ATE458751T1 - Kombinationschemotherapie mit chlorotoxin - Google Patents
Kombinationschemotherapie mit chlorotoxinInfo
- Publication number
- ATE458751T1 ATE458751T1 AT03731504T AT03731504T ATE458751T1 AT E458751 T1 ATE458751 T1 AT E458751T1 AT 03731504 T AT03731504 T AT 03731504T AT 03731504 T AT03731504 T AT 03731504T AT E458751 T1 ATE458751 T1 AT E458751T1
- Authority
- AT
- Austria
- Prior art keywords
- chlorotoxin
- combination chemotherapy
- combination
- derivative
- chemotherapy
- Prior art date
Links
- 101710164760 Chlorotoxin Proteins 0.000 title abstract 2
- QPAKKWCQMHUHNI-GQIQPHNSSA-N chlorotoxin Chemical compound C([C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]4CSSC[C@@H](C(N[C@@H](CCSC)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC4=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)=O)NC(=O)[C@@H](N)CCSC)C1=CC=C(O)C=C1 QPAKKWCQMHUHNI-GQIQPHNSSA-N 0.000 title abstract 2
- 229960005534 chlorotoxin Drugs 0.000 title abstract 2
- 238000009096 combination chemotherapy Methods 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Insects & Arthropods (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38417102P | 2002-05-31 | 2002-05-31 | |
| US40603302P | 2002-08-27 | 2002-08-27 | |
| PCT/US2003/017410 WO2003101474A1 (en) | 2002-05-31 | 2003-06-02 | Combination chemotherapy with chlorotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE458751T1 true ATE458751T1 (de) | 2010-03-15 |
Family
ID=29715313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03731504T ATE458751T1 (de) | 2002-05-31 | 2003-06-02 | Kombinationschemotherapie mit chlorotoxin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060166892A1 (de) |
| EP (4) | EP2431385A3 (de) |
| JP (3) | JP2005537234A (de) |
| AT (1) | ATE458751T1 (de) |
| AU (2) | AU2003240496B2 (de) |
| CA (2) | CA2487425A1 (de) |
| DE (1) | DE60331458D1 (de) |
| ES (1) | ES2341767T3 (de) |
| MX (1) | MXPA04011871A (de) |
| WO (2) | WO2003101475A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060088899A1 (en) * | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
| US20070275902A1 (en) * | 2003-11-26 | 2007-11-29 | Transmolecular, Inc. | Treatment of Phosphatidylinositol Phospholipid Disorders |
| ATE459642T1 (de) * | 2004-04-06 | 2010-03-15 | Transmolecular Inc | Diagnose und behandlung von myeloid- und lymphoidzellenkrebs mit chlorotoxin oder derivat |
| DE602006020710D1 (de) * | 2005-04-22 | 2011-04-28 | Fred Hutchinson Cancer Res Foundation | Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs |
| EP2013233A2 (de) * | 2006-03-31 | 2009-01-14 | Transmolecular, Inc. | Verwendung von tm-601 für die diagnose und behandlung von tumoren |
| EP2029157A4 (de) * | 2006-05-19 | 2009-11-18 | Georgia Tech Res Inst | Abc-transporterligand |
| CN100590130C (zh) * | 2007-07-31 | 2010-02-17 | 厦门北大之路生物工程有限公司 | 抗癌活性肽 |
| US20110091380A1 (en) * | 2007-08-07 | 2011-04-21 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
| AU2008310664A1 (en) * | 2007-10-12 | 2009-04-16 | Transmolecular, Inc. | Systemic administration of chlorotoxin agents for the diagnosis and treatment of tumors |
