JP2010533705A5 - - Google Patents
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- JP2010533705A5 JP2010533705A5 JP2010516648A JP2010516648A JP2010533705A5 JP 2010533705 A5 JP2010533705 A5 JP 2010533705A5 JP 2010516648 A JP2010516648 A JP 2010516648A JP 2010516648 A JP2010516648 A JP 2010516648A JP 2010533705 A5 JP2010533705 A5 JP 2010533705A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- fragment
- cathelicidin
- diseases
- effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 claims 5
- POIUWJQBRNEFGX-XAMSXPGMSA-N Cathelicidin Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C1=CC=CC=C1 POIUWJQBRNEFGX-XAMSXPGMSA-N 0.000 claims 4
- 200000000018 inflammatory disease Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 201000004681 psoriasis Diseases 0.000 claims 2
- 108010017434 CAP18 lipopolysaccharide-binding protein Proteins 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010022489 Insulin resistance Diseases 0.000 claims 1
- 208000008466 Metabolic Disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010031149 Osteitis Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033307 Overweight Diseases 0.000 claims 1
- 208000006641 Skin Disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002757 inflammatory Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 235000020825 overweight Nutrition 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000241 respiratory Effects 0.000 claims 1
Claims (6)
- 疾患治療用薬剤の調合において、哺乳類のカテリシジンまたはその有効な断片またはカテリシジンまたは、その断片の有効な修飾されたフォームを使用する方法。
- 前記病状が、自己免疫性炎症性疾患、代謝性および炎症性疾患、炎症性皮膚疾患、軽度の炎症性疾患、胃腸炎、骨の炎症、呼吸器の炎症からなる群から選択される炎症に関係する疾病である請求項１に記載の方法。
- 前記病状が、間節炎、多発性硬化症、乾癬、肥満、過剰体重、インスリン抵抗性、骨粗鬆症、糖尿病および炎症性大腸炎以下の疾病からなる群から選択される疾病であることを特徴とする請求項１に記載の方法。
- 病状が、乾癬である請求項１に記載の方法。
- 前述の化合物がLL-37 ペプチドおよび配列番号１−５９に示すペプチドからなる群から選択される請求項１−４のいずれかに記載の方法。
- 哺乳類のカテリシジンまたはその有効な断片、またはカテリシジンまたはその断片の有効な修飾されたフォームそして 薬学的に受容可能な賦形剤またはキャリアである有効成分として含まれている医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL184611A IL184611A0 (en) | 2007-07-15 | 2007-07-15 | Disease treatment via antimicrobial peptides or their inhibitors |
| IL187627A IL187627A0 (en) | 2007-11-26 | 2007-11-26 | Disease treatment via antimicrobial peptides or their inhibitors |
| PCT/IL2008/000977 WO2009010968A2 (en) | 2007-07-15 | 2008-07-15 | Disease treatment via antimicrobial peptides or their inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014157915A Division JP5860937B2 (ja) | 2007-07-15 | 2014-08-01 | 抗菌ペプチドまたはその阻害剤を用いた疾病治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533705A JP2010533705A (ja) | 2010-10-28 |
| JP2010533705A5 true JP2010533705A5 (ja) | 2011-08-18 |
Family
ID=39944436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516648A Pending JP2010533705A (ja) | 2007-07-15 | 2008-07-15 | 抗菌ペプチドまたはその阻害剤を用いた疾病治療 |
| JP2014157915A Expired - Fee Related JP5860937B2 (ja) | 2007-07-15 | 2014-08-01 | 抗菌ペプチドまたはその阻害剤を用いた疾病治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014157915A Expired - Fee Related JP5860937B2 (ja) | 2007-07-15 | 2014-08-01 | 抗菌ペプチドまたはその阻害剤を用いた疾病治療 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2200628A2 (ja) |
| JP (2) | JP2010533705A (ja) |
| AU (1) | AU2008277257B2 (ja) |
| CA (1) | CA2696833A1 (ja) |
| WO (1) | WO2009010968A2 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101351474A (zh) * | 2005-12-29 | 2009-01-21 | 堪萨斯州立大学研究基金会 | 抗微生物导管素肽 |
| WO2009040085A2 (en) * | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Use of exendin-4 and optionally salusin-alpha as therapeutic agent(s) |
| WO2009033789A2 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| CA2825137A1 (en) * | 2010-01-22 | 2011-07-28 | University Of Louisville Research Foundation, Inc | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
| EP2538964A4 (en) * | 2010-02-25 | 2013-07-31 | Univ Manitoba | MODULATION OF CYTOKININDUCED CHRONIC INFLAMMATORY REACTIONS |
| CA2948455C (en) | 2014-05-09 | 2023-09-19 | Universiteit Utrecht Holding B.V. | New cath2 derivatives |
| DE202014007548U1 (de) | 2014-09-16 | 2014-12-02 | Pegasor Oy | Vorrichtung zur Spülung einer Partikelmessvorrichtung |
| WO2017098474A1 (en) | 2015-12-09 | 2017-06-15 | Universidade Do Minho | Antimicrobial peptide-loaded hyaluronic acid-based formulations, method of production and uses thereof |
| CN108570103B (zh) * | 2018-04-03 | 2019-07-30 | 东北农业大学 | 一种富含色氨酸抗菌肽wk12及其制备方法和应用 |
| CN111375051A (zh) * | 2018-12-29 | 2020-07-07 | 江苏吉锐生物技术有限公司 | 一种多肽在制备预防和治疗人乳头瘤病毒感染制剂的应用 |
| KR102475936B1 (ko) * | 2020-10-15 | 2022-12-09 | 코스맥스 주식회사 | 펩타이드 ll-37을 발현하는 효모를 포함하는 화장료 조성물 |
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| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
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| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
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| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
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| GB1585061A (en) | 1977-03-15 | 1981-02-25 | Nat Res Dev | Synthesis of peptides |
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-
2008
- 2008-07-15 WO PCT/IL2008/000977 patent/WO2009010968A2/en active Application Filing
- 2008-07-15 CA CA2696833A patent/CA2696833A1/en not_active Abandoned
- 2008-07-15 JP JP2010516648A patent/JP2010533705A/ja active Pending
- 2008-07-15 EP EP08776610A patent/EP2200628A2/en not_active Withdrawn
- 2008-07-15 AU AU2008277257A patent/AU2008277257B2/en not_active Ceased
-
2014
- 2014-08-01 JP JP2014157915A patent/JP5860937B2/ja not_active Expired - Fee Related
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