JP2018502883A5 - - Google Patents
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- Publication number
- JP2018502883A5 JP2018502883A5 JP2017538593A JP2017538593A JP2018502883A5 JP 2018502883 A5 JP2018502883 A5 JP 2018502883A5 JP 2017538593 A JP2017538593 A JP 2017538593A JP 2017538593 A JP2017538593 A JP 2017538593A JP 2018502883 A5 JP2018502883 A5 JP 2018502883A5
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- group
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 37
- 238000000034 method Methods 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims 6
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims 6
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 206010071436 Systolic dysfunction Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 208000020446 Cardiac disease Diseases 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 2
- 229940125364 angiotensin receptor blocker Drugs 0.000 claims 2
- 239000002876 beta blocker Substances 0.000 claims 2
- 229940097320 beta blocking agent Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 208000038002 heart failure with reduced ejection fraction Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000001991 pathophysiological effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 125000004511 1,2,3-thiadiazolyl group Chemical group 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 1
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 claims 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 claims 1
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 1
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 claims 1
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 claims 1
- 102000003505 Myosin Human genes 0.000 claims 1
- 108060008487 Myosin Proteins 0.000 claims 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 1
- 239000000808 adrenergic beta-agonist Substances 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 230000008602 contraction Effects 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 229960001089 dobutamine Drugs 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 239000002308 endothelin receptor antagonist Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 229960003883 furosemide Drugs 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 208000038003 heart failure with preserved ejection fraction Diseases 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000004041 inotropic agent Substances 0.000 claims 1
- 125000004501 isothiazol-5-yl group Chemical group S1N=CC=C1* 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 229960003574 milrinone Drugs 0.000 claims 1
- PZRHRDRVRGEVNW-UHFFFAOYSA-N milrinone Chemical compound N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C PZRHRDRVRGEVNW-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 230000002644 neurohormonal effect Effects 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 239000002461 renin inhibitor Substances 0.000 claims 1
- 229940086526 renin-inhibitors Drugs 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
- 0 *C(*)(C(*)(CC1)CCN1C(N[Al]I)=O)S([Al]*)(=O)=O Chemical compound *C(*)(C(*)(CC1)CCN1C(N[Al]I)=O)S([Al]*)(=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562106571P | 2015-01-22 | 2015-01-22 | |
| US62/106,571 | 2015-01-22 | ||
| PCT/US2016/014365 WO2016118774A1 (en) | 2015-01-22 | 2016-01-21 | 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502883A JP2018502883A (ja) | 2018-02-01 |
| JP2018502883A5 true JP2018502883A5 (enExample) | 2019-02-28 |
| JP6712275B2 JP6712275B2 (ja) | 2020-06-17 |
Family
ID=55275230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538593A Active JP6712275B2 (ja) | 2015-01-22 | 2016-01-21 | 拡張型心筋症（ｄｃｍ）の処置のための４−メチルスルホニル置換ピペリジンウレア化合物 |