| CA2724384A1 (en) * | 2008-05-15 | 2009-11-19 | Transmolecular, Inc. | Treatment of metastatic tumors |
| CN102438646A (zh) * | 2008-05-15 | 2012-05-02 | 特兰斯莫莱库拉公司 | 转移性肿瘤的治疗 |
| WO2010086964A1 (ja) * | 2009-01-28 | 2010-08-05 | 株式会社 静岡カフェイン工業所 | がん治療のための併用療法 |
| HRP20171291T1 (hr) * | 2010-02-04 | 2017-10-20 | Morphotek, Inc. | Polipeptidi i konjugati klorotoksina i njihove uporabe |
| CN103097403B (zh) * | 2010-05-11 | 2017-04-19 | 弗雷德哈钦森癌症研究中心 | 氯毒素变体、缀合物及其使用方法 |
| CU24055B1 (es) * | 2010-09-27 | 2014-12-26 | Grupo Empresarial De Producciones Biofarmacéuticas Y Químicas Labiofam | Composiciones farmacéuticas de veneno de escorpión rhopalurus junceus |
| GB201106004D0 (en) | 2011-04-08 | 2011-05-25 | Univ Edinburgh | Optical imaging probes |
| WO2013003507A1 (en) | 2011-06-27 | 2013-01-03 | Morphotek, Inc. | Multifunctional agents |
| AU2013249307B2 (en) | 2012-04-17 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for non-invasive imaging |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| CA2913127A1 (en) | 2012-12-10 | 2014-06-19 | Fred Hutchinson Cancer Research Center | Methods for screening |
| US20160051674A1 (en) * | 2013-04-18 | 2016-02-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions (ctps 1 inhibitors, e.g. norleucine) for inhibiting t cell proliferation in a subject in need thereof |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| WO2015061592A1 (en) * | 2013-10-23 | 2015-04-30 | Merrimack Pharmaceuticals, Inc. | Liposomes for non-invasive imaging and drug delivery |
| US9522114B1 (en) * | 2014-03-27 | 2016-12-20 | University Of South Florida | Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| PL3337467T3 (pl) | 2015-08-20 | 2021-06-14 | Ipsen Biopharm Ltd. | Terapia skojarzona z zastosowaniem liposomalnego irynotekanu i inhibitora parp do leczenia nowotworu |
| PL3337478T5 (pl) | 2015-08-21 | 2026-05-04 | Ipsen Biopharm Ltd. | Kombinacja leków obejmująca liposomalny irynotekan, oksaliplatynę, 5-fluorouracyl i leukoworynę do leczenia nowotworu trzustki z przerzutami |
| US10745478B2 (en) * | 2016-02-19 | 2020-08-18 | Dignity Health | Antibody fusion protein and related compositions for targeting cancer |
| CA3021011A1 (en) | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| KR101678393B1 (ko) | 2016-08-25 | 2016-12-06 | (주)넥스젠바이오텍 | 피부 세포 증식 효과가 증가한 전갈독 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선, 피부 탄력 증대 및 항노화 화장료 조성물 |
| EP3535026A1 (de) | 2016-11-02 | 2019-09-11 | Ipsen Biopharm Limited | Behandlung von magenkrebs durch kombinationstherapien mit liposomalem irinotecan, oxaliplatin, 5-fluoruracil (und leucovorin) |
| CN111542345B (zh) | 2017-09-15 | 2025-02-25 | 卫材公司 | 氯毒素剂及其用途 |
| CA3086040A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2066428C (en) * | 1989-09-08 | 2000-11-28 | Bert Vogelstein | Structural alterations of the egf receptor gene in human gliomas |
