JP2013507442A5 - - Google Patents
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- Publication number
- JP2013507442A5 JP2013507442A5 JP2012534272A JP2012534272A JP2013507442A5 JP 2013507442 A5 JP2013507442 A5 JP 2013507442A5 JP 2012534272 A JP2012534272 A JP 2012534272A JP 2012534272 A JP2012534272 A JP 2012534272A JP 2013507442 A5 JP2013507442 A5 JP 2013507442A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- days
- pharmaceutically acceptable
- acceptable salt
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000003839 salts Chemical class 0.000 claims 18
- 239000012453 solvate Substances 0.000 claims 13
- CGBJSGAELGCMKE-UHFFFAOYSA-N omipalisib Chemical compound COC1=NC=C(C=2C=C3C(C=4C=NN=CC=4)=CC=NC3=CC=2)C=C1NS(=O)(=O)C1=CC=C(F)C=C1F CGBJSGAELGCMKE-UHFFFAOYSA-N 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 6
- -1 2-Amino-4-pyrimidinyl Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 229940125431 BRAF inhibitor Drugs 0.000 claims 2
- 125000001207 fluorophenyl group Chemical group 0.000 claims 2
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 2
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims 2
- DWBWMAAYLWUXQK-UHFFFAOYSA-N 2,3-difluorobenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC(F)=C1F DWBWMAAYLWUXQK-UHFFFAOYSA-N 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25063509P | 2009-10-12 | 2009-10-12 | |
| US61/250,635 | 2009-10-12 | ||
| PCT/US2010/052242 WO2011046894A1 (en) | 2009-10-12 | 2010-10-12 | Combination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507442A JP2013507442A (ja) | 2013-03-04 |
| JP2013507442A5 true JP2013507442A5 (enExample) | 2013-10-24 |
Family
ID=43876468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534272A Ceased JP2013507442A (ja) | 2009-10-12 | 2010-10-12 | 組合せ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20120202822A1 (enExample) |
| EP (1) | EP2488184A4 (enExample) |
| JP (1) | JP2013507442A (enExample) |
| KR (1) | KR20120097496A (enExample) |
| CN (1) | CN102665720A (enExample) |
| AU (1) | AU2010307043C1 (enExample) |
| BR (1) | BR112012008519A2 (enExample) |
| CA (1) | CA2777561A1 (enExample) |
| EA (1) | EA020965B1 (enExample) |
| IL (1) | IL219103A0 (enExample) |
| MX (1) | MX2012004259A (enExample) |
| WO (1) | WO2011046894A1 (enExample) |
| ZA (1) | ZA201202416B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012068231A1 (en) * | 2010-11-16 | 2012-05-24 | Glaxosmithkline Llc | Method of administration and treatment |
| EP3574904A1 (en) * | 2012-08-07 | 2019-12-04 | Array Biopharma, Inc. | Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor |
| PT2884979T (pt) | 2012-08-17 | 2019-09-04 | Hoffmann La Roche | Terapêuticas combinadas para o melanoma, compreendendo a administração de cobimetinib e vemurafinib |
| CN103936728B (zh) * | 2013-01-18 | 2016-08-10 | 通化济达医药有限公司 | 噻唑激酶抑制剂 |
| CN103936730A (zh) * | 2013-01-22 | 2014-07-23 | 通化济达医药有限公司 | 苯磺酰胺噻唑激酶抑制剂 |
| CN103965180B (zh) * | 2013-01-24 | 2016-09-07 | 通化济达医药有限公司 | 苯磺酰胺噁唑和噻唑激酶抑制剂 |
| US20150352121A1 (en) * | 2013-03-12 | 2015-12-10 | Glaxosmithkline Llc | Combination |
| SG11201507730UA (en) | 2013-03-21 | 2015-10-29 | Novartis Ag | Combination therapy comprising a b-raf inhibitor and a second inhibitor |
| WO2015003571A1 (zh) * | 2013-07-08 | 2015-01-15 | 杭州普晒医药科技有限公司 | 达拉菲尼甲磺酸盐的新晶型及其制备方法 |
| EP3082957B1 (en) * | 2013-12-20 | 2022-04-06 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of pi3k/akt pathway and erk inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000042003A1 (en) * | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzenesulfonamide derivatives and their use as mek inhibitors |
| US7691377B2 (en) * | 2004-04-16 | 2010-04-06 | Rutgers, The State University Of New Jersey | Methods and compositions for treating melanoma |
| US8835473B2 (en) * | 2004-04-16 | 2014-09-16 | Rutgers, The State University Of New Jersey | Methods and compositions for treating cancer |
| EP1981884B1 (en) * | 2006-01-18 | 2012-06-13 | Amgen, Inc | Thiazole compounds as protein kinase b (pkb) inhibitors |
| PE20090717A1 (es) * | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| UA103319C2 (en) * | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
-
2010
- 2010-10-12 EP EP20100823916 patent/EP2488184A4/en not_active Withdrawn
- 2010-10-12 KR KR1020127011760A patent/KR20120097496A/ko not_active Withdrawn
- 2010-10-12 US US13/501,387 patent/US20120202822A1/en not_active Abandoned
- 2010-10-12 JP JP2012534272A patent/JP2013507442A/ja not_active Ceased
- 2010-10-12 CN CN2010800564396A patent/CN102665720A/zh active Pending
- 2010-10-12 MX MX2012004259A patent/MX2012004259A/es active IP Right Grant
- 2010-10-12 EA EA201270537A patent/EA020965B1/ru not_active IP Right Cessation
- 2010-10-12 AU AU2010307043A patent/AU2010307043C1/en not_active Ceased
- 2010-10-12 CA CA2777561A patent/CA2777561A1/en not_active Abandoned
- 2010-10-12 BR BR112012008519A patent/BR112012008519A2/pt not_active IP Right Cessation
- 2010-10-12 WO PCT/US2010/052242 patent/WO2011046894A1/en not_active Ceased
-
2012
- 2012-04-03 ZA ZA2012/02416A patent/ZA201202416B/en unknown
- 2012-04-05 IL IL219103A patent/IL219103A0/en unknown