Country Status (36)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10758525B2 (en) | 2015-01-22 | 2020-09-01 | MyoKardia, Inc. | 4-methylsulfonyl-substituted piperidine urea compounds |
| PE20200924A1 (es) | 2017-09-13 | 2020-09-14 | Amgen Inc | Compuestos de bisamida sustituida que activan el sarcomero cardiaco |
| HUE067913T2 (hu) | 2018-01-19 | 2024-11-28 | Cytokinetics Inc | Dihidrobenzofurán és indén analógok mint szív szarkomer gátlók |
| MY209060A (en) | 2018-02-01 | 2025-06-18 | Myokardia Inc | Pyrazole compounds and preparation thereof |
| US12187712B2 (en) | 2018-06-26 | 2025-01-07 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| JP7438148B2 (ja) | 2018-06-26 | 2024-02-26 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| GB201813312D0 (en) | 2018-08-15 | 2018-09-26 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| MA53491A (fr) | 2018-08-31 | 2021-09-15 | Cytokinetics Inc | Inhibiteurs de sarcomes cardiaques |
| GB201905520D0 (en) | 2019-04-18 | 2019-06-05 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| BR112021023074A2 (pt) * | 2019-05-19 | 2022-03-29 | Myokardia Inc | Tratamento de disfunção sistólica e insuficiência cardíaca com fração de ejeção reduzida com o composto (r)-4-(l-(1-((3-(difluorometil)-l--1-metil-1h-pirazol-4-il)sulfonil)-l-1-fluoroetil)-n-(isoxazol-3-il)piperidina-l-1-carboxamida |
| WO2021011586A1 (en) * | 2019-07-16 | 2021-01-21 | MyoKardia, Inc. | Polymorphic forms of (r)-4-(1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-n-(isoxazol-3-yl)piperidine-1-carboxamide |
| CN110407744A (zh) * | 2019-08-13 | 2019-11-05 | 上海毕得医药科技有限公司 | 一种1-(4-氨基吡啶-2-基)乙酮的合成方法 |
| EP4146626A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent, Inc. | CHEMOTHERAPEUTIC AGENTS BASED ON HETEROAROMATIC MACROCYCLIC ETHERS |
| PH12022552787A1 (en) | 2020-05-05 | 2024-03-25 | Nuvalent Inc | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| WO2021257456A1 (en) * | 2020-06-15 | 2021-12-23 | MyoKardia, Inc. | Treatment of atrial dysfunction |
| KR102541297B1 (ko) | 2020-08-18 | 2023-06-09 | 가톨릭대학교 산학협력단 | 확장성 심근병 모델 및 이의 제조방법 |
| CN117083275A (zh) | 2021-03-04 | 2023-11-17 | 赛特凯恩蒂克公司 | 心脏肌节抑制剂 |
| CA3231813A1 (en) | 2021-10-01 | 2023-04-06 | Sibao CHEN | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
| CN116082326B (zh) * | 2022-12-16 | 2024-12-27 | 药康众拓(江苏)医药科技有限公司北京分公司 | 一种氘代吡唑磺酰甲基-哌啶异噁唑脲类化合物及其用途 |
| WO2025244956A1 (en) | 2024-05-20 | 2025-11-27 | MyoKardia, Inc. | Methods of manufacturing danicamtiv |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050250789A1 (en) | 2004-04-20 | 2005-11-10 | Burns David M | Hydroxamic acid derivatives as metalloprotease inhibitors |
| US7507735B2 (en) * | 2004-06-17 | 2009-03-24 | Cytokinetics, Inc. | Compounds, compositions and methods |
| WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| US8324178B2 (en) * | 2008-10-31 | 2012-12-04 | The Regents Of The University Of California | Method of treatment using alpha-1-adrenergic agonist compounds |
| US8598356B2 (en) * | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| MX2012005426A (es) * | 2009-11-11 | 2012-06-19 | Dainippon Sumitomo Pharma Co | Derivado de 8-azabiciclo[3.2.1]octan-8-carboxamida. |
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2016
- 2016-01-21 CN CN202010152637.8A patent/CN111393414B/zh active Active
- 2016-01-21 SG SG11201705928XA patent/SG11201705928XA/en unknown
- 2016-01-21 IL IL313678A patent/IL313678A/en unknown
- 2016-01-21 SG SG10201913047UA patent/SG10201913047UA/en unknown
- 2016-01-21 MY MYPI2017702553A patent/MY203427A/en unknown
