RU2470016C2 - Производное бипиразола - Google Patents

Производное бипиразола Download PDF

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RU2470016C2
RU2470016C2 RU2010119648/04A RU2010119648A RU2470016C2 RU 2470016 C2 RU2470016 C2 RU 2470016C2 RU 2010119648/04 A RU2010119648/04 A RU 2010119648/04A RU 2010119648 A RU2010119648 A RU 2010119648A RU 2470016 C2 RU2470016 C2 RU 2470016C2
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pharmaceutically acceptable
bipyrazolyl
hydroxyadamantan
obesity
butyl
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RU2010119648/04A
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RU2010119648A (ru
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Кевин Уилльям АНДЕРСОН
Надер ФОТУИ
Пол ДЖИЛЛЕСПАЙ
Роберт Алан Джр. ГУДНАУ
Кевин Ричард ГУИРТИН
Нанси-Эллен ХЕЙНЕС
Майкл Пол МАЙЕРС
Шерри Линн ПИТРАНИКОКОУЛ
Лида ЦИ
Памела Лорин РОССМАН
Натан Роберт СКОТТ
Кшитий Чхабилбхай ТАККАР
Джефферсон Райт ТИЛЛИ
Цян Чжан
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Ф.Хоффманн-Ля Рош Аг
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    • A—HUMAN NECESSITIES
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Изобретение относится к фармацевтической композиции для лечения диабета, ожирения или метаболического синдрома, которая включает терапевтически эффективное количество (5-гидроксиадамантан-2-ил)амида транс-2'-трет-бутил-2'H-[1,3']бипиразолил-4'-карбоновой кислоты или его фармацевтически приемлемых солей, и фармацевтически приемлемый носитель. Изобретение также относится и к применению вышеназванного соединения для приготовления лекарственного средства, предназначенного для лечения указанных выше заболеваний. 2 н.п. ф-лы, 1 табл., 99 пр.

Description

Текст описания приведен в факсимильном виде.
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Claims (2)

1. Фармацевтическая композиция для лечения диабета, ожирения или метаболического синдрома, включающая терапевтически эффективное количество (5-гидроксиадамантан-2-ил)амида транс-2'-трет-бутил-2'H-[1,3']бипиразолил-4'-карбоновой кислоты или его фармацевтически приемлемых солей, и фармацевтически приемлемый носитель.
2. Применение (5-гидроксиадамантан-2-ил)амида транс-2'-трет-бутил-2'H-[1,3']бипиразолил-4'-карбоновой кислоты для приготовления лекарственных средств, предназначенных для лечения диабета, ожирения или метаболического синдрома.
RU2010119648/04A 2006-03-22 2007-03-12 Производное бипиразола RU2470016C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78483106P 2006-03-22 2006-03-22
US60/784,831 2006-03-22
US87527406P 2006-12-15 2006-12-15
US60/875,274 2006-12-15

Related Parent Applications (1)

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RU2008141434/04A Division RU2402517C2 (ru) 2006-03-22 2007-03-12 Пиразолы в качестве ингибиторов 11-бета-hsd-1

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RU2010119648A RU2010119648A (ru) 2011-11-27
RU2470016C2 true RU2470016C2 (ru) 2012-12-20

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RU2010119648/04A RU2470016C2 (ru) 2006-03-22 2007-03-12 Производное бипиразола
RU2008141434/04A RU2402517C2 (ru) 2006-03-22 2007-03-12 Пиразолы в качестве ингибиторов 11-бета-hsd-1

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US (1) US7728029B2 (ru)
EP (2) EP1999114B1 (ru)
JP (1) JP5031817B2 (ru)
KR (2) KR20110007258A (ru)
CN (1) CN101405270B (ru)
AR (1) AR059983A1 (ru)
AU (1) AU2007228887B2 (ru)
BR (1) BRPI0708974A2 (ru)
CA (1) CA2645856C (ru)
CR (1) CR10288A (ru)
DK (1) DK1999114T3 (ru)
EC (1) ECSP088747A (ru)
ES (1) ES2548002T3 (ru)
HK (1) HK1130780A1 (ru)
HR (1) HRP20151078T1 (ru)
HU (1) HUE026011T2 (ru)
IL (1) IL193900A (ru)
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MX (1) MX2008012017A (ru)
MY (1) MY149622A (ru)
NO (1) NO341746B1 (ru)
NZ (1) NZ570973A (ru)
PL (1) PL1999114T3 (ru)
PT (1) PT1999114E (ru)
RS (1) RS54216B1 (ru)
RU (2) RU2470016C2 (ru)
SG (1) SG155961A1 (ru)
SI (1) SI1999114T1 (ru)
TW (2) TW201103916A (ru)
WO (1) WO2007107470A2 (ru)

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CN103209957A (zh) 2010-08-09 2013-07-17 盐野义制药株式会社 氨基金刚烷氨基甲酸酯衍生物的制备方法
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