| US5223253A (en) * | 1989-09-28 | 1993-06-29 | American Home Products Corporation | Bovine vaccine compositions and method for preventing trichomonas infections using same |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| CZ286550B6 (cs) * | 1993-01-14 | 2000-05-17 | Cancer Research Campaign Technology Ltd. | Kombinovaný farmaceutický prostředek pro léčbu lidských nádorových buněk, použití inhibitoru ATasy a temozolomidu pro jeho přípravu a souprava |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5756340A (en) * | 1995-05-08 | 1998-05-26 | The Regents Of The University Of California | Insect control with multiple toxins |
| JP3809502B2 (ja) * | 1995-05-30 | 2006-08-16 | 二郎 有川 | ハンタウィルス抗原蛋白質およびモノクローナル抗体 |
| JPH0971599A (ja) * | 1995-09-06 | 1997-03-18 | Nippon Seibutsu Kagaku Kenkyusho | 鶏貧血ウイルス（ｃａｖ）感染鶏血清と高い反応性を示すポリペプチド及びこのポリペプチドに対する抗体、鶏貧血ウイルス感染の診断法及びワクチン |
| US6667156B2 (en) * | 1995-12-27 | 2003-12-23 | Uab Research Foundation | Diagnosis and treatment of neuroectodermal tumors |
| US5905027A (en) * | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
| CN1284083A (zh) * | 1997-12-05 | 2001-02-14 | 伊东恭悟 | 肿瘤抗原肽衍生物 |
-
2003
- 2003-06-02 JP JP2004508829A patent/JP2005537234A/ja active Pending
- 2003-06-02 AU AU2003240496A patent/AU2003240496B2/en not_active Expired
- 2003-06-02 DE DE60331458T patent/DE60331458D1/de not_active Expired - Lifetime
- 2003-06-02 ES ES03731504T patent/ES2341767T3/es not_active Expired - Lifetime
- 2003-06-02 AT AT03731504T patent/ATE458751T1/de not_active IP Right Cessation
- 2003-06-02 WO PCT/US2003/017411 patent/WO2003101475A1/en not_active Ceased
- 2003-06-02 EP EP10178613A patent/EP2431385A3/de not_active Withdrawn
- 2003-06-02 EP EP09176234A patent/EP2182004A1/de not_active Withdrawn
- 2003-06-02 AU AU2003237347A patent/AU2003237347B2/en not_active Ceased
- 2003-06-02 CA CA002487425A patent/CA2487425A1/en not_active Abandoned
- 2003-06-02 US US10/522,810 patent/US20060166892A1/en not_active Abandoned
- 2003-06-02 WO PCT/US2003/017410 patent/WO2003101474A1/en not_active Ceased
- 2003-06-02 MX MXPA04011871A patent/MXPA04011871A/es active IP Right Grant
- 2003-06-02 EP EP03731504A patent/EP1553962B1/de not_active Expired - Lifetime
- 2003-06-02 EP EP03736810A patent/EP1539207A4/de not_active Withdrawn
- 2003-06-02 CA CA002494451A patent/CA2494451A1/en not_active Abandoned
-
2011
- 2011-03-09 JP JP2011052039A patent/JP5856744B2/ja not_active Expired - Lifetime
-
2015
- 2015-07-03 JP JP2015134259A patent/JP2015214562A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2182004A1 (de) | 2010-05-05 |
| WO2003101474A1 (en) | 2003-12-11 |
| CA2487425A1 (en) | 2003-12-11 |
| JP5856744B2 (ja) | 2016-02-10 |
| JP2015214562A (ja) | 2015-12-03 |
| EP1553962B1 (de) | 2010-02-24 |
| EP2431385A3 (de) | 2012-07-04 |
| AU2003240496B2 (en) | 2008-01-10 |
| EP1539207A1 (de) | 2005-06-15 |
| AU2003240496A1 (en) | 2003-12-19 |
| US20060166892A1 (en) | 2006-07-27 |
| JP2005537234A (ja) | 2005-12-08 |
| WO2003101475A1 (en) | 2003-12-11 |
| EP1553962A4 (de) | 2008-01-02 |
| CA2494451A1 (en) | 2003-12-11 |
| ES2341767T3 (es) | 2010-06-28 |
| EP2431385A2 (de) | 2012-03-21 |
| AU2003237347A1 (en) | 2003-12-19 |
| EP1553962A1 (de) | 2005-07-20 |
| DE60331458D1 (de) | 2010-04-08 |
| JP2011153149A (ja) | 2011-08-11 |
| AU2003237347B2 (en) | 2009-07-23 |
| MXPA04011871A (es) | 2005-07-26 |
| EP1539207A4 (de) | 2008-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |