 | Morphotek, Inc. | Treatment of metastatic tumors |
| WO2010086964A1 (ja) * | 2009-01-28 | 2010-08-05 | 株式会社 静岡カフェイン工業所 | がん治療のための併用療法 |
| JP5858932B2 (ja) | 2010-02-04 | 2016-02-10 | モルフォテック， インコーポレイテッド | クロロトキシンポリペプチドおよびコンジュゲートならびにその使用 |
| JP2013532126A (ja) * | 2010-05-11 | 2013-08-15 | フレッド ハッチンソン キャンサー リサーチ センター | クロロトキシン変異体、コンジュゲート、およびそれらを使用する方法 |
| CU24055B1 (es) * | 2010-09-27 | 2014-12-26 | Grupo Empresarial De Producciones Biofarmacéuticas Y Químicas Labiofam | Composiciones farmacéuticas de veneno de escorpión rhopalurus junceus |
| GB201106004D0 (en) | 2011-04-08 | 2011-05-25 | Univ Edinburgh | Optical imaging probes |
| WO2013003507A1 (en) | 2011-06-27 | 2013-01-03 | Morphotek, Inc. | Multifunctional agents |
| AU2013249307B2 (en) | 2012-04-17 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for non-invasive imaging |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| CN105008393A (zh) | 2012-12-10 | 2015-10-28 | 弗莱德哈钦森癌症研究中心 | 用于筛选的方法 |
| CN105473136A (zh) * | 2013-04-18 | 2016-04-06 | 国家健康与医学研究院 | 用于在有此需要的受试者中抑制淋巴细胞增殖的方法和药物组合物 |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| WO2015061592A1 (en) * | 2013-10-23 | 2015-04-30 | Merrimack Pharmaceuticals, Inc. | Liposomes for non-invasive imaging and drug delivery |
| US9522114B1 (en) * | 2014-03-27 | 2016-12-20 | University Of South Florida | Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| EP3337467B1 (de) | 2015-08-20 | 2020-12-09 | Ipsen Biopharm Ltd. | Kombinationstherapie unter verwendung von liposomalem irinotecan und einem parp-hemmer zur behandlung von krebs |
| MX385425B (es) | 2015-08-21 | 2025-03-18 | Ipsen Biopharm Ltd | Irinotecán liposomal y oxaliplatino, 5-fluoroacilo y leucovorina para usarse en el tratamiento de cáncer pancreático metastásico. |
| WO2017143259A1 (en) * | 2016-02-19 | 2017-08-24 | Dignity Health | Antibody fusion protein and related compositions for targeting cancer |
| WO2017181149A1 (en) | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| KR101678393B1 (ko) * | 2016-08-25 | 2016-12-06 | (주)넥스젠바이오텍 | 피부 세포 증식 효과가 증가한 전갈독 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선, 피부 탄력 증대 및 항노화 화장료 조성물 |
| EP3535026A1 (de) | 2016-11-02 | 2019-09-11 | Ipsen Biopharm Limited | Behandlung von magenkrebs durch kombinationstherapien mit liposomalem irinotecan, oxaliplatin, 5-fluoruracil (und leucovorin) |
| EP3681540A4 (de) | 2017-09-15 | 2021-05-19 | Eisai, Inc. | Chlortoxinmittel und verwendungen davon |
| EP3727146A4 (de) | 2017-12-19 | 2021-10-06 | Blaze Bioscience, Inc. | Tumor-homing und zelldurchdringende peptid-immuno-onkologie-agent-komplexe und verfahren zu deren verwendung |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0491007B1 (de) * | 1989-09-08 | 1996-03-13 | The Johns Hopkins University | Modifikationen der struktur des egf-rezeptor-gens in menschlichen glioma |
