JP2013528655A5 - - Google Patents
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- Publication number
- JP2013528655A5 JP2013528655A5 JP2013515492A JP2013515492A JP2013528655A5 JP 2013528655 A5 JP2013528655 A5 JP 2013528655A5 JP 2013515492 A JP2013515492 A JP 2013515492A JP 2013515492 A JP2013515492 A JP 2013515492A JP 2013528655 A5 JP2013528655 A5 JP 2013528655A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- xanthine oxidase
- oxidase inhibitor
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 201000005569 Gout Diseases 0.000 claims 5
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 claims 5
- 239000003064 xanthine oxidase inhibitor Substances 0.000 claims 5
- 201000001431 Hyperuricemia Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000018251 Hypoxanthine Phosphoribosyltransferase Human genes 0.000 claims 2
- 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 claims 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 2
- 229960003459 allopurinol Drugs 0.000 claims 2
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical group OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229960005101 febuxostat Drugs 0.000 claims 2
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical group C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 2
- 229940116269 uric acid Drugs 0.000 claims 2
- 206010007027 Calculus urinary Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 claims 1
- 208000000913 Kidney Calculi Diseases 0.000 claims 1
- 208000009625 Lesch-Nyhan syndrome Diseases 0.000 claims 1
- 206010029148 Nephrolithiasis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000035317 Total hypoxanthine-guanine phosphoribosyl transferase deficiency Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000018937 joint inflammation Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000008127 lead poisoning Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000008281 urolithiasis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35549110P | 2010-06-16 | 2010-06-16 | |
| US61/355,491 | 2010-06-16 | ||
| PCT/US2011/040585 WO2011159839A2 (en) | 2010-06-16 | 2011-06-15 | Thioacetate compounds, compositions and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014105611A Division JP5768166B2 (ja) | 2010-06-16 | 2014-05-21 | チオ酢酸化合物、組成物、および、その使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528655A JP2013528655A (ja) | 2013-07-11 |
| JP2013528655A5 true JP2013528655A5 (enExample) | 2014-05-15 |
| JP5551310B2 JP5551310B2 (ja) | 2014-07-16 |
Family
ID=45348850
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515492A Active JP5551310B2 (ja) | 2010-06-16 | 2011-06-15 | チオ酢酸化合物、組成物、および、その使用方法 |
| JP2014105611A Active JP5768166B2 (ja) | 2010-06-16 | 2014-05-21 | チオ酢酸化合物、組成物、および、その使用方法 |
| JP2015120633A Active JP6112318B2 (ja) | 2010-06-16 | 2015-06-15 | チオ酢酸化合物、組成物、および、その使用方法 |
| JP2017035549A Active JP6364515B2 (ja) | 2010-06-16 | 2017-02-27 | チオ酢酸化合物、組成物、および、その使用方法 |
| JP2018123691A Pending JP2018168174A (ja) | 2010-06-16 | 2018-06-28 | チオ酢酸化合物、組成物、および、その使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014105611A Active JP5768166B2 (ja) | 2010-06-16 | 2014-05-21 | チオ酢酸化合物、組成物、および、その使用方法 |
| JP2015120633A Active JP6112318B2 (ja) | 2010-06-16 | 2015-06-15 | チオ酢酸化合物、組成物、および、その使用方法 |
| JP2017035549A Active JP6364515B2 (ja) | 2010-06-16 | 2017-02-27 | チオ酢酸化合物、組成物、および、その使用方法 |
| JP2018123691A Pending JP2018168174A (ja) | 2010-06-16 | 2018-06-28 | チオ酢酸化合物、組成物、および、その使用方法 |
Country Status (41)
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR081930A1 (es) | 2010-06-16 | 2012-10-31 | Ardea Biosciences Inc | Compuestos de tioacetato |
| BR112012032193A2 (pt) | 2010-06-16 | 2019-09-24 | Ardea Biosciences Inc | composto, composiçoes e métodos de uso de feniltioacetato |
| EP3501520A1 (en) * | 2011-11-03 | 2019-06-26 | Ardea Biosciences, Inc. | 3,4-di-substituted pyridine compound, methods of using and compositions comprising the same |
| UA117359C2 (uk) * | 2012-11-14 | 2018-07-25 | Тейдзін Фарма Лімітед | Похідне піридину |
| LT2998296T (lt) | 2013-05-13 | 2018-08-10 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Cikloalkilo rūgšties darinys, jo gavimo būdas ir jo farmacinis taikymas |
| EP3013796B9 (en) | 2013-06-27 | 2020-07-01 | LG Chem, Ltd. | Biaryl derivatives as gpr120 agonists |
| US9856237B2 (en) * | 2014-05-13 | 2018-01-02 | Teijin Pharma Limited | Pyrazine derivatives |
| CN105439946B (zh) * | 2014-08-13 | 2018-02-02 | 益方生物科技（上海）有限公司 | 羧酸化合物及其制备方法和用途 |
| BR112017013465A2 (pt) * | 2014-12-24 | 2018-03-06 | Lg Chem, Ltd | derivado de biarila, e, composição farmacêutica. |
| ES2865182T3 (es) * | 2014-12-29 | 2021-10-15 | Nippon Chemiphar Co | Inhibidor de URAT1 |
| CN108026043A (zh) * | 2015-08-14 | 2018-05-11 | 广东东阳光药业有限公司 | 一种萘环化合物的晶型 |
| CN105418495B (zh) * | 2015-11-25 | 2018-09-14 | 乳源瑶族自治县大众药品贸易有限公司 | 一种硫醚的制备方法 |
| WO2017097182A1 (zh) * | 2015-12-07 | 2017-06-15 | 成都海创药业有限公司 | 喹啉类化合物及其制备方法和作为尿酸盐转运体抑制剂类药物的用途 |
| PE20181521A1 (es) * | 2015-12-08 | 2018-09-24 | Ardea Biosciences Inc | Composicion farmaceutica que comprende un potente inhibidor de urat1 |
| JP6898330B2 (ja) * | 2015-12-28 | 2021-07-07 | シャンハイ フォチョン ファーマシューティカル カンパニー リミテッド | インドリジン誘導体、組成物、及び使用方法 |
| WO2017121308A1 (en) * | 2016-01-11 | 2017-07-20 | Chongqing Fochon Pharmaceutical Co., Ltd. | Fused pyridine compounds, compositions and methods of use |
| ES2836724T3 (es) * | 2016-02-15 | 2021-06-28 | Inst Nat Sante Rech Med | Uso de estiripentol y sus derivados para disminuir la concentración de oxalato urinario en un individuo |
| CN105884807A (zh) * | 2016-04-26 | 2016-08-24 | 昆药集团股份有限公司 | 硼酸频那醇酯衍生物的制备方法、硫代乙酸盐化合物的制备方法 |
| CN106117130A (zh) * | 2016-06-28 | 2016-11-16 | 昆药集团股份有限公司 | 一种2‑((3‑(4‑氰基萘‑1‑基)吡啶‑4‑基)硫基)‑2‑甲基丙酸的晶型及其制备方法和药物组合物 |
| CN106083847B (zh) * | 2016-08-03 | 2018-10-30 | 山东大学 | 一种咪唑并吡啶巯乙酸类衍生物及其制备方法与应用 |
| CN110121359A (zh) | 2016-11-11 | 2019-08-13 | 怀特黑德生物制剂研究所 | 人血浆培养基 |
| CN106748987B (zh) * | 2016-11-18 | 2019-05-31 | 昆药集团股份有限公司 | 2-((3-(4-氰基萘-1-基)吡啶-4-基)硫基)-2-甲基丙酸钠盐的晶型 |
| EP3555050A1 (en) | 2016-12-16 | 2019-10-23 | Basf Se | Pesticidal compounds |
| CN106883169A (zh) * | 2017-04-01 | 2017-06-23 | 浙江永宁药业股份有限公司 | 一种3‑(4‑氰基‑1‑萘基)‑4‑卤代吡啶的制备方法及其应用 |
| WO2018202039A1 (zh) * | 2017-05-03 | 2018-11-08 | 成都海创药业有限公司 | 杂环化合物及其制备方法 |
| KR20200064101A (ko) * | 2017-10-04 | 2020-06-05 | 니뽄 다바코 산교 가부시키가이샤 | 질소 함유 헤테로아릴 화합물 및 그의 의약 용도 |
| CN107955029B (zh) * | 2017-12-07 | 2020-08-11 | 成都美域高制药有限公司 | 一种雷西纳德的制备方法 |
| CN108084153A (zh) * | 2017-12-20 | 2018-05-29 | 广东赛烽医药科技有限公司 | 吡啶基硫代乙酸化合物、组合物及其应用 |
| CN108069940B (zh) * | 2017-12-20 | 2021-04-30 | 广东赛烽医药科技有限公司 | 硫代乙酸化合物、组合物及其应用 |
| CN108440397B (zh) * | 2018-03-06 | 2020-06-05 | 南方医科大学 | 3-(萘-1-甲基取代)吡啶衍生物及其合成方法和应用 |
| WO2019183835A1 (en) * | 2018-03-28 | 2019-10-03 | Inventisbio Shanghai Ltd. | Novel salt forms of urat-1 inhibitors |
| CN109608432B (zh) * | 2018-12-17 | 2022-10-11 | 江苏艾立康医药科技有限公司 | 作为urat1抑制剂的噻吩类衍生物 |
| CA3145997A1 (en) | 2019-07-16 | 2021-01-21 | Astrazeneca Ab | Dose dumping resistant pharmaceutical compositions comrising verinurad |
| CN114315715B (zh) * | 2020-09-29 | 2024-02-20 | 杭州中美华东制药有限公司 | 一类urat1抑制剂及其制备方法与应用 |
| CN114621136B (zh) * | 2020-12-09 | 2023-11-07 | 江苏正大清江制药有限公司 | 吡啶巯乙酸类化合物及其制备方法、药学衍生物或配剂以及应用 |
| EP4301749A1 (en) * | 2021-03-01 | 2024-01-10 | Orion Corporation | Solid forms of a 4h-pyran-4-one structured cyp11a1 inhibitor |
| AR124985A1 (es) * | 2021-03-01 | 2023-05-24 | Orion Corp | Nuevas formas de sal de un inhibidor de cyp11a1 estructurado en 4h-piran-4-ona |
| CN118439998A (zh) * | 2021-05-19 | 2024-08-06 | 江苏正大清江制药有限公司 | 一种喹啉巯乙酸磺酰胺类衍生物的制备及其应用 |
| CN113979931B (zh) * | 2021-10-08 | 2023-06-13 | 南方医科大学 | 一种吡啶3-胺衍生物及其制备方法和应用 |
| CN114214361A (zh) * | 2022-01-07 | 2022-03-22 | 中国农业科学院兰州兽医研究所 | 一种urat1人源化小鼠模型的构建方法及其应用 |
| CN117362223A (zh) * | 2023-09-14 | 2024-01-09 | 河北远征药业有限公司 | 一种4-巯基吡啶的制备方法 |
| WO2025060752A1 (zh) * | 2023-09-19 | 2025-03-27 | 湘北威尔曼制药股份有限公司 | 一种硫醚衍生物及其制备方法和应用 |
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2011
- 2011-06-14 AR ARP110102068A patent/AR081930A1/es active IP Right Grant
- 2011-06-15 ME MEP-2014-42A patent/ME01830B/me unknown
- 2011-06-15 ES ES15166826.6T patent/ES2673426T3/es active Active
- 2011-06-15 CN CN201180029484.7A patent/CN103068801B/zh active Active
- 2011-06-15 TR TR2018/08344T patent/TR201808344T4/tr unknown
- 2011-06-15 DK DK11796396.7T patent/DK2585437T3/da active
- 2011-06-15 PL PL11796396T patent/PL2585437T3/pl unknown
- 2011-06-15 CA CA2802535A patent/CA2802535C/en active Active
- 2011-06-15 RS RS20150668A patent/RS54375B1/sr unknown
- 2011-06-15 EP EP15166826.6A patent/EP2975025B1/en active Active
- 2011-06-15 JP JP2013515492A patent/JP5551310B2/ja active Active
- 2011-06-15 CU CU20120170A patent/CU24126B1/es active IP Right Grant
- 2011-06-15 PT PT131988438T patent/PT2712861E/pt unknown
- 2011-06-15 PL PL13198843T patent/PL2712861T3/pl unknown
- 2011-06-15 US US13/703,890 patent/US10266493B2/en active Active
- 2011-06-15 RS RS20140227A patent/RS53301B/sr unknown
- 2011-06-15 LT LTEP15166826.6T patent/LT2975025T/lt unknown
- 2011-06-15 EP EP11796396.7A patent/EP2585437B1/en active Active
- 2011-06-15 RS RS20180652A patent/RS57363B1/sr unknown
- 2011-06-15 SI SI201130639T patent/SI2712861T1/sl unknown
- 2011-06-15 CN CN201410141662.0A patent/CN103864677B/zh active Active
- 2011-06-15 KR KR1020137000923A patent/KR101432950B1/ko active Active
- 2011-06-15 BR BR112012032028-9A patent/BR112012032028B1/pt active IP Right Grant
- 2011-06-15 MY MYPI2012005401 patent/MY153039A/en unknown
- 2011-06-15 DK DK13198843.8T patent/DK2712861T3/en active
- 2011-06-15 TW TW103135886A patent/TWI501949B/zh active
- 2011-06-15 UA UAA201300527A patent/UA107115C2/ru unknown
- 2011-06-15 SM SM20180304T patent/SMT201800304T1/it unknown
- 2011-06-15 PT PT117963967T patent/PT2585437E/pt unknown
- 2011-06-15 HU HUE15166826A patent/HUE040209T2/hu unknown
- 2011-06-15 WO PCT/US2011/040585 patent/WO2011159839A2/en not_active Ceased
- 2011-06-15 MX MX2014004120A patent/MX343583B/es unknown
- 2011-06-15 EP EP19178229.1A patent/EP3611167A1/en not_active Withdrawn
- 2011-06-15 KR KR1020147006531A patent/KR101608604B1/ko active Active
- 2011-06-15 EP EP13198843.8A patent/EP2712861B1/en active Active
- 2011-06-15 ES ES11796396.7T patent/ES2459146T3/es active Active
- 2011-06-15 PT PT151668266T patent/PT2975025T/pt unknown
- 2011-06-15 EA EA201270803A patent/EA022933B1/ru unknown
- 2011-06-15 SG SG2012091195A patent/SG186298A1/en unknown
- 2011-06-15 SI SI201130149T patent/SI2585437T1/sl unknown
- 2011-06-15 HU HUE13198843A patent/HUE025962T2/en unknown
- 2011-06-15 AU AU2011268360A patent/AU2011268360B2/en active Active
- 2011-06-15 HR HRP20140391AT patent/HRP20140391T1/hr unknown
- 2011-06-15 TW TW100120935A patent/TWI460173B/zh active
- 2011-06-15 PH PH1/2012/502460A patent/PH12012502460A1/en unknown
- 2011-06-15 PL PL15166826T patent/PL2975025T3/pl unknown
- 2011-06-15 MX MX2012014863A patent/MX2012014863A/es active IP Right Grant
- 2011-06-15 ES ES13198843.8T patent/ES2551114T3/es active Active
- 2011-06-15 DK DK15166826.6T patent/DK2975025T3/en active
- 2011-06-15 ME MEP-2015-173A patent/ME02302B/me unknown
- 2011-06-15 SG SG10201702527TA patent/SG10201702527TA/en unknown
- 2011-06-15 PE PE2012002423A patent/PE20131047A1/es active IP Right Grant
- 2011-06-15 EP EP18159710.5A patent/EP3409661A1/en not_active Withdrawn
- 2011-06-15 SI SI201131491T patent/SI2975025T1/en unknown
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2012
- 2012-12-04 IL IL223435A patent/IL223435A/en active IP Right Grant
- 2012-12-13 GT GT201200339A patent/GT201200339A/es unknown
- 2012-12-13 HN HN2012002664A patent/HN2012002664A/es unknown
- 2012-12-14 DO DO2012000314A patent/DOP2012000314A/es unknown
- 2012-12-14 CL CL2012003546A patent/CL2012003546A1/es unknown
- 2012-12-17 CO CO12228040A patent/CO6640311A2/es active IP Right Grant
- 2012-12-18 ZA ZA2012/09574A patent/ZA201209574B/en unknown
- 2012-12-18 CR CR20120649A patent/CR20120649A/es unknown
- 2012-12-20 EC ECSP12012353 patent/ECSP12012353A/es unknown
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2013
- 2013-04-04 US US13/857,108 patent/US8541589B2/en active Active
- 2013-06-07 US US13/913,272 patent/US8629278B2/en active Active
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2014
- 2014-04-24 SM SM201400055T patent/SMT201400055B/xx unknown
- 2014-05-21 JP JP2014105611A patent/JP5768166B2/ja active Active
- 2014-12-03 IL IL236039A patent/IL236039A0/en active IP Right Grant
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2015
- 2015-06-15 JP JP2015120633A patent/JP6112318B2/ja active Active
- 2015-10-19 HR HRP20151105TT patent/HRP20151105T1/hr unknown
- 2015-10-22 SM SM201500260T patent/SMT201500260B/it unknown
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2017
- 2017-02-27 JP JP2017035549A patent/JP6364515B2/ja active Active
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2018
- 2018-05-25 HR HRP20180829TT patent/HRP20180829T1/hr unknown
- 2018-06-27 CY CY20181100629T patent/CY1120337T1/el unknown
- 2018-06-28 JP JP2018123691A patent/JP2018168174A/ja active Pending
- 2018-11-14 US US16/190,925 patent/US10919858B2/en active Active
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2020
- 2020-12-16 US US17/123,380 patent/US20210171466A1/en not_active Abandoned
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