- 2016-01-21 PH PH1/2017/501279A patent/PH12017501279B1/en unknown
- 2016-01-21 HU HUE16702652A patent/HUE063410T2/hu unknown
- 2016-01-21 MX MX2021010778A patent/MX394704B/es unknown
- 2016-01-21 EP EP23170487.5A patent/EP4234017A3/en active Pending
- 2016-01-21 CA CA2974370A patent/CA2974370C/en active Active
- 2016-01-21 MX MX2017009540A patent/MX385960B/es unknown
- 2016-01-21 KR KR1020177022900A patent/KR102585550B1/ko active Active
- 2016-01-21 HR HRP20230737TT patent/HRP20230737T1/hr unknown
- 2016-01-21 EP EP16702652.5A patent/EP3247707B1/en active Active
- 2016-01-21 LT LTEPPCT/US2016/014365T patent/LT3247707T/lt unknown
- 2016-01-21 EA EA201791656A patent/EA036923B1/ru not_active IP Right Cessation
- 2016-01-21 PE PE2017001241A patent/PE20171511A1/es unknown
- 2016-01-21 KR KR1020247024828A patent/KR20240119163A/ko active Pending
- 2016-01-21 CN CN201680017126.7A patent/CN107428719B/zh active Active
- 2016-01-21 PL PL16702652.5T patent/PL3247707T3/pl unknown
- 2016-01-21 PH PH1/2021/553074A patent/PH12021553074A1/en unknown
- 2016-01-21 IL IL295547A patent/IL295547A/en unknown
- 2016-01-21 FI FIEP16702652.5T patent/FI3247707T3/fi active
- 2016-01-21 SI SI201631723T patent/SI3247707T1/sl unknown
- 2016-01-21 SM SM20230259T patent/SMT202300259T1/it unknown
- 2016-01-21 US US15/003,662 patent/US9925177B2/en active Active
- 2016-01-21 DK DK16702652.5T patent/DK3247707T3/da active
- 2016-01-21 PT PT167026525T patent/PT3247707T/pt unknown
- 2016-01-21 CR CR20170370A patent/CR20170370A/es unknown
- 2016-01-21 UA UAA201708527A patent/UA119905C2/uk unknown
- 2016-01-21 ES ES16702652T patent/ES2953480T3/es active Active
- 2016-01-21 PE PE2021001384A patent/PE20212253A1/es unknown
- 2016-01-21 RS RS20230542A patent/RS64432B1/sr unknown
- 2016-01-21 JP JP2017538593A patent/JP6712275B2/ja active Active
- 2016-01-21 BR BR112017015627-0A patent/BR112017015627B1/pt active IP Right Grant
- 2016-01-21 MX MX2022007040A patent/MX2022007040A/es unknown
- 2016-01-21 WO PCT/US2016/014365 patent/WO2016118774A1/en not_active Ceased
- 2016-01-21 AU AU2016209200A patent/AU2016209200B2/en active Active
- 2016-01-21 KR KR1020237033324A patent/KR102688851B1/ko active Active
- 2016-01-21 TN TNP/2017/000320A patent/TN2017000320A1/en unknown
- 2016-01-21 CN CN202410163448.9A patent/CN118164961A/zh active Pending
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2017
- 2017-07-14 ZA ZA2017/04777A patent/ZA201704777B/en unknown
- 2017-07-18 IL IL253552A patent/IL253552B/en active IP Right Grant
- 2017-07-19 DO DO2017000166A patent/DOP2017000166A/es unknown
- 2017-07-20 GT GT201700163A patent/GT201700163A/es unknown
- 2017-07-20 CL CL2017001871A patent/CL2017001871A1/es unknown
- 2017-08-17 CO CONC2017/0008398A patent/CO2017008398A2/es unknown
- 2017-08-21 EC ECIEPI201754181A patent/ECSP17054181A/es unknown
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2019
- 2019-11-28 IL IL271034A patent/IL271034A/en active IP Right Grant
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2020
- 2020-09-30 AU AU2020244490A patent/AU2020244490B2/en active Active
- 2020-12-06 IL IL279247A patent/IL279247A/en unknown
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2021
- 2021-09-13 IL IL286369A patent/IL286369A/en unknown
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2022
- 2022-08-24 DO DO2022000172A patent/DOP2022000172A/es unknown
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2023
- 2023-01-24 AU AU2023200361A patent/AU2023200361B2/en active Active
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2024
- 2024-11-21 AU AU2024266781A patent/AU2024266781A1/en active Pending
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