| US5223253A (en) * | 1989-09-28 | 1993-06-29 | American Home Products Corporation | Bovine vaccine compositions and method for preventing trichomonas infections using same |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| UA29466C2 (uk) * | 1993-01-14 | 2000-11-15 | Канзер Рісерч Кампейн Технолоджі, Лтд | Фармацевтична композиція з антипухлинною активністю |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5756340A (en) * | 1995-05-08 | 1998-05-26 | The Regents Of The University Of California | Insect control with multiple toxins |
| JP3809502B2 (ja) * | 1995-05-30 | 2006-08-16 | 二郎 有川 | ハンタウィルス抗原蛋白質およびモノクローナル抗体 |
| JPH0971599A (ja) * | 1995-09-06 | 1997-03-18 | Nippon Seibutsu Kagaku Kenkyusho | 鶏貧血ウイルス（ｃａｖ）感染鶏血清と高い反応性を示すポリペプチド及びこのポリペプチドに対する抗体、鶏貧血ウイルス感染の診断法及びワクチン |
| US6667156B2 (en) * | 1995-12-27 | 2003-12-23 | Uab Research Foundation | Diagnosis and treatment of neuroectodermal tumors |
| US5905027A (en) * | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
| AU748250B2 (en) * | 1997-12-05 | 2002-05-30 | Kyogo Itoh | Tumor antigen peptide derivatives |
-
2003
- 2003-06-02 WO PCT/US2003/017410 patent/WO2003101474A1/en not_active Ceased
- 2003-06-02 AT AT03731504T patent/ATE458751T1/de not_active IP Right Cessation
- 2003-06-02 EP EP03731504A patent/EP1553962B1/de not_active Expired - Lifetime
- 2003-06-02 US US10/522,810 patent/US20060166892A1/en not_active Abandoned
- 2003-06-02 WO PCT/US2003/017411 patent/WO2003101475A1/en not_active Ceased
- 2003-06-02 ES ES03731504T patent/ES2341767T3/es not_active Expired - Lifetime
- 2003-06-02 EP EP10178613A patent/EP2431385A3/de not_active Withdrawn
- 2003-06-02 CA CA002487425A patent/CA2487425A1/en not_active Abandoned
- 2003-06-02 AU AU2003237347A patent/AU2003237347B2/en not_active Ceased
- 2003-06-02 EP EP03736810A patent/EP1539207A4/de not_active Withdrawn
- 2003-06-02 CA CA002494451A patent/CA2494451A1/en not_active Abandoned
- 2003-06-02 JP JP2004508829A patent/JP2005537234A/ja active Pending
- 2003-06-02 EP EP09176234A patent/EP2182004A1/de not_active Withdrawn
- 2003-06-02 AU AU2003240496A patent/AU2003240496B2/en not_active Expired
- 2003-06-02 MX MXPA04011871A patent/MXPA04011871A/es active IP Right Grant
- 2003-06-02 DE DE60331458T patent/DE60331458D1/de not_active Expired - Lifetime
-
2011
- 2011-03-09 JP JP2011052039A patent/JP5856744B2/ja not_active Expired - Lifetime
-
2015
- 2015-07-03 JP JP2015134259A patent/JP2015214562A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2431385A3 (de) | 2012-07-04 |
| JP2011153149A (ja) | 2011-08-11 |
| AU2003237347B2 (en) | 2009-07-23 |
| CA2494451A1 (en) | 2003-12-11 |
| EP2431385A2 (de) | 2012-03-21 |
| JP2005537234A (ja) | 2005-12-08 |
| EP1553962A4 (de) | 2008-01-02 |
| CA2487425A1 (en) | 2003-12-11 |
| WO2003101475A1 (en) | 2003-12-11 |
| AU2003240496A1 (en) | 2003-12-19 |
| ES2341767T3 (es) | 2010-06-28 |
| EP1539207A1 (de) | 2005-06-15 |
| US20060166892A1 (en) | 2006-07-27 |
| AU2003240496B2 (en) | 2008-01-10 |
| DE60331458D1 (de) | 2010-04-08 |
| EP1553962B1 (de) | 2010-02-24 |
| AU2003237347A1 (en) | 2003-12-19 |
| JP5856744B2 (ja) | 2016-02-10 |
| EP1539207A4 (de) | 2008-01-02 |
| EP1553962A1 (de) | 2005-07-20 |
| MXPA04011871A (es) | 2005-07-26 |
| EP2182004A1 (de) | 2010-05-05 |
| JP2015214562A (ja) | 2015-12-03 |
| WO2003101474A1 (en) | 2003-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |