JP2009500045A5 - - Google Patents
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- Publication number
- JP2009500045A5 JP2009500045A5 JP2008520699A JP2008520699A JP2009500045A5 JP 2009500045 A5 JP2009500045 A5 JP 2009500045A5 JP 2008520699 A JP2008520699 A JP 2008520699A JP 2008520699 A JP2008520699 A JP 2008520699A JP 2009500045 A5 JP2009500045 A5 JP 2009500045A5
- Authority
- JP
- Japan
- Prior art keywords
- damage
- thymosin
- derivative
- pharmaceutical composition
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- UGPMCIBIHRSCBV-XNBOLLIBSA-N 77591-33-4 Chemical class N([C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O UGPMCIBIHRSCBV-XNBOLLIBSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010011024 Corneal injury Diseases 0.000 claims 2
- 208000004981 Coronary Disease Diseases 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 201000008739 coronary artery disease Diseases 0.000 claims 2
- 230000037380 skin damage Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920000023 polynucleotide Polymers 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
Claims (6)
- 配列番号6に示されるアミノ酸配列を有するGly−Tβ4、及び配列番号5に示されるアミノ酸配列を有するAla−Tβ4から選択されるサイモシンβ4誘導体。
- 請求項1記載のサイモシンβ4誘導体をコードするポリヌクレオチド。
- 請求項1記載のサイモシンβ4誘導体及び所望により薬学的に許容される担体を含む、医薬組成物。
- 皮膚損傷、心臓障害、角膜損傷、及び/又は冠状動脈性心疾患の治療のための医薬の製造における、請求項1記載のサイモシンβ4誘導体の使用。
- 皮膚損傷、心臓障害、角膜損傷、及び/又は冠状動脈性心疾患の治療のために使用される、請求項3記載の医薬組成物。
- ヒトの治療のためのものである、請求項5記載の医薬組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200510083894 CN1896096A (zh) | 2005-07-15 | 2005-07-15 | 基因工程方法生产的高活性胸腺素β4衍生物 |
CN200510083894.6 | 2005-07-15 | ||
CN200510103293.7 | 2005-09-23 | ||
CNB2005101032937A CN100484957C (zh) | 2005-09-23 | 2005-09-23 | 胸腺素β4衍生物及其应用 |
PCT/CN2006/001679 WO2007009359A1 (fr) | 2005-07-15 | 2006-07-14 | Derives de thymosine beta 4 et utilisation |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009500045A JP2009500045A (ja) | 2009-01-08 |
JP2009500045A5 true JP2009500045A5 (ja) | 2009-07-23 |
JP5180074B2 JP5180074B2 (ja) | 2013-04-10 |
Family
ID=37668439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008520699A Active JP5180074B2 (ja) | 2005-07-15 | 2006-07-14 | サイモシンβ4誘導体及びその使用方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7816321B2 (ja) |
EP (1) | EP1908779B1 (ja) |
JP (1) | JP5180074B2 (ja) |
KR (1) | KR100984635B1 (ja) |
CN (1) | CN100582121C (ja) |
PL (1) | PL1908779T3 (ja) |
WO (1) | WO2007009359A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006272612B2 (en) | 2005-07-26 | 2011-10-06 | Regenerx Biopharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to congestive heart failure |
GB2476789A (en) | 2009-11-10 | 2011-07-13 | Gl Holdings Inc Bv | Use of thymosin for treatment of type 2 diabetes |
CA2811977A1 (en) * | 2010-09-30 | 2012-04-05 | Regenerx Biopharmaceuticals, Inc. | Method of achieving a thymosin beta 4 concentration in a human patient |
WO2012126047A1 (en) * | 2011-03-18 | 2012-09-27 | Adistem Ltd | Agent and method for treating pain and reducing inflammation |
CN103724422B (zh) * | 2014-01-13 | 2015-10-21 | 哈尔滨吉象隆生物技术有限公司 | 一种裂解胸腺素β4的方法 |
CN104311672B (zh) * | 2014-10-21 | 2017-07-11 | 中国药科大学 | 一种具有肿瘤细胞靶向性的抑制剂多肽 |
CN106692949B (zh) * | 2016-12-23 | 2022-03-15 | 北京诺思兰德生物技术股份有限公司 | 一种用于治疗眼部疾病的药物及其组合物 |
KR101910908B1 (ko) * | 2017-06-14 | 2018-10-24 | (주)휴온스 | Gly-Tβ4 (Gly-티모신β4)을 함유하는 안구건조증 치료용 약학적 조성물 |
KR101946789B1 (ko) * | 2018-01-26 | 2019-02-12 | (주)휴온스 | 이황화결합 이성질화효소 신호 펩타이드를 포함하는 재조합 벡터 및 이의 용도 |
US11311606B2 (en) * | 2018-03-13 | 2022-04-26 | Georgetown University | Enhancing chemotherapy in medulloblastoma and glioblastoma with high basal p53 levels |
KR102140531B1 (ko) * | 2018-08-07 | 2020-08-04 | (주)휴온스 | Gly-Tβ4의 제조방법 |
CN108853483B (zh) * | 2018-08-10 | 2022-03-15 | 北京诺思兰德生物技术股份有限公司 | 经修饰的胸腺素β4在治疗脑缺血再灌注损伤方面的用途 |
CN110215513B (zh) * | 2018-11-15 | 2022-02-22 | 北京诺思兰德生物技术股份有限公司 | 经修饰的胸腺素β4在治疗放射性肠炎方面的用途 |
CN109865127B (zh) * | 2018-11-22 | 2022-03-04 | 北京诺思兰德生物技术股份有限公司 | 经修饰的胸腺素β4在治疗糖尿病周围神经病变方面的用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4297276A (en) | 1979-03-23 | 1981-10-27 | Hoffman-La Roche Inc. | Thymosin beta 3 and beta 4 |
US4395404A (en) * | 1982-05-14 | 1983-07-26 | George Washington University | Synthetic thymosin β3 and β4 analogues |
CA2338928A1 (en) * | 1998-07-30 | 2000-02-10 | Hynda K. Kleinman | Thymosin .beta.4 promotes wound repair |
JP4897792B2 (ja) * | 2005-04-20 | 2012-03-14 | ビロメッド カンパニー, リミテッド | 融合タンパク質の分離のための組成物および方法 |
-
2006
- 2006-07-14 WO PCT/CN2006/001679 patent/WO2007009359A1/zh active Application Filing
- 2006-07-14 JP JP2008520699A patent/JP5180074B2/ja active Active
- 2006-07-14 PL PL06761426T patent/PL1908779T3/pl unknown
- 2006-07-14 EP EP06761426A patent/EP1908779B1/en active Active
- 2006-07-14 KR KR1020087003496A patent/KR100984635B1/ko active IP Right Grant
- 2006-07-14 CN CN200680025339A patent/CN100582121C/zh active Active
- 2006-07-14 US US11/995,817 patent/US7816321B2/en active Active
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