KR100984635B1 - 티모신 β4 유도체 및 이의 용도 - Google Patents

티모신 β4 유도체 및 이의 용도 Download PDF

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Publication number
KR100984635B1
KR100984635B1 KR1020087003496A KR20087003496A KR100984635B1 KR 100984635 B1 KR100984635 B1 KR 100984635B1 KR 1020087003496 A KR1020087003496 A KR 1020087003496A KR 20087003496 A KR20087003496 A KR 20087003496A KR 100984635 B1 KR100984635 B1 KR 100984635B1
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ala
gly
thymosin
group
rat
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Korean (ko)
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KR20080040708A (ko
Inventor
리야 니에
수용 마
송샨 쥬
메이유 웬
Original Assignee
주식회사 바이오톡스텍
베이징 노쓰랜드 바이오테크 컴퍼니 리미티드
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Priority claimed from CN 200510083894 external-priority patent/CN1896096A/zh
Priority claimed from CNB2005101032937A external-priority patent/CN100484957C/zh
Application filed by 주식회사 바이오톡스텍, 베이징 노쓰랜드 바이오테크 컴퍼니 리미티드 filed Critical 주식회사 바이오톡스텍
Publication of KR20080040708A publication Critical patent/KR20080040708A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020087003496A 2005-07-15 2006-07-14 티모신 β4 유도체 및 이의 용도 Active KR100984635B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200510083894.6 2005-07-15
CN 200510083894 CN1896096A (zh) 2005-07-15 2005-07-15 基因工程方法生产的高活性胸腺素β4衍生物
CNB2005101032937A CN100484957C (zh) 2005-09-23 2005-09-23 胸腺素β4衍生物及其应用
CN200510103293.7 2005-09-23

Publications (2)

Publication Number Publication Date
KR20080040708A KR20080040708A (ko) 2008-05-08
KR100984635B1 true KR100984635B1 (ko) 2010-10-01

Family

ID=37668439

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087003496A Active KR100984635B1 (ko) 2005-07-15 2006-07-14 티모신 β4 유도체 및 이의 용도

Country Status (7)

Country Link
US (1) US7816321B2 (enExample)
EP (1) EP1908779B1 (enExample)
JP (1) JP5180074B2 (enExample)
KR (1) KR100984635B1 (enExample)
CN (1) CN100582121C (enExample)
PL (1) PL1908779T3 (enExample)
WO (1) WO2007009359A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020032444A1 (ko) * 2018-08-07 2020-02-13 (주)휴온스 GLY-Tβ4의 제조방법

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007014253A2 (en) * 2005-07-26 2007-02-01 Regenerx Biopharmaceuticals, Inc. Method of treating or preventing tissue deterioration, injury or damage due to congestive heart failure
GB2476789A (en) 2009-11-10 2011-07-13 Gl Holdings Inc Bv Use of thymosin for treatment of type 2 diabetes
US9504730B2 (en) 2010-09-30 2016-11-29 Regenerx Biopharmaceuticals, Inc. Method of achieving a thymosin beta 4 concentration in a human patient
WO2012126047A1 (en) * 2011-03-18 2012-09-27 Adistem Ltd Agent and method for treating pain and reducing inflammation
CN103724422B (zh) * 2014-01-13 2015-10-21 哈尔滨吉象隆生物技术有限公司 一种裂解胸腺素β4的方法
CN104311672B (zh) * 2014-10-21 2017-07-11 中国药科大学 一种具有肿瘤细胞靶向性的抑制剂多肽
CN106692949B (zh) * 2016-12-23 2022-03-15 北京诺思兰德生物技术股份有限公司 一种用于治疗眼部疾病的药物及其组合物
KR101910908B1 (ko) * 2017-06-14 2018-10-24 (주)휴온스 Gly-Tβ4 (Gly-티모신β4)을 함유하는 안구건조증 치료용 약학적 조성물
KR101946789B1 (ko) * 2018-01-26 2019-02-12 (주)휴온스 이황화결합 이성질화효소 신호 펩타이드를 포함하는 재조합 벡터 및 이의 용도
WO2019178059A1 (en) * 2018-03-13 2019-09-19 Georgetown University ENHANCING CHEMOTHERAPY IN MEDULLOBLASTOMA AND GLIOBLASTOMA WITH HIGH BASAL p53 LEVELS
CN108853483B (zh) * 2018-08-10 2022-03-15 北京诺思兰德生物技术股份有限公司 经修饰的胸腺素β4在治疗脑缺血再灌注损伤方面的用途
CN110215513B (zh) * 2018-11-15 2022-02-22 北京诺思兰德生物技术股份有限公司 经修饰的胸腺素β4在治疗放射性肠炎方面的用途
CN109865127B (zh) * 2018-11-22 2022-03-04 北京诺思兰德生物技术股份有限公司 经修饰的胸腺素β4在治疗糖尿病周围神经病变方面的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297276A (en) * 1979-03-23 1981-10-27 Hoffman-La Roche Inc. Thymosin beta 3 and beta 4
US4395404A (en) * 1982-05-14 1983-07-26 George Washington University Synthetic thymosin β3 and β4 analogues
EP1591128A1 (en) * 1998-07-30 2005-11-02 The Government of the United States of America, as repres. by the Secretary of Health and Human Services, Nat. Inst. of Health Thymosin beta 4 promotes wound repair
ATE466868T1 (de) 2005-04-20 2010-05-15 Viromed Co Ltd Zusammensetzungen und verfahren zur trennung von fusionsproteinen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
‘Expression of thymosin beta 4 mRNA expression in keloid tissues and fibroblasts cultured from keloid and its significance', February 2005. vol17, No.2. pp80-83.
‘Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences’, Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020032444A1 (ko) * 2018-08-07 2020-02-13 (주)휴온스 GLY-Tβ4의 제조방법
KR20200016597A (ko) * 2018-08-07 2020-02-17 (주)휴온스 Gly-Tβ4의 제조방법
KR102140531B1 (ko) * 2018-08-07 2020-08-04 (주)휴온스 Gly-Tβ4의 제조방법

Also Published As

Publication number Publication date
EP1908779A1 (en) 2008-04-09
JP5180074B2 (ja) 2013-04-10
EP1908779A4 (en) 2009-09-30
CN100582121C (zh) 2010-01-20
KR20080040708A (ko) 2008-05-08
US20090298758A1 (en) 2009-12-03
JP2009500045A (ja) 2009-01-08
PL1908779T3 (pl) 2013-06-28
EP1908779B1 (en) 2013-01-09
US7816321B2 (en) 2010-10-19
CN101218249A (zh) 2008-07-09
WO2007009359A1 (en) 2007-01-25

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