DK3247707T3 - 4-methylsulfonyl-substituerede piperidin urea-forbindelser, nyttige til behandling af hjertelidelser som dilateret kardiomyopati (dcm) - Google Patents
4-methylsulfonyl-substituerede piperidin urea-forbindelser, nyttige til behandling af hjertelidelser som dilateret kardiomyopati (dcm) Download PDFInfo
- Publication number
- DK3247707T3 DK3247707T3 DK16702652.5T DK16702652T DK3247707T3 DK 3247707 T3 DK3247707 T3 DK 3247707T3 DK 16702652 T DK16702652 T DK 16702652T DK 3247707 T3 DK3247707 T3 DK 3247707T3
- Authority
- DK
- Denmark
- Prior art keywords
- dcm
- treatment
- compounds useful
- dilated cardiomyopathy
- urea compounds
- Prior art date
Links
- 206010056370 Congestive cardiomyopathy Diseases 0.000 title 2
- 201000010046 Dilated cardiomyopathy Diseases 0.000 title 2
- 208000019622 heart disease Diseases 0.000 title 1
- MSCIISHDSZZFEH-UHFFFAOYSA-N piperidine;urea Chemical class NC(O)=N.C1CCNCC1 MSCIISHDSZZFEH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562106571P | 2015-01-22 | 2015-01-22 | |
| PCT/US2016/014365 WO2016118774A1 (en) | 2015-01-22 | 2016-01-21 | 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3247707T3 true DK3247707T3 (da) | 2023-07-03 |
Family
ID=55275230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16702652.5T DK3247707T3 (da) | 2015-01-22 | 2016-01-21 | 4-methylsulfonyl-substituerede piperidin urea-forbindelser, nyttige til behandling af hjertelidelser som dilateret kardiomyopati (dcm) |
Country Status (36)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10758525B2 (en) * | 2015-01-22 | 2020-09-01 | MyoKardia, Inc. | 4-methylsulfonyl-substituted piperidine urea compounds |
| MA50173A (fr) | 2017-09-13 | 2020-07-29 | Amgen Inc | Composés activateurs de bisamide sarcomère et leurs utilisations |
| MX2020007532A (es) | 2018-01-19 | 2020-09-09 | Cytokinetics Inc | Inhibidores de sarcomero cardiaco. |
| IL276410B2 (en) | 2018-02-01 | 2024-09-01 | Myokardia Inc | Pyrazole compounds and preparation thereof |
| JP7610985B2 (ja) | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| US11964967B2 (en) | 2018-06-26 | 2024-04-23 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| GB201813312D0 (en) | 2018-08-15 | 2018-09-26 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| CN118955409A (zh) | 2018-08-31 | 2024-11-15 | 赛特凯恩蒂克公司 | 心脏肌小节抑制剂 |
| GB201905520D0 (en) | 2019-04-18 | 2019-06-05 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| CA3138080A1 (en) * | 2019-05-19 | 2020-11-26 | Jean-Francois TAMBY | Treatment of systolic dysfunction and heart failure with reduced ejection fraction with the compound(r)-4-(1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl) n-(isoxazol-3-yl)piperidine-1-carboxamid |
| TW202116765A (zh) | 2019-07-16 | 2021-05-01 | 美商邁奧卡迪亞公司 | (r)-4-(1-((3-(二氟甲基)-1-甲基-1h-吡唑-4-基)磺醯基)-1-氟乙基)-n-(異噁唑-3-基)哌啶-1-甲醯胺之多晶型物形式 |
| CN110407744A (zh) * | 2019-08-13 | 2019-11-05 | 上海毕得医药科技有限公司 | 一种1-(4-氨基吡啶-2-基)乙酮的合成方法 |
| PE20230608A1 (es) | 2020-05-05 | 2023-04-13 | Nuvalent Inc | Quimioterapicos de eter macrociclico heteroaromatico |
| EP4146205A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent, Inc. | HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS |
| BR112022025551A2 (pt) * | 2020-06-15 | 2023-03-07 | Myokardia Inc | Tratamento de disfunção atrial |
| KR102541297B1 (ko) | 2020-08-18 | 2023-06-09 | 가톨릭대학교 산학협력단 | 확장성 심근병 모델 및 이의 제조방법 |
| JP2024508526A (ja) | 2021-03-04 | 2024-02-27 | サイトキネティックス， インコーポレイテッド | 心筋サルコメア阻害剤 |
| CN118234725A (zh) | 2021-10-01 | 2024-06-21 | 纽威伦特公司 | 杂芳族大环醚化合物的固体形式、药物组合物及制备 |
| CN116082326B (zh) * | 2022-12-16 | 2024-12-27 | 药康众拓(江苏)医药科技有限公司北京分公司 | 一种氘代吡唑磺酰甲基-哌啶异噁唑脲类化合物及其用途 |
| WO2025244956A1 (en) | 2024-05-20 | 2025-11-27 | MyoKardia, Inc. | Methods of manufacturing danicamtiv |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117882A2 (en) * | 2004-04-20 | 2005-12-15 | Incyte Corporation | Hydroxamic acid derivatives as metalloprotease inhibitors |
| RS53600B1 (sr) * | 2004-06-17 | 2015-02-27 | Cytokinetics, Inc. | Jedinjenja, preparati i metode |
| US20090069288A1 (en) * | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
| US8324178B2 (en) * | 2008-10-31 | 2012-12-04 | The Regents Of The University Of California | Method of treatment using alpha-1-adrenergic agonist compounds |
| WO2010068452A1 (en) * | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| US8933229B2 (en) * | 2009-11-11 | 2015-01-13 | Sumitomo Dainippon Pharma Co., Ltd. | 8-azabicyclo[3.2.1]octane-8-carboxamide derivative |
-
2016
- 2016-01-21 HR HRP20230737TT patent/HRP20230737T1/hr unknown
- 2016-01-21 US US15/003,662 patent/US9925177B2/en active Active
- 2016-01-21 MX MX2022007040A patent/MX2022007040A/es unknown
- 2016-01-21 KR KR1020247024828A patent/KR20240119163A/ko active Pending
- 2016-01-21 KR KR1020177022900A patent/KR102585550B1/ko active Active
- 2016-01-21 EP EP23170487.5A patent/EP4234017A3/en active Pending
- 2016-01-21 AU AU2016209200A patent/AU2016209200B2/en active Active
- 2016-01-21 SG SG11201705928XA patent/SG11201705928XA/en unknown
- 2016-01-21 PT PT167026525T patent/PT3247707T/pt unknown
- 2016-01-21 PH PH1/2017/501279A patent/PH12017501279B1/en unknown
- 2016-01-21 CN CN202410163448.9A patent/CN118164961A/zh active Pending
- 2016-01-21 EA EA201791656A patent/EA036923B1/ru not_active IP Right Cessation
- 2016-01-21 UA UAA201708527A patent/UA119905C2/uk unknown
- 2016-01-21 CN CN201680017126.7A patent/CN107428719B/zh active Active
- 2016-01-21 EP EP16702652.5A patent/EP3247707B1/en active Active
- 2016-01-21 MX MX2017009540A patent/MX385960B/es unknown
- 2016-01-21 PE PE2021001384A patent/PE20212253A1/es unknown
- 2016-01-21 TN TNP/2017/000320A patent/TN2017000320A1/en unknown
- 2016-01-21 PL PL16702652.5T patent/PL3247707T3/pl unknown
- 2016-01-21 SI SI201631723T patent/SI3247707T1/sl unknown
- 2016-01-21 JP JP2017538593A patent/JP6712275B2/ja active Active
- 2016-01-21 MX MX2021010778A patent/MX394704B/es unknown
- 2016-01-21 PH PH1/2021/553074A patent/PH12021553074A1/en unknown
- 2016-01-21 BR BR112017015627-0A patent/BR112017015627B1/pt active IP Right Grant
- 2016-01-21 SG SG10201913047UA patent/SG10201913047UA/en unknown
- 2016-01-21 MY MYPI2017702553A patent/MY203427A/en unknown
- 2016-01-21 FI FIEP16702652.5T patent/FI3247707T3/fi active
- 2016-01-21 IL IL295547A patent/IL295547A/en unknown
- 2016-01-21 KR KR1020237033324A patent/KR102688851B1/ko active Active
- 2016-01-21 RS RS20230542A patent/RS64432B1/sr unknown
- 2016-01-21 LT LTEPPCT/US2016/014365T patent/LT3247707T/lt unknown
- 2016-01-21 CR CR20170370A patent/CR20170370A/es unknown
- 2016-01-21 IL IL313678A patent/IL313678A/en unknown
- 2016-01-21 CN CN202010152637.8A patent/CN111393414B/zh active Active
- 2016-01-21 ES ES16702652T patent/ES2953480T3/es active Active
- 2016-01-21 DK DK16702652.5T patent/DK3247707T3/da active
- 2016-01-21 PE PE2017001241A patent/PE20171511A1/es unknown
- 2016-01-21 WO PCT/US2016/014365 patent/WO2016118774A1/en not_active Ceased
- 2016-01-21 HU HUE16702652A patent/HUE063410T2/hu unknown
- 2016-01-21 CA CA2974370A patent/CA2974370C/en active Active
- 2016-01-21 SM SM20230259T patent/SMT202300259T1/it unknown
-
2017
- 2017-07-14 ZA ZA2017/04777A patent/ZA201704777B/en unknown
- 2017-07-18 IL IL253552A patent/IL253552B/en active IP Right Grant
- 2017-07-19 DO DO2017000166A patent/DOP2017000166A/es unknown
- 2017-07-20 GT GT201700163A patent/GT201700163A/es unknown
- 2017-07-20 CL CL2017001871A patent/CL2017001871A1/es unknown
- 2017-08-17 CO CONC2017/0008398A patent/CO2017008398A2/es unknown
- 2017-08-21 EC ECIEPI201754181A patent/ECSP17054181A/es unknown
-
2019
- 2019-11-28 IL IL271034A patent/IL271034A/en active IP Right Grant
-
2020
- 2020-09-30 AU AU2020244490A patent/AU2020244490B2/en active Active
- 2020-12-06 IL IL279247A patent/IL279247A/en unknown
-
2021
- 2021-09-13 IL IL286369A patent/IL286369A/en unknown
-
2022
- 2022-08-24 DO DO2022000172A patent/DOP2022000172A/es unknown
-
2023
- 2023-01-24 AU AU2023200361A patent/AU2023200361B2/en active Active
-
2024
- 2024-11-21 AU AU2024266781A patent/AU2024266781A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3247707T3 (da) | 4-methylsulfonyl-substituerede piperidin urea-forbindelser, nyttige til behandling af hjertelidelser som dilateret kardiomyopati (dcm) | |
| DK3577110T3 (da) | 8-oxetan-3-yl-3,8-diazabicyclo[3.2.1]octan-3-yl-substituerede forbindelser som hiv-inhibitorer | |
| IL256898A (en) | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors | |
| HUE053819T2 (hu) | Ciklikus dinukleotid-vegyületek | |
| DK3341355T3 (da) | (s)-3-amino-4-(difluormethylenyl)cyclopent-1-en-1-carboxylsyre og tilhørende forbindelser som gaba-aminotransferaseinaktivatorer til behandling af epilepsi, afhængighed og hepatocellulært karcinom | |
| DK3513809T3 (da) | Medicinsk sammensætning, som omfatter tivozanib | |
| DK3407888T3 (da) | Pyridopyrroloquinoxalinforbindelser, deres sammensætninger og anvendelser | |
| LT3159409T (lt) | Antiprasminė nukleorūgštis, skirta panaudoti diušeno raumenų distrofijos gydymui | |
| EP2970306A4 (en) | SUBSTITUTED 6.5-CONDENSED BICYCLIC HETEROARYL COMPOUNDS | |
| DK3297605T3 (da) | Topiske, farmaceutiske sammesætninger | |
| DK3497081T3 (da) | Fremgangsmåde til fremstilling af 4-ammonium-2,2,6,6-tetraalkylpiperidinylsalte | |
| EP2681216A4 (en) | SUBSTITUTED 6.5-CONDENSED BICYCLIC HETEROARYL COMPOUNDS | |
| DK3230278T3 (da) | Hidtil ukendte methyl-piperidin-forbindelser, som er anvendelige til inhibering af mikrosomale prostaglandin-e2-syntase-1 | |
| DK2935303T3 (da) | 4`-fluornukleosider, 4`-fluornukleotider og analoger dertil til behandling af HCV | |
| DK3308688T3 (da) | Opvaskemaskine i form af en kommerciel bestikopvaskemaskine eller opvaskemaskine, designet som en batch-opvaskemaskine | |
| DK3099333T3 (da) | Bag3 som mål for behandling af hjertesvigt | |
| EP3494119A4 (en) | CONNECTIONS AND COMPOSITIONS AND USES THEREOF | |
| DK3524255T3 (da) | Sammensætning til behandling af acne | |
| DK3355329T3 (da) | Metode til fremstilling af lithium-ion-kondensator og kondensator som opnås med den nævnte metode | |
| DK3242957T3 (da) | Bakterieholdige sammensætninger og fremgangsmåder til anvendelse af samme til behandling og/eller forebyggelse af gastrointestinale, metaboliske og/eller andre sygdomme | |
| EA201300946A1 (ru) | Асимметричные мочевины и их медицинское применение | |
| HUE052833T2 (hu) | Eljárás 2,5-furándikarbonsav (FDCA) elõállítására | |
| EP3552017A4 (en) | CONNECTIONS, COMPOSITIONS AND METHODS | |
| DK3662925T3 (da) | Sammensætning, der omfatter fsh, til behandling af infertilitet | |
| HUE053263T2 (hu) | Több elársztott mosófejjel ellátott, többszintes gázmosó |